Romain Volle, Lingjie Luo, Richter Razafindratsimandresy, Serge Alain Sadeuh-Mba, Ionela Gouandjika-Valisache, Paul Horwood, Veasna Duong, Philippe Buchy, Marie-Line Joffret, Zhong Huang, Erwin Duizer, Javier Martin, Lisa A Chakrabarti, Philippe Dussart, Nolwenn Jouvenet, Francis Delpeyroux, Maël Bessaud
Enterovirus 71 (EV-A71) is a major public health problem, causing a range of illnesses from hand-foot-and-mouth disease to severe neurological manifestations. EV-A71 strains have been phylogenetically classified into eight genogroups (A to H), based on their capsid-coding genomic region. Genogroups B and C have caused large outbreaks worldwide and represent the two canonical circulating EV-A71 subtypes. Little is known about the antigenic diversity of new genogroups as compared to the canonical ones. Here, we compared the antigenic features of EV-A71 strains that belong to the canonical B and C genogroups and to genogroups E and F, which circulate in Africa...
November 2023: Journal of General Virology