Jessica Huston, Stacey Curtis, Eric F Egelund
OBJECTIVE: This article reviews the published data encompassing the development, pharmacology, efficacy, and safety of brincidofovir, a nucleotide analogue DNA polymerase inhibitor developed for the treatment of smallpox. DATA SOURCES: A literature review was conducted in PubMed, MEDLINE, and Clinicaltrials.gov from inception up to December 2022, using terms Tembexa, brincidofovir, CMX001, smallpox treatment , and variola treatment . STUDY SELECTION AND DATA EXTRACTION: Data were limited to studies published in English language, which evaluated the efficacy and safety of brincidofovir...
January 23, 2023: Annals of Pharmacotherapy