journal
https://read.qxmd.com/read/38362845/the-genetic-epidemiology-of-schizotypal-personality-disorder
#61
JOURNAL ARTICLE
Kenneth S Kendler, Henrik Ohlsson, Jan Sundquist, Kristina Sundquist
BACKGROUND: The concept of schizotypal personality disorder (SPD) emerged from observations of personality characteristics common in relatives of schizophrenic patients. While often studied in family designs, few studies and none with genetic measures, have examined SPD in epidemiological samples. METHODS: We studied individuals born in Sweden 1940-2000 with an ICD-10 diagnosis of SPD with no prior schizophrenia (SZ) diagnosis ( n = 2292). Demographic features, patterns of comorbidity, and Family Genetic Risk Scores (FGRS) were assessed from multiple Swedish registries...
February 16, 2024: Psychological Medicine
https://read.qxmd.com/read/38362835/the-association-between-neighborhood-level-social-fragmentation-and-distressing-psychotic-like-experiences-in-early-adolescence-the-moderating-role-of-close-friends
#62
JOURNAL ARTICLE
Benson S Ku, Jiyuan Ren, Michael T Compton, Benjamin G Druss, Shuyi Guo, Elaine F Walker
BACKGROUND: Early exposure to neighborhood social fragmentation has been shown to be associated with schizophrenia. The impact of social fragmentation and friendships on distressing psychotic-like experiences (PLE) remains unknown. We investigate the relationships between neighborhood social fragmentation, number of friends, and distressing PLE among early adolescents. METHODS: Data were collected from the Adolescent Brain Cognitive Development Study. Generalized linear mixed models tested associations between social fragmentation and distressing PLE, as well as the moderating role of the number of total and close friends...
February 16, 2024: Psychological Medicine
https://read.qxmd.com/read/38362834/frequency-dependent-alterations-of-global-signal-topography-in-patients-with-major-depressive-disorder
#63
JOURNAL ARTICLE
Chengxiao Yang, Bharat Biswal, Qian Cui, Xiujuan Jing, Yujia Ao, Yifeng Wang
BACKGROUND: Major depressive disorder (MDD) is associated not only with disorders in multiple brain networks but also with frequency-specific brain activities. The abnormality of spatiotemporal networks in patients with MDD remains largely unclear. METHODS: We investigated the alterations of the global spatiotemporal network in MDD patients using a large-sample multicenter resting-state functional magnetic resonance imaging dataset. The spatiotemporal characteristics were measured by the variability of global signal (GS) and its correlation with local signals (GSCORR) at multiple frequency bands...
February 16, 2024: Psychological Medicine
https://read.qxmd.com/read/38357733/enlarged-pituitary-gland-volume-a-possible-state-rather-than-trait-marker-of-psychotic-disorders
#64
JOURNAL ARTICLE
Synthia Guimond, Ahmad Alftieh, Gabriel A Devenyi, Luke Mike, M Mallar Chakravarty, Jai L Shah, David A Parker, John A Sweeney, Godfrey Pearlson, Brett A Clementz, Carol A Tamminga, Matcheri Keshavan
BACKGROUND: Enlarged pituitary gland volume could be a marker of psychotic disorders. However, previous studies report conflicting results. To better understand the role of the pituitary gland in psychosis, we examined a large transdiagnostic sample of individuals with psychotic disorders. METHODS: The study included 751 participants (174 with schizophrenia, 114 with schizoaffective disorder, 167 with psychotic bipolar disorder, and 296 healthy controls) across six sites in the Bipolar-Schizophrenia Network on Intermediate Phenotypes consortium...
