journal

American Journal of Psychiatry

journal
https://read.qxmd.com/read/32600153/pervasively-thinner-neocortex-as-a-transdiagnostic-feature-of-general-psychopathology
#1
Adrienne L Romer, Maxwell L Elliott, Annchen R Knodt, Maria L Sison, David Ireland, Renate Houts, Sandhya Ramrakha, Richie Poulton, Ross Keenan, Tracy R Melzer, Terrie E Moffitt, Avshalom Caspi, Ahmad R Hariri
OBJECTIVE: Neuroimaging research has revealed that structural brain alterations are common across broad diagnostic families of disorders rather than specific to a single psychiatric disorder. Such overlap in the structural brain correlates of mental disorders mirrors already well-documented phenotypic comorbidity of psychiatric symptoms and diagnoses, which can be indexed by a general psychopathology or p factor. The authors hypothesized that if general psychopathology drives the convergence of structural alterations common across disorders, then 1) there should be few associations unique to any one diagnostic family of disorders, and 2) associations with the p factor should overlap with those for the broader diagnostic families...
June 30, 2020: American Journal of Psychiatry
https://read.qxmd.com/read/32600152/from-rare-copy-number-variants-to-biological-processes-in-adhd
#2
Benjamin Harich, Monique van der Voet, Marieke Klein, Pavel Čížek, Michaela Fenckova, Annette Schenck, Barbara Franke
OBJECTIVE: Attention deficit hyperactivity disorder (ADHD) is a highly heritable psychiatric disorder. The objective of this study was to define ADHD-associated candidate genes and their associated molecular modules and biological themes, based on the analysis of rare genetic variants. METHODS: The authors combined data from 11 published copy number variation studies in 6,176 individuals with ADHD and 25,026 control subjects and prioritized genes by applying an integrative strategy based on criteria including recurrence in individuals with ADHD, absence in control subjects, complete coverage in copy number gains, and presence in the minimal region common to overlapping copy number variants (CNVs), as well as on protein-protein interactions and information from cross-species genotype-phenotype annotation...
June 30, 2020: American Journal of Psychiatry
https://read.qxmd.com/read/32539529/callous-unemotional-traits-and-risk-of-gun-carrying-and-use-during-crime
#3
Emily L Robertson, Paul J Frick, Toni M Walker, Emily C Kemp, James V Ray, Laura C Thornton, Tina D Wall Myers, Laurence Steinberg, Elizabeth Cauffman
OBJECTIVE: With the addition of the "with limited prosocial emotions" specifier within the diagnosis of conduct disorder (DSM-5) and of conduct-dissocial disorder (ICD-11) to designate those with elevated callous-unemotional traits, the authors examined the role that callous-unemotional traits play in the risk for gun carrying and gun use during a crime in a sample at high risk for gun violence. METHODS: Male juvenile offenders (N=1,215) from three regions of the United States were assessed after their first arrest and then reassessed every 6 months for 36 months and again at 48 months...
June 16, 2020: American Journal of Psychiatry
https://read.qxmd.com/read/32539528/antibodies-from-children-with-pandas-bind-specifically-to-striatal-cholinergic-interneurons-and-alter-their-activity
#4
Jian Xu, Rong-Jian Liu, Shaylyn Fahey, Luciana Frick, James Leckman, Flora Vaccarino, Ronald S Duman, Kyle Williams, Susan Swedo, Christopher Pittenger
OBJECTIVE: Pediatric obsessive-compulsive disorder (OCD) sometimes appears rapidly, even overnight, often after an infection. Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections, or PANDAS, describes such a situation after infection with Streptococcus pyogenes . PANDAS may result from induced autoimmunity against brain antigens, although this remains unproven. Pilot work suggests that IgG antibodies from children with PANDAS bind to cholinergic interneurons (CINs) in the striatum...
