journal
https://read.qxmd.com/read/37712551/off-label-reduced-dose-apixaban-in-older-adults-with-atrial-fibrillation-and-associated-outcomes
#1
JOURNAL ARTICLE
Ashley M Campbell, Elizabeth Pae, Eunice Lee, Timothy Jacisin, Alina Price, Jessica DeAngelo
BACKGROUND: Apixaban is commonly used to prevent stroke in older adults with nonvalvular atrial fibrillation (AF). Although its package insert has specific dose reduction criteria, providers may dose reduce outside of these parameters based on clinical scenarios. OBJECTIVE: The primary objective was to determine the incidence of apixaban off-label reduced dosing, while secondarily determining the safety and efficacy outcomes associated with such dosing. METHODS: A retrospective analysis of patients aged 65 and older with orders for apixaban for AF was institutional review board (IRB)-approved and conducted across 3 academic medical centers...
September 15, 2023: Annals of Pharmacotherapy
https://read.qxmd.com/read/37706310/sparsentan-a-first-in-class-dual-endothelin-and-angiotensin-ii-receptor-antagonist
#2
REVIEW
Ada W Chiu, Nina Bredenkamp
OBJECTIVE: To provide an overview of the guidelines on the management of immunoglobulin A nephropathy (IgAN) and focal segmental glomerulosclerosis (FSGS), review the evidence for sparsentan, and discuss its place in therapy. DATA SOURCES: A literature search was conducted using MEDLINE, EMBASE, and clinicaltrials.gov using the search terms "sparsentan" and "RE-021" up to the end of Jun 2023. STUDY SELECTION AND DATA EXTRACTION: English studies were included if they evaluated the pharmacology, pharmacokinetics, efficacy, and safety of sparsentan in human subjects...
September 14, 2023: Annals of Pharmacotherapy
https://read.qxmd.com/read/37702380/cyp3a5-genotype-dependent-drug-drug-interaction-between-tacrolimus-and-voriconazole-in-chinese-kidney-transplant-patients
#3
JOURNAL ARTICLE
Yundi Zhang, Yue Du, Shuyu Ren, Yue Li, Xiaoming Zhang, Xiaohong Cao, Fengxi Liu, Huiying Zong, Yan Li
BACKGROUND: The effect of drug-drug interaction (DDI) between tacrolimus and voriconazole on the pharmacokinetics of tacrolimus in different CYP3A5 genotypes has not been reported in previous studies. OBJECTIVE: The objective of this study was to investigate whether CYP3A5 genotype could influence tacrolimus-voriconazole DDI in Chinese kidney transplant patients. METHODS: All kidney transplant patients were divided into combination and non-combination groups based on whether tacrolimus was combined with or without voriconazole...
September 13, 2023: Annals of Pharmacotherapy
https://read.qxmd.com/read/37700573/targeted-therapies-for-previously-undruggable-kras-mutated-non-small-cell-lung-cancer-a-review-of-sotorasib-and-adagrasib
#4
REVIEW
Natalie Mausey, Zachery Halford
OBJECTIVE: To evaluate the safety and efficacy of the novel KRAS-targeting agents, sotorasib and adagrasib, in treating KRAS G12C -mutated non-small cell lung cancer (NSCLC). DATA SOURCES: A comprehensive English-based literature search of PubMed and Clinicaltrials.gov between January 2000 and July 2023 was conducted using the terms sotorasib , Lumakras , AMG 510 , adagrasib , Krazati , and MRTX849 . STUDY SELECTION AND DATA EXTRACTION: Relevant prescribing information, clinical trials, and treatment guidelines were evaluated...
September 12, 2023: Annals of Pharmacotherapy
https://read.qxmd.com/read/37700565/evaluation-of-basal-plus-versus-sliding-scale-insulin-therapy-on-glucose-variability-in-critically-ill-patients-without-preexisting-diabetes
#5
JOURNAL ARTICLE
Rachel E Webster, Julie J Belfer, Kyle J Schmidt
BACKGROUND: There is limited evidence evaluating the impact of insulin treatment strategies on glucose variability in critically ill patients without preexisting diabetes. OBJECTIVE: Compare basal plus insulin (BPI) and sliding scale insulin (SSI) impact on glycemic control outcomes in critically ill patients without preexisting diabetes experiencing hyperglycemia. METHODS: This multicenter, retrospective review analyzed critically ill patients with hyperglycemia who received either BPI or SSI...
September 12, 2023: Annals of Pharmacotherapy
https://read.qxmd.com/read/37675960/intranasal-theophylline-potential-treatment-for-long-covid-olfactory-dysfunction
#6
LETTER
Olga Hilas, Tina Caliendo
No abstract text is available yet for this article.
September 7, 2023: Annals of Pharmacotherapy
https://read.qxmd.com/read/37650424/invasive-scc-and-tirbanibulin-experience-in-patient-with-epidermodysplasia-verruciformis
#7
LETTER
Andrea Agostini, Nicole Macagno, Rebecca Senetta, Pietro Quaglino, Paolo Broganelli
No abstract text is available yet for this article.