February 15, 2024: Psychological Medicine
https://read.qxmd.com/read/38350600/a-randomized-controlled-trial-of-a-digital-cognitive-behavioral-therapy-program-compass-for-managing-depression-and-anxiety-related-to-living-with-a-long-term-physical-health-condition
#65
JOURNAL ARTICLE
Federica Picariello, Katrin Hulme, Natasha Seaton, Joanna L Hudson, Sam Norton, Abigail Wroe, Rona Moss-Morris
BACKGROUND: To evaluate the clinical efficacy of COMPASS, a therapist-supported digital therapeutic for reducing psychological distress (anxiety/depression) in people living with long-term physical health conditions (LTCs). METHODS: A two-armed randomized-controlled trial recruiting from LTC charities. Participants with anxiety and/or depression symptoms related to their LTC(s) were randomized (concealed allocation via independent administrator) to COMPASS (access to 11 tailored modules plus five thirty-minute therapist support sessions) or standard charity support (SCS)...
February 14, 2024: Psychological Medicine
https://read.qxmd.com/read/38347808/interplay-of-polygenic-liability-with-birth-related-somatic-and-psychosocial-factors-in-anorexia-nervosa-risk-a-nationwide-study
#66
JOURNAL ARTICLE
Natalie M Papini, Emily Presseller, Cynthia M Bulik, Katrine Holde, Janne T Larsen, Laura M Thornton, Clara Albiñana, Bjarni J Vilhjálmsson, Preben B Mortensen, Zeynep Yilmaz, Liselotte V Petersen
BACKGROUND: Although several types of risk factors for anorexia nervosa (AN) have been identified, including birth-related factors, somatic, and psychosocial risk factors, their interplay with genetic susceptibility remains unclear. Genetic and epidemiological interplay in AN risk were examined using data from Danish nationwide registers. AN polygenic risk score (PRS) and risk factor associations, confounding from AN PRS and/or parental psychiatric history on the association between the risk factors and AN risk, and interactions between AN PRS and each level of target risk factor on AN risk were estimated...
February 13, 2024: Psychological Medicine
https://read.qxmd.com/read/38343379/higher-emotion-regulation-flexibility-predicts-more-stable-negative-emotions-and-faster-affective-recovery-in-early-psychosis-an-experience-sampling-study
#67
JOURNAL ARTICLE
Xu Li, Thomas Vaessen, Ginette Lafit, Evelyne van Aubel, Anu P Hiekkaranta, Marlies Houben, Annelie Beijer-Klippel, Lieuwe de Haan, Frederike Schirmbeck, Ulrich Reininghaus, Inez Myin-Germeys
BACKGROUND: While evidence shows that people with early psychosis are flexible in using different emotion regulation (ER) strategies to manage the varying contextual demands, no studies have examined the effectiveness of such regulatory flexibility in this population. We addressed this issue by investigating whether and how ER flexibility relate to different dynamic aspects (variability, instability, inertia, and recovery) of negative affect (NA) in a combined early psychosis sample, consisting of both individuals at high clinical risk for psychosis and those diagnosed with first-episode psychosis...
February 12, 2024: Psychological Medicine
https://read.qxmd.com/read/38343378/20-year-neurocognitive-development-following-a-schizophrenia-spectrum-disorder-and-associations-with-symptom-severity-and-functional-outcomes
#68
JOURNAL ARTICLE
Marie Starzer, Helene Gjervig Hansen, Carsten Hjorthøj, Nikolai Albert, Kathryn E Lewandowski, Louise Birkedal Glenthøj, Merete Nordentoft
BACKGROUND: Cognitive deficits are a core feature of schizophrenia and are closely associated with poor functional outcomes. It remains unclear if cognitive deficits progress over time or remain stable. Determining patients at increased risk of progressive worsening might help targeted neurocognitive remediation approaches. METHODS: This 20-year follow-up study examined neurocognitive outcomes of 156 participants from the OPUS I trial. Neurocognition was assessed using the brief assessment of cognition in schizophrenia at the 10- and 20-year follow-up, allowing us to examine changes in neurocognition over ten years...
