Kuldeep Kumar, Claudia Modenato, Clara Moreau, Christopher R K Ching, Annabelle Harvey, Sandra Martin-Brevet, Guillaume Huguet, Martineau Jean-Louis, Elise Douard, Charles-Olivier Martin, Nadine Younis, Petra Tamer, Anne M Maillard, Borja Rodriguez-Herreros, Aurélie Pain, Leila Kushan, Dmitry Isaev, Kathryn Alpert, Anjani Ragothaman, Jessica A Turner, Lei Wang, Tiffany C Ho, Lianne Schmaal, Ana I Silva, Marianne B M van den Bree, David E J Linden, Michael J Owen, Jeremy Hall, Sarah Lippé, Guillaume Dumas, Bogdan Draganski, Boris A Gutman, Ida E Sønderby, Ole A Andreassen, Laura M Schultz, Laura Almasy, David C Glahn, Carrie E Bearden, Paul M Thompson, Sébastien Jacquemont
OBJECTIVE: Copy number variants (CNVs) are well-known genetic pleiotropic risk factors for multiple neurodevelopmental and psychiatric disorders (NPDs), including autism (ASD) and schizophrenia. Little is known about how different CNVs conferring risk for the same condition may affect subcortical brain structures and how these alterations relate to the level of disease risk conferred by CNVs. To fill this gap, the authors investigated gross volume, vertex-level thickness, and surface maps of subcortical structures in 11 CNVs and six NPDs...
September 1, 2023: American Journal of Psychiatry