journal
https://read.qxmd.com/read/38418890/editorial-expression-of-concern-p63-and-p73-are-required-for-p53-dependent-apoptosis-in-response-to-dna-damage
#1
Elsa R Flores, Kenneth Y Tsai, Denise Crowley, Shomit Sengupta, Annie Yang, Frank McKeon, Tyler Jacks
No abstract text is available yet for this article.
February 28, 2024: Nature
https://read.qxmd.com/read/38418889/latitudinal-patterns-in-stabilizing-density-dependence-of-forest-communities
#2
JOURNAL ARTICLE
Lisa Hülsmann, Ryan A Chisholm, Liza Comita, Marco D Visser, Melina de Souza Leite, Salomon Aguilar, Kristina J Anderson-Teixeira, Norman A Bourg, Warren Y Brockelman, Sarayudh Bunyavejchewin, Nicolas Castaño, Chia-Hao Chang-Yang, George B Chuyong, Keith Clay, Stuart J Davies, Alvaro Duque, Sisira Ediriweera, Corneille Ewango, Gregory S Gilbert, Jan Holík, Robert W Howe, Stephen P Hubbell, Akira Itoh, Daniel J Johnson, David Kenfack, Kamil Král, Andrew J Larson, James A Lutz, Jean-Remy Makana, Yadvinder Malhi, Sean M McMahon, William J McShea, Mohizah Mohamad, Musalmah Nasardin, Anuttara Nathalang, Natalia Norden, Alexandre A Oliveira, Renan Parmigiani, Rolando Perez, Richard P Phillips, Nantachai Pongpattananurak, I-Fang Sun, Mark E Swanson, Sylvester Tan, Duncan Thomas, Jill Thompson, Maria Uriarte, Amy T Wolf, Tze Leong Yao, Jess K Zimmerman, Daniel Zuleta, Florian Hartig
Numerous studies have shown reduced performance in plants that are surrounded by neighbours of the same species1,2 , a phenomenon known as conspecific negative density dependence (CNDD)3 . A long-held ecological hypothesis posits that CNDD is more pronounced in tropical than in temperate forests4,5 , which increases community stabilization, species coexistence and the diversity of local tree species6,7 . Previous analyses supporting such a latitudinal gradient in CNDD8,9 have suffered from methodological limitations related to the use of static data10-12 ...
February 28, 2024: Nature
https://read.qxmd.com/read/38418888/integrated-lithium-niobate-microwave-photonic-processing-engine
#3
JOURNAL ARTICLE
Hanke Feng, Tong Ge, Xiaoqing Guo, Benshan Wang, Yiwen Zhang, Zhaoxi Chen, Sha Zhu, Ke Zhang, Wenzhao Sun, Chaoran Huang, Yixuan Yuan, Cheng Wang
Integrated microwave photonics (MWP) is an intriguing technology for the generation, transmission and manipulation of microwave signals in chip-scale optical systems1,2 . In particular, ultrafast processing of analogue signals in the optical domain with high fidelity and low latency could enable a variety of applications such as MWP filters3-5 , microwave signal processing6-9 and image recognition10,11 . An ideal integrated MWP processing platform should have both an efficient and high-speed electro-optic modulation block to faithfully perform microwave-optic conversion at low power and also a low-loss functional photonic network to implement various signal-processing tasks...
February 28, 2024: Nature
https://read.qxmd.com/read/38418887/imaging-the-meissner-effect-in-hydride-superconductors-using-quantum-sensors
#4
JOURNAL ARTICLE
P Bhattacharyya, W Chen, X Huang, S Chatterjee, B Huang, B Kobrin, Y Lyu, T J Smart, M Block, E Wang, Z Wang, W Wu, S Hsieh, H Ma, S Mandyam, B Chen, E Davis, Z M Geballe, C Zu, V Struzhkin, R Jeanloz, J E Moore, T Cui, G Galli, B I Halperin, C R Laumann, N Y Yao
By directly altering microscopic interactions, pressure provides a powerful tuning knob for the exploration of condensed phases and geophysical phenomena1 . The megabar regime represents an interesting frontier, in which recent discoveries include high-temperature superconductors, as well as structural and valence phase transitions2-6 . However, at such high pressures, many conventional measurement techniques fail. Here we demonstrate the ability to perform local magnetometry inside a diamond anvil cell with sub-micron spatial resolution at megabar pressures...
