journal
https://read.qxmd.com/read/38372674/microbiome-analyses-in-chronic-rhinosinusitis
#1
JOURNAL ARTICLE
T Smulders, S Reitsma, C M van Drunen
In this edition of Rhinology we feature the work of Connell and colleagues from Australia on chronic rhinosinusitis that describes an interesting new pipeline to characterize the bacterial composition of microbiota. We are constantly exposed to a multitude of micro-organisms in the environment and our immune system has the important task discerning and fighting off potential threats. In most people the immune system is doing its job properly and prevents anything untoward from happening. On occasion, a microbe slips by the first (innate) level of defense and we might suffer from an infection...
February 19, 2024: Rhinology
https://read.qxmd.com/read/38372647/nasal-hyperreactivity-in-allergic-rhinitis-and-chronic-rhinosinusitis-with-polyps-a-role-for-neuronal-pathways
#2
JOURNAL ARTICLE
W Backaert, B Steelant, T Wils, Z Qian, E Dilissen, A-C Jonckheere, B Boonen, M Jorissen, R Schrijvers, M A Bullens, K Talavera, P W Hellings, L Van Gerven
BACKGROUND: Nasal hyperreactivity (NHR) is prevalent in all chronic upper airway inflammatory phenotypes, including allergic rhinitis (AR) and chronic rhinosinusitis with nasal polyps (CRSwNP). Although NHR in patients with non-allergic rhinitis is mediated by neuronal pathways, AR and CRSwNP are mainly characterized by type 2 inflammation. METHODS: Eighteen healthy controls and 45 patients with symptomatic AR/CRSwNP underwent a cold, dry air (CDA) provocation test for objective diagnosis of NHR...
February 19, 2024: Rhinology
https://read.qxmd.com/read/38353499/prelacrimal-window-approach-to-the-maxillary-sinus-a-systematic-review-and-meta-analysis-of-the-literature
#3
JOURNAL ARTICLE
A Machado, J Pereira, F Alvarez, H R Briner, D Simmen
BACKGROUND: The prelacrimal window approach (PLWA) is a minimally invasive surgical technique that has been proposed as an alternative to the traditional approaches to access the maxillary sinus. METHODOLOGY: A systematic review with meta-analysis was performed following PRISMA guidelines and identified 368 articles for initial review of which 14 (610 participants) met the criteria for meta-analysis. Four databases, including PubMed, Google Scholar, Web of Science and Scopus, were searched to identify relevant articles...
February 14, 2024: Rhinology
https://read.qxmd.com/read/38299637/low-levels-of-mir-143-3p-are-associated-with-severe-chronic-rhinosinusitis-with-nasal-polyps
#4
JOURNAL ARTICLE
V Tubita, M Fuentes, B Callejas, M Bantulà, C Marin, I Alobid, J Bartra, A Valero, J Roca-Ferrer, J Mullol
microRNAs (miRNAs) are small, single-stranded, non-coding RNA molecules that regulate post-transcriptional gene expression. Accumulating evidence suggests their involvement in regulating various biological and pathological processes, including inflammation. Studies have revealed distinct expression patterns of miRNAs in Chronic Rhinosinusitis with (CRSwNP) and without (CRSsNP) nasal polyps (1). Specifically, miR-155 and miR-21 have been observed to be upregulated in CRSwNP, increasing and attenuating the expression of pro-inflammatory cytokines, respectively (2,3)...
February 1, 2024: Rhinology
https://read.qxmd.com/read/38217847/two-year-outcomes-of-radiofrequency-device-treatment-of-the-nasal-valve-for-nasal-airway-obstruction
#5
JOURNAL ARTICLE
S L Silvers, C M McDuffie, D M Yen, J N Rosenthal, S E Davis, J K Han
BACKGROUND: Temperature-controlled radiofrequency (TCRF) device treatment of nasal valve dysfunction (NVD) was superior to a sham procedure control in reducing the symptoms of nasal airway obstruction (NAO) in this randomised controlled trial (RCT). METHODOLOGY: Two-year outcomes for 108 patients actively treated in a prospective, multicenter, patient-blinded RCT were used to determine treatment effect durability and changes in medication/nasal dilator usage. A responder was defined as ≥20% reduction in NOSE score or ≥1 reduction in severity class...
