Glenn F van Wigcheren, Jorge Cuenca-Escalona, Suzan Stelloo, Julia Brake, Eline Peeters, Sophie K Horrevorts, Siebren Frölich, Iván Ramos-Tomillero, Yvonne Wesseling-Rozendaal, Carla M L van Herpen, Anja van de Stolpe, Michiel Vermeulen, I Jolanda M de Vries, Carl G Figdor, Georgina Flórez-Grau
Imbalanced immune responses are a prominent hallmark of cancer and autoimmunity. Overactive as well as suppressed immunological activity is evidenced to promote disease. This immunological disbalance is often driven through disrupted immunomodulation by innate myeloid immune cells. Myeloid cells can be overly suppressive, inhibiting protective immune responses or be inactive not controlling autoreactive immune cells. Understanding the mechanisms that induce and drive suppressive myeloid cells, such as myeloid-derived suppressor cells (MDSCs) and tolerogenic dendritic cells (TolDCs), can facilitate the development of immune-restoring therapeutic approaches in patients...
September 20, 2023: Journal of Biological Chemistry