February 12, 2024: Psychological Medicine
https://read.qxmd.com/read/38343374/age-dependent-effects-of-early-intervention-in-borderline-personality-disorder-in-adolescents
#69
JOURNAL ARTICLE
Michael Kaess, Madelyn Thomson, Stefan Lerch, Julian Koenig, Gloria Fischer-Waldschmidt, Corinna Reichl, Marialuisa Cavelti
BACKGROUND: Psychological treatments for young people with sub-threshold or full-syndrome borderline personality disorder (BPD) are found to be effective. However, little is known about the age at which adolescents benefit from early intervention. This study investigated whether age affects the effectiveness of early intervention for BPD. METHODS: N = 626 participants ( M age = 15 years, 82.7% female) were consecutively recruited from a specialized outpatient service for early intervention in BPD in adolescents aged 12- to 17-years old...
February 12, 2024: Psychological Medicine
https://read.qxmd.com/read/38317430/genetic-and-non-genetic-predictors-of-risk-for-opioid-dependence
#70
JOURNAL ARTICLE
Peter J Na, Joseph D Deak, Henry R Kranzler, Robert H Pietrzak, Joel Gelernter
BACKGROUND: Elucidation of the interaction of biological and psychosocial/environmental factors on opioid dependence (OD) risk can inform our understanding of the etiology of OD. We examined the role of psychosocial/environmental factors in moderating polygenic risk for opioid use disorder (OUD). METHODS: Data from 1958 European ancestry adults who participated in the Yale-Penn 3 study were analyzed. Polygenic risk scores (PRS) were based on a large-scale multi-trait analysis of genome-wide association studies (MTAG) of OUD...
February 6, 2024: Psychological Medicine
https://read.qxmd.com/read/38314526/social-cognition-and-social-motivation-in-schizophrenia-and-bipolar-disorder-are-impairments-linked-to-the-disorder-or-to-being-socially-isolated
#71
JOURNAL ARTICLE
Michael F Green, Jonathan K Wynn, Naomi I Eisenberger, William P Horan, Junghee Lee, Amanda McCleery, David J Miklowitz, Eric A Reavis, L Felice Reddy
BACKGROUND: People with schizophrenia on average are more socially isolated, lonelier, have more social cognitive impairment, and are less socially motivated than healthy individuals. People with bipolar disorder also have social isolation, though typically less than that seen in schizophrenia. We aimed to disentangle whether the social cognitive and social motivation impairments observed in schizophrenia are a specific feature of the clinical condition v. social isolation generally. METHODS: We compared four groups (clinically stable patients with schizophrenia or bipolar disorder, individuals drawn from the community with self-described social isolation, and a socially connected community control group) on loneliness, social cognition, and approach and avoidance social motivation...
February 5, 2024: Psychological Medicine
https://read.qxmd.com/read/38314519/longitudinal-study-of-peer-victimization-social-support-and-mental-health-during-early-adolescence
#72
JOURNAL ARTICLE
Matías Martínez, Katherine S Damme, Teresa Vargas, Beiming Yang, D J Rompilla, Jacquelyn Stephens, Yang Qu, Vijay A Mittal, Claudia M Haase
BACKGROUND: Peer victimization predicts the development of mental health symptoms in the transition to adolescence, but it is unclear whether and how parents and school environments can buffer this link. METHODS: We analyzed two-year longitudinal data from the Adolescent Brain Cognitive Development (ABCD) study, involving a diverse sample of 11 844 children across the United States (average at baseline = 9.91 years; standard deviation = 0.63; range = 8.92-11.08; complete case sample = 8385)...
February 5, 2024: Psychological Medicine
https://read.qxmd.com/read/38314515/the-predictive-effect-of-family-genetic-risk-scores-as-an-indirect-measure-of-causal-effects-of-one-disorder-on-another
#73
JOURNAL ARTICLE
Kenneth S Kendler, Henrik Ohlsson, Jan Sundquist, Kristina Sundquist
BACKGROUND: One potential cause of comorbidity is the direct causal effect of one disorder - A - on risk for subsequent onset of disorder B. Could genetic risk scores be utilized to test for such an effect? If disorder A causally impacts on risk for disorder B, then genetic risk for disorder A should be lower in cases of disorder A with v. without a prior onset of B. METHODS: In all individuals ( n = 905 736) born in Sweden from 1980 to 1990, from six psychiatric and drug use disorders (major depression, anxiety disorders, alcohol use disorder, drug use disorder, bipolar disorder, and schizophrenia), we formed 14 pairs of disorders A and B...