January 13, 2024: Rhinology
https://read.qxmd.com/read/38217844/mepolizumab-improves-sense-of-smell-in-severe-chronic-rhinosinusitis-with-nasal-polyps-synapse
#6
JOURNAL ARTICLE
J Mullol, V J Lund, M Wagenmann, J K Han, A N Sousa, S G Smith, B Mayer, R H Chan, W J Fokkens
BACKGROUND: Loss of smell is one of the most bothersome and difficult-to-treat symptoms in patients with severe chronic rhinosinusitis with nasal polyps (CRSwNP). METHODOLOGY: SYNAPSE was a 52-week Phase III study of 4-weekly mepolizumab (100 mg subcutaneously) plus standard of care in adults with severe bilateral CRSwNP. This post hoc analysis assessed changes from baseline to study end in loss of smell visual analogue scale (VAS) symptom score, in patients stratified by several baseline clinical characteristics...
January 13, 2024: Rhinology
https://read.qxmd.com/read/38217624/comparison-of-nasal-valve-dysfunction-treatment-outcomes-for-temperature-controlled-radiofrequency-and-functional-rhinoplasty-surgery-a-systematic-review-and-meta-analyses
#7
REVIEW
J K Han, J Perkins, D Lerner, M T Yim, L E Ishii
BACKGROUND: Nasal valve dysfunction (NVD) is a substantial contributor to nasal airway obstruction. Minimally-invasive temp-erature-controlled radiofrequency (TCRF) treatment of the nasal valve is available and comparison with surgical techniques is warranted. METHODOLOGY: Databases: Medline (PubMed), Embase, Cochrane Library. POPULATION: adults with preprocedural nasal obstruction symptom evaluation (NOSE) score ≥45. Treatment effects were derived from a random effects model and reported as weighted mean difference in NOSE score between baseline; 3, 6, and 12 months postprocedure...
January 13, 2024: Rhinology
https://read.qxmd.com/read/38217529/epos2020-euforea-expert-opinion-on-defining-disease-states-and-therapeutic-goals-in-crswnp
#8
JOURNAL ARTICLE
W J Fokkens, E De Corso, V Backer, M Bernal-Sprekelsen, L Bjermer, C von Buchwald, A Chaker, Z Diamant, P Gevaert, J Han, C Hopkins, V Hox, L Klimek, V J Lund, S Lee, A Luong, J Mullol, A Peters, O Pfaar, S Reitsma, S Toppila-Salmi, G K Scadding, A R Sedaghat, A-S Viskens, M Wagenmann, P W Hellings
Severe chronic rhinosinusitis with nasal polyps (CRSwNP), a form of diffuse bilateral (usually type 2) CRS, is a debilitating disease with a significant impact on quality of life (QoL). With novel knowledge and treatment options becoming available, there is a growing need to update or revise key definitions to enable communication across different specialties dealing with CRS, and to agree on novel goals of care in CRSwNP. The European Forum for Research and Education in Allergy and Airway diseases (EUFOREA) and EPOS expert members discussed how to measure treatment responses and set new treatment goals for CRSwNP...
January 13, 2024: Rhinology
https://read.qxmd.com/read/38189590/diagnostic-value-of-serum-squamous-cell-carcinoma-antigen-and-cytokeratin-fragment-antigen-21-1-for-sinonasal-inverted-papilloma-an-exploratory-study
#9
JOURNAL ARTICLE
Z Zhang, B Xu, L Wang, X Yan, S Li, Y Jiang, L Yu
BACKGROUND: Serum tumor markers have not yet been developed for the clinical diagnosis and treatment of sinonasal inverted papilloma (SNIP), one of the most significant sinonasal tumors. Therefore, this study aimed to determine the diagnostic value of serum squamous cell carcinoma antigen (SCCA) and cytokeratin fragment antigen 21-1 (CYFRA 21-1) for SNIP. METHODS: Clinical data were obtained from 101, 56, and 116 patients with SNIP, sinonasal squamous cell carcinoma (SNSCC), and unilateral chronic rhinosinusitis (CRS), respectively...
January 8, 2024: Rhinology
https://read.qxmd.com/read/38189480/clinical-and-technical-factors-in-endoscopic-skull-base-surgery-associated-with-reconstructive-success
#10
JOURNAL ARTICLE
A Abiri, B F Bitner, T V Nguyen, J C Pang, K M Roman, M Vasudev, D D Chung, S H Tripathi, J C Harris, N Kosaraju, R M Shih, M Ko, J E Miller, J E Douglas, D J Lee, J G Eide, R S Kshirsagar, K M Phillips, A R Sedaghat, M Bergsneider, M B Wang, J N Palmer, N D Adappa, F P K Hsu, E C Kuan
BACKGROUND: In this study, we identified key discrete clinical and technical factors that may correlate with primary reconstructive success in endoscopic skull base surgery (ESBS). METHODS: ESBS cases with intraoperative cerebrospinal fluid (CSF) leaks at four tertiary academic rhinology programs were retrospectively reviewed. Logistic regression identified factors associated with surgical outcomes by defect subsite (anterior cranial fossa [ACF], suprasellar [SS], purely sellar, posterior cranial fossa [PCF])...
