Chunmei Lan, Yuanshu Chen, Yingying Zhang, Juan Kou, Linghong Huang, Ting Xu, Xi Yang, Dan Xu, Wenxu Yang, Keith M Kendrick, Weihua Zhao
INTRODUCTION: Oxytocin (OXT) is proposed as a potential therapeutic peptide for social dysfunction due to its modulatory actions on socioemotional regulation in humans. While the majority of studies have used intranasal OXT administration we have recently shown that oral (lingual spray), but not intranasal, administration can significantly enhance activity of the brain reward system in response to emotional faces in males, however its effects on females are unknown. METHODS: Seventy healthy females participated in the current randomized, placebo-controlled, pharmaco-imaging clinical trial and the results were compared with our previous data from 75 males who underwent the same protocol...
May 13, 2023: Neuroendocrinology