August 31, 2023: Annals of Pharmacotherapy
https://read.qxmd.com/read/37650387/oteseconazole-for-the-treatment-of-recurrent-vulvovaginal-candidiasis-a-drug-review
#8
REVIEW
Cameron Lanier, Tyler C Melton
OBJECTIVE: The objective of the study is to describe and analyze the pharmacodynamics and pharmacokinetics of oteseconazole as well as the clinical evidence supporting the efficacy of oteseconazole in treating recurrent vulvovaginal candidiasis (RVVC). DATA SOURCES: A literature search was conducted using MEDLINE and EMBASE databases (2015-June 2023). Search terms included "oteseconazole" OR "VT-1161" or "VIVJOA" AND "RVVC" or "recurrent vulvovaginal candidiasis" or "vulvovaginal candidiasis...
August 31, 2023: Annals of Pharmacotherapy
https://read.qxmd.com/read/37614020/authors-reply-to-comment-on-rotshild-et-al-s-the-risk-for-prostate-cancer-with-calcium-channel-blockers
#9
LETTER
Victoria Rotshild, Ilan Matok
No abstract text is available yet for this article.
August 23, 2023: Annals of Pharmacotherapy
https://read.qxmd.com/read/37614019/comment-on-rotshild-et-al-s-the-risk-for-prostate-cancer-with-calcium-channel-blockers
#10
LETTER
Kuan-Fu Liao, Bing-Fang Hwang, Chiu-Shong Liu, Shih-Wei Lai
No abstract text is available yet for this article.
August 23, 2023: Annals of Pharmacotherapy
https://read.qxmd.com/read/37608463/the-role-of-dexmedetomidine-in-paroxysmal-sympathetic-hyperactivity-a-systematic-review
#11
REVIEW
Cole R Jerousek, Justin P Reinert
OBJECTIVE: The objective was to evaluate the efficacy and safety of dexmedetomidine in the treatment and prophylaxis of paroxysmal sympathetic hyperactivity (PSH). DATA SOURCES: A review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria and queried Embase, MEDLINE (PubMed), Cochrane CENTRAL, Web of Science, SciELO, Korean Journal Index (Clarivate), Global Index Medicus, and CINAHL Plus for results through June 2023...
August 22, 2023: Annals of Pharmacotherapy
https://read.qxmd.com/read/37606361/a-comparison-of-injectable-diazepam-and-lorazepam-in-the-goal-directed-management-of-severe-alcohol-withdrawal
#12
JOURNAL ARTICLE
Kendall H Brickel, Emily K Hodge, Daria Zavgorodnyaya, John M Schroeder, Lawrence H Brown, Mitchell J Daley
BACKGROUND: Benzodiazepines are the gold standard for treatment of alcohol withdrawal, yet the selection of a preferred benzodiazepine is limited due to a lack of comparative studies. OBJECTIVES: The primary objective of this study was to compare the efficacy and safety of injectable lorazepam (LZP) and diazepam (DZP) in the treatment of severe alcohol withdrawal syndrome (AWS). METHODS: Retrospective cohort study of adult patients admitted to an intensive care unit with a primary diagnosis of AWS...
August 22, 2023: Annals of Pharmacotherapy
https://read.qxmd.com/read/37605427/e-cigarette-or-vaping-product-use-associated-lung-injury-evali-continues-an-opportunity-for-pharmacist-intervention
#13
JOURNAL ARTICLE
Miranda R Andrus
Electronic cigarette (e-cigarette), or vaping, product use-associated lung injury (EVALI) was first identified and reported in 2019, but media coverage and reporting of cases drastically decreased when the COVID-19 pandemic started in early 2020. The syndrome has continued to occur since that time and it is critical that pharmacists are aware of how EVALI presents, and when it should be considered as a potential diagnosis. Inpatient and outpatient pharmacists play a vital role in the treatment of EVALI, and should be knowledgeable of the utility of corticosteroids, even though data are extremely limited...
August 21, 2023: Annals of Pharmacotherapy
https://read.qxmd.com/read/37589369/bacterial-vaginosis-treatment-patterns-associated-complications-and-health-care-economic-burden-of-women-with-medicaid-coverage-in-the-united-states
#14
JOURNAL ARTICLE
Eren Watkins, Clifton M Chow, Melissa Lingohr-Smith, Jay Lin, Candice Yong, Krishna Tangirala, Kevin Collins, James Li, Roy Brooks, Jennifer Amico
BACKGROUND: Bacterial vaginosis (BV) is a highly prevalent vaginal infection. OBJECTIVES: Primary objectives of this study were to examine treatment patterns among female patients with Medicaid coverage who were diagnosed with incident BV, the frequency of BV-associated complications, and health care resource utilization (HCRU) and associated costs of incident BV and its recurrence. Secondary objectives were to identify predictors of total all-cause health care costs and number of treatment courses...
