journal
https://read.qxmd.com/read/33845483/multilevel-proteomics-reveals-host-perturbations-by-sars-cov-2-and-sars-cov
#1
Alexey Stukalov, Virginie Girault, Vincent Grass, Ozge Karayel, Valter Bergant, Christian Urban, Darya A Haas, Yiqi Huang, Lila Oubraham, Anqi Wang, M Sabri Hamad, Antonio Piras, Fynn M Hansen, Maria C Tanzer, Igor Paron, Luca Zinzula, Thomas Enghleitner, Maria Reinecke, Teresa M Lavacca, Rosina Ehmann, Roman Wölfel, Jörg Jores, Bernhard Kuster, Ulrike Protzer, Roland Rad, John Ziebuhr, Volker Thiel, Pietro Scaturro, Matthias Mann, Andreas Pichlmair
The global emergence of SARS-CoV-2 urgently requires an in-depth understanding of molecular functions of viral proteins and their interactions with the host proteome. Several individual omics studies have extended our knowledge of COVID-19 pathophysiology1-10 . Integration of such datasets to obtain a holistic view of virus-host interactions and to define the pathogenic properties of SARS-CoV-2 is limited by the heterogeneity of the experimental systems. We therefore conducted a concurrent multi-omics study of SARS-CoV-2 and SARS-CoV...
April 12, 2021: Nature
https://read.qxmd.com/read/33837375/coronapod-one-whistle-blower-s-quest-to-take-politics-out-of-coronavirus-surveillance
#2
Noah Baker, Amy Maxmen
No abstract text is available yet for this article.
April 9, 2021: Nature
https://read.qxmd.com/read/33837372/want-fresh-results-analysis-of-thousands-of-papers-suggests-trying-new-teammates
#3
(no author information available yet)
No abstract text is available yet for this article.
April 9, 2021: Nature
https://read.qxmd.com/read/33837373/daily-briefing-thrilling-muon-result-shakes-up-physics
#4
Flora Graham
No abstract text is available yet for this article.
April 8, 2021: Nature
https://read.qxmd.com/read/33833462/a-hurricane-wrecks-monkey-island-and-leads-to-new-monkey-friendships
#5
(no author information available yet)
No abstract text is available yet for this article.
April 8, 2021: Nature
https://read.qxmd.com/read/33833461/what-manta-rays-remember-the-best-spots-to-get-spruced-up
#6
(no author information available yet)
No abstract text is available yet for this article.
April 8, 2021: Nature
https://read.qxmd.com/read/33833460/brain-cell-bouquet-and-snaps-from-mars-march-s-best-science-images
#7
Emma Stoye
No abstract text is available yet for this article.
April 8, 2021: Nature
https://read.qxmd.com/read/33833458/a-guide-to-plan-s-the-open-access-initiative-shaking-up-science-publishing
#8
Holly Else
No abstract text is available yet for this article.
