journal
https://read.qxmd.com/read/36947577/seneca-valley-virus-enters-cells-through-multiple-pathways-and-traffics-intracellularly-via-the-endolysosomal-pathway
#1
JOURNAL ARTICLE
Wenqiang Liu, Xianfei Shang, Wei Wen, Xujiao Ren, Liuxing Qin, Xiangmin Li, Ping Qian
Seneca Valley virus (SVV, also known as Senecavirus A), an oncolytic virus, is a nonenveloped, positive-strand RNA virus and the sole member of the genus Senecavirus within the family Picornaviridae . The mechanisms of SVV entry into cells are currently almost unknown. In the present study, we found that SVV entry into HEK293T cells is acidic pH-dependent by using ammonium chloride (NH4 Cl) and chloroquine, both of which could inhibit SVV infection. We confirmed that dynamin II is required for SVV entry by using dynasore, silencing the dynamin II protein, or expressing the dominant-negative (DN) K44A mutant of dynamin II...
March 2023: Journal of General Virology
https://read.qxmd.com/read/36916406/ictv-virus-taxonomy-profile-sphaerolipoviridae-2023
#2
JOURNAL ARTICLE
Tatiana A Demina, Mike Dyall-Smith, Matti Jalasvuori, Shishen Du, Hanna M Oksanen
Members of the family Sphaerolipoviridae have non-enveloped tailless icosahedral virions with a protein-rich internal lipid membrane. The genome is a linear double-stranded DNA of about 30 kbp with inverted terminal repeats and terminal proteins. The capsid has a pseudo triangulation T= 28 dextro symmetry and is built of two major capsid protein types. Spike complexes decorate fivefold vertices. Sphaerolipoviruses have a narrow host range and a lytic life cycle, infecting haloarchaea in the class Halobacteria (phylum Euryarchaeota)...
March 2023: Journal of General Virology
https://read.qxmd.com/read/36857199/challenges-on-the-development-of-a-dengue-vaccine-a-comprehensive-review-of-the-state-of-the-art
#3
REVIEW
Jessica Pintado Silva, Ana Fernandez-Sesma
Dengue virus (DENV) is the mosquito-borne virus of greatest human health concern. There are four serotypes of DENV (1-4) that co-circulate in endemic areas. Each serotype of DENV is individually capable of causing the full spectrum of disease, ranging from self-resolving dengue fever to the more severe dengue haemorrhagic fever (DHF) or dengue shock syndrome (DSS). Based on data published by the CDC, one in four people who become infected with dengue will become ill. Of those that do develop symptomology, the symptoms can range from mild to severe...
March 2023: Journal of General Virology
https://read.qxmd.com/read/36809248/modulation-of-cellular-autophagy-by-genotype-1-hepatitis-e-virus-orf3-protein
#4
JOURNAL ARTICLE
Manjita Srivastava, Prudhvi Lal Bhukya, Muneesh Kumar Barman, Neha Bhise, Kavita S Lole
Hepatitis E virus (HEV) egresses from infected hepatocytes as quasienveloped particles containing open reading frame 3 (ORF3) protein. HEV ORF3 (small phosphoprotein) interacts with host proteins to establish a favourable environment for virus replication. It is a functional viroporin that plays an important role during virus release. Our study provides evidence that pORF3 plays a pivotal role in inducing Beclin1-mediated autophagy that helps HEV-1 replication as well as its exit from cells. The ORF3 interacts with host proteins involved in regulation of transcriptional activity, immune response, cellular and molecular processes, and modulation of autophagy, by interacting with proteins, DAPK1, ATG2B, ATG16L2 and also several histone deacetylases (HDACs)...
