journal

Nature

journal
https://read.qxmd.com/read/32651562/scientists-call-for-pandemic-investigations-to-focus-on-wildlife-trade
#1
Smriti Mallapaty
No abstract text is available yet for this article.
July 10, 2020: Nature
https://read.qxmd.com/read/32651561/the-mathematical-strategy-that-could-transform-coronavirus-testing
#2
Smriti Mallapaty
No abstract text is available yet for this article.
July 10, 2020: Nature
https://read.qxmd.com/read/32651560/pandemic-speeds-largest-test-yet-of-universal-basic-income
#3
Carrie Arnold
No abstract text is available yet for this article.
July 10, 2020: Nature
https://read.qxmd.com/read/32650338/structural-basis-for-rifin-mediated-activation-of-lilrb1-in-malaria
#4
Thomas E Harrison, Alexander M Mørch, James H Felce, Akihito Sakoguchi, Adam J Reid, Hisashi Arase, Michael L Dustin, Matthew K Higgins
The Plasmodium species that cause malaria are obligate intracellular parasites, and disease symptoms occur as they replicate within human blood. Despite risking immune detection, the parasite delivers proteins that bind host receptors to infected erythrocyte surfaces. In the causative agent of the most deadly human malaria, Plasmodium falciparum, RIFINs form the largest erythrocyte surface protein family1 . Some RIFINs can bind inhibitory immune receptors, acting as targets for unusual antibodies containing a LAIR1 ectodomain2-4 , or as ligands for LILRB15 ...
July 10, 2020: Nature
https://read.qxmd.com/read/32651563/blood-from-fit-mice-bestows-brain-benefits-of-exercise
#5
(no author information available yet)
No abstract text is available yet for this article.
July 9, 2020: Nature
https://read.qxmd.com/read/32647385/how-the-coronavirus-pandemic-is-changing-virtual-science-communication
#6
Nikki Forrester
No abstract text is available yet for this article.
July 9, 2020: Nature
https://read.qxmd.com/read/32647384/the-lockdown-walk-that-inspired-an-experiment
#7
Florencia A Yannelli, Wolf-Christian Saul
No abstract text is available yet for this article.
July 9, 2020: Nature
https://read.qxmd.com/read/32647383/this-material-is-almost-as-hard-as-diamond-but-as-light-as-graphite
#8
(no author information available yet)
No abstract text is available yet for this article.
July 9, 2020: Nature
https://read.qxmd.com/read/32647381/bleak-financial-outlook-for-phd-students-in-australia
#9
Chris Woolston
No abstract text is available yet for this article.
July 9, 2020: Nature
https://read.qxmd.com/read/32647380/your-new-lab-partner-a-mobile-robot-chemist
#10
(no author information available yet)
No abstract text is available yet for this article.
July 9, 2020: Nature
https://read.qxmd.com/read/32647382/mounting-evidence-suggests-coronavirus-is-airborne-but-health-advice-has-not-caught-up
#11
Dyani Lewis
No abstract text is available yet for this article.
July 8, 2020: Nature
https://read.qxmd.com/read/32641835/irritant-evoked-activation-and-calcium-modulation-of-the-trpa1-receptor
#12
Jianhua Zhao, John V Lin King, Candice E Paulsen, Yifan Cheng, David Julius
The transient receptor potential ion channel TRPA1 is expressed by primary afferent nerve fibres, in which it functions as a low-threshold sensor for structurally diverse electrophilic irritants, including small volatile environmental toxicants and endogenous algogenic lipids1 . TRPA1 is also a 'receptor-operated' channel whose activation downstream of metabotropic receptors elicits inflammatory pain or itch, making it an attractive target for novel analgesic therapies2 . However, the mechanisms by which TRPA1 recognizes and responds to electrophiles or cytoplasmic second messengers remain unknown...
July 8, 2020: Nature
https://read.qxmd.com/read/32641834/mitochondrial-ubiquinol-oxidation-is-necessary-for-tumour-growth
#13
Inmaculada Martínez-Reyes, Luzivette Robles Cardona, Hyewon Kong, Karthik Vasan, Gregory S McElroy, Marie Werner, Hermon Kihshen, Colleen R Reczek, Samuel E Weinberg, Peng Gao, Elizabeth M Steinert, Raul Piseaux, G R Scott Budinger, Navdeep S Chandel
The mitochondrial electron transport chain (ETC) is necessary for tumour growth1-6 and its inhibition has demonstrated anti-tumour efficacy in combination with targeted therapies7-9 . Furthermore, human brain and lung tumours display robust glucose oxidation by mitochondria10,11 . However, it is unclear why a functional ETC is necessary for tumour growth in vivo. ETC function is coupled to the generation of ATP-that is, oxidative phosphorylation and the production of metabolites by the tricarboxylic acid (TCA) cycle...