February 28, 2024: Nature
https://read.qxmd.com/read/38418886/ligand-channel-enabled-ultrafast-li-ion-conduction
#5
JOURNAL ARTICLE
Di Lu, Ruhong Li, Muhammad Mominur Rahman, Pengyun Yu, Ling Lv, Sheng Yang, Yiqiang Huang, Chuangchao Sun, Shuoqing Zhang, Haikuo Zhang, Junbo Zhang, Xuezhang Xiao, Tao Deng, Liwu Fan, Lixin Chen, Jianping Wang, Enyuan Hu, Chunsheng Wang, Xiulin Fan
Li-ion batteries (LIBs) for electric vehicles and aviation demand high energy density, fast charging and a wide operating temperature range, which are virtually impossible because they require electrolytes to simultaneously have high ionic conductivity, low solvation energy and low melting point and form an anion-derived inorganic interphase1-5 . Here we report guidelines for designing such electrolytes by using small-sized solvents with low solvation energy. The tiny solvent in the secondary solvation sheath pulls out the Li+ in the primary solvation sheath to form a fast ion-conduction ligand channel to enhance Li+ transport, while the small-sized solvent with low solvation energy also allows the anion to enter the first Li+ solvation shell to form an inorganic-rich interphase...
February 28, 2024: Nature
https://read.qxmd.com/read/38418885/crym-positive-striatal-astrocytes-gate-perseverative-behaviour
#6
JOURNAL ARTICLE
Matthias Ollivier, Joselyn S Soto, Kay E Linker, Stefanie L Moye, Yasaman Jami-Alahmadi, Anthony E Jones, Ajit S Divakaruni, Riki Kawaguchi, James A Wohlschlegel, Baljit S Khakh
Astrocytes are heterogeneous glial cells of the central nervous system1-3 . However, the physiological relevance of astrocyte diversity for neural circuits and behaviour remains unclear. Here we show that a specific population of astrocytes in the central striatum expresses μ-crystallin (encoded by Crym in mice and CRYM in humans) that is associated with several human diseases, including neuropsychiatric disorders4-7 . In adult mice, reducing the levels of μ-crystallin in striatal astrocytes through CRISPR-Cas9-mediated knockout of Crym resulted in perseverative behaviours, increased fast synaptic excitation in medium spiny neurons and dysfunctional excitatory-inhibitory synaptic balance...
February 28, 2024: Nature
https://read.qxmd.com/read/38418884/cst-polymerase-%C3%AE-primase-solves-a-second-telomere-end-replication-problem
#7
JOURNAL ARTICLE
Hiroyuki Takai, Valentina Aria, Pamela Borges, Joseph T P Yeeles, Titia de Lange
Telomerase adds G-rich telomeric repeats to the 3' ends of telomeres1 , counteracting telomere shortening caused by loss of telomeric 3' overhangs during leading-strand DNA synthesis ('the end-replication problem'2 ). Here we report a second end-replication problem that originates from the incomplete duplication of the C-rich telomeric repeat strand (C-strand) by lagging-strand DNA synthesis. This problem is resolved by fill-in synthesis mediated by polymerase α-primase bound to Ctc1-Stn1-Ten1 (CST-Polα-primase)...
February 28, 2024: Nature
https://read.qxmd.com/read/38418883/an-atlas-of-epithelial-cell-states-and-plasticity-in-lung-adenocarcinoma
#8
JOURNAL ARTICLE
Guangchun Han, Ansam Sinjab, Zahraa Rahal, Anne M Lynch, Warapen Treekitkarnmongkol, Yuejiang Liu, Alejandra G Serrano, Jiping Feng, Ke Liang, Khaja Khan, Wei Lu, Sharia D Hernandez, Yunhe Liu, Xuanye Cao, Enyu Dai, Guangsheng Pei, Jian Hu, Camille Abaya, Lorena I Gomez-Bolanos, Fuduan Peng, Minyue Chen, Edwin R Parra, Tina Cascone, Boris Sepesi, Seyed Javad Moghaddam, Paul Scheet, Marcelo V Negrao, John V Heymach, Mingyao Li, Steven M Dubinett, Christopher S Stevenson, Avrum E Spira, Junya Fujimoto, Luisa M Solis, Ignacio I Wistuba, Jichao Chen, Linghua Wang, Humam Kadara
Understanding the cellular processes that underlie early lung adenocarcinoma (LUAD) development is needed to devise intervention strategies1 . Here we studied 246,102 single epithelial cells from 16 early-stage LUADs and 47 matched normal lung samples. Epithelial cells comprised diverse normal and cancer cell states, and diversity among cancer cells was strongly linked to LUAD-specific oncogenic drivers. KRAS mutant cancer cells showed distinct transcriptional features, reduced differentiation and low levels of aneuploidy...
