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Journal of Pain and Symptom Management

Andie Bernard
No abstract text is available yet for this article.
July 10, 2019: Journal of Pain and Symptom Management
Jennifer Obi, Antonio M Esquinas, Stephen M Pastores
No abstract text is available yet for this article.
July 9, 2019: Journal of Pain and Symptom Management
Adinda Mieras, H Roeline W Pasman, Bregje D Onwuteaka-Philipsen Prof, Anne-Marie M C Dingemans, Edith V Kok, Robin Cornelissen, Wouter Jacobs, Jan-Willem van den Berg, Alle Welling, Brigitte A H A Bogaarts, Lemke Pronk, Annemarie Becker-Commissaris
INTRODUCTION: Metastatic lung cancer is an incurable disease which results in a high burden of symptoms, a poor quality of life and an expected prognosis of less than 1 year after diagnosis. Treatment shortly before death may result in potential burdensome and inappropriate hospital admissions and hospital deaths. Dying at home is, at a population level, considered a quality for good end-of-life care. AIM: We examined what percentage of patients with metastatic lung cancer died inside the hospital and if hospital death, or other characteristics of the patient, oncologist or healthcare, were associated with treatment in the last month of life...
July 5, 2019: Journal of Pain and Symptom Management
Hiroaki Watanabe, Ryo Matsunuma, Kozue Suzuki, Yoshinobu Matsuda, Masanori Mori, Takashi Yamaguchi
No abstract text is available yet for this article.
July 5, 2019: Journal of Pain and Symptom Management
Christopher J Barnes, Colleen Webber, Shirley H Bush, Marie McNamara-Kilian, Jennifer Brodeur, Katie Marchington, Elham Sabri, Peter G Lawlor
No abstract text is available yet for this article.
July 5, 2019: Journal of Pain and Symptom Management
Camilla Lykke, Ola Ekholm, Kjeld Schmiegelow, Marianne Olsen, Per Sjøgren
CONTEXT: Losing a child is the most burdensome event parents can experience involving risks of developing anxiety and depression. OBJECTIVE: To investigate anxiety and depression in bereaved parents during their child's life-limiting illness and imminent death and 3-5 years after the loss in order to target future interventions. METHODS: A Danish nationwide cross-sectional questionnaire survey. From 2012-2014 a register-based study identified causes of deaths of 951 children 0-18 years of age...
July 2, 2019: Journal of Pain and Symptom Management
Myrick C Shinall, Mohana Karlekar, Sara Martin, Cheryl L Gatto, Sumi Misra, Chan Y Chung, Michael K Porayko, Andrew E Scanga, Natasha J Schneider, E Wesley Ely, Jill M Pulley, Rebecca N Jerome, Mary Lynn Dear, Douglas Conway, Reagan Buie, Dandan Liu, Christopher J Lindsell, Gordon R Bernard
CONTEXT: Palliative care interventions have shown promise in improving quality of life and reducing healthcare utilization among patients with chronic organ failure. OBJECTIVES: To evaluate the effect of a palliative care intervention for adults with end stage liver disease (ESLD). METHODS: Randomized controlled trial of ESLD patients admitted to the hepatology service at a tertiary referral center whose attending hepatologist indicated they would not be surprised if the patient died in the following year on a standardized questionnaire...
July 2, 2019: Journal of Pain and Symptom Management
David Hui, Farley Hernandez, Liliana Larsson, Diane Liu, Kelly Kilgore, Jane Naberhuis, Avery Virgilio, Suresh Reddy, Akhila Reddy, Shalini Dalal, Ali Haider, Larry Driver, Ahsan Azhar, Rony Dev, Eduardo Bruera
CONTEXT: The optimal dose of fentanyl sublingual spray (FSS) for exertional dyspnea has not been determined. OBJECTIVE: We examined the effect of two doses of prophylactic FSS on exertional dyspnea. METHODS: In this parallel, dose-finding, double-blind randomized clinical trial, opioid-tolerant cancer patients completed a shuttle walk test at baseline. Patients completed a second shuttle walk test 10 minutes after a single dose of FSS equivalent to either 35-45% (high dose) or 15-25% (low dose) of the total daily opioid dose...
