journal
https://read.qxmd.com/read/38859703/association-of-occupational-dysfunction-and-hospital-admissions-with-different-polygenic-profiles-in-bipolar-disorder
#1
JOURNAL ARTICLE
Lina Jonsson, Elin Hörbeck, Amedeo Primerano, Jie Song, Robert Karlsson, Erik Smedler, Katherine Gordon-Smith, Lisa Jones, Nicholas Craddock, Ian Jones, Patrick F Sullivan, Erik Pålsson, Arianna Di Florio, Timea Sparding, Mikael Landén
OBJECTIVE: Many but not all persons with bipolar disorder require hospital care because of severe mood episodes. Likewise, some but not all patients experience long-term occupational dysfunction that extends beyond acute mood episodes. It is not known whether these dissimilar outcomes of bipolar disorder are driven by different polygenic profiles. Here, polygenic scores (PGSs) for major psychiatric disorders and educational attainment were assessed for associations with occupational functioning and psychiatric hospital admissions in bipolar disorder...
June 11, 2024: American Journal of Psychiatry
https://read.qxmd.com/read/38859702/cortical-and-subcortical-brain-alterations-in-specific-phobia-and-its-animal-and-blood-injection-injury-subtypes-a-mega-analysis-from-the-enigma-anxiety-working-group
#2
JOURNAL ARTICLE
Kevin Hilbert, Ole Jonas Boeken, Till Langhammer, Nynke A Groenewold, Janna Marie Bas-Hoogendam, Moji Aghajani, André Zugman, Fredrik Åhs, Volker Arolt, Katja Beesdo-Baum, Johannes Björkstrand, Jennifer U Blackford, Laura Blanco-Hinojo, Joscha Böhnlein, Robin Bülow, Marta Cano, Narcis Cardoner, Xavier Caseras, Udo Dannlowski, Katharina Domschke, Lydia Fehm, Brandee Feola, Mats Fredrikson, Liesbet Goossens, Hans J Grabe, Dominik Grotegerd, Raquel E Gur, Alfons O Hamm, Anita Harrewijn, Ingmar Heinig, Martin J Herrmann, David Hofmann, Andrea P Jackowski, Andreas Jansen, Antonia N Kaczkurkin, Merel Kindt, Ellen N Kingsley, Tilo Kircher, Anna L Klahn, Katja Koelkebeck, Axel Krug, Harald Kugel, Bart Larsen, Elisabeth J Leehr, Lieselotte Leonhardt, Martin Lotze, Jürgen Margraf, Jarosław Michałowski, Markus Muehlhan, Igor Nenadić, Pedro M Pan, Paul Pauli, Wenceslao Peñate, Andre Pittig, Jens Plag, Jesus Pujol, Jan Richter, Francisco L Rivero, Giovanni A Salum, Theodore D Satterthwaite, Axel Schäfer, Judith Schäfer, Anne Schienle, Silvia Schneider, Elisabeth Schrammen, Koen Schruers, Stefan M Schulz, Esther Seidl, Rudolf M Stark, Frederike Stein, Benjamin Straube, Thomas Straube, Andreas Ströhle, Boris Suchan, Sophia I Thomopoulos, Carlos Ventura-Bort, Renee Visser, Henry Völzke, Albert Wabnegger, André Wannemüller, Julia Wendt, Julian Wiemer, Hans-Ulrich Wittchen, Katharina Wittfeld, Barry Wright, Yunbo Yang, Anna Zilverstand, Peter Zwanzger, Dick J Veltman, Anderson M Winkler, Daniel S Pine, Neda Jahanshad, Paul M Thompson, Dan J Stein, Nic J A Van der Wee, Ulrike Lueken
OBJECTIVE: Specific phobia is a common anxiety disorder, but the literature on associated brain structure alterations exhibits substantial gaps. The ENIGMA Anxiety Working Group examined brain structure differences between individuals with specific phobias and healthy control subjects as well as between the animal and blood-injection-injury (BII) subtypes of specific phobia. Additionally, the authors investigated associations of brain structure with symptom severity and age (youths vs...
June 11, 2024: American Journal of Psychiatry
https://read.qxmd.com/read/38831706/testing-quantitative-and-qualitative-sex-effects-in-a-national-swedish-twin-sibling-study-of-posttraumatic-stress-disorder
#3
JOURNAL ARTICLE
Ananda B Amstadter, Sara L Lönn, Shannon Cusack, Jan Sundquist, Kenneth S Kendler, Kristina Sundquist
OBJECTIVE: Twin studies have demonstrated that posttraumatic stress disorder (PTSD) is moderately heritable, and the pattern of findings across studies suggests higher heritability in females compared with males. Formal testing of sex differences has yet to be done in twin studies of PTSD. The authors sought to estimate the genetic and environmental contributions to PTSD, and to formally test for sex differences, in the largest sample to date of both sexes, among twins and siblings. METHODS: Using the Swedish National Registries, the authors performed structural equation modeling to decompose genetic and environmental variance for PTSD and to formally test for quantitative and qualitative sex differences in twins (16,242 pairs) and in full siblings within 2 years of age of each other (376,093 pairs), using diagnostic codes from medical registries...