February 28, 2024: Nature
https://read.qxmd.com/read/38418882/the-crl5-spsb3-ubiquitin-ligase-targets-nuclear-cgas-for-degradation
#9
JOURNAL ARTICLE
Pengbiao Xu, Ying Liu, Chong Liu, Baptiste Guey, Lingyun Li, Pauline Melenec, Jonathan Ricci, Andrea Ablasser
Cyclic GMP-AMP synthase (cGAS) senses aberrant DNA during infection, cancer and inflammatory disease, and initiates potent innate immune responses through the synthesis of 2'3'-cyclic GMP-AMP (cGAMP)1-7 . The indiscriminate activity of cGAS towards DNA demands tight regulatory mechanisms that are necessary to maintain cell and tissue homeostasis under normal conditions. Inside the cell nucleus, anchoring to nucleosomes and competition with chromatin architectural proteins jointly prohibit cGAS activation by genomic DNA8-15 ...
February 28, 2024: Nature
https://read.qxmd.com/read/38418881/the-dimorphos-ejecta-plume-properties-revealed-by-liciacube
#10
JOURNAL ARTICLE
E Dotto, J D P Deshapriya, I Gai, P H Hasselmann, E Mazzotta Epifani, G Poggiali, A Rossi, G Zanotti, A Zinzi, I Bertini, J R Brucato, M Dall'Ora, V Della Corte, S L Ivanovski, A Lucchetti, M Pajola, M Amoroso, O Barnouin, A Campo Bagatin, A Capannolo, S Caporali, M Ceresoli, N L Chabot, A F Cheng, G Cremonese, E G Fahnestock, T L Farnham, F Ferrari, L Gomez Casajus, E Gramigna, M Hirabayashi, S Ieva, G Impresario, M Jutzi, R Lasagni Manghi, M Lavagna, J-Y Li, M Lombardo, D Modenini, P Palumbo, D Perna, S Pirrotta, S D Raducan, D C Richardson, A S Rivkin, A M Stickle, J M Sunshine, P Tortora, F Tusberti, M Zannoni
The Double Asteroid Redirection Test (DART) had an impact with Dimorphos (a satellite of the asteroid Didymos) on 26 September 20221 . Ground-based observations showed that the Didymos system brightened by a factor of 8.3 after the impact because of ejecta, returning to the pre-impact brightness 23.7 days afterwards2 . Hubble Space Telescope observations made from 15 minutes after impact to 18.5 days after, with a spatial resolution of 2.1 kilometres per pixel, showed a complex evolution of the ejecta3 , consistent with other asteroid impact events...
February 28, 2024: Nature
https://read.qxmd.com/read/38418880/compartmentalized-ocular-lymphatic-system-mediates-eye-brain-immunity
#11
JOURNAL ARTICLE
Xiangyun Yin, Sophia Zhang, Ju Hyun Lee, Huiping Dong, George Mourgkos, Gordon Terwilliger, Aurora Kraus, Luiz Henrique Geraldo, Mathilde Poulet, Suzanne Fischer, Ting Zhou, Farrah Shalima Mohammed, Jiangbing Zhou, Yongfu Wang, Seth Malloy, Nicolas Rohner, Lokesh Sharma, Irene Salinas, Anne Eichmann, Jean-Leon Thomas, W Mark Saltzman, Anita Huttner, Caroline Zeiss, Aaron Ring, Akiko Iwasaki, Eric Song
The eye, an anatomical extension of the central nervous system (CNS), exhibits many molecular and cellular parallels to the brain. Emerging research demonstrates that changes in the brain are often reflected in the eye, particularly in the retina1 . Still, the possibility of an immunological nexus between the posterior eye and the rest of the CNS tissues remains unexplored. Here, studying immune responses to herpes simplex virus in the brain, we observed that intravitreal immunization protects mice against intracranial viral challenge...
