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Journal of Periodontal Research

Steven W H Rademacher, Egija Zaura, Cornelis J Kleverlaan, Mark J Buijs, Wim Crielaard, Bruno G Loos, Marja L Laine
BACKGROUND AND OBJECTIVE: Metal-based dental restorations with a subgingival outline may enhance plaque accumulation and bacterial colonization. This study aimed to investigate whether metal-based restorations influence the composition of subgingival microbiome. MATERIAL AND METHODS: Per subject one site with a metal-based restoration and one contra-lateral site without a restoration were selected on basis of radiographic bone loss ≤2 mm, restoration outline at sulcus level/subgingivally, pocket depth ≤4 mm, and no root canal treatments...
February 8, 2019: Journal of Periodontal Research
Sung-Jin Kim, Young Don Ha, Eunji Kim, Woowon Jang, Soonshin Hwang, Tung Nguyen, Ching-Chang Ko, Yoon Jeong Choi, Kyung-Ho Kim, Chooryung J Chung
OBJECTIVE: The aim of this study was to investigate the dynamics of alveolar bone formation and healing pattern after the removal of orthodontic temporary anchorage devices (TADs). METHODS: Miniscrews (N = 32) were inserted into the buccal inter-radicular alveolar bone in beagle dogs. Afterward, miniscrews were removed at different time points during a 13-week period and six different in vivo fluorescent markers were injected at 1, 2, 6, 8, 10, and 12 weeks. Serial changes in bone apposition at the removal and intact control sites were evaluated using μCT, histology, and bone histomorphometry...
January 24, 2019: Journal of Periodontal Research
Luiz A Chisini, Mariana G Cademartori, Alejandro Francia, Matias Mederos, Guillermo Grazioli, Marcus C M Conde, Marcos B Correa
Recent studies have shown that there is also biological plausibility for a possible relationship between periodontal disease and Cannabis use, thus the aim of this study was to investigate whether the use of Cannabis is associated with periodontitis. Electronic searches were performed in PubMed, Scopus, ISI-Web of Science, BVS-Virtual health library and Scielo without restrictions. Search strategy was performed using relevant keywords considering the structure of each database. Longitudinal and cross-sectional studies that investigated the association between the use of Cannabis and periodontal disease were included...
January 24, 2019: Journal of Periodontal Research
Akira Hasuike, Daisuke Ueno, Hidekazu Nagashima, Tatsuya Kubota, Naoya Tsukune, Norihisa Watanabe, Shuichi Sato
BACKGROUND AND OBJECTIVES: The purpose of the present study was to evaluate the methodological quality and risk of bias in systematic reviews (SRs) on the effectiveness of peri-implantitis treatments. MATERIAL AND METHODS: We searched four electronic databases: MEDLINE, Web of Science, Cochrane Database of Systematic Reviews, and EMBASE. Previous SRs focusing on peri-implantitis treatment published between 2010 and 2017 were identified. After literature screening, eligible SRs were qualitatively assessed using two validated instruments: Assessing the Methodological Quality of Systematic Reviews (AMSTAR2) and Risk Of Bias In Systematic reviews (ROBIS)...
January 22, 2019: Journal of Periodontal Research
Patrícia Guerra Peixe Gonçalves, Salomão Israel Monteiro Lourenço, Bruno Cesar de Vasconcelos Gurgel
BACKGROUND AND OBJECTIVE: The aim of this study was to evaluate the angiogenesis and lymphangiogenesis in gingival tissue biopsy specimens of individuals with clinically healthy gingiva, chronic gingivitis, and chronic periodontitis (n = 30 per clinical condition). MATERIAL AND METHODS: Histological sections were stained using hematoxylin and eosin as well as immunohistochemically with hematopoietic progenitor cell antigen CD34 and podoplanin (PDPN) antibodies to evaluate the microvascular count, area, and perimeter of blood and lymphatic vessels, respectively...
January 17, 2019: Journal of Periodontal Research
Xin Wang, Yu Li, Yuan Feng, Haode Cheng, Dehua Li
BACKGROUND AND OBJECTIVES: Titanium particles/ions detected in peri-implant tissues have been considered as a potential etiologic factor for crestal bone loss around oral implants. However, the definite impact of titanium wear particles on the health of surrounding structures remains undetermined. The purpose of this study was to investigate the effects of titanium particles-induced foreign body reaction on peri-implant bone level and the related mechanism by using clodronate liposomes to deplete macrophages...
January 11, 2019: Journal of Periodontal Research
Yi Wang, Zhe Zhen, Hin Nam Liu, Ian Lai, George Pelekos, Hung-Fat Tse, Kai-Hang Yiu, Lijian Jin
BACKGROUND AND OBJECTIVE: Subjects with diabetes and periodontitis are at high risk of cardiovascular events, while the subclinical alterations of cardiac function in this cohort remain unclear. This cross-sectional study investigated the association of periodontitis with left ventricle (LV) structural and functional abnormalities in subjects with type 2 diabetes mellitus (T2DM). MATERIAL AND METHODS: A total of 115 subjects with T2DM were divided into Control group (n = 32) with no or mild periodontitis, and the rest with moderate to severe chronic periodontitis (CP) were further categorized into CP-1 (n = 41) and CP-2 (n = 42) based on disease severity...