January 8, 2024: Rhinology
https://read.qxmd.com/read/38165680/microrna-150-5p-regulates-th1-th2-cytokines-expression-levels-by-targeting-egr2-in-allergic-rhinitis
#11
JOURNAL ARTICLE
H Jiang, H Feng, L Zhu, X Li, Z Ma
BACKGROUND: MiR-150-5p is one of the miRNAs in the expression profile of miRNAs, and in many previous studies, it has been shown that miR-150-5p may play an important role in peripheral blood dendritic cells (DCs) of allergic rhinitis (AR) patients. We sought to investigate the role and mechanism of miR-150-5p in regulating DC function by modulating EGR2 and influencing T cell derivation to promote AR development. METHODS: The expression of miR-150-5p and EGR2 in AR patients was examined by real-time quantitative polymerase chain reaction (qRT-PCR), the expression of IL-4 cytokines in the supernatant of AR patients was tested by enzyme-linked immunosorbent assay (ELISA), and the expression of eosinophils in the supernatant of AR patients was measured by HE staining...
January 2, 2024: Rhinology
https://read.qxmd.com/read/38165666/enhanced-phylogenetic-insights-into-the-microbiome-of-chronic-rhinosinusitis-through-the-novel-application-of-long-read-16s-rrna-gene-amplicon-sequencing
#12
JOURNAL ARTICLE
J T Connell, K Yeo, G Bouras, A Bassiouni, K Fenix, C Cooksley, S Vreugde, P J Wormald, A J Psaltis
INTRODUCTION: 16S rRNA next generation sequencing (NGS) has been the de facto standard of microbiome profiling. A limitation of this technology is the inability to accurately assign taxonomy to a species order. Long read 16S sequencing platforms, including Oxford Nanopore Technologies (ONT), have the potential to overcome this limitation. The paranasal sinuses are an ideal niche to apply this technology, being a low biomass environment where bacteria are implicated in disease propagation...
January 2, 2024: Rhinology
https://read.qxmd.com/read/38088419/continuous-investigation-of-the-nasal-cycle-over-48-hours
#13
JOURNAL ARTICLE
J Lindemann, M O Scheithauer, F Sommer, T K Hoffmann, J Hahn, J Foerg
BACKGROUND: Previous results on the nasal cycle refer to measurements over up to 24h. The long-term rhinoflowmetry (LRFM) allows continuous observations over a longer period. The aim of the study was to observe the nasal cycle for the first time over 48h under everyday conditions. METHODOLOGY: The LRFM was continuously applied to 30 rhinologically healthy subjects (20 female, 10 male) over 48h. The different types of nasal cycle were classified as follows: "classic", "in concert", "one-sided", "no-cycle" and "mixed"...
December 13, 2023: Rhinology
https://read.qxmd.com/read/38085113/impaired-local-vitamin-d3-metabolism-contributes-to-il-36g-overproduction-in-epithelial-cells-in-chronic-rhinosinusitis-with-nasal-polyps
#14
JOURNAL ARTICLE
Q Xiao, H Wang, J Song, Z-Y Qin, L Pan, B Liao, Y-K Deng, J Ma, J-X Liu, J Hu, P Gao, R P Schleimer, Z Liu
BACKGROUND: Vitamin D (VD) possesses immunomodulatory properties, but its role in chronic rhinosinusitis with nasal polyps (CRSwNP) remains poorly studied. Herein, we aim to explore the regulation and function of VD3 in CRSwNP. METHODS: 25-hydroxyvitamin D3 (25VD3) levels in serum and tissue lysates were detected by ELISA. The expression of VD receptor (VDR) and cytochrome P450 family 27 subfamily B member 1 (CYP27B1), the enzyme that converts 25VD3 to the active 1,25-hydroxyvitamin D3 (1,25VD3), and their expression regulation in human nasal epithelial cells (HNECs) were studied by RT-PCR, western blotting, immunofluorescence, and flow cytometry...