February 28, 2024: Nature
https://read.qxmd.com/read/38418879/anti-tigit-antibody-improves-pd-l1-blockade-through-myeloid-and-t-reg-cells
#12
JOURNAL ARTICLE
Xiangnan Guan, Ruozhen Hu, Yoonha Choi, Shyam Srivats, Barzin Y Nabet, John Silva, Lisa McGinnis, Robert Hendricks, Katherine Nutsch, Karl L Banta, Ellen Duong, Alexis Dunkle, Patrick S Chang, Chia-Jung Han, Stephanie Mittman, Nandini Molden, Pallavi Daggumati, Wendy Connolly, Melissa Johnson, Delvys Rodriguez Abreu, Byoung Chul Cho, Antoine Italiano, Ignacio Gil-Bazo, Enriqueta Felip, Ira Mellman, Sanjeev Mariathasan, David S Shames, Raymond Meng, Eugene Y Chiang, Robert J Johnston, Namrata S Patil
Tiragolumab, an anti-TIGIT antibody with an active IgG1κ Fc, demonstrated improved outcomes in the phase 2 CITYSCAPE trial (ClinicalTrials.gov: NCT03563716 ) when combined with atezolizumab (anti-PD-L1) versus atezolizumab alone1 . However, there remains little consensus on the mechanism(s) of response with this combination2 . Here we find that a high baseline of intratumoural macrophages and regulatory T cells is associated with better outcomes in patients treated with atezolizumab plus tiragolumab but not with atezolizumab alone...
February 28, 2024: Nature
https://read.qxmd.com/read/38418878/mechanisms-of-calcium-homeostasis-orchestrate-plant-growth-and-immunity
#13
JOURNAL ARTICLE
Chao Wang, Ren-Jie Tang, Senhao Kou, Xiaoshu Xu, Yi Lu, Kenda Rauscher, Angela Voelker, Sheng Luan
Calcium (Ca2+ ) is an essential nutrient for plants and a cellular signal, but excessive levels can be toxic and inhibit growth1,2 . To thrive in dynamic environments, plants must monitor and maintain cytosolic Ca2+ homeostasis by regulating numerous Ca2+ transporters3 . Here we report two signalling pathways in Arabidopsis thaliana that converge on the activation of vacuolar Ca2+ /H+ exchangers (CAXs) to scavenge excess cytosolic Ca2+ in plants. One mechanism, activated in response to an elevated external Ca2+ level, entails calcineurin B-like (CBL) Ca2+ sensors and CBL-interacting protein kinases (CIPKs), which activate CAXs by phosphorylating a serine (S) cluster in the auto-inhibitory domain...
February 28, 2024: Nature
https://read.qxmd.com/read/38418877/neuronal-dynamics-direct-cerebrospinal-fluid-perfusion-and-brain-clearance
#14
JOURNAL ARTICLE
Li-Feng Jiang-Xie, Antoine Drieu, Kesshni Bhasiin, Daniel Quintero, Igor Smirnov, Jonathan Kipnis
The accumulation of metabolic waste is a leading cause of numerous neurological disorders, yet we still have only limited knowledge of how the brain performs self-cleansing. Here we demonstrate that neural networks synchronize individual action potentials to create large-amplitude, rhythmic and self-perpetuating ionic waves in the interstitial fluid of the brain. These waves are a plausible mechanism to explain the correlated potentiation of the glymphatic flow1,2 through the brain parenchyma. Chemogenetic flattening of these high-energy ionic waves largely impeded cerebrospinal fluid infiltration into and clearance of molecules from the brain parenchyma...
February 28, 2024: Nature
https://read.qxmd.com/read/38418876/multisensory-gamma-stimulation-promotes-glymphatic-clearance-of-amyloid
#15
JOURNAL ARTICLE
Mitchell H Murdock, Cheng-Yi Yang, Na Sun, Ping-Chieh Pao, Cristina Blanco-Duque, Martin C Kahn, TaeHyun Kim, Nicolas S Lavoie, Matheus B Victor, Md Rezaul Islam, Fabiola Galiana, Noelle Leary, Sidney Wang, Adele Bubnys, Emily Ma, Leyla A Akay, Madison Sneve, Yong Qian, Cuixin Lai, Michelle M McCarthy, Nancy Kopell, Manolis Kellis, Kiryl D Piatkevich, Edward S Boyden, Li-Huei Tsai
The glymphatic movement of fluid through the brain removes metabolic waste1-4 . Noninvasive 40 Hz stimulation promotes 40 Hz neural activity in multiple brain regions and attenuates pathology in mouse models of Alzheimer's disease5-8 . Here we show that multisensory gamma stimulation promotes the influx of cerebrospinal fluid and the efflux of interstitial fluid in the cortex of the 5XFAD mouse model of Alzheimer's disease. Influx of cerebrospinal fluid was associated with increased aquaporin-4 polarization along astrocytic endfeet and dilated meningeal lymphatic vessels...
