Shuming Zhong, Pan Chen, Shunkai Lai, Yiliang Zhang, Guanmao Chen, Jiali He, Youling Pan, Guixian Tang, Ying Wang, Yanbin Jia
Introduction Suicide in bipolar disorder (BD) is a multifaceted behavior, involving specific neuroendocrine and psychological mechanisms. According to previous studies, we hypothesized that suicidal BD patients may exhibit impaired dynamic functional connectivity (dFC) variability of hippocampal subregions and hypothalamic-pituitary-adrenal (HPA) axis activity, which may be associate with suicide-related personality traits. The objective of our study was to clarify this. Methods Resting-state functional magnetic resonance imaging data were obtained from 79 patients with BD, 39 with suicidal attempt (SA) and 40 without SA, and 35 healthy controls...
September 20, 2023: Neuroendocrinology
Junki Takenaka, Shiro Watanabe, Takashige Abe, Takahiro Tsuchikawa, Satoshi Takeuchi, Kenji Hirata, Rina Kimura, Naoto Wakabayashi, Nobuo Shinohara, Kohsuke Kudo
Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumours that produce catecholamines. [131I] MIBG-avid unresectable or metastatic PPGLs are treated with [131I] MIBG therapy. A high metabolic tumour volume (MTV) and total lesion glycolysis (TLG) can be poor prognostic factors. Therefore, we evaluated the metabolic responses to [131I] MIBG therapy with respect to other clinical factors.A retrospective study was performed on a series of 20 patients who underwent FDG-PET before and after [131I] MIBG therapy...
September 19, 2023: Neuroendocrinology
Junlin Huang, Bingyan Xu, Xiaomin Chen, Linjie Yang, Deying Liu, Jiayang Lin, Yating Liu, Xuzhen Lei, Chensihan Huang, Weijuan Dou, Dan Guo, Xueyun Wei, Peizhen Zhang, Yan Huang, Xuejiang Gu, Huijie Zhang
INTRODUCTION: The association of serum sex hormone-binding globulin (SHBG) concentrations with dementia risk remains uncertain in middle-aged to older women. We examined associations of serum SHBG levels with incidence of all-cause dementia and its subtypes in middle-aged to older women from the large population-based UK Biobank cohort study. METHODS: Serum total SHBG levels were measured by immunoassay. The incidence of all-cause dementia and its subtypes was recorded...
September 19, 2023: Neuroendocrinology
Boryeong Jeong, Subin Heo, Dong Wook Kim, Kyung Won Kim
INTRODUCTION: Lymph node metastasis of nonfunctioning pancreatic neuroendocrine neoplasms (pNENs) potentially leads to poor survival. Given the contradictory results in the literature regarding factors associated with lymph node metastasis of nonfunctioning pNENs, we conducted a systematic review and meta-analysis to determine the preoperative predictors of lymph node metastasis. METHODS: Original studies reporting factors associated with lymph node metastasis in patients with nonfunctioning pNENs were identified in PubMed, EMBASE, and Cochrane Library databases, and data from eligible studies were analyzed using random-effects meta-analysis to obtain pooled estimates of odds ratios (OR) and their 95% confidence intervals (CI)...
September 13, 2023: Neuroendocrinology
Jun-Xi Xiang, Ye-Rong Qian, Jin He, Alexandra G Lopez-Aguiar, George Poultsides, Flavio Rocha, Sharon Weber, Ryan Fields, Kamran Idrees, Cliff Cho, Shishir K Maithel, Yi Lv, Xu-Feng Zhang, Timothy M Pawlik
INTRODUCTION: To investigate the impact of prognostic nutritional index (PNI) on short- and long-term outcomes of patients who underwent curative-intent resection for gastro-entero-pancreatic neuroendocrine tumors (GEP-NETs). METHODS: Patients with GET-NETs who underwent curative-intent resection were identified from a multi-center database. The prognostic impact of clinicopathological factors including PNI on post-operative outcomes were evaluated. A novel nomogram was developed and externally validated...
September 13, 2023: Neuroendocrinology
Mi Ae Kim, Tae Ha Kim, Priyadharshini Kannan, Kang Hee Kho, Keunwan Park, Young Chang Sohn
INTRODUCTION: The proposed evolutionary origins and corresponding nomenclature of bilaterian gonadotropin-releasing hormone (GnRH)-related neuropeptides have changed tremendously with the aid of receptor deorphanization. However, the reclassification of the GnRH and corazonin (CRZ) signaling systems in Lophotrochozoa remains unclear. METHODS: We characterized GnRH and CRZ receptors in the mollusk Pacific abalone, Haliotis discus hannai (Hdh), by phylogenetic and gene expression analyses, bioluminescence-based reporter, western blotting, substitution of peptide amino acids, in vivo neuropeptide injection, and RNA interference assays...
