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Journal of Clinical Periodontology

Alberto Pulcini, Juan Bollaín, Ignacio Sanz-Sánchez, Elena Figuero, Bettina Alonso, Mariano Sanz, David Herrera
AIM: To evaluate the efficacy of a 0.03% chlorhexidine and 0.05% cetylpyridinium chloride mouth-rinse, as an adjunct to professionally and patient-administered mechanical plaque removal, in the treatment of peri-implant mucositis (PiM). MATERIAL AND METHODS: Patients displaying PiM in, at least, one implant were included in this randomized, double-blinded, clinical trial. Subjects received professional prophylaxis (baseline and 6-months) and were instructed to regular oral hygiene practices and to rinse, twice daily, with the test or placebo mouth-rinses, during one year...
February 18, 2019: Journal of Clinical Periodontology
Qian Zhao, Shi-Bin Wang, Guodong Xu, Yiqing Song, Xiaozhe Han, Zhiqiang Liu, Xuan Zhou, Tianyi Zhang, Kewu Huang, Ting Yang, Yingxiang Lin, Sinan Wu, Zuomin Wang, Chen Wang
AIM: To assess the status of periodontal health knowledge, attitudes and practices (KAP) among Chinese adults. MATERIALS AND METHODS: A cross-sectional study was conducted in a nationally representative sample of adults (N=50991) aged 20 years or older from ten provinces, autonomous regions, and municipalities. Percentages of Chinese adults with correct periodontal knowledge, positive periodontal attitudes and practices were estimated. Multiple logistic regression analyses were used to examine the related factors...
February 15, 2019: Journal of Clinical Periodontology
Juliane Schulz, Carina Knappe, Christian Graetz, Louisa Mewes, Kathrin Türk, Anna K Black, Wolfgang Lieb, Arne S Schäfer, Karim M Fawzy El-Sayed, Christof E Dörfer, Stefan Schreiber, Matthias Laudes, Dominik M Schulte
AIM: Recombinant secreted frizzled-related protein 5 (sFRP5) improved periodontal status in mice. Thus, this study aimed to investigate this finding in human periodontitis using an epidemiological approach. MATERIALS AND METHODS: sFRP5 and wnt5a concentrations were determined in human serum from the Food Chain Plus cohort using ELISAs. 128 patients with periodontitis and tooth loss and 245 patients with periodontitis without tooth loss were compared to 373 sex-, smoker-, age- and BMI-matched individuals in a nested case-control design...
February 14, 2019: Journal of Clinical Periodontology
Marlon M Montenegro, Ingrid W J Ribeiro, Cassio Kampits, Marco A L Saffi, Mariana V Furtado, Carisi A Polanczyk, Alex N Haas, Cassiano K Rösing
AIM: To assess the effect of periodontal therapy (PT) on cardiovascular blood biomarkers. MATERIALS AND METHODS: This single-blind, parallel design, randomized controlled trial included patients with stable coronary artery disease and periodontitis. The test group (TG) received non-surgical PT, whereas the control group (CG) received one session of plaque removal. Plasma levels of C reactive protein (CRP), glycated hemoglobin, lipids, and cytokines (IL-1β, IL-6, IL-8, IL-10, IFN-γ, and TNF-α) were measured at baseline and after 3 months...
February 14, 2019: Journal of Clinical Periodontology
M P Toniazzo, D Nodari, F W M G Muniz, P Weidlich
AIM: To evaluate the effectiveness of mobile applications and text messages, compared with conventional oral hygiene instructions, for improving oral health knowledge and/or reducing gingival inflammation, when delivered to adolescents, adults and mothers of young children. METHODS: Randomized clinical trials evaluating the use of mobile applications or text messages related to oral hygiene and/or oral health education were screened. A search was performed in the Medline-PubMed, Scopus and Embase databases and the gray literature...
February 13, 2019: Journal of Clinical Periodontology
H Dommisch, P Skora, J Hirschfeld, G Olk, L Hildebrandt, S Jepsen
AIM: To evaluate the sequential and differential expression of antimicrobial peptides (AMPs), human beta-defensins (hBD-2, hBD-3), CC-chemokine ligand 20 (CCL20), S100A7/psoriasin (S100A7), and calgranulin A/B (S100A8, S100A9), during the development of an experimentally induced gingivitis in humans. MATERIAL AND METHODS: In twenty healthy volunteers, gingival inflammation was induced by abstention from oral hygiene at 6 teeth. Bleeding on probing (BOP) and plaque index (PI) were assessed, and gingival biopsies and gingival crevicular fluid (GCF) were collected at 8 different time-points (t0-t35)...