February 2023: Journal of General Virology
https://read.qxmd.com/read/36802334/the-coat-protein-of-the-ilarvirus-prunus-necrotic-ringspot-virus-mediates-long-distance-movement
#5
JOURNAL ARTICLE
Chengyong He, Fei Xing, Xiaoli Zhao, Shifang Li, Binhui Zhan, Zhen Liu, Tengfei Xu, Dehang Gao, Zhenfei Dong, Hongqing Wang, Zhixiang Zhang
The coat protein (CP) of plant viruses generally has multiple functions involving infection, replication, movement and pathogenicity. Functions of the CP of prunus necrotic ringspot virus (PNRSV), the causal agent of several threatening diseases of Prunus fruit trees, are poorly studied. Previously, we identified a novel virus in apple, apple necrotic mosaic virus (ApNMV), which is phylogenetically related to PNRSV and probably associated with apple mosaic disease in China. Full-length cDNA clones of PNRSV and ApNMV were constructed, and both are infectious in cucumber ( Cucumis sativus L...
February 2023: Journal of General Virology
https://read.qxmd.com/read/36800222/the-health-of-influenza-surveillance-and-pandemic-preparedness-in-the-wake-of-the-covid-19-pandemic
#6
JOURNAL ARTICLE
Rodney Stuart Daniels, John William McCauley
The COVID-19 pandemic is the first to have emerged when Next Generation Sequencing was readily available and it has played the major role in following evolution of the causative agent, Severe Acute Respiratory Syndrome Coronavirus 2. Response to the pandemic was greatly facilitated though use of existing influenza surveillance networks: World Health Organization (WHO) Global Influenza Surveillance and Response System (GISRS), focussing largely on human influenza, and the OFFLU network of expertise on avian influenza established by the Food and Agricultural Organization of the United Nations (FAO) and the World Organization for Animal Health (WOAH)...
February 2023: Journal of General Virology
https://read.qxmd.com/read/36787173/a-novel-antiviral-formulation-containing-caprylic-acid-inhibits-sars-cov-2-infection-of-a-human-bronchial-epithelial-cell-model
#7
JOURNAL ARTICLE
Kevin Purves, Ruth Haverty, Tiina O'Neill, David Folan, Sophie O'Reilly, Alan W Baird, Dimitri Scholz, Patrick W Mallon, Virginie Gautier, Michael Folan, Nicola F Fletcher
A novel proprietary formulation, ViruSAL, has previously been demonstrated to inhibit diverse enveloped viral infections in vitro and in vivo . We evaluated the ability of ViruSAL to inhibit SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2) infectivity , using physiologically relevant models of the human bronchial epithelium, to model early infection of the upper respiratory tract. ViruSAL potently inhibited SARS-CoV-2 infection of human bronchial epithelial cells cultured as an air-liquid interface (ALI) model, in a concentration- and time-dependent manner...
February 2023: Journal of General Virology
https://read.qxmd.com/read/36757871/genome-wide-identification-of-lncrnas-associated-with-viral-infection-in-spodoptera-frugiperda
#8
JOURNAL ARTICLE
Stéphanie Robin, Fabrice Legeai, Véronique Jouan, Mylène Ogliastro, Isabelle Darboux
The role of lncRNAs in immune defence has been demonstrated in many multicellular and unicellular organisms. However, investigation of the identification and characterization of long non-coding RNAs (lncRNAs) involved in the insect immune response is still limited. In this study, we used RNA sequencing (RNA-seq) to investigate the expression profiles of lncRNAs and mRNAs in the fall armyworm Spodoptera frugiperda in response to virus infection. To assess the tissue- and virus-specificity of lncRNAs, we analysed and compared their expression profiles in haemocytes and fat body of larvae infected with two entomopathogenic viruses with different lifestyles, i...