June 4, 2024: American Journal of Psychiatry
https://read.qxmd.com/read/38831705/national-trends-in-emergency-department-visits-for-suicide-attempts-and-intentional-self-harm
#4
JOURNAL ARTICLE
Tanner J Bommersbach, Mark Olfson, Taeho Greg Rhee
OBJECTIVE: This study estimated national annual trends and characteristics of emergency department visits for suicide attempts and intentional self-harm in the United States from 2011 to 2020. METHODS: Data were from the National Hospital Ambulatory Medical Care Survey, an annual cross-sectional national sample survey of emergency departments. Visits for suicide attempts and intentional self-harm were identified using discharge diagnosis codes (ICD-9-CM for 2011-2015; ICD-10-CM for 2016-2020) or reason-for-visit codes...
June 4, 2024: American Journal of Psychiatry
https://read.qxmd.com/read/38745458/genome-wide-association-study-of-treatment-resistant-depression-shared-biology-with-metabolic-traits
#5
JOURNAL ARTICLE
JooEun Kang, Victor M Castro, Michael Ripperger, Sanan Venkatesh, David Burstein, Richard Karlsson Linnér, Daniel B Rocha, Yirui Hu, Drew Wilimitis, Theodore Morley, Lide Han, Rachel Youngjung Kim, Yen-Chen Anne Feng, Tian Ge, Stephan Heckers, Georgios Voloudakis, Christopher Chabris, Panos Roussos, Thomas H McCoy, Colin G Walsh, Roy H Perlis, Douglas M Ruderfer
OBJECTIVE: Treatment-resistant depression (TRD) occurs in roughly one-third of all individuals with major depressive disorder (MDD). Although research has suggested a significant common variant genetic component of liability to TRD, with heritability estimated at 8% when compared with non-treatment-resistant MDD, no replicated genetic loci have been identified, and the genetic architecture of TRD remains unclear. A key barrier to this work has been the paucity of adequately powered cohorts for investigation, largely because of the challenge in prospectively investigating this phenotype...
May 15, 2024: American Journal of Psychiatry
https://read.qxmd.com/read/38745457/long-term-course-of-remission-and-recovery-in-psychotic-disorders
#6
JOURNAL ARTICLE
Sara Tramazzo, Wenxuan Lian, Olesya Ajnakina, Gabrielle Carlson, Evelyn Bromet, Roman Kotov, Katherine Jonas
OBJECTIVE: Understanding prognosis is critical to anticipating public health needs and providing care to individuals with psychotic disorders. However, the long-term course of remission and recovery remains unclear. In this study, the most common trajectories of illness course are described for a cohort of individuals followed for 25 years since first admission for psychosis. METHODS: Participants are from the Suffolk County Mental Health Project, an epidemiological study of first-admission psychosis...
May 15, 2024: American Journal of Psychiatry
https://read.qxmd.com/read/38685859/pharmacogenomic-clinical-support-tools-for-the-treatment-of-depression
#7
REVIEW
Matthew L Baum, Alik S Widge, Linda L Carpenter, William M McDonald, Bruce M Cohen, Charles B Nemeroff
OBJECTIVE: In this review, the authors update the 2018 position statement of the American Psychiatric Association Council of Research Workgroup on Biomarkers and Novel Treatments on pharmacogenomic (PGx) tools for treatment selection in depression. METHODS: The literature was reviewed for new clinical trials and meta-analyses, published from 2017 to 2022, of studies using PGx tools for treatment selection in depression. The blinding and control conditions, as well as primary and secondary outcomes and post hoc analyses, were summarized...
April 30, 2024: American Journal of Psychiatry
https://read.qxmd.com/read/38685857/association-of-lower-rostral-anterior-cingulate-gaba-and-dysregulated-cortisol-stress-response-with-altered-functional-connectivity-in-young-adults-with-lifetime-depression-a-multimodal-imaging-investigation-of-trait-and-state-effects
#8
JOURNAL ARTICLE
Maria Ironside, Jessica M Duda, Amelia D Moser, Laura M Holsen, Chun S Zuo, Fei Du, Sarah Perlo, Christine E Richards, Xi Chen, Lisa D Nickerson, Kaylee E Null, Shiba M Esfand, Madeline M Alexander, David J Crowley, Meghan Lauze, Madhusmita Misra, Jill M Goldstein, Diego A Pizzagalli
OBJECTIVE: Preclinical work suggests that excess glucocorticoids and reduced cortical γ-aminobutyric acid (GABA) may affect sex-dependent differences in brain regions implicated in stress regulation and depressive phenotypes. The authors sought to address a critical gap in knowledge, namely, how stress circuitry is functionally affected by glucocorticoids and GABA in current or remitted major depressive disorder (MDD). METHODS: Multimodal imaging data were collected from 130 young adults (ages 18-25), of whom 44 had current MDD, 42 had remitted MDD, and 44 were healthy comparison subjects...
April 30, 2024: American Journal of Psychiatry
https://read.qxmd.com/read/38822589/cognitive-remediation-in-schizophrenia-spectrum-illness-evidence-for-treatment-persistence
#9
EDITORIAL
Matthew M Kurtz
No abstract text is available yet for this article.