July 2, 2019: Journal of Pain and Symptom Management
Siew Tzuh Tang, Wen-Chi Chou, Wen-Cheng Chang, Jen-Shi Chen, Chia-Hsun Hsieh, Fur-Hsing Wen, Shih-Chi Chung
BACKGROUND: Emotional preparedness for death is a distinct but related concept to prognostic awareness (PA). Both allow patients to prepare psychologically and interpersonally for death but they have primarily been examined in cross-sectional studies. OBJECTIVE: To (1) explore the courses of change in good emotional preparedness for death and accurate PA and (2) evaluate their associations with severe anxiety symptoms, severe depressive symptoms, and quality of life (QOL) in cancer patients' last year...
July 2, 2019: Journal of Pain and Symptom Management
Catherine E Mosher, Ekin Secinti, Adam T Hirsh, Nasser Hanna, Lawrence H Einhorn, Shadia I Jalal, Gregory Durm, Victoria L Champion, Shelley A Johns
CONTEXT: Advanced lung cancer patients typically have a poor prognosis and many symptoms that interfere with functioning, contributing to high rates of emotional distress in both patients and family caregivers. There remains a need for evidence-based interventions to improve functional outcomes and distress in this population. OBJECTIVES: This pilot trial examined the feasibility and preliminary efficacy of telephone-based Acceptance and Commitment Therapy (ACT) for symptomatic, advanced lung cancer patients and their distressed family caregivers...
June 27, 2019: Journal of Pain and Symptom Management
Donald H Taylor, Brystana G Kaufman, Andrew Olson, Matthew Harker, David Anderson, Sarah H Cross, Lindsay Bonsignore, Janet Bull
CONTEXT: Palliative care improves patient and family outcomes and may reduce the cost of care, but this service is underutilized among Medicare beneficiaries. OBJECTIVES: To describe enrollment patterns and outcomes associated with the Center for Medicare and Medicaid Innovation (CMMI) expansion of a multi-setting community palliative care program in North and South Carolina. METHODS: This observational study characterizes the CMMI cohort's care and cost trajectories after enrollment...
June 26, 2019: Journal of Pain and Symptom Management
Hiromichi Matsuoka, Satoru Iwase, Tempei Miyaji, Takashi Kawaguchi, Keisuke Ariyoshi, Shunsuke Oyamada, Eriko Satomi, Hiroto Ishiki, Hideaki Hasuo, Hiroko Sakuma, Akihiro Tokoro, Toshiaki Shinomiya, Hiroyuki Otani, Yoichi Otake, Hiroaki Tsukuura, Yoshihisa Matsumoto, Yoshikazu Hasegawa, Yuki Kataoka, Masatomo Otsuka, Kiyohiro Sakai, Yoshinobu Matsuda, Tatsuya Morita, Atsuko Koyama, Takuhiro Yamaguchi
CONTEXT: Although opioids and pregabalin are widely used for cancer-related neuropathic pain (CNP), no clinical trials exist to determine which medications are effective when an opioid-pregabalin combination therapy fails. OBJECTIVES: We investigated the efficacy of duloxetine for CNP nonresponsive or intolerant to opioid-pregabalin combination therapy. METHODS: A multicenter, randomized, double-blind, placebo-controlled trial was performed at 12 specialized palliative care services in Japan...
June 26, 2019: Journal of Pain and Symptom Management
Xin Shelley Wang, Qiuling Shi, Nishin Bhadkamkar, Charles S Cleeland, Araceli Garcia-Gonzalez, Jonathan Aguilar, Cobi Heijnen, Cathy Eng
CONTEXT: The most debilitating symptoms during oxaliplatin-based chemotherapy in patients with colorectal cancer (CRC) are neuropathy and fatigue. Inflammation has been suggested to contribute to these symptoms, and the anti-inflammatory agent minocycline is safe and readily available. OBJECTIVES: This proof-of-concept study investigated minocycline's capacity to reduce treatment-related neuropathy and fatigue and its impact on inflammatory markers during chemotherapy in a phase II randomized, double-blind, placebo-controlled clinical trial...