June 16, 2020: American Journal of Psychiatry
https://read.qxmd.com/read/32539527/subcortical-brain-volume-regional-cortical-thickness-and-cortical-surface-area-across-disorders-findings-from-the-enigma-adhd-asd-and-ocd-working-groups
#5
Premika S W Boedhoe, Daan van Rooij, Martine Hoogman, Jos W R Twisk, Lianne Schmaal, Yoshinari Abe, Pino Alonso, Stephanie H Ameis, Anatoly Anikin, Alan Anticevic, Celso Arango, Paul D Arnold, Philip Asherson, Francesca Assogna, Guillaume Auzias, Tobias Banaschewski, Alexander Baranov, Marcelo C Batistuzzo, Sarah Baumeister, Ramona Baur-Streubel, Marlene Behrmann, Mark A Bellgrove, Francesco Benedetti, Jan C Beucke, Joseph Biederman, Irene Bollettini, Anushree Bose, Janita Bralten, Ivanei E Bramati, Daniel Brandeis, Silvia Brem, Brian P Brennan, Geraldo F Busatto, Sara Calderoni, Anna Calvo, Rosa Calvo, Francisco X Castellanos, Mara Cercignani, Tiffany M Chaim-Avancini, Kaylita C Chantiluke, Yuqi Cheng, Kang Ik K Cho, Anastasia Christakou, David Coghill, Annette Conzelmann, Ana I Cubillo, Anders M Dale, Sara Dallaspezia, Eileen Daly, Damiaan Denys, Christine Deruelle, Adriana Di Martino, Ilan Dinstein, Alysa E Doyle, Sarah Durston, Eric A Earl, Christine Ecker, Stefan Ehrlich, Benjamin A Ely, Jeffrey N Epstein, Thomas Ethofer, Damien A Fair, Andreas J Fallgatter, Stephen V Faraone, Jennifer Fedor, Xin Feng, Jamie D Feusner, Jackie Fitzgerald, Kate D Fitzgerald, Jean-Paul Fouche, Christine M Freitag, Egill A Fridgeirsson, Thomas Frodl, Matt C Gabel, Louise Gallagher, Tinatin Gogberashvili, Ilaria Gori, Patricia Gruner, Deniz A Gürsel, Shlomi Haar, Jan Haavik, Geoffrey B Hall, Neil A Harrison, Catharina A Hartman, Dirk J Heslenfeld, Yoshiyuki Hirano, Pieter J Hoekstra, Marcelo Q Hoexter, Sarah Hohmann, Marie F Høvik, Hao Hu, Chaim Huyser, Neda Jahanshad, Maria Jalbrzikowski, Anthony James, Joost Janssen, Fern Jaspers-Fayer, Terry L Jernigan, Dmitry Kapilushniy, Bernd Kardatzki, Georgii Karkashadze, Norbert Kathmann, Christian Kaufmann, Clare Kelly, Sabin Khadka, Joseph A King, Kathrin Koch, Gregor Kohls, Kerstin Kohls, Masaru Kuno, Jonna Kuntsi, Gerd Kvale, Jun Soo Kwon, Luisa Lázaro, Sara Lera-Miguel, Klaus-Peter Lesch, Liesbeth Hoekstra, Yanni Liu, Christine Lochner, Mario R Louza, Beatriz Luna, Astri J Lundervold, Charles B Malpas, Paulo Marques, Rachel Marsh, Ignacio Martínez-Zalacaín, David Mataix-Cols, Paulo Mattos, Hazel McCarthy, Jane McGrath, Mitul A Mehta, José M Menchón, Maarten Mennes, Mauricio Moller Martinho, Pedro S Moreira, Astrid Morer, Pedro Morgado, Filippo Muratori, Clodagh M Murphy, Declan G M Murphy, Akiko Nakagawa, Takashi Nakamae, Tomohiro Nakao, Leyla Namazova-Baranova, Janardhanan C Narayanaswamy, Rosa Nicolau, Joel T Nigg, Stephanie E Novotny, Erika L Nurmi, Eileen Oberwelland Weiss, Ruth L O'Gorman Tuura, Kirsten O'Hearn, Joseph O'Neill, Jaap Oosterlaan, Bob Oranje, Yannis Paloyelis, Mara Parellada, Paul Pauli, Chris Perriello, John Piacentini, Fabrizio Piras, Federica Piras, Kerstin J Plessen, Olga Puig, J Antoni Ramos-Quiroga, Y C Janardhan Reddy, Andreas Reif, Liesbeth Reneman, Alessandra Retico, Pedro G P Rosa, Katya Rubia, Oana Georgiana Rus, Yuki Sakai, Anouk Schrantee, Lena Schwarz, Lizanne J S Schweren, Jochen Seitz, Philip Shaw, Devon Shook, Tim J Silk, H Blair Simpson, Norbert Skokauskas, Juan Carlos Soliva Vila, Anastasia Solovieva, Noam Soreni, Carles Soriano-Mas, Gianfranco Spalletta, Emily R Stern, Michael C Stevens, S Evelyn Stewart, Gustavo Sudre, Philip R Szeszko, Leanne Tamm, Margot J Taylor, David F Tolin, Michela Tosetti, Fernanda Tovar-Moll, Aki Tsuchiyagaito, Theo G M van Erp, Guido A van Wingen, Alasdair Vance, Ganesan Venkatasubramanian, Oscar Vilarroya, Yolanda Vives-Gilabert, Georg G von Polier, Susanne Walitza, Gregory L Wallace, Zhen Wang, Thomas Wolfers, Yuliya N Yoncheva, Je-Yeon Yun, Marcus V Zanetti, Fengfeng Zhou, Georg C Ziegler, Kathrin C Zierhut, Marcel P Zwiers, Paul M Thompson, Dan J Stein, Jan Buitelaar, Barbara Franke, Odile A van den Heuvel
