Yuko Maejima, Shoko Yokota, Shizu Hidema, Katsuhiko Nishimori, Heidi de Wet, Kenju Shimomura
INTRODUCTION: GLP-1 receptor agonists are the number one drug prescribed for the treatment of obesity and type 2 diabetes. These drugs are not, however, without side-effects and in an effort to maximize therapeutic effect while minimizing adverse effects, gut hormone co-agonists received considerable attention as new drug targets in the fight against obesity. Numerous previous reports identified the neuropeptide oxytocin (OXT) as a promising anti-obesity drug. The aim of this study is to evaluate OXT as a possible co-agonist for GLP-1 and examine the effects of its co-administration on food intake (FI) and body weight (BW) in mice...
April 10, 2024: Neuroendocrinology
Mélodie Devère, Saloua Takhlidjt, Gaëtan Prévost, Nicolas Chartrel, Jérôme Leprince, Marie Picot
BACKGROUND: Obesity and type 2 diabetes are strongly associated pathologies, currently considered as a worldwide epidemic problem. Understanding the mechanisms that drive the development of these diseases would enable to develop new therapeutic strategies for their prevention and treatment. Particularly, the role of the brain in the energy and glucose homeostasis has been studied for two decades. In specific, the hypothalamus contains well-identified neural networks regulating appetite and potentially also glucose homeostasis...
April 10, 2024: Neuroendocrinology
(no author information available yet)
No abstract text is available yet for this article.
April 8, 2024: Neuroendocrinology
Liqin Zeng, Xiaozhuang Zhang, Qingjun Shen, Li He, Xiaohan Liu, Xiangyue Zeng, Qiaozhu Wu, Irene Ma, Shuangyun Zheng, Liqin Cheng, Ling Li, Paul Yao
INTRODUCTION: Progestin, commonly used in oral contraception and preventing preterm birth, elicits various off-target side effects on brain and gastrointestinal (GI) functions, yet the precise mechanisms remain elusive. This study aims to probe progestin's impact on GI function and anxiety-like behaviors in female mice. METHODS: Colon stem cells were utilized to explore the mechanism underlying progestin 17-hydroxyprogesterone caproate (17-OHPC)-mediated suppression of claudin-1 (CLDN1), crucial for epithelial integrity...
April 6, 2024: Neuroendocrinology
Prabahan Chakraborty, Hugo Lamat, Emilie M André, Pierre Fontanaud, Freddy Jeanneteau
Introduction Exposure to social trauma may alter engagement with both fear-related and unrelated social stimuli long after. Intriguingly, how simultaneous discrimination of social fear and safety is affected in neurodevelopmental conditions remains underexplored. The role of the neuropeptide oxytocin is established in social behaviors, and yet unexplored during such a challenge post-social trauma. Methods Using Magel2 knockout mice, an animal model of Prader Willi Syndrome (PWS) and Schaaf-Yang Syndrome (SYS), we tested memory of social fear and safety after a modified social fear conditioning task...
April 4, 2024: Neuroendocrinology
Junjun Li, Hao Song, Ting Chen, Sixi Zhang, Chao Zhang, Chen Ma, Lingye Zhang, Tengfei Wang, Yuan Qian, Xingli Deng
INTRODUCTION: Growth hormone (GH) secreting pituitary adenoma is considered one of the most harmful types of Pituitary Neuroendocrine Tumors (PitNETs). Our previous research has found that high expression of Lysine Methyltransferase 5A (KMT5A) is closely related to the proliferation of PitNETs. The aim of this study was to investigate the role and molecular mechanism of KMT5A in the progression of GH PitNETs. METHODS: Immunohistochemistry, qRT-PCR and Western blot (WB) were used to assess the expression levels of KMT5A in human normal pituitary and GH PitNETs, as well as in rat normal pituitary and GH3 cells...
April 2, 2024: Neuroendocrinology
Xing Ming, Shengli Gao, Jinqiu Sun, Nana Zhang, Ruixiao Guo, Xufei Feng, Xinchi Luan, Han Xing, Yang Jiao, Feifei Guo
INTRODUCTION: Irritable bowel syndrome with diarrhea (IBS-D) is frequently accompanied by depression and anxiety, resulting in a reduced quality of life and increased medical expenditures. Although psychological factors are known to play an important role in the genesis and development of IBS-D, an understanding of the central neural control of intestinal dysfunction remains elusive. Melanin-concentrating hormone (MCH) is a gut-brain peptide involved in regulating feeding, sleep-wake rhythms, and emotional states...
