Erica Shen, Nathan K Leclair, Kristi Herlth, Melissa Soucy, Nick Renzette, Xinming Zhuo, Kevin Kelly, Gregory Omerza, Hilary Onyiuke, Ian McNeill, Leo Wolansky, Kevin Becker, Lei Li, Qian Wu, Ketan R Bulsara
BACKGROUND: Meningiomas are the most common intracranial tumors. Recent advancements in the genetic profiling of tumors have allowed information including DNA copy number analysis, mutational analysis, and RNA sequencing to be more frequently reported, in turn allowing better characterization of meningiomas. In recent years, analysis of tumor methylomes that reflects both cell-origin methylation signatures and somatically acquired DNA methylation changes has been utilized to better classify meningiomas with great success...
March 15, 2023: Acta Neurochirurgica