February 5, 2024: Psychological Medicine
https://read.qxmd.com/read/38314511/cross-cultural-validation-of-the-revised-green-et-al-paranoid-thoughts-scale
#74
JOURNAL ARTICLE
Björn Schlier, Tania M Lincoln, Jessica L Kingston, Suzanne H So, Brandon A Gaudiano, Eric M J Morris, Lyn Ellett
BACKGROUND: With efforts increasing worldwide to understand and treat paranoia, there is a pressing need for cross-culturally valid assessments of paranoid beliefs. The recently developed Revised Green et al., Paranoid Thoughts Scale (R-GPTS) constitutes an easy to administer self-report assessment of mild ideas of reference and more severe persecutory thoughts. Moreover, it comes with clinical cut-offs for increased usability in research and clinical practice. With multiple translations of the R-GPTS already available and in use, a formal test of its measurement invariance is now needed...
February 5, 2024: Psychological Medicine
https://read.qxmd.com/read/38314509/screen-time-brain-network-development-and-socio-emotional-competence-in-childhood-moderation-of-associations-by-parent-child-reading
#75
JOURNAL ARTICLE
Pei Huang, Shi Yu Chan, Zhen Ming Ngoh, Zi Yan Ong, Xi Zhen Low, Evelyn C Law, Peter D Gluckman, Michelle Z L Kee, Marielle V Fortier, Yap Seng Chong, Juan H Zhou, Michael J Meaney, Ai Peng Tan
BACKGROUND: Screen time in infancy is linked to changes in social-emotional development but the pathway underlying this association remains unknown. We aim to provide mechanistic insights into this association using brain network topology and to examine the potential role of parent-child reading in mitigating the effects of screen time. METHODS: We examined the association of screen time on brain network topology using linear regression analysis and tested if the network topology mediated the association between screen time and later socio-emotional competence...
February 5, 2024: Psychological Medicine
https://read.qxmd.com/read/38311905/association-of-psychiatric-disorders-with-clinical-diagnosis-of-long-covid-in-us-veterans
#76
JOURNAL ARTICLE
Kristen Nishimi, Thomas C Neylan, Daniel Bertenthal, Karen H Seal, Aoife O'Donovan
BACKGROUND: Psychiatric disorders may be a risk factor for long COVID, broadly defined as COVID-19 conditions continuing three months post-acute infection. In US Veterans with high psychiatric burden, we examined associations between psychiatric disorders and clinical diagnosis of long COVID. METHODS: We conducted a retrospective cohort study using health records from VA patients with a positive SARS-CoV-2 test from February 2020 to February 2023. Generalized linear models estimated associations between any psychiatric disorder and likelihood of subsequent diagnosis with long COVID (i...
February 5, 2024: Psychological Medicine
https://read.qxmd.com/read/38305128/the-interaction-between-early-life-complications-and-a-polygenic-risk-score-for-schizophrenia-is-associated-with-brain-activity-during-emotion-processing-in-healthy-participants
#77
JOURNAL ARTICLE
Veronica Debora Toro, Linda A Antonucci, Tiziana Quarto, Roberta Passiatore, Leonardo Fazio, Gianluca Ursini, Qiang Chen, Rita Masellis, Silvia Torretta, Leonardo Sportelli, Gianluca Christos Kikidis, Francesco Massari, Enrico D'Ambrosio, Antonio Rampino, Giulio Pergola, Daniel R Weinberger, Alessandro Bertolino, Giuseppe Blasi
BACKGROUND: Previous evidence suggests that early life complications (ELCs) interact with polygenic risk for schizophrenia (SCZ) in increasing risk for the disease. However, no studies have investigated this interaction on neurobiological phenotypes. Among those, anomalous emotion-related brain activity has been reported in SCZ, even if evidence of its link with SCZ-related genetic risk is not solid. Indeed, it is possible this relationship is influenced by non-genetic risk factors. Thus, this study investigated the interaction between SCZ-related polygenic risk and ELCs on emotion-related brain activity...
