journal
https://read.qxmd.com/read/38606591/the-relationship-between-childhood-trauma-psychotic-symptoms-and-cognitive-schemas-in-patients-with-schizophrenia-their-siblings-and-healthy-controls-results-from-the-eu-gei-study
#1
JOURNAL ARTICLE
Alp Üçok, Handan Noyan, Sinan Gülöksüz, Meram Can Saka, Köksal Alptekin, Cem Atbaşoğlu, Elçin Akturan, Gülşah Karadayı, Zeynep Baran Tatar, Berna Akdede, Tolga Binbay, Vesile Altınyazar, Halis Ulaş, Berna Yalınçetin, Güvem Gümüş-Akay, Burçin Cihan, Haldun Soygür, Eylem Şahin Cankurtaran, Semra Ulusoy Kaymak, Bart P F Rutten, Jim van Os
BACKGROUND: The relationship between childhood trauma (CT) and psychotic symptoms in patients with schizophrenia (SCZ), and subthreshold psychotic experiences in non-clinical populations is well-established. However, little is known about the relationship between subtypes of trauma and specific symptoms in patients, their siblings, and controls. It is also not clear which variables mediate the relationship between trauma and psychotic symptoms. METHODS: Seven hundred and forty-two patients with SCZ, 718 of their unaffected siblings and 1039 controls from three EU-GEI sites were assessed for CT, symptom severity, and cognitive schemas about self/others...
April 12, 2024: Psychological Medicine
https://read.qxmd.com/read/38606582/the-effectiveness-and-safety-of-dialectical-behavior-therapy-for-suicidal-ideation-and-behavior-in-autistic-adults-a-pragmatic-randomized-controlled-trial
#2
JOURNAL ARTICLE
Anne Huntjens, L M C Wies van den Bosch, Bram Sizoo, Ad Kerkhof, Filip Smit, Mark van der Gaag
BACKGROUNDS: Many autistic people in mental health are suicidal. This study evaluated the effectiveness of dialectical behavior therapy (DBT) v. treatment as usual (TAU) in reducing suicidal ideation and suicide attempts. METHODS: At six Dutch mental health centers, 123 outpatients (18-65 years) with DSM-5 diagnosed autism spectrum disorder (ASD) and suicidal behavior were randomly assigned to the DBT intervention group ( n = 63) or TAU control group ( n = 60). Assessments were conducted at baseline, post-treatment at 6 months and 12-month follow-up...
April 12, 2024: Psychological Medicine
https://read.qxmd.com/read/38587021/early-auditory-processing-abnormalities-alter-individual-learning-trajectories-and-sensitivity-to-computerized-cognitive-training-in-schizophrenia
#3
JOURNAL ARTICLE
Juan L Molina, Yash B Joshi, John A Nungaray, Joyce Sprock, Mouna Attarha, Bruno Biagianti, Michael L Thomas, Neal R Swerdlow, Gregory A Light
BACKGROUND: Auditory system plasticity is a promising target for neuromodulation, cognitive rehabilitation and therapeutic development in schizophrenia (SZ). Auditory-based targeted cognitive training (TCT) is a 'bottom up' intervention designed to enhance the speed and accuracy of auditory information processing, which has been shown to improve neurocognition in certain SZ patients. However, the dynamics of TCT learning as a function of training exercises and their impact on neurocognitive functioning and therapeutic outcomes are unknown...
April 8, 2024: Psychological Medicine
https://read.qxmd.com/read/38587016/investigating-change-in-network-structure-of-eating-disorder-symptoms-after-delivery-of-a-smartphone-app-based-intervention
#4
JOURNAL ARTICLE
Jake Linardon, Christopher J Greenwood, Stephanie Aarsman, Matthew Fuller-Tyszkiewicz
BACKGROUND: Eating disorder (ED) research has embraced a network perspective of psychopathology, which proposes that psychiatric disorders can be conceptualized as a complex system of interacting symptoms. However, existing intervention studies using the network perspective have failed to find that symptom reductions coincide with reductions in strength of associations among these symptoms. We propose that this may reflect failure of alignment between network theory and study design and analysis...
April 8, 2024: Psychological Medicine
https://read.qxmd.com/read/38571303/use-of-antipsychotic-medication-benzodiazepines-and-psychiatric-hospitalization-in-cannabis-related-versus-cannabis-unrelated-schizophrenia-a-nationwide-register-based-cohort-study
#5
JOURNAL ARTICLE
Carsten Hjorthøj, Anne Stürup, Mette Karlsen, Helene Speyer, Merete Osler, Dost Ongur, Merete Nordentoft
BACKGROUND: Evidence suggests that cannabis may be a causal factor for development of schizophrenia. We aimed to investigate whether use of antipsychotic medication, benzodiazepines, and psychiatric service use differs among patients with schizophrenia depending on whether psychosis was precipitated by a diagnosis of cannabis use disorder (CUD). METHODS: We utilized the nationwide Danish registries to identify all individuals with an incident diagnosis of schizophrenia from 1995 to 2016...