April 8, 2021: Nature
https://read.qxmd.com/read/33833441/author-correction-dense-sampling-of-bird-diversity-increases-power-of-comparative-genomics
#9
Shaohong Feng, Josefin Stiller, Yuan Deng, Joel Armstrong, Qi Fang, Andrew Hart Reeve, Duo Xie, Guangji Chen, Chunxue Guo, Brant C Faircloth, Bent Petersen, Zongji Wang, Qi Zhou, Mark Diekhans, Wanjun Chen, Sergio Andreu-Sánchez, Ashot Margaryan, Jason Travis Howard, Carole Parent, George Pacheco, Mikkel-Holger S Sinding, Lara Puetz, Emily Cavill, Ângela M Ribeiro, Leopold Eckhart, Jon Fjeldså, Peter A Hosner, Robb T Brumfield, Les Christidis, Mads F Bertelsen, Thomas Sicheritz-Ponten, Dieter Thomas Tietze, Bruce C Robertson, Gang Song, Gerald Borgia, Santiago Claramunt, Irby J Lovette, Saul J Cowen, Peter Njoroge, John Philip Dumbacher, Oliver A Ryder, Jérôme Fuchs, Michael Bunce, David W Burt, Joel Cracraft, Guanliang Meng, Shannon J Hackett, Peter G Ryan, Knud Andreas Jønsson, Ian G Jamieson, Rute R da Fonseca, Edward L Braun, Peter Houde, Siavash Mirarab, Alexander Suh, Bengt Hansson, Suvi Ponnikas, Hanna Sigeman, Martin Stervander, Paul B Frandsen, Henriette van der Zwan, Rencia van der Sluis, Carina Visser, Christopher N Balakrishnan, Andrew G Clark, John W Fitzpatrick, Reed Bowman, Nancy Chen, Alison Cloutier, Timothy B Sackton, Scott V Edwards, Dustin J Foote, Subir B Shakya, Frederick H Sheldon, Alain Vignal, André E R Soares, Beth Shapiro, Jacob González-Solís, Joan Ferrer-Obiol, Julio Rozas, Marta Riutort, Anna Tigano, Vicki Friesen, Love Dalén, Araxi O Urrutia, Tamás Székely, Yang Liu, Michael G Campana, André Corvelo, Robert C Fleischer, Kim M Rutherford, Neil J Gemmell, Nicolas Dussex, Henrik Mouritsen, Nadine Thiele, Kira Delmore, Miriam Liedvogel, Andre Franke, Marc P Hoeppner, Oliver Krone, Adam M Fudickar, Borja Milá, Ellen D Ketterson, Andrew Eric Fidler, Guillermo Friis, Ángela M Parody-Merino, Phil F Battley, Murray P Cox, Nicholas Costa Barroso Lima, Francisco Prosdocimi, Thomas Lee Parchman, Barney A Schlinger, Bette A Loiselle, John G Blake, Haw Chuan Lim, Lainy B Day, Matthew J Fuxjager, Maude W Baldwin, Michael J Braun, Morgan Wirthlin, Rebecca B Dikow, T Brandt Ryder, Glauco Camenisch, Lukas F Keller, Jeffrey M DaCosta, Mark E Hauber, Matthew I M Louder, Christopher C Witt, Jimmy A McGuire, Joann Mudge, Libby C Megna, Matthew D Carling, Biao Wang, Scott A Taylor, Glaucia Del-Rio, Alexandre Aleixo, Ana Tereza Ribeiro Vasconcelos, Claudio V Mello, Jason T Weir, David Haussler, Qiye Li, Huanming Yang, Jian Wang, Fumin Lei, Carsten Rahbek, M Thomas P Gilbert, Gary R Graves, Erich D Jarvis, Benedict Paten, Guojie Zhang
No abstract text is available yet for this article.
April 8, 2021: Nature
https://read.qxmd.com/read/33833440/author-correction-protecting-the-global-ocean-for-biodiversity-food-and-climate
#10
Enric Sala, Juan Mayorga, Darcy Bradley, Reniel B Cabral, Trisha B Atwood, Arnaud Auber, William Cheung, Christopher Costello, Francesco Ferretti, Alan M Friedlander, Steven D Gaines, Cristina Garilao, Whitney Goodell, Benjamin S Halpern, Audra Hinson, Kristin Kaschner, Kathleen Kesner-Reyes, Fabien Leprieur, Jennifer McGowan, Lance E Morgan, David Mouillot, Juliano Palacios-Abrantes, Hugh P Possingham, Kristin D Rechberger, Boris Worm, Jane Lubchenco
No abstract text is available yet for this article.
April 8, 2021: Nature
https://read.qxmd.com/read/33837374/is-the-standard-model-broken-physicists-cheer-major-muon-result
#11
Davide Castelvecchi
No abstract text is available yet for this article.
April 7, 2021: Nature
https://read.qxmd.com/read/33833459/daily-briefing-european-regulator-links-astrazeneca-vaccine-to-rare-blood-clots
#12
Flora Graham
No abstract text is available yet for this article.
