Ammad Shaukat, Mahnoor Hussain Bakhtiari, Daim Shiraz Chaudhry, Muhammad Haider Farooq Khan, Jawad Akhtar, Ahmed Hassan Abro, Muhammad Abdul Haseeb, Aaminah Sarwar, Khalida Mazhar, Zain Umer, Muhammad Tariq
The Trithorax group (trxG) proteins counteract the repressive effect of Polycomb group (PcG) complexes and maintain transcriptional memory of active states of key developmental genes. Although chromatin structure and modifications appear to play a fundamental role in this process, it is not clear how trxG prevents PcG-silencing and heritably maintains an active gene expression state. Here, we report a hitherto unknown role of Drosophila Multiple ankyrin repeats single KH domain (Mask), which emerged as one of the candidate trxG genes in our reverse genetic screen...
November 17, 2023: Developmental Biology