January 11, 2019: Journal of Periodontal Research
Guang Li, Samantha Robles, Zhongyang Lu, Yanchun Li, Joe W Krayer, Renata S Leite, Yan Huang
BACKGROUND AND OBJECTIVE: Metabolic syndrome (MetS) exacerbates periodontitis. Since saturated fatty acid (SFA) is increased in MetS and enhances lipopolysaccharide (LPS)-induced proinflammatory cytokine expression in macrophages, it has been considered to play a role in MetS-exacerbated periodontitis. However, it remains unknown how fatty acid receptors, which mediate the interaction of cells with SFA and uptake of SFA, are expressed and regulated in the periodontal tissue. In this study, we tested our hypothesis that the periodontal expression of fatty acid receptors GPR40 and CD36 is increased in patients with both MetS and periodontitis...
December 30, 2018: Journal of Periodontal Research
Kengo Iwasaki, Mizuki Nagata, Keiko Akazawa, Tetsuro Watabe, Ikuo Morita
OBJECTIVES: The periodontal ligament (PDL) has important roles in maintaining homeostasis, wound healing, and regeneration of periodontal tissues by supplying stem/progenitor cells. Periodontal ligament stem cells (PDLSCs) have mesenchymal stem cell (MSC)-like characteristics and can be isolated from periodontal tissues. The aim of this study was to examine the effect of three-dimensional spheroid culture on the characteristics of PDLSCs. MATERIAL AND METHODS: Periodontal ligament stem cells were isolated and cultured from healthy teeth, and PDLSC spheroids were formed by pellet culture in polypropylene tubes...
December 30, 2018: Journal of Periodontal Research
Aneesha Acharya, Simin Li, Xiangqiong Liu, George Pelekos, Dirk Ziebolz, Nikos Mattheos
BACKGROUND AND OBJECTIVE: Primary research concerning molecular pathways that link rheumatoid arthritis with periodontitis is limited. Biomedical literature data mining can offer insights into putative linkage mechanisms toward hypothesis development, based on information discovery. The aim of this study was to explore potential Periodontitis-Rheumatoid Arthritis biological links by analysing "overlapping" genes reported in biomedical abstracts. MATERIAL AND METHODS: PubMed abstracts for terms: (a) "Periodontitis" or "Periodontal Diseases" (PD), (b) "Rheumatoid arthritis" (RA), and (c) their combination with "AND" (RA+PD), were each text-mined to extract genes using "Human Genome Nomenclature Committee" (HGNC) symbols...
December 10, 2018: Journal of Periodontal Research
Mandeep S Ghuman, Maher Al-Masri, Guilherme Xavier, Martyn T Cobourne, Ian J McKay, Francis J Hughes
OBJECTIVES: The inhibitory action of the superficial gingival connective tissues may limit the regenerative potential of alveolar bone in periodontal therapy or dental implant applications. The aims of this study were to investigate the hypothesis that gingival fibroblasts (GF) can inhibit bone morphogenetic protein (BMP)-induced osteoblastic differentiation, to determine their expression of BMP inhibitors, and finally to determine whether reduction of these inhibitors can relieve suppression of osteoblastic differentiation...
December 3, 2018: Journal of Periodontal Research
Lynn Yang, Misun Kang, Rui He, Bo Meng, Arvin Pal, Ling Chen, Andrew H Jheon, Sunita P Ho
The novel aspect of this study was to contextualize the co-localization of biomolecular expression in widened and narrowed periodontal ligament (PDL)-space within a mechanically activated periodontal complex. The PDL is unique as it is the only ligament with both innervation and vascularization. Maxillary molars in 6-week-old male C57BL/6 mice (N = 5) were experimentally translated for 2 weeks using an elastic spacer. Contralateral teeth were used as controls. Mechanical testing of the periodontal complex of a mouse in situ and imaging using X-ray micro-computed tomography (micro-XCT) illustrated deformations within blood vessels (BV) of the PDL...
November 28, 2018: Journal of Periodontal Research
Emilio Alfredo Cafferata, Alfredo Jerez, Rolando Vernal, Gustavo Monasterio, Nikolaos Pandis, Clovis M Faggion
This systematic review aimed to: (a) generate a descriptive synthesis of preclinical studies assessing the therapeutic potential of regulatory T lymphocytes (Tregs) to arrest periodontitis, (b) evaluate the methodological heterogeneity of the reviewed animal studies and (c) assess the risk of bias (RoB) of the included studies. The electronic search for animal studies included the MEDLINE, EMBASE, Web of Science and LILACS databases. In addition, a manual search assessed the high-ranked scientific journals in "periodontics/immunology" and the references listed in the included studies...