April 4, 2024: Psychological Medicine
https://read.qxmd.com/read/38571298/structure-function-coupling-and-hierarchy-specific-antidepressant-response-in-major-depressive-disorder
#6
JOURNAL ARTICLE
Xinyi Wang, Li Xue, Lingling Hua, Junneng Shao, Rui Yan, Zhijian Yao, Qing Lu
BACKGROUND: Extensive research has explored altered structural and functional networks in major depressive disorder (MDD). However, studies examining the relationships between structure and function yielded heterogeneous and inconclusive results. Recent work has suggested that the structure-function relationship is not uniform throughout the brain but varies across different levels of functional hierarchy. This study aims to investigate changes in structure-function couplings (SFC) and their relevance to antidepressant response in MDD from a functional hierarchical perspective...
April 4, 2024: Psychological Medicine
https://read.qxmd.com/read/38563302/assessing-regional-intracortical-myelination-in-schizophrenia-spectrum-and-bipolar-disorders-using-the-optimized-t1w-t2w-ratio
#7
JOURNAL ARTICLE
Kjetil Nordbø Jørgensen, Stener Nerland, Nora Berz Slapø, Linn B Norbom, Lynn Mørch-Johnsen, Laura Anne Wortinger, Claudia Barth, Dimitrios Andreou, Ivan I Maximov, Oliver M Geier, Ole A Andreassen, Erik G Jönsson, Ingrid Agartz
BACKGROUND: Dysmyelination could be part of the pathophysiology of schizophrenia spectrum (SCZ) and bipolar disorders (BPD), yet few studies have examined myelination of the cerebral cortex. The ratio of T1- and T2-weighted magnetic resonance images (MRI) correlates with intracortical myelin. We investigated the T1w/T2w-ratio and its age trajectories in patients and healthy controls (CTR) and explored associations with antipsychotic medication use and psychotic symptoms. METHODS: Patients with SCZ ( n = 64; mean age = 30...
April 2, 2024: Psychological Medicine
https://read.qxmd.com/read/38563297/age-atypical-brain-functional-networks-in-autism-spectrum-disorder-a-normative-modeling-approach
#8
JOURNAL ARTICLE
Anhang Jiang, Xuefeng Ma, Shuang Li, Lingxiao Wang, Bo Yang, Shizhen Wang, Mei Li, Guangheng Dong
BACKGROUND: Despite extensive research into the neural basis of autism spectrum disorder (ASD), the presence of substantial biological and clinical heterogeneity among diagnosed individuals remains a major barrier. Commonly used case‒control designs assume homogeneity among subjects, which limits their ability to identify biological heterogeneity, while normative modeling pinpoints deviations from typical functional network development at individual level. METHODS: Using a world-wide multi-site database known as Autism Brain Imaging Data Exchange, we analyzed individuals with ASD and typically developed (TD) controls (total n = 1218) aged 5-40 years, generating individualized whole-brain network functional connectivity (FC) maps of age-related atypicality in ASD...
April 2, 2024: Psychological Medicine
https://read.qxmd.com/read/38563288/the-mediating-role-of-reflective-functioning-and-general-psychopathology-in-the-relationship-between-childhood-conduct-disorder-and-adult-aggression-among-offenders
#9
JOURNAL ARTICLE
Karen Yirmiya, Matthew Constantinou, Elizabeth Simes, Anthony Bateman, James Wason, Jessica Yakeley, Mary McMurran, Mike Crawford, Alison Frater, Paul Moran, Barbara Barrett, Angus Cameron, Zoe Hoare, Elizabeth Allison, Stephen Pilling, Stephen Butler, Peter Fonagy
BACKGROUND: The nature of the pathway from conduct disorder (CD) in adolescence to antisocial behavior in adulthood has been debated and the role of certain mediators remains unclear. One perspective is that CD forms part of a general psychopathology dimension, playing a central role in the developmental trajectory. Impairment in reflective functioning (RF), i.e., the capacity to understand one's own and others' mental states, may relate to CD, psychopathology, and aggression. Here, we characterized the structure of psychopathology in adult male-offenders and its role, along with RF, in mediating the relationship between CD in their adolescence and current aggression...