OBJECTIVE: Attention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and obsessive-compulsive disorder (OCD) are common neurodevelopmental disorders that frequently co-occur. The authors sought to directly compare these disorders using structural brain imaging data from ENIGMA consortium data. METHODS: Structural T1 -weighted whole-brain MRI data from healthy control subjects (N=5,827) and from patients with ADHD (N=2,271), ASD (N=1,777), and OCD (N=2,323) from 151 cohorts worldwide were analyzed using standardized processing protocols...
June 16, 2020: American Journal of Psychiatry
https://read.qxmd.com/read/32539526/diagnostic-classification-for-human-autism-and-obsessive-compulsive-disorder-based-on-machine-learning-from-a-primate-genetic-model
#6
Yafeng Zhan, Jianze Wei, Jian Liang, Xiu Xu, Ran He, Trevor W Robbins, Zheng Wang
OBJECTIVE: Psychiatric disorders commonly comprise comorbid symptoms, such as autism spectrum disorder (ASD), obsessive-compulsive disorder (OCD), and attention deficit hyperactivity disorder (ADHD), raising controversies over accurate diagnosis and overlap of their neural underpinnings. The authors used noninvasive neuroimaging in humans and nonhuman primates to identify neural markers associated with DSM-5 diagnoses and quantitative measures of symptom severity. METHODS: Resting-state functional connectivity data obtained from both wild-type and methyl-CpG binding protein 2 ( MECP2 ) transgenic monkeys were used to construct monkey-derived classifiers for diagnostic classification in four human data sets (ASD: Autism Brain Imaging Data Exchange [ABIDE-I], N=1,112; ABIDE-II, N=1,114; ADHD-200 sample: N=776; OCD local institutional database: N=186)...
June 16, 2020: American Journal of Psychiatry
https://read.qxmd.com/read/32456505/parietal-prefrontal-feedforward-connectivity-in-association-with-schizophrenia-genetic-risk-and-delusions
#7
Danielle L B Greenman, Michelle A N La, Shefali Shah, Qiang Chen, Karen F Berman, Daniel R Weinberger, Hao Yang Tan
OBJECTIVE: Conceptualizations of delusion formation implicate deficits in feedforward information updating across the posterior to prefrontal cortices, resulting in dysfunctional integration of new information about contexts in working memory and, ultimately, failure to update overfamiliar prior beliefs. The authors used functional MRI and machine learning models to address individual variability in feedforward parietal-prefrontal information updating in patients with schizophrenia. They examined relationships between feedforward connectivity, and delusional thinking and polygenic risk for schizophrenia...
May 27, 2020: American Journal of Psychiatry
https://read.qxmd.com/read/32456504/hormonal-treatments-for-major-depressive-disorder-state-of-the-art
#8
Jennifer B Dwyer, Awais Aftab, Alik Widge, Carolyn I Rodriguez, Linda L Carpenter, Charles B Nemeroff, Ned H Kalin
Major depressive disorder is a common psychiatric disorder associated with marked suffering, morbidity, mortality, and cost. The World Health Organization projects that by 2030, major depression will be the leading cause of disease burden worldwide. While numerous treatments for major depression exist, many patients do not respond adequately to traditional antidepressants. Thus, more effective treatments for major depression are needed, and targeting certain hormonal systems is a conceptually based approach that has shown promise in the treatment of this disorder...
