journal

American Journal of Psychiatry

journal
https://read.qxmd.com/read/31906710/a-population-based-cohort-study-examining-the-incidence-and-impact-of-psychotic-experiences-from-childhood-to-adulthood-and-prediction-of-psychotic-disorder
#1
Sarah A Sullivan, Daphne Kounali, Mary Cannon, Anthony S David, Paul C Fletcher, Peter Holmans, Hannah Jones, Peter B Jones, David E J Linden, Glyn Lewis, Michael J Owen, Michael O'Donovan, Alexandros Rammos, Andrew Thompson, Dieter Wolke, Jon Heron, Stanley Zammit
OBJECTIVE: The authors investigated the incidence, course, and outcome of psychotic experiences from childhood through early adulthood in the general population and examined prediction of psychotic disorder. METHODS: This was a population-based cohort study using the semistructured Psychosis-Like Symptoms Interview at ages 12, 18, and 24 (N=7,900 with any data). Incidence rates were estimated using flexible parametric modeling, and positive predictive values (PPVs), sensitivity, specificity, and area under the curve were estimated for prediction...
January 7, 2020: American Journal of Psychiatry
https://read.qxmd.com/read/31906709/efficacy-of-deep-brain-stimulation-of-the-ventral-anterior-limb-of-the-internal-capsule-for-refractory-obsessive-compulsive-disorder-a-clinical-cohort-of-70-patients
#2
Damiaan Denys, Ilse Graat, Roel Mocking, Pelle de Koning, Nienke Vulink, Martijn Figee, Pieter Ooms, Mariska Mantione, Pepijn van den Munckhof, Rick Schuurman
OBJECTIVE: Deep brain stimulation (DBS) is an effective treatment option for patients with refractory obsessive-compulsive disorder (OCD). However, clinical experience with DBS for OCD remains limited. The authors examined the tolerability and effectiveness of DBS in an open study of patients with refractory OCD. METHODS: Seventy consecutive patients, including 16 patients from a previous trial, received bilateral DBS of the ventral anterior limb of the internal capsule (vALIC) between April 2005 and October 2017 and were followed for 12 months...
January 7, 2020: American Journal of Psychiatry
https://read.qxmd.com/read/31906708/reproducible-genetic-risk-loci-for-anxiety-results-from-%C3%A2-200-000-participants-in-the-million-veteran-program
#3
Daniel F Levey, Joel Gelernter, Renato Polimanti, Hang Zhou, Zhongshan Cheng, Mihaela Aslan, Rachel Quaden, John Concato, Krishnan Radhakrishnan, Julien Bryois, Patrick F Sullivan, Murray B Stein
OBJECTIVE: Anxiety disorders are common and often disabling. The goal of this study was to examine the genetic architecture of anxiety disorders and anxiety symptoms, which are also frequently comorbid with other mental disorders, such as major depressive disorder. METHODS: Using one of the world's largest biobanks including genetic, environmental, and medical information, the Million Veteran Program, the authors performed a genome-wide association study (GWAS) of a continuous trait for anxiety (based on score on the Generalized Anxiety Disorder 2-item scale [GAD-2], N=199,611) as the primary analysis and self-report of physician diagnosis of anxiety disorder (N=224,330) as a secondary analysis...
January 7, 2020: American Journal of Psychiatry
https://read.qxmd.com/read/31838873/dose-response-meta-analysis-of-antipsychotic-drugs-for-acute-schizophrenia
#4
Stefan Leucht, Alessio Crippa, Spyridon Siafis, Maxine X Patel, Nicola Orsini, John M Davis
OBJECTIVE: The dose-response relationships of antipsychotic drugs for schizophrenia are not well defined, but such information would be important for decision making by clinicians. The authors sought to fill this gap by conducting dose-response meta-analyses. METHODS: A search of multiple electronic databases (through November 2018) was conducted for all placebo-controlled dose-finding studies for 20 second-generation antipsychotic drugs and haloperidol (oral and long-acting injectable, LAI) in people with acute schizophrenia symptoms...
December 16, 2019: American Journal of Psychiatry
https://read.qxmd.com/read/31838872/effect-of-cbt-on-biased-semantic-network-in-panic-disorder-a-multicenter-fmri-study-using-semantic-priming
#5
Yunbo Yang, Ulrike Lueken, Jan Richter, Alfons Hamm, André Wittmann, Carsten Konrad, Andreas Ströhle, Bettina Pfleiderer, Martin J Herrmann, Thomas Lang, Martin Lotze, Jürgen Deckert, Volker Arolt, Hans-Ulrich Wittchen, Benjamin Straube, Tilo Kircher
OBJECTIVE: Cognitive-behavioral therapy (CBT) has been hypothesized to act by reducing the pathologically enhanced semantic, anxiety-related associations of patients with panic disorder. This study investigated the effects of CBT on the behavioral and neural correlates of the panic-related semantic network in patients with panic disorder. METHODS: An automatic semantic priming paradigm specifically tailored for panic disorder, in which panic symptoms (e.g., "dizziness") were primed by panic triggers (e...