February 2023: Journal of General Virology
https://read.qxmd.com/read/36757863/pathogenesis-of-wild-type-and-vaccine-based-recombinant-peste-des-petits-ruminants-virus-pprv-expressing-egfp-in-experimentally-infected-domestic-goats
#9
JOURNAL ARTICLE
Katharina S Schmitz, Phaedra L Eblé, René G P van Gennip, Mieke A Maris-Veldhuis, Rory D de Vries, Lucien J M van Keulen, Rik L de Swart, Piet A van Rijn
Peste des petits ruminants virus (PPRV) is a highly contagious morbillivirus related to measles and canine distemper virus, mostly affecting small ruminants. The corresponding PPR disease has a high clinical impact in goats and is characterized by fever, oral and nasal erosions, diarrhoea and pneumonia. In addition, massive infection of lymphoid tissues causes lymphopaenia and immune suppression. This results in increased susceptibility to secondary bacterial infections, explaining the observed high mortality in some outbreaks...
February 2023: Journal of General Virology
https://read.qxmd.com/read/36748631/the-n-terminal-glycine-of-ehv-1-ul11-is-essential-for-the-localization-of-ul11-and-ehv-1-replication-in-cultured-cells
#10
JOURNAL ARTICLE
Noriko Fukushi, Yassien Badr, Hideto Fukushi
Equine herpesvirus type 1 (EHV-1) UL11 is a 74-amino-acid (aa) protein encoded by ORF51. UL11 is modified by acylation including myristoylation and palmitoylation. Myristoylation of EHV-1 UL11 is assumed to occur on the N-terminal glycine, while palmitoylation is assumed to occur on the seventh and ninth cysteines. ORF51, which encodes the first 24 aa, overlaps ORF50 encoding UL12. We previously demonstrated that UL11 was essential for EHV-1 replication in cultured cells and that UL11 was localized at the Golgi apparatus where herpesviruses obtain their final envelope...
January 2023: Journal of General Virology
https://read.qxmd.com/read/36748548/ictv-virus-taxonomy-profile-yadokariviridae-2023
#11
JOURNAL ARTICLE
Yukiyo Sato, Subha Das, Leonardo Velasco, Massimo Turina, Hideki Osaki, Ioly Kotta-Loizou, Robert H A Coutts, Hideki Kondo, Sead Sabanadzovic, Nobuhiro Suzuki, Ictv Report Consortium
The family Yadokariviridae , with the genera Alphayadokarivirus and Betayadokarivirus , includes capsidless non-segmented positive-sense (+) RNA viruses that hijack capsids from phylogenetically distant double-stranded RNA viruses. Yadokarivirids likely replicate inside the hijacked heterocapsids using their own RNA-directed RNA polymerase, mimicking dsRNA viruses despite their phylogenetic placement in a (+) RNA virus lineage. Yadokarivirids can have negative or positive impacts on their host fungi, through interactions with the capsid donor dsRNA viruses...
January 2023: Journal of General Virology
https://read.qxmd.com/read/36748533/longitudinal-detection-of-prion-shedding-in-nasal-secretions-of-cwd-infected-white-tailed-deer
#12
JOURNAL ARTICLE
Caitlyn N Kraft, Nathaniel D Denkers, Candace K Mathiason, Edward A Hoover
Chronic wasting disease (CWD) is an emergent prion disease spreading in cervid populations in North America, South Korea and Scandinavia. Rapid detection of CWD prions shed by live animals using minimally invasive methods remains an important need. Previous studies in deer, elk and hamsters have demonstrated prion replication in the nasal olfactory mucosa, yet the temporal profile of CWD prion shedding in nasal secretions has not been well characterized. Here we report nasal prion shedding in 18 deer orally exposed to low doses of CWD prions and monitored longitudinally by several parameters...