July 8, 2020: Nature
https://read.qxmd.com/read/32641833/extracellular-proteostasis-prevents-aggregation-during-pathogenic-attack
#14
Ivan Gallotta, Aneet Sandhu, Maximilian Peters, Martin Haslbeck, Raimund Jung, Sinem Agilkaya, Jane L Blersch, Christian Rödelsperger, Waltraud Röseler, Chaolie Huang, Ralf J Sommer, Della C David
In metazoans, the secreted proteome participates in intercellular signalling and innate immunity, and builds the extracellular matrix scaffold around cells. Compared with the relatively constant intracellular environment, conditions for proteins in the extracellular space are harsher, and low concentrations of ATP prevent the activity of intracellular components of the protein quality-control machinery. Until now, only a few bona fide extracellular chaperones and proteases have been shown to limit the aggregation of extracellular proteins1-5 ...
July 8, 2020: Nature
https://read.qxmd.com/read/32641832/glucose-metabolism-links-astroglial-mitochondria-to-cannabinoid-effects
#15
Daniel Jimenez-Blasco, Arnau Busquets-Garcia, Etienne Hebert-Chatelain, Roman Serrat, Carlos Vicente-Gutierrez, Christina Ioannidou, Paula Gómez-Sotres, Irene Lopez-Fabuel, Monica Resch-Beusher, Eva Resel, Dorian Arnouil, Dave Saraswat, Marjorie Varilh, Astrid Cannich, Francisca Julio-Kalajzic, Itziar Bonilla-Del Río, Angeles Almeida, Nagore Puente, Svein Achicallende, Maria-Luz Lopez-Rodriguez, Charlotte Jollé, Nicole Déglon, Luc Pellerin, Charlène Josephine, Gilles Bonvento, Aude Panatier, Beat Lutz, Pier-Vincenzo Piazza, Manuel Guzmán, Luigi Bellocchio, Anne-Karine Bouzier-Sore, Pedro Grandes, Juan P Bolaños, Giovanni Marsicano
Astrocytes take up glucose from the bloodstream to provide energy to the brain, thereby allowing neuronal activity and behavioural responses1-5 . By contrast, astrocytes are under neuronal control through specific neurotransmitter receptors5-7 . However, whether the activation of astroglial receptors can directly regulate cellular glucose metabolism to eventually modulate behavioural responses is unclear. Here we show that activation of mouse astroglial type-1 cannabinoid receptors associated with mitochondrial membranes (mtCB1 ) hampers the metabolism of glucose and the production of lactate in the brain, resulting in altered neuronal functions and, in turn, impaired behavioural responses in social interaction assays...
July 8, 2020: Nature
https://read.qxmd.com/read/32641831/massive-haplotypes-underlie-ecotypic-differentiation-in-sunflowers
#16
Marco Todesco, Gregory L Owens, Natalia Bercovich, Jean-Sébastien Légaré, Shaghayegh Soudi, Dylan O Burge, Kaichi Huang, Katherine L Ostevik, Emily B M Drummond, Ivana Imerovski, Kathryn Lande, Mariana A Pascual-Robles, Mihir Nanavati, Mojtaba Jahani, Winnie Cheung, S Evan Staton, Stéphane Muños, Rasmus Nielsen, Lisa A Donovan, John M Burke, Sam Yeaman, Loren H Rieseberg
Species often include multiple ecotypes that are adapted to different environments1 . However, it is unclear how ecotypes arise and how their distinctive combinations of adaptive alleles are maintained despite hybridization with non-adapted populations2-4 . Here, by resequencing 1,506 wild sunflowers from 3 species (Helianthus annuus, Helianthus petiolaris and Helianthus argophyllus), we identify 37 large (1-100 Mbp in size), non-recombining haplotype blocks that are associated with numerous ecologically relevant traits, as well as soil and climate characteristics...