April 2, 2024: Psychological Medicine
https://read.qxmd.com/read/38563286/clinical-illness-course-and-family-related-outcomes-among-parents-with-a-first-episode-of-schizophrenia-spectrum-disorder-a-20-year-follow-up-of-the-opus-trial
#10
JOURNAL ARTICLE
Helene Gjervig Hansen, Ida Christine Tholstrup Gjøde, Marie Starzer, Anne Ranning, Carsten Hjorthøj, Nikolai Albert, Merete Nordentoft, Anne Amalie Elgaard Thorup
BACKGROUND: Studies investigating parenthood and how it affects long-term outcomes are lacking among individuals with schizophrenia spectrum disorders. This study aimed to examine the life of participants 20 years after their first diagnosis with a special focus on parenthood, clinical illness course, and family-related outcomes. METHODS: Among 578 individuals diagnosed with first-episode schizophrenia spectrum disorder between 1998 and 2000, a sample of 174 participants was reassessed at the 20-year follow-up...
April 2, 2024: Psychological Medicine
https://read.qxmd.com/read/38563285/relative-associations-of-behavioral-and-physiological-risks-for-cardiometabolic-disease-with-cognition-in-bipolar-disorder-during-mid-and-later-life-findings-from-the-uk-biobank
#11
JOURNAL ARTICLE
Elysha Ringin, David W Dunstan, Denny Meyer, Roger S McIntyre, Neville Owen, Michael Berk, Mats Hallgren, Susan L Rossell, Tamsyn E Van Rheenen
BACKGROUND: Cardiometabolic disease risk factors are disproportionately prevalent in bipolar disorder (BD) and are associated with cognitive impairment. It is, however, unknown which health risk factors for cardiometabolic disease are relevant to cognition in BD. This study aimed to identify the cardiometabolic disease risk factors that are the most important correlates of cognitive impairment in BD; and to examine whether the nature of the relationships vary between mid and later life...
April 2, 2024: Psychological Medicine
https://read.qxmd.com/read/38563284/associations-between-attention-deficit-hyperactivity-disorder-genetic-liability-and-icd-10-medical-conditions-in-adults-utilizing-electronic-health-records-in-a-phenome-wide-association-study
#12
JOURNAL ARTICLE
Elis Haan, Kristi Krebs, Urmo Võsa, Isabell Brikell, Henrik Larsson, Kelli Lehto
BACKGROUND: Attention-deficit hyperactivity disorder (ADHD) is often comorbid with other medical conditions in adult patients. However, ADHD is extremely underdiagnosed in adults and little is known about the medical comorbidities in undiagnosed adult individuals with high ADHD liability. In this study we investigated associations between ADHD genetic liability and electronic health record (EHR)-based ICD-10 diagnoses across all diagnostic categories, in individuals without ADHD diagnosis history...
April 2, 2024: Psychological Medicine
https://read.qxmd.com/read/38563283/shared-genetic-basis-and-causality-between-schizophrenia-and-inflammatory-bowel-disease-evidence-from-a-comprehensive-genetic-analysis
#13
JOURNAL ARTICLE
Jing Wang, Guang-Yu Luo, Tian Tian, Yu-Qiang Zhao, Shi-Yin Meng, Jun-Hua Wu, Wen-Xiu Han, Bin Deng, Jing Ni
BACKGROUND: The comorbidity between schizophrenia (SCZ) and inflammatory bowel disease (IBD) observed in epidemiological studies is partially attributed to genetic overlap, but the magnitude of shared genetic components and the causality relationship between them remains unclear. METHODS: By leveraging large-scale genome-wide association study (GWAS) summary statistics for SCZ, IBD, ulcerative colitis (UC), and Crohn's disease (CD), we conducted a comprehensive genetic pleiotropic analysis to uncover shared loci, genes, or biological processes between SCZ and each of IBD, UC, and CD, independently...
April 2, 2024: Psychological Medicine
https://read.qxmd.com/read/38533794/optimizing-precision-medicine-for-second-step-depression-treatment-a-machine-learning-approach
#14
JOURNAL ARTICLE
Joshua Curtiss, Jordan W Smoller, Paola Pedrelli
BACKGROUND: Less than a third of patients with depression achieve successful remission with standard first-step antidepressant monotherapy. The process for determining appropriate second-step care is often based on clinical intuition and involves a protracted course of trial and error, resulting in substantial patient burden and unnecessary delay in the provision of optimal treatment. To address this problem, we adopt an ensemble machine learning approach to improve prediction accuracy of remission in response to second-step treatments...
March 27, 2024: Psychological Medicine
https://read.qxmd.com/read/38533787/adaptive-to-maladaptive-gradient-of-emotion-regulation-tendencies-are-embedded-in-the-functional-structural-hybrid-connectome
#15
JOURNAL ARTICLE
Wonyoung Kim, M Justin Kim
BACKGROUND: Emotion regulation tendencies are well-known transdiagnostic markers of psychopathology, but their neurobiological foundations have mostly been examined within the theoretical framework of cortical-subcortical interactions. METHODS: We explored the connectome-wide neural correlates of emotion regulation tendencies using functional and diffusion magnetic resonance images of healthy young adults ( N = 99; age 20-30; 28 females). We first tested the importance of considering both the functional and structural connectome through intersubject representational similarity analyses...