August 17, 2023: Annals of Pharmacotherapy
https://read.qxmd.com/read/37589097/a-narrative-review-on-the-administration-of-inhaled-prostaglandins-in-critically-ill-adult-patients-with-acute-respiratory-distress-syndrome
#15
REVIEW
Lydia R Ware, Christine S Kim, Paul M Szumita, Jeremy R DeGrado
OBJECTIVE: To describe the effect of inhaled prostaglandins on both oxygenation and mortality in critically ill patients with acute respiratory distress syndrome (ARDS), with a focus on safety and efficacy in coronavirus disease 2019 (COVID-19)-associated ARDS and non-COVID-19 ARDS. DATA SOURCES: A literature search of MEDLINE was performed using the following search terms: inhaled prostaglandins, inhaled epoprostenol , inhaled nitric oxide , ARDS , critically ill...
August 17, 2023: Annals of Pharmacotherapy
https://read.qxmd.com/read/37589096/baclofen-and-tizanidine-adverse-effects-observed-among-community-dwelling-adults-above-the-age-of-50-years-a-systematic-review
#16
REVIEW
Lisa Killam-Worrall, Romana Brand, Janine R Castro, Dipa S Patel, Katherine Huynh, Bryn Lindley, Brittany Palasik Torres
OBJECTIVE: This review highlights adverse effects of baclofen and tizanidine in older community-dwelling adults. DATA SOURCES: A literature search was conducted, including search terms of "adverse effect," "baclofen," "elderly," "falls," "fractures," and "tizanidine." Studies were included if they described community-dwelling adults aged 50 years and older who received oral baclofen or tizanidine. The Federal Drug Administration Adverse Event Reporting System (FAERS) data were compiled for adverse effect incidence...
August 17, 2023: Annals of Pharmacotherapy
https://read.qxmd.com/read/37568270/a-review-of-the-safety-and-efficacy-of-bexagliflozin-for-the-management-of-type-2-diabetes
#17
REVIEW
Kevin Cowart, Scott Coon, Nicholas W Carris
OBJECTIVE: To review the pharmacology of bexagliflozin in addition to its safety and efficacy from available clinical trials used for its approval, as well as available clinical evidence to date. DATA SOURCES: A search of the National Institutes of Health Clinical Trials Registry (https://www.clinicaltrials.gov) and PubMed database was performed from inception through June 1, 2023. STUDY SELECTION AND DATA EXTRACTION QUANTIFICATION: The following study designs were included: meta-analyses, systematic review, clinical trial, or observational study design...
August 11, 2023: Annals of Pharmacotherapy
https://read.qxmd.com/read/37559252/artificial-neural-network-analysis-of-determinants-of-tacrolimus-pharmacokinetics-in-liver-transplant-recipients
#18
JOURNAL ARTICLE
Yue Du, Yundi Zhang, Zhiyan Yang, Yue Li, Xinyu Wang, Ziqiang Li, Lei Ren, Yan Li
BACKGROUND: The efficacy and toxicity of tacrolimus are closely related to its trough blood concentrations. Identifying the influencing factors of pharmacokinetics of tacrolimus in the early postoperative period is conducive to the optimization of the individualized tacrolimus administration protocol and to help liver transplant (LT) recipients achieve the target blood concentrations. OBJECTIVE: This study aimed to develop an artificial neural network (ANN) for predicting the blood concentration of tacrolimus soon after liver transplantation and for identifying determinants of the concentration based on Shapley additive explanation (SHAP)...
August 9, 2023: Annals of Pharmacotherapy
https://read.qxmd.com/read/37559251/angiotensin-receptor-blocker-related-sprue-like-enteropathy-review-of-food-and-drug-administration-adverse-event-reporting-system
#19
JOURNAL ARTICLE
Ryan Meader, Sam Papasotiriou, Hardeep Ahdi, Hoang Dang, Eli D Ehrenpreis
BACKGROUND: Sprue-like enteropathy (SE) related to olmesartan use was first reported in 2012. In 2017, the manufacturer of Benicar paid $300 million for 2300 claims for olmesartan-related SE. OBJECTIVE: A study in 2019 suggested that SE was related to olmesartan and with the possibility of angiotensin receptor blocker (ARB) class effect. To further characterize this condition, our group examined reports of ARB-related SE to Food and Drug Administration Adverse Event Reporting System (FAERS)...
August 9, 2023: Annals of Pharmacotherapy
https://read.qxmd.com/read/37542422/the-impact-of-sglt2-inhibitors-on-cardiovascular-outcomes-in-patients-with-heart-failure-with-preserved-ejection-fraction
#20
REVIEW
Jessica A Starr, Nathan A Pinner
OBJECTIVE: To evaluate the role of sodium-glucose cotransporter-2 (SGLT2) inhibitors in patients with heart failure with preserved ejection fraction (HFpEF). DATA SOURCES: A literature search of PubMed, the Cochrane Library, and Google Scholar databases (January 2015 to June 20, 2023) was performed with keywords: sodium-glucose co-transporter 2 inhibitors OR SGLT2 inhibitors OR bexagliflozin OR canagliflozin OR dapagliflozin OR empagliflozin OR ertugliflozin OR sotagliflozin AND heart failure OR heart failure with preserved ejection fraction, and terms related to CV outcomes including cardiovascular death, hospitalization, hospitalization for heart failure, mortality, death, and major adverse cardiovascular event (MACE)...
August 5, 2023: Annals of Pharmacotherapy
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