April 7, 2021: Nature
https://read.qxmd.com/read/33828303/leading-hadronic-contribution-to-the-muon-magnetic-moment-from-lattice-qcd
#13
Sz Borsanyi, Z Fodor, J N Guenther, C Hoelbling, S D Katz, L Lellouch, T Lippert, K Miura, L Parato, K K Szabo, F Stokes, B C Toth, Cs Torok, L Varnhorst
The standard model of particle physics describes the vast majority of experiments and observations involving elementary particles. Any deviation from its predictions would be a sign of new, fundamental physics. One long-standing discrepancy concerns the anomalous magnetic moment of the muon, a measure of the magnetic field surrounding that particle. Standard-model predictions1 exhibit disagreement with measurements2 that is tightly scattered around 3.7 standard deviations. Today, theoretical and measurement errors are comparable; however, ongoing and planned experiments aim to reduce the measurement error by a factor of four...
April 7, 2021: Nature
https://read.qxmd.com/read/33828302/cell-programmed-nutrient-partitioning-in-the-tumour-microenvironment
#14
Bradley I Reinfeld, Matthew Z Madden, Melissa M Wolf, Anna Chytil, Jackie E Bader, Andrew R Patterson, Ayaka Sugiura, Allison S Cohen, Ahmed Ali, Brian T Do, Alexander Muir, Caroline A Lewis, Rachel A Hongo, Kirsten L Young, Rachel E Brown, Vera M Todd, Tessa Huffstater, Abin Abraham, Richard T O'Neil, Matthew H Wilson, Fuxue Xin, M Noor Tantawy, W David Merryman, Rachelle W Johnson, Christopher S Williams, Emily F Mason, Frank M Mason, Katherine E Beckermann, Matthew G Vander Heiden, H Charles Manning, Jeffrey C Rathmell, W Kimryn Rathmell
Cancer cells characteristically consume glucose through Warburg metabolism1 , a process that forms the basis of tumour imaging by positron emission tomography (PET). Tumour-infiltrating immune cells also rely on glucose, and impaired immune cell metabolism in the tumour microenvironment (TME) contributes to immune evasion by tumour cells2-4 . However, whether the metabolism of immune cells is dysregulated in the TME by cell-intrinsic programs or by competition with cancer cells for limited nutrients remains unclear...
April 7, 2021: Nature
https://read.qxmd.com/read/33828301/car-directs-t-cell-adaptation-to-bile-acids-in-the-small-intestine
#15
Mei Lan Chen, Xiangsheng Huang, Hongtao Wang, Courtney Hegner, Yujin Liu, Jinsai Shang, Amber Eliason, Huitian Diao, HaJeung Park, Blake Frey, Guohui Wang, Sarah A Mosure, Laura A Solt, Douglas J Kojetin, Alex Rodriguez-Palacios, Deborah A Schady, Casey T Weaver, Matthew E Pipkin, David D Moore, Mark S Sundrud
Bile acids are lipid-emulsifying metabolites synthesized in hepatocytes and maintained in vivo through enterohepatic circulation between the liver and small intestine1 . As detergents, bile acids can cause toxicity and inflammation in enterohepatic tissues2 . Nuclear receptors maintain bile acid homeostasis in hepatocytes and enterocytes3 , but it is unclear how mucosal immune cells tolerate high concentrations of bile acids in the small intestine lamina propria (siLP). CD4+ T effector (Teff ) cells upregulate expression of the xenobiotic transporter MDR1 (encoded by Abcb1a) in the siLP to prevent bile acid toxicity and suppress Crohn's disease-like small bowel inflammation4 ...
April 7, 2021: Nature
https://read.qxmd.com/read/33828300/fossoriality-and-evolutionary-development-in-two-cretaceous-mammaliamorphs
#16
Fangyuan Mao, Chi Zhang, Cunyu Liu, Jin Meng
Mammaliamorpha comprises the last common ancestor of Tritylodontidae and Mammalia plus all its descendants1 . Tritylodontids are nonmammaliaform herbivorous cynodonts that originated in the Late Triassic epoch, diversified in the Jurassic period2-5 and survived into the Early Cretaceous epoch6,7 . Eutriconodontans have generally been considered to be an extinct mammalian group, although different views exist8 . Here we report a newly discovered tritylodontid and eutriconodontan from the Early Cretaceous Jehol Biota of China...