November 25, 2018: Journal of Periodontal Research
Yixiao Xing, Yunpeng Zhang, Xuan Wu, Bin Zhao, Yawen Ji, Xin Xu
BACKGROUND AND OBJECTIVE: Mesenchymal stem cells (MSCs) have been widely used in tissue engineering, such as for regenerating the supporting structures of teeth destroyed by periodontal diseases. In recent decades, dental tissue-derived MSCs have drawn much attention owing to their accessibility, plasticity and applicability. Dental pulp stem cells (DPSCs), periodontal ligament stem cells (PDLSCs) and gingival MSCs (GMSCs) are the most readily available MSCs among all types of dental MSCs...
November 25, 2018: Journal of Periodontal Research
Shunsuke Fukuba, Tatsuya Akizuki, Shu Hoshi, Takanori Matsuura, Ammar Shujaa Addin, Munehiro Okada, Yasuhiko Tabata, Makoto Matsui, Makoto J Tabata, Makoto Sugiura-Nakazato, Yuichi Izumi
BACKGROUND AND OBJECTIVE: It is well known that recombinant human fibroblast growth factor-2 (rhFGF-2) signaling plays an important role in tissue repair and regeneration. rhFGF-2 strongly binds to acidic gelatin via ionic linkages and is gradually released upon gelatin decomposition. On the other hand, the linkage between rhFGF-2 and basic gelatin is so weak that most rhFGF-2 is rapidly released from basic gelatin by simple desorption. Gelatin/β-tricalcium phosphate (β-TCP) sponges, which comprise 50 wt% gelatin and 50 wt% β-TCP in a cross-linked structure, can release rhFGF-2 gradually owing to their electrical features...
November 25, 2018: Journal of Periodontal Research
Lorenzo Bevilacqua, Chiara O Navarra, Nicola Pirastu, Roberto Di Lenarda, Paolo Gasparini, Antonietta Robino
BACKGROUND AND OBJECTIVE: Periodontitis in one of the most prevalent dental diseases. Despite numerous studies have investigated its aetiopathogenetic factors, few works have focused on its genetic predisposition and most of them took into account only candidate genes. Therefore, we conducted a Genome Wide Association Study in an Italian isolated population aimed at uncovering genetic variants that predispose to this disorder. METHODS: Diagnosis of chronic periodontitis was made following the criteria of the American Academy of Periodontology...
December 2018: Journal of Periodontal Research
Suzana P Pimentel, Melline Fontes, Fernanda V Ribeiro, Mônica G Corrêa, Denise Nishii, Fabiano R Cirano, Marcio Z Casati, Renato C V Casarin
BACKGROUND AND OBJECTIVE: Smoking is a recognized risk factor for peri-implant disease and leads to microbiological changes in mucositis and peri-implantitis. However, there is no knowledge about the impact of smoking in healthy peri-implant tissue. The aim of the study was to evaluate the microbiome in a peri-implant environment in smokers with healthy peri-implant conditions. METHODS: Peri-implant biofilm was collected around single clinically healthy, screwed-retained, teeth-surrounded implants in 12 non-smoker (NSMK) and 12 smoker (SMK) non-periodontitis subjects (no bleeding and probing depth <4 mm)...
December 2018: Journal of Periodontal Research
Lingfei Wei, Yuxi Jiang, Wenjuan Zhou, Shutai Liu, Yuelian Liu, Xiaohui Rausch-Fan, Zhonghao Liu
BACKGROUND AND OBJECTIVE: Periodontitis is a chronic inflammatory disease characterized by the destruction of the periodontium. The strontium ion (Sr2+ ) can prevent the bone loss associated with periodontitis and promote the regeneration of the bone. The mechanisms by which the Sr2+ works remain poorly understood. We aim to investigate the effects of the Sr2+ ion on cell proliferation, inflammatory regulation and osteogenic differentiation of human periodontal ligament cells (hPDLCs) in pathological conditions...
December 2018: Journal of Periodontal Research
Carolina Bizelli-Silveira, Helen Pullisaar, Lisbeth A Abildtrup, Ole Z Andersen, Rubens Spin-Neto, Morten Foss, David C E Kraft
BACKGROUND AND OBJECTIVE: Strontium (Sr) enhances osteogenic differentiation of certain multipotent cells. Periodontal ligament cells (PDLCs) are known to be multipotent, and Sr might be useful in periodontal bone tissue engineering. This study investigates the effect of high concentration of Sr on the proliferation and osteogenic behavior of PDLCs in vitro. MATERIAL AND METHODS: Primary human PDLCs were cultured in MEM + 10% FBS without (Ctrl) or with Sr in four diverse concentrations: Sr1, 11...
December 2018: Journal of Periodontal Research
Ya-Hsin Wu, Ryutaro Kuraji, Yuji Taya, Hiroshi Ito, Yukihiro Numabe
BACKGROUND AND OBJECTIVE: Theaflavins (TFs), the major polyphenol in black tea, have the ability to reduce inflammation and bone resorption. The aim of this study was to evaluate the effects of TFs on experimental periodontitis in rats. MATERIAL AND METHODS: Thirty rats were divided into five groups: Control (glycerol application without ligation), Ligature (glycerol application with ligation), TF1 (1 mg/mL TF application with ligation), TF10 (10 mg/mL TF application with ligation), and TF100 (100 mg/mL TF application with ligation)...
December 2018: Journal of Periodontal Research
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