January 2023: Journal of General Virology
https://read.qxmd.com/read/36748518/knockdown-of-neat1-restricts-dengue-virus-replication-by-augmenting-interferon-alpha-inducible-protein-27-via-the-rig-i-pathway
#13
JOURNAL ARTICLE
Jaya Saini, Umesh Thapa, Bhaswati Bandyopadhyay, Sudhanshu Vrati, Arup Banerjee
The lncRNA NEAT1 plays a vital role in mitochondrial function and antiviral response. We have previously identified NEAT1 as dysregulated lncRNAs and found an inverse correlation with interferon alpha-inducible protein 27 (IFI27) expression associated with developing dengue severity. However, the role of NEAT1 in dengue virus (DV) infection remains elusive. Here, we undertook a study to evaluate the functional consequences of NEAT1 and IFI27 modulation on antiviral response and viral replication in dengue infection...
January 2023: Journal of General Virology
https://read.qxmd.com/read/36748490/ictv-virus-taxonomy-profile-hadakaviridae-2023
#14
JOURNAL ARTICLE
Yukiyo Sato, Massimo Turina, Sotaro Chiba, Ryo Okada, Muhammad F Bhatti, Ioly Kotta-Loizou, Robert H A Coutts, Hideki Kondo, Sead Sabanadzovic, Nobuhiro Suzuki, Ictv Report Consortium
The family Hadakaviridae , including the genus Hadakavirus , accommodates capsidless viruses with a 10- or 11-segmented positive-sense (+) RNA genome. Currently known hosts are ascomycetous filamentous fungi. Although phylogenetically related to polymycovirids with a segmented double-stranded RNA genome and certain encapsidated picorna-like viruses, hadakavirids are distinct in their lack of a capsid ('hadaka' means naked in Japanese) and their consequent inability to be pelleted by conventional ultracentrifugation; they show ribonuclease susceptibility in host tissue homogenates...
January 2023: Journal of General Virology
https://read.qxmd.com/read/36748697/development-of-an-in-vitro-homeostasis-model-between-airway-epithelial-cells-bacteria-and-bacteriophages-a-time-lapsed-observation-of-cell-viability-and-inflammatory-response
#15
JOURNAL ARTICLE
Panagiota Tzani-Tzanopoulou, Ramazan Rozumbetov, Styliani Taka, Anastassios Doudoulakakis, Evangelia Lebessi, Nina Chanishvili, Elene Kakabadze, Nata Bakuradze, Nino Grdzelishvili, Marina Goderdzishvili, Evangelia Legaki, Evangelos Andreakos, Maria Papadaki, Spyridon Megremis, Paraskevi Xepapadaki, Grigoris Kaltsas, Cezmi A Akdis, Nikolaos G Papadopoulos
Bacteriophages represent the most extensive group of viruses within the human virome and have a significant impact on general health and well-being by regulating bacterial population dynamics. Staphylococcus aureus , found in the anterior nostrils, throat and skin, is an opportunistic pathobiont that can cause a wide range of diseases, from chronic inflammation to severe and acute infections. In this study, we developed a human cell-based homeostasis model between a clinically isolated strain of S. aureus 141 and active phages for this strain (PYOSa141 ) isolated from the commercial Pyophage cocktail (PYO)...
December 2022: Journal of General Virology
https://read.qxmd.com/read/36748634/ictv-virus-taxonomy-profile-secoviridae-2022
#16
JOURNAL ARTICLE
Marc Fuchs, Jean-Michel Hily, Karel Petrzik, Hélène Sanfaçon, Jeremy R Thompson, René van der Vlugt, Thierry Wetzel, Ictv Report Consortium
Members of the family Secoviridae are non-enveloped plant viruses with mono- or bipartite linear positive-sense ssRNA genomes with a combined genome of 9 to 13.7 kb and icosahedral particles 25-30 nm in diameter. They are related to picornaviruses and are members of the order Picornavirales . Genera in the family are distinguished by the host range, vector, genomic features and phylogeny of the member viruses. Most members infect dicotyledonous plants, and many cause serious disease epidemics...