February 28, 2024: Nature
https://read.qxmd.com/read/38418875/sox17-enables-immune-evasion-of-early-colorectal-adenomas-and-cancers
#16
JOURNAL ARTICLE
Norihiro Goto, Peter M K Westcott, Saori Goto, Shinya Imada, Martin S Taylor, George Eng, Jonathan Braverman, Vikram Deshpande, Tyler Jacks, Judith Agudo, Ömer H Yilmaz
A hallmark of cancer is the avoidance of immune destruction. This process has been primarily investigated in locally advanced or metastatic cancer1-3 ; however, much less is known about how pre-malignant or early invasive tumours evade immune detection. Here, to understand this process in early colorectal cancers (CRCs), we investigated how naive colon cancer organoids that were engineered in vitro to harbour Apc-null, KrasG12D and Trp53-null (AKP) mutations adapted to the in vivo native colonic environment...
February 28, 2024: Nature
https://read.qxmd.com/read/38418874/incomplete-transcripts-dominate-the-mycobacterium-tuberculosis-transcriptome
#17
JOURNAL ARTICLE
Xiangwu Ju, Shuqi Li, Ruby Froom, Ling Wang, Mirjana Lilic, Madeleine Delbeau, Elizabeth A Campbell, Jeremy M Rock, Shixin Liu
Mycobacterium tuberculosis (Mtb) is a bacterial pathogen that causes tuberculosis (TB), an infectious disease that is responsible for major health and economic costs worldwide1 . Mtb encounters diverse environments during its life cycle and responds to these changes largely by reprogramming its transcriptional output2 . However, the mechanisms of Mtb transcription and how they are regulated remain poorly understood. Here we use a sequencing method that simultaneously determines both termini of individual RNA molecules in bacterial cells3 to profile the Mtb transcriptome at high resolution...
February 28, 2024: Nature
https://read.qxmd.com/read/38418873/mutualisms-weaken-the-latitudinal-diversity-gradient-among-oceanic-islands
#18
JOURNAL ARTICLE
Camille S Delavaux, Thomas W Crowther, James D Bever, Patrick Weigelt, Evan M Gora
The latitudinal diversity gradient (LDG) dominates global patterns of diversity1,2 , but the factors that underlie the LDG remain elusive. Here we use a unique global dataset3 to show that vascular plants on oceanic islands exhibit a weakened LDG and explore potential mechanisms for this effect. Our results show that traditional physical drivers of island biogeography4 -namely area and isolation-contribute to the difference between island and mainland diversity at a given latitude (that is, the island species deficit), as smaller and more distant islands experience reduced colonization...
February 28, 2024: Nature
https://read.qxmd.com/read/38418872/durable-and-efficient-gene-silencing-in-vivo-by-hit-and-run-epigenome-editing
#19
JOURNAL ARTICLE
Martino Alfredo Cappelluti, Valeria Mollica Poeta, Sara Valsoni, Piergiuseppe Quarato, Simone Merlin, Ivan Merelli, Angelo Lombardo
Permanent epigenetic silencing using programmable editors equipped with transcriptional repressors holds great promise for the treatment of human diseases1-3 . However, to unlock its full therapeutic potential, an experimental confirmation of durable epigenetic silencing after the delivery of transient delivery of editors in vivo is needed. To this end, here we targeted Pcsk9, a gene expressed in hepatocytes that is involved in cholesterol homeostasis. In vitro screening of different editor designs indicated that zinc-finger proteins were the best-performing DNA-binding platform for efficient silencing of mouse Pcsk9...
February 28, 2024: Nature
https://read.qxmd.com/read/38418737/private-moon-lander-is-dying-it-scored-some-wins-for-science
#20
Alexandra Witze
No abstract text is available yet for this article.
February 28, 2024: Nature
journal
journal
20317
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.