March 27, 2024: Psychological Medicine
https://read.qxmd.com/read/38533784/the-stability-and-change-of-wellbeing-across-the-lifespan-a-longitudinal-twin-sibling-study
#16
JOURNAL ARTICLE
Lianne P de Vries, Dirk H M Pelt, Meike Bartels
BACKGROUND: Wellbeing is relatively stable over the life span. However, individuals differ in this stability and change. One explanation for these differences could be the influence of different genetic or environmental factors on wellbeing over time. METHODS: To investigate causes of stability and change of wellbeing across the lifespan, we used cohort-sequential data on wellbeing from twins and their siblings of the Netherlands Twin Register (NTR) (total N = 46...
March 27, 2024: Psychological Medicine
https://read.qxmd.com/read/38523254/using-latent-class-analysis-to-investigate-enduring-effects-of-intersectional-social-disadvantage-on-long-term-vocational-and-financial-outcomes-in-the-20-year-prospective-chicago-longitudinal-study
#17
JOURNAL ARTICLE
Nev Jones, Liping Tong, Shannon Pagdon, Ikenna D Ebuenyi, Martin Harrow, Rajiv P Sharma, Cherise Rosen
BACKGROUND: Class and social disadvantage have long been identified as significant factors in the etiology and epidemiology of psychosis. Few studies have explicitly examined the impact of intersecting social disadvantage on long-term employment and financial independence. METHODS: We applied latent class analysis (LCA) to 20-year longitudinal data from participants with affective and non-affective psychosis ( n = 256) within the Chicago Longitudinal Research. LCA groups were modeled using multiple indicators of pre-morbid disadvantage (parental social class, educational attainment, race, gender, and work and social functioning prior to psychosis onset)...
March 25, 2024: Psychological Medicine
https://read.qxmd.com/read/38523252/dynamic-aberrances-of-substantia-nigra-relevant-coactivation-patterns-in-first-episode-treatment-na%C3%A3-ve-patients-with-schizophrenia
#18
JOURNAL ARTICLE
Lihong Deng, Wei Wei, Chunxia Qiao, Yubing Yin, Xiaojing Li, Hua Yu, Lingqi Jian, Xiaohong Ma, Liansheng Zhao, Qiang Wang, Wei Deng, Wanjun Guo, Tao Li
BACKGROUND: Although dopaminergic disturbances are well-known in schizophrenia, the understanding of dopamine-related brain dynamics remains limited. This study investigates the dynamic coactivation patterns (CAPs) associated with the substantia nigra (SN), a key dopaminergic nucleus, in first-episode treatment-naïve patients with schizophrenia (FES). METHODS: Resting-state fMRI data were collected from 84 FES and 94 healthy controls (HCs). Frame-wise clustering was implemented to generate CAPs related to SN activation or deactivation...
March 25, 2024: Psychological Medicine
https://read.qxmd.com/read/38523245/interventions-targeting-social-determinants-of-mental-disorders-and-the-sustainable-development-goals-a-systematic-review-of-reviews
#19
REVIEW
Tassia Kate Oswald, Minh Thu Nguyen, Luwaiza Mirza, Crick Lund, Hannah Grace Jones, Grace Crowley, Daron Aslanyan, Kimberlie Dean, Peter Schofield, Matthew Hotopf, Jayati Das-Munshi
Globally, mental disorders account for almost 20% of disease burden and there is growing evidence that mental disorders are socially determined. Tackling the United Nations Sustainable Development Goals (UN SDGs), which address social determinants of mental disorders, may be an effective way to reduce the global burden of mental disorders. We conducted a systematic review of reviews to examine the evidence base for interventions that map onto the UN SDGs and seek to improve mental health through targeting known social determinants of mental disorders...
March 25, 2024: Psychological Medicine
https://read.qxmd.com/read/38515277/no-relationship-between-male-pubertal-timing-and-depression-new-insights-from-epidemiology-and-mendelian-randomization
#20
JOURNAL ARTICLE
Raphael Hirtz, Corinna Grasemann, Heike Hölling, Björn-Hergen von Holt, Nicola Albers, Anke Hinney, Johannes Hebebrand, Triinu Peters
BACKGROUND: In males, the relationship between pubertal timing and depression is understudied and less consistent than in females, likely for reasons of unmeasured confounding. To clarify this relationship, a combined epidemiological and genetic approach was chosen to exploit the methodological advantages of both approaches. METHODS: Data from 2026 males from a nationwide, representative study were used to investigate the non-/linear relationship between pubertal timing defined by the age at voice break and depression, considering a multitude of potential confounders and their interactions with pubertal timing...
March 22, 2024: Psychological Medicine
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