December 16, 2019: American Journal of Psychiatry
https://read.qxmd.com/read/31838871/distinct-polygenic-score-profiles-in-schizophrenia-subgroups-with-different-trajectories-of-cognitive-development
#6
Dwight Dickinson, Sofia R Zaidman, Evan J Giangrande, Daniel P Eisenberg, Michael D Gregory, Karen F Berman
OBJECTIVE: Different cognitive development histories in schizophrenia may reflect variation across dimensions of genetic influence. The authors derived and characterized cognitive development trajectory subgroups within a schizophrenia sample and profiled the subgroups across polygenic scores (PGSs) for schizophrenia, cognition, educational attainment, and attention deficit hyperactivity disorder (ADHD). METHODS: Demographic, clinical, and genetic data were collected at the National Institute of Mental Health from 540 schizophrenia patients, 247 unaffected siblings, and 844 control subjects...
December 16, 2019: American Journal of Psychiatry
https://read.qxmd.com/read/31838870/individual-patterns-of-abnormality-in-resting-state-functional-connectivity-reveal-two-data-driven-ptsd-subgroups
#7
Adi Maron-Katz, Yu Zhang, Manjari Narayan, Wei Wu, Russell T Toll, Sharon Naparstek, Carlo De Los Angeles, Parker Longwell, Emmanuel Shpigel, Jennifer Newman, Duna Abu-Amara, Charles Marmar, Amit Etkin
OBJECTIVE: A major challenge in understanding and treating posttraumatic stress disorder (PTSD) is its clinical heterogeneity, which is likely determined by various neurobiological perturbations. This heterogeneity likely also reduces the effectiveness of standard group comparison approaches. The authors tested whether a statistical approach aimed at identifying individual-level neuroimaging abnormalities that are more prevalent in case subjects than in control subjects could reveal new clinically meaningful insights into the heterogeneity of PTSD...
December 16, 2019: American Journal of Psychiatry
https://read.qxmd.com/read/31786934/a-single-ketamine-infusion-combined-with-motivational-enhancement-therapy-for-alcohol-use-disorder-a-randomized-midazolam-controlled-pilot-trial
#8
Elias Dakwar, Frances Levin, Carl L Hart, Cale Basaraba, Jean Choi, Martina Pavlicova, Edward V Nunes
OBJECTIVE: Pharmacotherapy and behavioral treatments for alcohol use disorder are limited in their effectiveness, and new treatments with innovative mechanisms would be valuable. In this pilot study, the authors tested whether a single subanesthetic infusion of ketamine administered to adults with alcohol dependence and engaged in motivational enhancement therapy affects drinking outcomes. METHODS: Participants were randomly assigned to a 52-minute intravenous administration of ketamine (0...
December 2, 2019: American Journal of Psychiatry
https://read.qxmd.com/read/31786933/acute-care-prescription-opioid-use-and-overdose-following-discontinuation-of-long-term-buprenorphine-treatment-for-opioid-use-disorder
#9
Arthur Robin Williams, Hillary Samples, Stephen Crystal, Mark Olfson
OBJECTIVE: Although buprenorphine treatment reduces risk of overdose and death in opioid use disorder, most patients discontinue treatment within a few weeks or months. Adverse health outcomes following buprenorphine discontinuation were compared among patients who were successfully retained beyond 6 months of continuous treatment, a minimum treatment duration recently endorsed by the National Quality Forum. METHODS: A retrospective longitudinal cohort analysis was performed using the MarketScan multistate Medicaid claims database (2013-2017), covering 12 million beneficiaries annually...