March 28, 2024: Neuroendocrinology
Wei Ying Tham, Hian Liang Huang, David Wai Meng Tai, John C Allen, Jacqueline S G Hwang, Lih Ming Loh, Brian K P Goh, Simon Y K Ong, Peng Chin Kek, Damien M Y Tan, David C E Ng, Kelvin S H Loke
Peptide-receptor radionuclide therapy (PRRT) is a targeted molecular therapy used to treat neuroendocrine tumours (NET). It has been shown to be effective and well-tolerated in patients with metastatic neuroendocrine tumours in several centres in United States (US), Europe and Australia. Tolerability and efficacy data emerging from Asian centres remain few. Epidemiological evidence suggests that there are differences in neuroendocrine neoplasms between the population groups. We aim to describe the treatment and safety outcomes of PRRT in the Asian population...
March 26, 2024: Neuroendocrinology
Junyan Xu, Xiaoping Xu, Meng Zhang, Wensheng Liu, Jie Chen, Shaoli Song
Insulinomas are the most frequent functional neuroendocrine tumors of pancreas. In about 10% cases, insulinomas are associated with hereditary syndrome including multiple endocrine neoplasia 1 (MEN1). Herein, we presented a case of 44-year-old female with recurrent hypoglycemia. In December 1998, this patient has undergone resection of two pancreatic lesions due to hypoglycemia and diagnosed as insulinoma. After operation, the symptom of hypoglycemia disappeared. However, from 2021, hypoglycemic symptoms reappeared frequently and even coma...
March 12, 2024: Neuroendocrinology
Ling Fung Nelson Yit, Youquan Li
BACKGROUND: Neuroendocrine neoplasms (NENs) are rare tumors that develop from neuroendocrine cells in various parts of the body. The management of this disease poses a significant challenge because of the heterogeneous clinical presentation and varying degrees of aggressiveness. A multidisciplinary approach is often required in complex clinical situations. Radiation therapy (RT) plays a key role in managing NENs in both curative and palliative settings. SUMMARY: In this review, we summarize and discuss recent developments in the field of advanced RT in early-stage, locally advanced, and metastatic NENs...
March 2, 2024: Neuroendocrinology
Alexandre Caron, André C Carpentier, Yves Deshaies, Jean-Pierre Després, Frédéric Picard, Serge Rivest, André Tchernof
No abstract text is available yet for this article.
February 23, 2024: Neuroendocrinology
Juan Chen, Zhigao Xiang, Zhuo Zhang, Yan Yang, Kai Shu, Ting Lei
INTRODUCTION: Acromegaly patients, in addition to the most prominent physical and endocrine changes, also exhibit a higher risk of cognitive dysfunction. However, the reasons and mechanisms underlying cognitive impairments in acromegaly patients remain unknown. METHODS: Acromegalic rats were induced by subcutaneous injection of tumor cells, with continuous monitoring of body weight and hormonal to confirm the occurrence of acromegaly. Behavioral assessments, including Open Field Test, Novel Object Recognition Test, and Barnes maze Test, were conducted to evaluate the animals' cognitive function...
February 16, 2024: Neuroendocrinology
Breanna N Harris, Masha Yavari, Latha Ramalingam, P Logan Mounce, Kaylee Alers Maldonado, Angela C Chavira, Sarah Thomas, Shane Scoggin, Caroline Biltz, Naima Moustaid-Moussa
INTRODUCTION: Alzheimer's disease (AD) alters neurocognitive and emotional function and causes dysregulation of multiple homeostatic processes. The leading AD framework pins amyloid beta plaques and tau tangles as primary drivers of dysfunction. However, many additional variables, including diet, stress, sex, age, and pain tolerance, interact in ways that are not fully understood to impact the onset and progression of AD pathophysiology. We asked: 1) does high-fat diet, compared to low-fat diet, exacerbate AD pathophysiology and behavioral decline? And, 2) can supplementation with eicosapentaenoic (EPA)-enriched fish oil prevent high-fat-diet-induced changes? METHODS: Male and female APPswePSdE9 mice, and their non-transgenic littermates, were randomly assigned to a diet condition (low-fat, high-fat, high-fat with EPA) and followed from 2 to 10 months of age...
February 1, 2024: Neuroendocrinology
Sami Agus, Yavuz Yavuz, Deniz Atasoy, Bayram Yilmaz
INTRODUCTION: Post-weaning social isolation (PWSI) in rodents is an advanced psychosocial stress model in early life. Some psychosocial stress, such as restrain and isolation, disrupt reproductive physiology in young and adult period. Mechanisms of early life stress (ELS) effects on central regulation of reproduction needs to be elucidated. We have investigated the effects of PWSI on function of Arcuate Kisspeptin (ARCKISS1) neurons by using electrophysiological techniques combining with monitoring of puberty onset and estrous cycle in male and female Kiss1-Cre mice...