September 13, 2023: Neuroendocrinology
Khaggeswar Bheemanapally, Karen P Briski
The ventromedial hypothalamic nucleus (VMN) is an estrogen receptor (ER)-rich structure that regulates glucostasis. The role of nuclear, but not membrane G-protein-coupled ER-1 (GPER) in that function has been studied. Gene silencing and laser-catapult-microdissection/immunoblot tools were used to examine whether GPER regulates transmitter and energy sensor function in dorsomedial (VMNdm) and/or ventrolateral (VMNvl) VMN counter-regulatory nitrergic and -aminobutyric acid (GABA) neurons. Intra-VMN GPER siRNA administration to euglycemic animals did not affect VMNdm or -vl nitrergic neuron neuron nitric oxide synthase (nNOS), but up-regulated (VMNdm) or lacked influence on (VMNvl) GABA nerve cell glutamate decarboxylase65/67 (GAD) protein...
September 12, 2023: Neuroendocrinology
Paulina Kober, Julia Rymuza, Szymon Baluszek, Maria Maksymowicz, Aleksandra Nyc, Beata J Mossakowska, Grzegorz Zieliński, Jacek Kunicki, Mateusz Bujko
INTRODUCTION: Growth hormone secretion by sporadic somatotroph neuroendocrine pituitary tumors (PitNETs) is major cause of acromegaly. These tumors are relatively heterogenous in terms of histopathological and molecular features. Our previous transcriptomic profiling of somatotroph tumors revealed three distinct molecular subtypes. This study was aimed to investigate difference in DNA methylation pattern in subtypes of somatotroph PitNETs and its role in distinctive gene expression. METHODS: Genome-wide DNA methylation was investigated in 48 somatotroph PitNETs with EPIC microarrays...
September 12, 2023: Neuroendocrinology
Noah C Helderman, Manon Suerink, Gül Kilinç, José G Van Den Berg, Maartje Nielsen, Margot E T Tesselaar
Practice of neuroendocrine neoplasms (NENs) of the digestive tract, which comprise a highly diverse group of tumors with a rising incidence, faces multiple biological, diagnostic, and therapeutic issues. Part of these issues are due to misuse and misinterpretation of the classification and terminology of NENs of the digestive tract, which make it increasingly challenging to evaluate and compare literature. For instance, grade 3 neuroendocrine tumors (NETs) are frequently referred to as neuroendocrine carcinomas (NECs) and vice versa, while NECs are by definition high grade and therefore constitute a separate entity from NETs...
September 8, 2023: Neuroendocrinology
Chethan Yamichannaiah, Saba Samad Memon, Vijaya Sarathi, Anurag Ranjan Lila, Shilpa Sankhe, Sneha Arya, Manjiri Karlekar, Virendra Ashokrao Patil, Nalini Shah, Tushar Bandgar
INTRODUCTION: Cushing's disease (CD) due to macrocorticotropinoma (MC) in children and adolescents is a rare entity with limited information regarding its characteristics. The objective of the study is to describe the clinical, biochemical, imaging, management, outcome and genetic characteristics of children and adolescents with CD due to MC and compare them with those of microcorticotropinoma (mc). METHODS: This retrospective study was conducted in a single tertiary care center...
August 25, 2023: Neuroendocrinology
Katja Schumann, Rea Rodriguez-Raecke, Rik Sijben, Jessica Freiherr
INTRODUCTION: Brain insulin reactivity has been reported in connection with systematic energy metabolism, enhancement in cognition, olfactory sensitivity and neuroendocrine circuits. High receptor densities exist in regions important for sensory processing. The main aim of the study was to examine whether intranasal insulin would modulate the activity of areas in charge of olfactory-visual integration. METHODS: As approach, a placebo-controlled double-blind within crossover design was chosen...
August 25, 2023: Neuroendocrinology
Hanyu Xi, Xingru Li, Yun Zhou, Yaojun Sun
Hypertension is among the most harmful factors of cardiovascular and cerebrovascular diseases and poses an urgent problem for the development of human society. In addition to previous studies on its pathogenesis focusing on the peripheral sympathetic nervous system, investigating the central causes of high blood pressure involving the neuroendocrine and neuroinflammatory mechanisms of the hypothalamic paraventricular nucleus (PVN) is paramount. This nucleus is considered to regulate the output of neurohormones and sympathetic nerve activity...
August 19, 2023: Neuroendocrinology
Sida Zhao, Bin Li, Hua Gao, Yazhuo Zhang
INTRODUCTION: Aberrant miR-320a has been reported to be involved in the tumorigenesis of several cancers. In our previous study, we identified the low expression of circulating miR-320a in patients with somatotroph PitNET; however, the role of miR-320a in somatotroph PitNET proliferation is still unclear. METHODS: Cell viability and colony formation assays were used to detect the effect of miR-320a and BCAT1 on GH3 cells. TargetScan was used to identify the target genes of miR-320a...
August 17, 2023: Neuroendocrinology
Emilie Rissman, Wendy J Lynch
No abstract text is available yet for this article.
