Maria Daniela Torres-Rodriguez, Soon Goo Lee, Swarup Roy Choudhury, Rabindranath Paul, Balaji Selvam, Diwakar Shukla, Joseph M Jez, Sona Pandey
Heterotrimeric GTP-binding protein alpha subunit (Gα) and its cognate regulator of G-protein signaling (RGS) protein transduce signals in eukaryotes spanning protists, amoeba, animals, fungi, and plants. The core catalytic mechanisms of the GTPase activity of Gα and the interaction interface with RGS for acceleration of GTP hydrolysis seem to be conserved across these groups; however, the RGS gene is under low selective pressure in plants, resulting in its frequent loss. Our current understanding of the structural basis of Gα:RGS regulation in plants has been shaped by Arabidopsis Gα, (AtGPA1), which has a cognate RGS protein...
April 1, 2024: Journal of Biological Chemistry