April 7, 2021: Nature
https://read.qxmd.com/read/33828299/type-iii-a-crispr-immunity-promotes-mutagenesis-of-staphylococci
#17
Charlie Y Mo, Jacob Mathai, Jakob T Rostøl, Andrew Varble, Dalton V Banh, Luciano A Marraffini
Horizontal gene transfer and mutation are the two major drivers of microbial evolution that enable bacteria to adapt to fluctuating environmental stressors1 . Clustered, regularly interspaced, short palindromic repeats (CRISPR) systems use RNA-guided nucleases to direct sequence-specific destruction of the genomes of mobile genetic elements that mediate horizontal gene transfer, such as conjugative plasmids2 and bacteriophages3 , thus limiting the extent to which bacteria can evolve by this mechanism. A subset of CRISPR systems also exhibit non-specific degradation of DNA4,5 ; however, whether and how this feature affects the host has not yet been examined...
April 7, 2021: Nature
https://read.qxmd.com/read/33828298/a-biosensor-for-the-direct-visualization-of-auxin
#18
Ole Herud-Sikimić, Andre C Stiel, Martina Kolb, Sooruban Shanmugaratnam, Kenneth W Berendzen, Christian Feldhaus, Birte Höcker, Gerd Jürgens
One of the most important regulatory small molecules in plants is indole-3-acetic acid, also known as auxin. Its dynamic redistribution has an essential role in almost every aspect of plant life, ranging from cell shape and division to organogenesis and responses to light and gravity1,2 . So far, it has not been possible to directly determine the spatial and temporal distribution of auxin at a cellular resolution. Instead it is inferred from the visualization of irreversible processes that involve the endogenous auxin-response machinery3-7 ; however, such a system cannot detect transient changes...
April 7, 2021: Nature
https://read.qxmd.com/read/33828297/genome-wide-enhancer-maps-link-risk-variants-to-disease-genes
#19
Joseph Nasser, Drew T Bergman, Charles P Fulco, Philine Guckelberger, Benjamin R Doughty, Tejal A Patwardhan, Thouis R Jones, Tung H Nguyen, Jacob C Ulirsch, Fritz Lekschas, Kristy Mualim, Heini M Natri, Elle M Weeks, Glen Munson, Michael Kane, Helen Y Kang, Ang Cui, John P Ray, Thomas M Eisenhaure, Ryan L Collins, Kushal Dey, Hanspeter Pfister, Alkes L Price, Charles B Epstein, Anshul Kundaje, Ramnik J Xavier, Mark J Daly, Hailiang Huang, Hilary K Finucane, Nir Hacohen, Eric S Lander, Jesse M Engreitz
Genome-wide association studies (GWAS) have identified thousands of noncoding loci that are associated with human diseases and complex traits, each of which could reveal insights into the mechanisms of disease1 . Many of the underlying causal variants may affect enhancers2,3 , but we lack accurate maps of enhancers and their target genes to interpret such variants. We recently developed the activity-by-contact (ABC) model to predict which enhancers regulate which genes and validated the model using CRISPR perturbations in several cell types4 ...
April 7, 2021: Nature
https://read.qxmd.com/read/33828296/astrocytes-close-a-motor-circuit-critical-period
#20
Sarah D Ackerman, Nelson A Perez-Catalan, Marc R Freeman, Chris Q Doe
Critical periods-brief intervals during which neural circuits can be modified by activity-are necessary for proper neural circuit assembly. Extended critical periods are associated with neurodevelopmental disorders; however, the mechanisms that ensure timely critical period closure remain poorly understood1,2 . Here we define a critical period in a developing Drosophila motor circuit and identify astrocytes as essential for proper critical period termination. During the critical period, changes in activity regulate dendrite length, complexity and connectivity of motor neurons...
April 7, 2021: Nature
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