February 13, 2019: Journal of Clinical Periodontology
Atsushi Saito, Takahiro Bizenjima, Takahiro Takeuchi, Eiichi Suzuki, Masahiro Sato, Kouki Yoshikawa, Yurie Kitamura, Daisuke Matsugami, Hideto Aoki, Daichi Kita, Kentaro Imamura, Daisuke Irokawa, Fumi Seshima, Sachiyo Tomita
AIM: To evaluate the use of recombinant human fibroblast growth factor (rhFGF)-2 in combination with deproteinized bovine bone mineral (DBBM) compared with rhFGF-2 alone, in the treatment of intrabony periodontal defects. MATERIALS AND METHODS: Patients with periodontitis who had received initial periodontal therapy and had intrabony defects of > 3 mm were enrolled. Sites were randomly assigned to receive 0.3% rhFGF-2+DBBM (test) or rhFGF-2 alone (control). Clinical parameters and a patient-reported outcome measure (PROM) were evaluated at baseline and at 3 and 6 months postoperatively...
February 13, 2019: Journal of Clinical Periodontology
Eduardo Bernabé, Matti Knuuttila, Anna L Suominen
AIM: To investigate the relationship between frequency of interdental cleaning and 11-year change in teeth with periodontal pocketing in Finnish adults. METHODS: Data from 1667 dentate adults, aged 30 to 82 years, who participated in the Health 2000 survey and were re-examined in 2004 and/or 2011 were analysed. Participants reported their frequency of interdental cleaning (either dental floss or interdental brush) at baseline. Teeth with periodontal pocketing (PD)>4mm were counted in every survey and treated as a repeated outcome...
February 8, 2019: Journal of Clinical Periodontology
Mario Romandini, Ilaria De Tullio, Francesca Congedi, Zamira Kalemaj, Mattia D'Ambrosio, Andreina Laforí, Ciro Quaranta, Jacopo Buti, Giorgio Perfetti
AIM: This systematic review of randomized controlled trials (RCTs) aims to answer to the following question: "In patients undergoing dental implant placement, which is the best antibiotic prophylaxis protocol to prevent early failures?". MATERIALS AND METHODS: The MEDLINE, SCOPUS, CENTRAL and Web of Knowledge electronic databases were searched in duplicate for RCTs up to July 2017. Additional relevant literature was identified through 1) hand-searching on both relevant journals and on reference lists, and 2) searching in databases for grey literature...
February 7, 2019: Journal of Clinical Periodontology
Lewis Winning, Chris C Patterson, Kathy M Cullen, Frank Kee, Gerard J Linden
OBJECTIVE: To investigate whether there was an association between chronic periodontitis and reduced respiratory function. METHODS: A group of dentate 58-72 year-old men in Northern Ireland had a comprehensive periodontal examination. Parallel to the periodontal examination, participants completed questionnaires gathering information on their medical history, social circumstances, demographic background and tobacco use. A physical examination assessed anthropometric measures...
February 3, 2019: Journal of Clinical Periodontology
Hyun-Chang Lim, Daniel B Wiedemeier, Christoph H F Hämmerle, Daniel S Thoma
AIM: (i) to investigate the influence of the keratinized mucosa (KM) on peri-implant health or disease, and (ii) to identify a threshold value for the width of KM for peri-implant health. MATERIALS & METHODS: The total dataset was subsampled, i.e. one implant was randomly chosen per patient. In 87 patients, data were extracted at baseline (prosthesis insertion) and 5 years including the width of mid-buccal KM, bleeding on probing, probing depth, plaque index and marginal bone level (MB)...
February 2, 2019: Journal of Clinical Periodontology
A H Llanos, V M Sapata, R E Jung, C H Hämmerle, D S Thoma, J B César Neto, C M Pannuti, G A Romito
AIM: To test the non-inferiority of demineralized bovine bone mineral (DBBM) compared to DBBM with 10% collagen (DBBM-C) for maintenance of bone volume after tooth extraction in the anterior maxilla. MATERIALS AND METHODS: Sixty-six patients were randomly treated with DBBM or DBBM-C, both of which were covered with a collagen matrix for ridge preservation in the anterior maxilla. Cone beam computed tomographic analysis was performed immediately and 4 months after treatment...
February 1, 2019: Journal of Clinical Periodontology
Ahmed Sabbah, Jeffery Hicks, Barbara MacNeill, Antonio Arbona, Alfonso Aguilera, Qianqian Liu, Jonathan Gelfond, Wayne Gardner
AIM: This 5 years retrospective cohort survival study compared failure rates of dental implants placed in HIV (+) and HIV (-) patients relative to several risk factors. MATERIALS AND METHODS: Between 2006 and 2015, 484 implants placed in HIV (+) patients and 805 implants placed in HIV (-) patients were assessed for survival. The effects of HIV were estimated using propensity weighting. The effects of age, smoking status, diabetes, restoration status, gender, implant type, placement site, hepatitis C status, baseline CD4 count and CD4%, post-placement average CD4%, nadir CD4%, nadir CD4 count and antiviral therapy were analysed...