August 10, 2023: Neuroendocrinology
Jacqueline Kiewa, Sally Mortlock, Samantha Meltzer-Brody, Christel Middeldorp, Naomi R Wray, Enda M Byrne
Introduction Sex steroid hormone fluctuations may underlie both reproductive disorders and sex difference in lifetime depression prevalence. Previous studies report high comorbidity among reproductive disorders and between reproductive disorders and depression. This study sought to assess the multivariate genetic architecture of reproductive disorders and their loading onto a common genetic factor, and investigated whether this latent factor shares a common genetic architecture with female depression, including perinatal depression (PND)...
August 4, 2023: Neuroendocrinology
Tenna Bering, Aurea Susana Blancas-Velazquez, Martin Fredensborg Rath
INTRODUCTION: In the hippocampus, clock gene expression is important for memory and mood; however, the signaling mechanism controlling clock gene expression in the hippocampus is unknown. Recent findings suggest that circadian glucocorticoid rhythms driven by the suprachiasmatic nucleus (SCN) control rhythmic clock gene expression in neurons; in addition, dexamethasone modulates hippocampal clock gene expression. We therefore hypothesized that oscillations of clock genes in the hippocampus could be driven by SCN-controlled circadian rhythms in glucocorticoids...
July 29, 2023: Neuroendocrinology
Coskun Yolas, Ayhan Kanat, Mete Zeynal, Mehmet Hakan Sahin, Mehmet Kursat Karadag, Osman Nuri Keles, Nezih Akca, Eyup Dil, Mehmet Dumlu Aydin, Omer Lutfi Gundogdu
INTRODUCTION: Olfaction and its relation to human health is an area of growing interest. Although olfaction disorders have been considered a part of Kallmann Syndrome, the role of olfactory dysfunction on spermatogenesis has not been studied yet. We studied if olfactory bulbectomy causes dysfunction in spermatogenesis as a result of Onuf's nucleus damage. METHODS: Twenty-eight male rats were divided into three groups: six as the control (G-1; n=6), six as the only frontal burr-hole applied animals SHAM (G-1I; n=6), and 16 as the study group (G-III; n=16) in which OBX was performed...
July 27, 2023: Neuroendocrinology
Julia R Martz, Adriana Vasquez, Juan M Dominguez
INTRODUCTION: The mPOA is an important regulator of natural and drug-induced reward. It contains one of the brain's highest concentrations of sex-steroid hormone receptors and connects with the mesolimbic dopamine system. However, despite the mPOA being implicated in sexually dimorphic reward responses, sex differences in medial preoptic efferents to the VTA have not been investigated. METHODS: Male and female rats received unilateral injections of the tract-tracer Fluoro-Gold (FLG) into VTA...
July 10, 2023: Neuroendocrinology
Elias Karam, Marcus Hollenbach, Einas Abou Ali, Francesco Auriemma, Andrea Anderloni, Louise Barbier, Giulio Belfiori, Fabrice Caillol, Stefano Crippa, Marco Del Chiaro, Charles De Ponthaud, Yanis Dahel, Massimo Falconi, Marc Giovannini, Dominik Heling, Yosuke Inoue, William R Jarnagin, Galen Leung, Renato M Lupinacci, Alberto Mariani, Viliam Masaryk, Rainer Christoph Miksch, Nicolas Musquer, Bertrand Napoleon, Atsushi Oba, Stefano Partelli, Maria C Petrone, Frédéric Prat, Alessandro Repici, Alain Sauvanet, Katrin Salzmann, Mark A Schattner, Richard Schulick, Lilian Schwarz, Kevin Soares, François R Souche, Stéphanie Truant, Jean C Vaillant, Tiegong Wang, Edris Wedi, Jens Werner, Tobias J Weismüller, Dörte Wichmann, Uwe Will, Piera Zaccari, Aiste Gulla, Christian Heise, Sara Regner, Sébastien Gaujoux
INTRODUCTION: Ampullary neuroendocrine neoplasia (NEN) are rare and evidence regarding their management is scarce. This study aimed to describe clinico-pathological features, management and prognosis of ampullary NEN according to their endoscopic or surgical management. METHODS: From a multi-institutional international database patients treated with either endoscopic papillectomy (EP), transduodenal ampullectomy (TSA) or pancreatoduodenectomy (PD) for ampullary NEN were included...
June 27, 2023: Neuroendocrinology
Diana-Ioana Lupu, Andrea Cediel Ulloa, Joëlle Rüegg
Hormones are important regulators of key processes during fetal brain development. Thus, the developing brain is vulnerable to the action of chemicals that can interfere with endocrine signals. Epidemiological studies have pointed toward sexually dimorphic associations between neurodevelopmental outcomes, such as cognitive abilities, in children and prenatal exposure to endocrine disrupting chemicals (EDCs). This points toward disruption of sex steroid signalling in the development of neural structures underlying cognitive functions, such as the hippocampus, an essential mediator of learning and memory processes...
June 24, 2023: Neuroendocrinology
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