December 12, 2023: Rhinology
https://read.qxmd.com/read/38078376/strategies-for-patients-with-recurrent-nasopharyngeal-carcinoma-involved-internal-carotid-artery-who-are-intolerant-to-embolization
#15
JOURNAL ARTICLE
W-B Wu, X-B Zhang, Z-K Feng, H-F Li, Y-P Liu, J-L Liang, Y-L Xie, Y-J Hua, R Sun, S-L Wang, J-H Chen, M-Y Chen
BACKGROUND: The surgical treatment of recurrent nasopharyngeal carcinoma (rNPC) involving the internal carotid artery (ICA) is challenging, as the massive bleeding caused by intraoperative rupture of the ICA is life-threatening. We reported that ICA embolization is an effective pretreatment to avoid fatal bleeding, but some patients cannot tolerate the procedure. We used endovascular vascular protection (ICA stents), vascular sacrifice (bypass grafting) and extravascular vascular protection (transcervical external stent placement) of the ICA to provide alternative options for these patients...
December 11, 2023: Rhinology
https://read.qxmd.com/read/38073582/aetiology-of-cerebrospinal-fluid-rhinorrhoea-in-a-dutch-retrospective-cohort-from-two-tertiary-referral-centres
#16
JOURNAL ARTICLE
W B de Jong, J Hoogmoed, G F J P M Adriaensen, A P Nagtegaal, S Reitsma
BACKGROUND: Cerebrospinal fluid (CSF) rhinorrhoea has different aetiologies, with spontaneous leaks related to female gender and obesity. Limited data is available on patient characteristics and surgical outcomes across different aetiologies of CSF leaks in relatively non-obese populations. METHODS: Retrospective cohort study from two tertiary referral centres including adult patients that underwent surgical closure of a CSF leak, divided into four aetiologies: traumatic, iatrogenic, secondary to structural intracranial pathology (SIP), and spontaneous...
December 11, 2023: Rhinology
https://read.qxmd.com/read/38010118/comparative-investigation-of-transport-and-deposition-of-nebulized-particles-in-nasal-airways-following-various-middle-turbinectomy
#17
JOURNAL ARTICLE
R Ma, L Tian, Y Wang, S Sun, J Zhang, M Lou, Z Hu, M Gong, F Yang, G Zheng, J Dong, Y Zhang
BACKGROUND: Topical intranasal medication is required following functional endoscopic sinus surgery (FESS). The optimal particle size of transnasal nebulization aimed at the sinonasal cavities is not conclusive. The current study aims to evaluate the effect of particle size and various surgery scope of middle turbinectomy (MT) on post-full FESS drug delivery to the sinonasal cavities. METHODS: Sinonasal reconstructions were performed from post-full FESS CT scans in 6 chronic rhinosinusitis with nasal polyps (CRSwNP) patients...
November 27, 2023: Rhinology
https://read.qxmd.com/read/38009901/determinants-of-the-microbiome-spatial-variability-in-chronic-rhinosinusitis
#18
JOURNAL ARTICLE
J Szaleniec, V Bezshapkin, A Krawczyk, K Kopera, B Zapała, T Gosiewski, T Kosciolek
BACKGROUND: The sinus microbiome in patients with chronic rhinosinusitis (CRS) is considered homogenous across the sinonasal cavity. The middle nasal meatus is the recommended sampling site for 16S rRNA sequencing. However, individuals with unusually high between-site variability between the middle meatus and the sinuses were identified in previous studies. This study aimed to identify which factors determine increased microbial heterogeneity between sampling sites in the sinuses. METHODOLOGY: In this cross-sectional study samples for 16S rRNA sequencing were obtained from the middle meatus, the maxillary and the frontal sinus in 50 patients with CRS...
November 27, 2023: Rhinology
https://read.qxmd.com/read/38009582/evidence-for-a-role-of-metformin-in-preventing-olfactory-dysfunction-among-older-adults
#19
JOURNAL ARTICLE
S Assi, V Vohra, W Zhang, N S Reed, A P Lane, M Ramanathan, N R Rowan
BACKGROUND: Olfactory dysfunction (OD) is increasingly recognized as a hallmark of unhealthy aging and is intimately associated with mortality, but therapies remain elusive. Recognizing the increased prevalence of OD in individuals with diabetes, and the potential anti-aging effects of metformin, we studied the association of metformin use with OD. METHODS: Cross-temporal study of participants from Waves 2 (2010-11) and 3 (2015-16) of the National Social Life, Health, and Aging Project (NSHAP), a nationally representative cohort study of community-dwelling older adults...
November 27, 2023: Rhinology
https://read.qxmd.com/read/38279902/treatment-advances-in-rhinology
#20
JOURNAL ARTICLE
B N Landis
No abstract text is available yet for this article.
February 1, 2024: Rhinology
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