January 31, 2019: Journal of Clinical Periodontology
A Sculean, A Stavropoulos, D D Bosshardt
OBJECTIVE: To provide an overview on the self-regenerative capacity of various types of intraoral bone defects. MATERIALS AND METHODS: This paper has narratively reviewed the most important aspects of bone biology and the healing outcomes related to the self-regenerative capacity (i.e. without the placement of any biomaterial) of bone defects that occur following tooth extraction, autogenous graft harvesting, periapical lesions, cystic lesions of the jaws, third molar extraction and experimentally created ridge defects...
January 30, 2019: Journal of Clinical Periodontology
Daniel S Thoma, Stefan P Bienz, Elena Figuero, Ronald E Jung, Ignacio Sanz-Martin
OBJECTIVES: To analyze the evidence regarding the efficacy of lateral bone augmentation procedures in terms of defect resolution in cases of horizontal ridge deficiencies after implant placement. MATERIALS AND METHODS: Included studies met the following inclusion criteria: randomized controlled trials (RCTs) or controlled clinical trials (CCT's), re-entry procedure to assess defect resolution, minimum of 10 patients (5 per group). Meta-analyses were performed whenever possible, including subgroup analysis based on membranes and grafting materials...
January 23, 2019: Journal of Clinical Periodontology
Omar Omar, Ibrahim Elgali, Christer Dahlin, Peter Thomsen
AIM: To review the knowledge on the mechanisms controlling membrane-host interactions in guided bone regeneration (GBR) and investigate the possible role of GBR membranes as bioactive compartments in addition to their established role as barriers. MATERIAL & METHODS: A narrative review was utilized based on in vitro, in vivo and available clinical studies on the cellular and molecular mechanisms underlying GBR and the possible bioactive role of membranes. RESULTS: Emerging data demonstrate that the membrane contributes bioactively to the regeneration of underlying defects...
January 22, 2019: Journal of Clinical Periodontology
Cristiano Tomasi, Erik Regidor, Alberto Ortiz-Vigón, Jan Derks
OBJECTIVES: The present systematic review aimed at evaluating the efficacy of reconstructive surgical therapy at peri-implantitis-related bone defects. METHODS: Studies reporting on outcomes of reconstructive surgery at peri-implantitis-related bone defects at 12 months were identified through an electronic search. Following data extraction, two different sets of meta-analyses were performed. Primarily, controlled studies were used to evaluate the potential benefit of reconstructive surgical therapy over controls...
January 22, 2019: Journal of Clinical Periodontology
Istvan A Urban, Eduardo Montero, Alberto Monje, Ignacio Sanz-Sánchez
AIM: The primary aim of this systematic review was to evaluate the effect of various techniques used for vertical ridge augmentation on clinical vertical bone gain. MATERIAL AND METHODS: A protocol was developed to answer the following focused question: "In patients with vertical alveolar ridge deficiencies, how effective are different augmentation procedures for clinical alveolar ridge gain?" Randomized and controlled clinical trials and prospective and retrospective case series were included, and meta-analyses were performed to evaluate vertical bone gain based on the type of procedure and to compare bone gains in controlled studies...
January 22, 2019: Journal of Clinical Periodontology
Filippo Graziani, Stefano Gennai, Morena Petrini, Laura Bettini, Maurizio Tonetti
AIM: An acute phase response is induced after non-surgical periodontal treatment (SRP). The main aim of this study was to compare acute-phase (24-h) and medium-term (3-months) inflammation and clinical outcomes after SRP with or without application of enamel matrix derivative (EMD) in sites with PPD≥6mm. METHODS: Thirty-eight periodontitis-affected subjects were randomized to SRP or SRP+EMD. Periodontal parameters were recorded at baseline and 3 months. Serum samples were collected at baseline, 1, and 90 days after treatment...
January 21, 2019: Journal of Clinical Periodontology
Zhengchuan Zhang, Yu Dong, Jiamin Yang, Ruogu Xu, Feilong Deng
AIM: To study the soft and hard tissue alterations of the alveolar ridge after socket-shield technique. MATERIALS AND METHODS: In four Beagle dogs, the following treatments (Tx) were randomly assigned to 32 extraction sockets: Tx1: blood clot; Tx2: Bio-Oss Collagen; Tx3: socket-shield technique and blood clot; Tx4: socket-shield technique and Bio-Oss Collagen. The width and height alterations of the buccal bone plate were calculated by CBCT scans. The dimensional alterations of the buccal aspect of the alveolar ridge at different time points were calculated by impressions using digital imaging analysis...
January 19, 2019: Journal of Clinical Periodontology
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