February 2, 2024: Psychological Medicine
https://read.qxmd.com/read/38305099/depression-is-associated-with-blunted-affective-responses-to-naturalistic-reward-prediction-errors
#78
JOURNAL ARTICLE
William J Villano, Aaron S Heller
BACKGROUND: Depression is characterized by abnormalities in emotional processing, but the specific drivers of such emotional abnormalities are unknown. Computational work indicates that both surprising outcomes (prediction errors; PEs) and outcomes (values) themselves drive emotional responses, but neither has been consistently linked to affective disturbances in depression. As a result, the computational mechanisms driving emotional abnormalities in depression remain unknown. METHODS: Here, in 687 individuals, one-third of whom qualify as depressed via a standard self-report measure (the PHQ-9), we use high-stakes, naturalistic events - the reveal of midterm exam grades - to test whether individuals with heightened depression display a specific reduction in emotional response to positive PEs...
February 2, 2024: Psychological Medicine
https://read.qxmd.com/read/38288603/variation-of-subclinical-psychosis-across-16-sites-in-europe-and-brazil-findings-from-the-multi-national-eu-gei-study
#79
JOURNAL ARTICLE
Giuseppe D'Andrea, Diego Quattrone, Kathryn Malone, Giada Tripoli, Giulia Trotta, Edoardo Spinazzola, Charlotte Gayer-Anderson, Hannah E Jongsma, Lucia Sideli, Simona A Stilo, Caterina La Cascia, Laura Ferraro, Antonio Lasalvia, Sarah Tosato, Andrea Tortelli, Eva Velthorst, Lieuwe de Haan, Pierre-Michel Llorca, Paulo Rossi Menezes, Jose Luis Santos, Manuel Arrojo, Julio Bobes, Julio Sanjuán, Miguel Bernardo, Celso Arango, James B Kirkbride, Peter B Jones, Bart P Rutten, Jim Van Os, Jean-Paul Selten, Evangelos Vassos, Franck Schürhoff, Andrei Szöke, Baptiste Pignon, Michael O'Donovan, Alexander Richards, Craig Morgan, Marta Di Forti, Ilaria Tarricone, Robin M Murray
BACKGROUND: Incidence of first-episode psychosis (FEP) varies substantially across geographic regions. Phenotypes of subclinical psychosis (SP), such as psychotic-like experiences (PLEs) and schizotypy, present several similarities with psychosis. We aimed to examine whether SP measures varied across different sites and whether this variation was comparable with FEP incidence within the same areas. We further examined contribution of environmental and genetic factors to SP. METHODS: We used data from 1497 controls recruited in 16 different sites across 6 countries...
January 30, 2024: Psychological Medicine
https://read.qxmd.com/read/38287656/clarifying-directional-dependence-among-measures-of-early-auditory-processing-and-cognition-in-schizophrenia-leveraging-gaussian-graphical-models-and-bayesian-networks
#80
JOURNAL ARTICLE
Samuel J Abplanalp, David L Braff, Gregory A Light, Yash B Joshi, Keith H Nuechterlein, Michael F Green
BACKGROUND: Research using latent variable models demonstrates that pre-attentive measures of early auditory processing (EAP) and cognition may initiate a cascading effect on daily functioning in schizophrenia. However, such models fail to account for relationships among individual measures of cognition and EAP, thereby limiting their utility. Hence, EAP and cognition may function as complementary and interacting measures of brain function rather than independent stages of information processing...
January 30, 2024: Psychological Medicine
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