Chiaki Yamada, Anny Ho, Christopher Garcia, Adrian L Oblak, Stephanie Bissel, Tatiana Porosencova, Egor Porosencov, Diana Uncuta, Bidii Ngala, Dmytro Shepilov, Galyna Skibo, Ana Karina Mascarenhas, Juliet Akkaoui, Madepalli K Lakshmana, Uma Sankar, Frank Nichols, Bruce T Lamb, Stanislav Groppa, Alexandru Movila
BACKGROUND: Periodontitis is a chronic inflammatory disease defined by the pathologic loss of the periodontal ligament and alveolar bone in relation to aging. Although clinical cohort studies reported that periodontitis is significantly elevated in males compared to females, emerging evidence indicates that females with dementia are at a greater risk for periodontitis and decreased alveolar bone. OBJECTIVE: This study aimed to evaluate whether dementia is a potential sex-dependent risk factor for periodontal bone loss using an experimental model of periodontitis induced in the triple transgenic (3x-Tg) dementia-like mice and clinical samples collected from senior 65 plus age patients with diagnosed dementia...
January 20, 2024: Journal of Periodontal Research