June 26, 2019: Journal of Pain and Symptom Management
Paulo Reis-Pina, Elham Sabri, Nicholas J Birkett, Antonio Barbosa, Peter G Lawlor
INTRODUCTION: Multidimensional assessment is pivotal in managing cancer related pain. OBJECTIVES: To determine time to stable pain control (SPC) and identify its baseline clinico-demographic predictors in patients with cancer pain. METHODS: A prospective longitudinal study of patients attending a cancer pain clinic. Scheduled clinic attendances and weekly investigator-led phone calls enabled monitoring of patients' daily pain diary, opioid use and other analgesic interventions...
June 25, 2019: Journal of Pain and Symptom Management
Brianna Morgan, Elise Tarbi
No abstract text is available yet for this article.
June 24, 2019: Journal of Pain and Symptom Management
Matthew G Kestenbaum, Krista Harrison, Domitilla Masi, Emily A Kuhl, J Cameron Muir
BACKGROUND: Clinicians play an important role in containing pharmaceutical spending at the patient level, as well as ensuring efficacy and quality outcomes, yet little research has examined how to achieve this goal. MEASURES: Using auditing and feedback (A&F) as part of a Pharmacy and Therapeutics (P&T) Committee, we evaluated our community-based hospice program's prescribing habits for opioids, antipsychotics, and antidepressants and calculated oral pharmaceutical prescription costs per-patient-day (PPD)...
June 24, 2019: Journal of Pain and Symptom Management
Maciej Wilski, Piotr Kocur, Mirosław Górny, Magdalena Koper, Anna Nadolska, Bartosz Chmielewski, Maciej Tomczak
OBJECTIVE: To examine the relationship between perception of multiple sclerosis (MS) impact and treatment efficacy beliefs in patients with MS and the extent to which self and illness appraisals can be regarded as mediator variables in this relationship. METHOD: The cross-sectional study included 278 MS patients who completed the Treatment Beliefs Scale, Multiple Sclerosis Impact Scale, Generalized Self-Efficacy Scale, Rosenberg Self-Esteem Scale, and Brief Illness Perception Questionnaire...
June 21, 2019: Journal of Pain and Symptom Management
Francesca Ricchini, Augusto Caraceni, Ernesto Zecca, Alessandra Pigni, Fabio Centurioni, Andrea Manzoni, Stein Kaasa, Cinzia Brunelli
CONTEXT: Few studies have addressed the impact of previous opioid exposure on the effect of opioids for the treatment of severe cancer pain episodes. OBJECTIVES: We aimed to test whether previous exposure to higher opioid doses was associated with a reduced analgesic effect of fentanyl sublingual tablets (FST) and subcutaneous morphine (SCM) and whether it had an influence on their relative effect. METHODS: This is a secondary analysis of a placebo controlled randomized trial comparing 100 μg FST to 5 mg SCM for the acute treatment of severe cancer pain episodes...
June 21, 2019: Journal of Pain and Symptom Management
Kathleen T Unroe, Erin O'Kelly Phillips, Shannon Effler, Mary Ersek, Susan E Hickman
CONTEXT: Nursing facility residents and their families may identify "comfort measures" as their overall goal of care, yet some hospital transfers still occur. OBJECTIVES: Describe nursing facility residents with comfort measures and their hospital transfers. METHODS: Mixed methods, including root cause analyses of transfers by RNs and interviews with a subset of healthcare providers and family members involved in transfers. Participants were residents in 19 central Indiana facilities with comfort measures orders who experienced unplanned transfers to the hospital January 1, 2015 - June 30, 2016...
June 21, 2019: Journal of Pain and Symptom Management
G Aresi, H C Rayner, L Hassan, J O Burton, S Mitra, C Sanders, S N Van der Veer
CONTEXT: Uraemic pruritus, or itch, is common in people with chronic kidney disease (CKD) and has a negative impact on their lives and well-being. However, for reasons currently unknown, itch often remains unreported and therefore untreated. OBJECTIVES: To explore reasons for underreporting of itch in order to provide pointers for improving itch reporting and management in people with CKD. METHODS: We interviewed adult patients with CKD who self-reported experiencing itching in the last three years (n=25), nephrologists (n=10) and nurses (n=12) from three kidney services in the United Kingdom...
June 19, 2019: Journal of Pain and Symptom Management
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