Alyson Zwicker, Janice M Fullerton, Niamh Mullins, Frances Rice, Danella M Hafeman, Neeltje E M van Haren, Nikita Setiaman, John A Merranko, Benjamin I Goldstein, Alessandra G Ferrera, Emma K Stapp, Elena de la Serna, Dolores Moreno, Gisela Sugranyes, Sergio Mas Herrero, Gloria Roberts, Claudio Toma, Peter R Schofield, Howard J Edenberg, Holly C Wilcox, Melvin G McInnis, Victoria Powell, Lukas Propper, Eileen Denovan-Wright, Guy Rouleau, Josefina Castro-Fornieles, Manon H J Hillegers, Boris Birmaher, Anita Thapar, Philip B Mitchell, Cathryn M Lewis, Martin Alda, John I Nurnberger, Rudolf Uher
OBJECTIVE: Family history is an established risk factor for mental illness. The authors sought to investigate whether polygenic scores (PGSs) can complement family history to improve identification of risk for major mood and psychotic disorders. METHODS: Eight cohorts were combined to create a sample of 1,884 participants ages 2-36 years, including 1,339 offspring of parents with mood or psychotic disorders, who were prospectively assessed with diagnostic interviews over an average of 5...
February 22, 2023: American Journal of Psychiatry