June 1, 2024: American Journal of Psychiatry
https://read.qxmd.com/read/38822588/adhd-and-asd-time-to-split-or-lump
#10
EDITORIAL
Philip Shaw
No abstract text is available yet for this article.
June 1, 2024: American Journal of Psychiatry
https://read.qxmd.com/read/38822587/the-more-things-change
#11
EDITORIAL
René S Kahn
No abstract text is available yet for this article.
June 1, 2024: American Journal of Psychiatry
https://read.qxmd.com/read/38822586/neuromelanin-sensitive-mri-a-biomarker-for-treatment-resistant-schizophrenia
#12
EDITORIAL
Luke J Vano, Mattia Veronese, Robert A McCutcheon, Oliver D Howes
No abstract text is available yet for this article.
June 1, 2024: American Journal of Psychiatry
https://read.qxmd.com/read/38822585/aligning-stem-cell-models-and-postmortem-studies-to-query-striatal-neurodevelopment-in-schizophrenia
#13
EDITORIAL
Kristen J Brennand
No abstract text is available yet for this article.
June 1, 2024: American Journal of Psychiatry
https://read.qxmd.com/read/38822584/the-genesis-of-schizophrenia-an-origin-story
#14
REVIEW
Rebecca Birnbaum, Daniel R Weinberger
Schizophrenia is routinely referred to as a neurodevelopmental disorder, but the role of brain development in a disorder typically diagnosed during early adult life is enigmatic. The authors revisit the neurodevelopmental model of schizophrenia with genomic insights from the most recent schizophrenia clinical genetic association studies, transcriptomic and epigenomic analyses from human postmortem brain studies, and analyses from cellular models that recapitulate neurodevelopment. Emerging insights into schizophrenia genetic risk continue to converge on brain development, particularly stages of early brain development, that may be perturbed to deviate from a typical, normative course, resulting in schizophrenia clinical symptomatology...
June 1, 2024: American Journal of Psychiatry
https://read.qxmd.com/read/38822583/network-connection-issues-in-adhd
#15
EDITORIAL
Katya Rubia
No abstract text is available yet for this article.
June 1, 2024: American Journal of Psychiatry
https://read.qxmd.com/read/38822582/advances-in-understanding-schizophrenia-adhd-and-asd
#16
EDITORIAL
Ned H Kalin
No abstract text is available yet for this article.
June 1, 2024: American Journal of Psychiatry
https://read.qxmd.com/read/38685858/shared-and-specific-neural-correlates-of-attention-deficit-hyperactivity-disorder-and-autism-spectrum-disorder-a-meta-analysis-of-243-task-based-functional-mri-studies
#17
JOURNAL ARTICLE
Hiroki Tamon, Junya Fujino, Takashi Itahashi, Lennart Frahm, Valeria Parlatini, Yuta Y Aoki, Francisco Xavier Castellanos, Simon B Eickhoff, Samuele Cortese
OBJECTIVE: To investigate shared and specific neural correlates of cognitive functions in attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD), the authors performed a comprehensive meta-analysis and considered a balanced set of neuropsychological tasks across the two disorders. METHODS: A broad set of electronic databases was searched up to December 4, 2022, for task-based functional MRI studies investigating differences between individuals with ADHD or ASD and typically developing control subjects...
June 1, 2024: American Journal of Psychiatry
https://read.qxmd.com/read/38476046/reduction-in-trauma-related-symptoms-after-anesthetic-induced-intra-operative-dreaming
#18
LETTER
Laura M Hack, Pilleriin Sikka, Kelly Zhou, Makoto Kawai, Harrison S Chow, Boris Heifets
No abstract text is available yet for this article.
June 1, 2024: American Journal of Psychiatry
https://read.qxmd.com/read/38476044/neuromelanin-sensitive-mri-as-candidate-marker-for-treatment-resistance-in-first-episode-schizophrenia
#19
JOURNAL ARTICLE
Marieke van der Pluijm, Kenneth Wengler, Pascalle N Reijers, Clifford M Cassidy, Kaithlyn Tjong Tjin Joe, Olav R de Peuter, Guillermo Horga, Jan Booij, Lieuwe de Haan, Elsmarieke van de Giessen
OBJECTIVE: Markers for treatment resistance in schizophrenia are needed to reduce delays in effective treatment. Nigrostriatal hyperdopaminergic function plays a critical role in the pathology of schizophrenia, yet antipsychotic nonresponders do not show increased dopamine function. Neuromelanin-sensitive MRI (NM-MRI), which indirectly measures dopamine function in the substantia nigra, has potential as a noninvasive marker for nonresponders. Increased NM-MRI signal has been shown in psychosis, but has not yet been assessed in nonresponders...
June 1, 2024: American Journal of Psychiatry
https://read.qxmd.com/read/38706340/the-developmental-trajectory-to-cannabis-use-disorder
#20
JOURNAL ARTICLE
Jesse D Hinckley, Jacqueline-Marie N Ferland, Yasmin L Hurd
No abstract text is available yet for this article.
May 1, 2024: American Journal of Psychiatry
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