January 25, 2024: Neuroendocrinology
Banalata Mohanty
Introduction This study sought to decipher the mechanism of transitions between life-history stages in a seasonally reproducing subtropical finch, Amandava amandava delineating the plasticity of the gonadotropes (LH cells), lactotropes (PRL cells) and thyrotropes (TSH cells) in the pituitary gland including the pars tuberalis (PT), with regard to the in-situ expression, morphological characteristics, and alteration in the plasma levels of hormones. Methods Immunohistochemistry of LH, PRL, TSH cells, morphometry and densitometry of expressed hormones (Imge J software analysis), and ELISA for plasma hormonal levels were performed...
January 23, 2024: Neuroendocrinology
Karine Rousseau, Fabrice Girardot, Caroline Parmentier, Hervé Tostivint
The caudal neurosecretory system (CNSS) is a neuroendocrine complex, whose existence is specific to fishes. In teleosts, it consists of neurosecretory cells (Dahlgren cells) whose fibers are associated with a neurohemal terminal tissue (urophysis). In other actinopterygians as well as in chondrichthyes, the system is devoid of urophysis, so that Dahlgren cells end in a diffuse neurohemal region. Structurally, it has many similarities with the hypothalamic-neurohypophysial system. However, it differs regarding its position at the caudal end of the spinal cord and the nature of the hormones it secretes, the most notable ones being urotensins...
January 16, 2024: Neuroendocrinology
Siyuan Zhu, Yidan Pang, Xiangwei Zhang, Chunying Yang, Junjie Gao, Ping Fang, Yaohui Zhang, Yunjin Yao, Fangyu Ju, Fang Ye, Hongyi Zhu, Peng Liao, Lufeng Yao, Lulu Dai, Jun Xu, Bo Wu, Jun Pan, Yijun Wu
INTRODUCTION: Aging is characterized by the deterioration of a wide range of functions in tissues and organs, and Alzheimer's disease (AD) is a neurodegenerative disease characterized by cognitive impairment. Hypothyroidism occurs when there is insufficient production of thyroid hormones (THs) by the thyroid. The relationship between hypothyroidism and aging as well as AD is controversial at present. METHODS: We established an animal model of AD (FAD4T) with mutations in the APP and PSEN1 genes, and we performed a thyroid function test and RNA-sequencing (RNA-Seq) of the thyroid from FAD4T and naturally aging mice...
January 16, 2024: Neuroendocrinology
Viktor Stratilov, Oleg Vetrovoy, Sophia Potapova, Ekaterina Tyulkova
INTRODUCTION: Previous studies have shown that fetal hypoxia predisposes individuals to develop addictive disorders in adulthood. However, the specific impact of maternal stress, mediated through glucocorticoids and often coexisting with fetal hypoxia, is not yet fully comprehended. METHODS: To delineate the potential effects of these pathological factors, we designed models of prenatal severe hypoxia (PSH) in conjunction with maternal stress and prenatal intrauterine ischemia (PII)...
January 10, 2024: Neuroendocrinology
J Anna Juras, Soledad Pitra, Bret N Smith
INTRODUCTION: Previous work showed that increasing the electrical activity of inhibitory neurons in the dorsal vagal complex (DVC) is sufficient to increase whole-body glucose concentration in normoglycemic mice. Here we tested the hypothesis that deactivating GABAergic neurons in the dorsal hindbrain of hyperglycemic mice decreases synaptic inhibition of parasympathetic motor neurons in the dorsal motor nucleus of the vagus (DMV) and reduces systemic glucose levels. METHODS: Chemogenetic activation or inactivation of GABAergic neurons in the nucleus tractus solitarius (NTS) was used to assess effects of modulating parasympathetic output on blood glucose concentration in normoglycemic and hyperglycemic mice...
January 9, 2024: Neuroendocrinology
Linfeng Miao, Chenying Tian, Qingqing Xiong, Jing Zhao, Yunfei Feng, Hong Yu, Huahua Du
UNLABELLED: Lipocalin 2 (Lcn2) is a key factor in appetite suppression. However, the effect of Lcn2 on appetite in terms of sex differences has not been thoroughly studied. METHODS: Young (3-month-old) whole-body Lcn2 knockout (Lcn2-/-) mice, which were fed normal diet (ND) or high-fat diet (HFD) for eight-weeks to investigate obesity, food intake, serum metabolism, hepatic lipid metabolism, and regulation of gastrointestinal hormones. RESULTS: Lcn2 deficiency significantly increased the body weight and food intake of male mice when fed ND instead of HFD, and females when fed HFD but not ND...
January 9, 2024: Neuroendocrinology
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