December 2, 2019: American Journal of Psychiatry
https://read.qxmd.com/read/31711302/polygenic-risk-score-contribution-to-psychosis-prediction-in-a-target-population-of-persons-at-clinical-high-risk
#10
Diana O Perkins, Loes Olde Loohuis, Jenna Barbee, John Ford, Clark D Jeffries, Jean Addington, Carrie E Bearden, Kristin S Cadenhead, Tyrone D Cannon, Barbara A Cornblatt, Daniel H Mathalon, Thomas H McGlashan, Larry J Seidman, Ming Tsuang, Elaine F Walker, Scott W Woods
OBJECTIVE: The 2-year risk of psychosis in persons who meet research criteria for a high-risk syndrome is about 15%-25%; improvements in risk prediction accuracy would benefit the development and implementation of preventive interventions. The authors sought to assess polygenic risk score (PRS) prediction of subsequent psychosis in persons at high risk and to determine the impact of adding the PRS to a previously validated psychosis risk calculator. METHODS: Persons meeting research criteria for psychosis high risk (N=764) and unaffected individuals (N=279) were followed for up to 2 years...
November 12, 2019: American Journal of Psychiatry
https://read.qxmd.com/read/31892302/childhood-maltreatment-hampers-interpersonal-distance-and-social-touch-in-adulthood
#11
EDITORIAL
Martin H Teicher
No abstract text is available yet for this article.
January 1, 2020: American Journal of Psychiatry
https://read.qxmd.com/read/31892301/highlights-from-the-residents-journal-december-2019
#12
(no author information available yet)
No abstract text is available yet for this article.
January 1, 2020: American Journal of Psychiatry
https://read.qxmd.com/read/31892300/deficiency-of-inflammatory-response-to-acute-trauma-exposure-as-a-neuroimmune-mechanism-driving-the-development-of-chronic-ptsd-another-paradigmatic-shift-for-the-conceptualization-of-stress-related-disorders
#13
EDITORIAL
https://read.qxmd.com/read/31892299/2019-articles-of-import-and-impact
#14
EDITORIAL
Ned H Kalin, Elisabeth Binder, Kathleen T Brady, David A Lewis, Daniel S Pine, Carolyn Rodriguez, Madhukar Trivedi, Shapir Rosenberg
No abstract text is available yet for this article.
January 1, 2020: American Journal of Psychiatry
https://read.qxmd.com/read/31892298/early-life-environmental-factors-impacting-the-development-of-psychopathology
#15
EDITORIAL
Ned H Kalin
No abstract text is available yet for this article.
January 1, 2020: American Journal of Psychiatry
https://read.qxmd.com/read/31892297/more-information-needed-to-understand-low-levels-of-tnf%C3%AE-and-ifn%C3%AE-in-chronic-ptsd
#16
LETTER
Kyoung-Sae Na
No abstract text is available yet for this article.
January 1, 2020: American Journal of Psychiatry
https://read.qxmd.com/read/31892296/can-childhood-adversity-affect-telomeres-of-the-next-generation-possible-mechanisms-implications-and-next-generation-research
#17
EDITORIAL
Elissa S Epel
No abstract text is available yet for this article.
January 1, 2020: American Journal of Psychiatry
https://read.qxmd.com/read/31892295/maternal-bacterial-infection-during-pregnancy-a-potential-causal-risk-factor-for-psychosis-in-offspring
#18
EDITORIAL
Kenneth S Kendler
No abstract text is available yet for this article.
January 1, 2020: American Journal of Psychiatry
https://read.qxmd.com/read/31892293/further-study-warranted-to-evaluate-tnf%C3%AE-and-ifn%C3%AE-as-biomarkers-for-ptsd-risk-response-to-na
#19
LETTER
Vasiliki Michopoulos, Kerry J Ressler, Charles B Nemeroff
No abstract text is available yet for this article.
January 1, 2020: American Journal of Psychiatry
https://read.qxmd.com/read/31623458/lithium-exposure-during-pregnancy-and-the-postpartum-period-a-systematic-review-and-meta-analysis-of-safety-and-efficacy-outcomes
#20
Michele Fornaro, Elena Maritan, Roberta Ferranti, Leonardo Zaninotto, Alessandro Miola, Annalisa Anastasia, Andrea Murru, Eva Solé, Brendon Stubbs, André F Carvalho, Alessandro Serretti, Eduard Vieta, Paolo Fusar-Poli, Philip McGuire, Allan H Young, Paola Dazzan, Simone N Vigod, Christoph U Correll, Marco Solmi
OBJECTIVE: Uncertainty surrounds the risks of lithium use during pregnancy in women with bipolar disorder. The authors sought to provide a critical appraisal of the evidence related to the efficacy and safety of lithium treatment during the peripartum period, focusing on women with bipolar disorder and their offspring. METHODS: The authors conducted a systematic review and random-effects meta-analysis assessing case-control, cohort, and interventional studies reporting on the safety (primary outcome, any congenital anomaly) or efficacy (primary outcome, mood relapse prevention) of lithium treatment during pregnancy and the postpartum period...
January 1, 2020: American Journal of Psychiatry
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