July 8, 2020: Nature
https://read.qxmd.com/read/32641830/a-bacterial-cytidine-deaminase-toxin-enables-crispr-free-mitochondrial-base-editing
#17
Beverly Y Mok, Marcos H de Moraes, Jun Zeng, Dustin E Bosch, Anna V Kotrys, Aditya Raguram, FoSheng Hsu, Matthew C Radey, S Brook Peterson, Vamsi K Mootha, Joseph D Mougous, David R Liu
Bacterial toxins represent a vast reservoir of biochemical diversity that can be repurposed for biomedical applications. Such proteins include a group of predicted interbacterial toxins of the deaminase superfamily, members of which have found application in gene-editing techniques1,2 . Because previously described cytidine deaminases operate on single-stranded nucleic acids3 , their use in base editing requires the unwinding of double-stranded DNA (dsDNA)-for example by a CRISPR-Cas9 system. Base editing within mitochondrial DNA (mtDNA), however, has thus far been hindered by challenges associated with the delivery of guide RNA into the mitochondria4 ...
July 8, 2020: Nature
https://read.qxmd.com/read/32641829/fitness-trade-offs-incurred-by-ovary-to-gut-steroid-signalling-in-drosophila
#18
Sara Mahmoud H Ahmed, Julieta A Maldera, Damir Krunic, Gabriela O Paiva-Silva, Clothilde Pénalva, Aurelio A Teleman, Bruce A Edgar
Sexual dimorphism arises from genetic differences between male and female cells, and from systemic hormonal differences1-3 . How sex hormones affect non-reproductive organs is poorly understood, yet highly relevant to health given the sex-biased incidence of many diseases4 . Here we report that steroid signalling in Drosophila from the ovaries to the gut promotes growth of the intestine specifically in mated females, and enhances their reproductive output. The active ovaries of the fly produce the steroid hormone ecdysone, which stimulates the division and expansion of intestinal stem cells in two distinct proliferative phases via the steroid receptors EcR and Usp and their downstream targets Broad, Eip75B and Hr3...
July 8, 2020: Nature
https://read.qxmd.com/read/32641828/envelope-protein-ubiquitination-drives-entry-and-pathogenesis-of-zika-virus
#19
Maria I Giraldo, Hongjie Xia, Leopoldo Aguilera-Aguirre, Adam Hage, Sarah van Tol, Chao Shan, Xuping Xie, Gail L Sturdevant, Shelly J Robertson, Kristin L McNally, Kimberly Meade-White, Sasha R Azar, Shannan L Rossi, Wendy Maury, Michael Woodson, Holly Ramage, Jeffrey R Johnson, Nevan J Krogan, Marc C Morais, Sonja M Best, Pei-Yong Shi, Ricardo Rajsbaum
Zika virus (ZIKV) belongs to the family Flaviviridae, and is related to other viruses that cause human diseases. Unlike other flaviviruses, ZIKV infection can cause congenital neurological disorders and replicates efficiently in reproductive tissues1-3 . Here we show that the envelope protein (E) of ZIKV is polyubiquitinated by the E3 ubiquitin ligase TRIM7 through Lys63 (K63)-linked polyubiquitination. Accordingly, ZIKV replicates less efficiently in the brain and reproductive tissues of Trim7-/- mice. Ubiquitinated E is present on infectious virions of ZIKV when they are released from specific cell types, and enhances virus attachment and entry into cells...
July 8, 2020: Nature
https://read.qxmd.com/read/32641827/native-american-gene-flow-into-polynesia-predating-easter-island-settlement
#20
Alexander G Ioannidis, Javier Blanco-Portillo, Karla Sandoval, Erika Hagelberg, Juan Francisco Miquel-Poblete, J Víctor Moreno-Mayar, Juan Esteban Rodríguez-Rodríguez, Consuelo D Quinto-Cortés, Kathryn Auckland, Tom Parks, Kathryn Robson, Adrian V S Hill, María C Avila-Arcos, Alexandra Sockell, Julian R Homburger, Genevieve L Wojcik, Kathleen C Barnes, Luisa Herrera, Soledad Berríos, Mónica Acuña, Elena Llop, Celeste Eng, Scott Huntsman, Esteban G Burchard, Christopher R Gignoux, Lucía Cifuentes, Ricardo A Verdugo, Mauricio Moraga, Alexander J Mentzer, Carlos D Bustamante, Andrés Moreno-Estrada
The possibility of voyaging contact between prehistoric Polynesian and Native American populations has long intrigued researchers. Proponents have pointed to the existence of New World crops, such as the sweet potato and bottle gourd, in the Polynesian archaeological record, but nowhere else outside the pre-Columbian Americas1-6 , while critics have argued that these botanical dispersals need not have been human mediated7 . The Norwegian explorer Thor Heyerdahl controversially suggested that prehistoric South American populations had an important role in the settlement of east Polynesia and particularly of Easter Island (Rapa Nui)2 ...
July 8, 2020: Nature
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