December 2022: Journal of General Virology
https://read.qxmd.com/read/36748628/lncrna-neat1-regulates-hcv-induced-hepatocellular-carcinoma-by-modulating-the-mir-9-bgh3-axis
#17
JOURNAL ARTICLE
Sachin Kumar Tripathi, Apala Pal, Suchandrima Ghosh, Amit Goel, Rakesh Aggarwal, Soma Banerjee, Saumitra Das
Chronic hepatitis C virus (HCV) infection is a leading cause of end-stage liver diseases, such as fibrosis, cirrhosis and hepatocellular carcinoma (HCC). Several cellular entities, including paraspeckles and their related components, are involved in viral pathogenesis and cancer progression. NEAT1 lncRNA is a major component of paraspeckles that has been linked to several malignancies. In this study, analysis of the Cancer Genome Atlas (TCGA) database and validation in HCV-induced HCC tissue and serum samples showed significantly high expression of NEAT1 in patients with liver cancer...
December 2022: Journal of General Virology
https://read.qxmd.com/read/36748530/borna-disease-virus-1-impairs-dna-double-strand-break-repair-through-the-atr-chk1-signalling-pathway-resulting-in-learning-and-memory-impairment-in-rats
#18
JOURNAL ARTICLE
Xia Shen, Xiaoyan Xu, Yujie Guo, Hongli Yang, Juan He, Peng Xie
Borna disease virus 1 (BoDV-1) is a highly neurotropic RNA virus that can establish persistent infection in the central nervous system and cause cognitive dysfunction in neonatally infected rats. However, the mechanisms that lead to this cognitive impairment remain unclear. DNA double-strand breaks (DSBs) and their repair are associated with brain development and cognition. If DNA repair in the brain is reduced or delayed and DNA damage accumulates, abnormal cognitive function may result. We generated a rat model of BoDV-1 infection during the neonatal period and assessed behavioural changes using the open field test and Morris water maze...
December 2022: Journal of General Virology
https://read.qxmd.com/read/36748520/ictv-virus-taxonomy-profile-matonaviridae-2022
#19
JOURNAL ARTICLE
Annette Mankertz, Min-Hsin Chen, Tony L Goldberg, Judith M Hübschen, Florian Pfaff, Rainer G Ulrich, Ictv Report Consortium
The family Matonaviridae comprises enveloped viruses with positive-sense RNA genomes of 9.6-10 kb. The genus Rubivirus includes rubella virus (species Rubivirus rubellae ) infecting humans, ruhugu virus (species Rubivirus ruteetense ) infecting bats and rustrela virus (species Rubivirus strelense ) infecting rodents and zoo animals. Rubella virus is spread via droplets. Postnatal infection leads to benign disease with rash and fever. Infection of seronegative women with rubella virus during the first trimester of pregnancy will often result in severe foetal malformations, known as congenital rubella syndrome...
December 2022: Journal of General Virology
https://read.qxmd.com/read/36748498/pseudorabies-virus-infection-induces-endoplasmic-reticulum-stress-and-unfolded-protein-response-in-suspension-cultured-bhk-21-cells
#20
JOURNAL ARTICLE
Li Chen, Minshu Ni, Waqas Ahmed, Yue Xu, Xi Bao, Tenghan Zhuang, Lei Feng, Meijin Guo
Viral infections cause endoplasmic reticulum (ER) stress and subsequently unfolded protein response (UPR) which restores ER homeostasis. In this study, levels of proteins or transcription of three UPR pathways were examined in suspension-cultured BHK-21 cells to investigate Pseudorabies virus (PRV) infection-induced ER stress, in which glucose-related proteins 78 kD and 94 kD (GRP78 and GRP94) were upregulated. The downstream double-stranded RNA-activated protein kinase-like ER kinase (PERK) pathway was activated with upregulation of ATF4, CHOP, and GADD34, and the inositol requiring kinase 1 (IRE1) pathway was triggered by the splicing of X box-binding protein 1 (XBP1) mRNA and the enhanced expression of p58IPK and EDEM...
December 2022: Journal of General Virology
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