May 27, 2020: American Journal of Psychiatry
https://read.qxmd.com/read/32456503/association-between-the-use-of-cannabis-and-physical-violence-in-youths-a-meta-analytical-investigation
#9
Laura Dellazizzo, Stéphane Potvin, Bo Yi Dou, Mélissa Beaudoin, Mimosa Luigi, Charles-Édouard Giguère, Alexandre Dumais
OBJECTIVE: The aim of this meta-analysis was to investigate the extent to which cannabis use among youths is associated with the risk of perpetrating physical violence. METHODS: Searches were conducted in PubMed, PsycINFO, Web of Science, and Google Scholar for articles published from the inception of each database to July 2019. All studies that examined both cannabis use and the perpetration of physical violence in a sample of youths and young adults <30 years old were included...
May 27, 2020: American Journal of Psychiatry
https://read.qxmd.com/read/32375540/mental-health-response-to-the-covid-19-outbreak-in-china
#10
Junying Zhou, Liu Liu, Pei Xue, Xiaorong Yang, Xiangdong Tang
No abstract text is available yet for this article.
May 7, 2020: American Journal of Psychiatry
https://read.qxmd.com/read/32375537/a-prehistory-of-the-diathesis-stress-model-predisposing-and-exciting-causes-of-insanity-in-the-19th-century
#11
Kenneth S Kendler
Histories of the diathesis-stress model trace its origins to the 1950s. However, of 26 psychiatric texts published between 1800 and 1910, 17 noted that causes of insanity could be usefully divided into those that predispose to illness and those that excite onset. In this "predisposition-excitation framework" (PEF) for the etiology of insanity, hereditary or constitutional factors were critical predisposing causes, but education, occupation, sex, and marital status were typically included as well. Psychological traumas were key exciting causes, but so were somatic diseases, pregnancy, and substance abuse...
May 7, 2020: American Journal of Psychiatry
https://read.qxmd.com/read/32375536/neural-correlates-of-the-dual-pathway-model-for-adhd-in-adolescents
#12
Chun Shen, Qiang Luo, Tianye Jia, Qi Zhao, Sylvane Desrivières, Erin Burke Quinlan, Tobias Banaschewski, Sabina Millenet, Arun L W Bokde, Christian Büchel, Herta Flor, Vincent Frouin, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Eric Artiges, Marie-Laure Paillère-Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomáš Paus, Luise Poustka, Juliane H Fröhner, Michael N Smolka, Henrik Walter, Robert Whelan, Fei Li, Jianfeng Feng, Gunter Schumann, Barbara J Sahakian
OBJECTIVE: The dual-pathway model has been proposed to explain the heterogeneity in symptoms of attention deficit hyperactivity disorder (ADHD) by two independent psychological pathways based on distinct brain circuits. The authors sought to test whether the hypothesized cognitive and motivational pathways have separable neural correlates. METHODS: In a longitudinal community-based cohort of 1,963 adolescents, the neuroanatomical correlates of ADHD were identified by a voxel-wise association analysis and then validated using an independent clinical sample (99 never-medicated patients with ADHD, 56 medicated patients with ADHD, and 267 healthy control subjects)...
May 7, 2020: American Journal of Psychiatry
https://read.qxmd.com/read/32340465/is-depression-nature-or-nurture-yes
#13
EDITORIAL
Myrna M Weissman
No abstract text is available yet for this article.
April 28, 2020: American Journal of Psychiatry
https://read.qxmd.com/read/32312111/20-year-trends-in-the-pharmacologic-treatment-of-bipolar-disorder-by-psychiatrists-in-outpatient-care-settings
#14
Taeho Greg Rhee, Mark Olfson, Andrew A Nierenberg, Samuel T Wilkinson
OBJECTIVE: Pharmacological options for treating bipolar disorder have increased over the past 20 years, with several second-generation antipsychotics receiving regulatory approval in the 1990s. The authors describe trends in use of pharmacological agents in the outpatient management of bipolar disorder. METHODS: Using nationally representative data from the 1997-2016 National Ambulatory Medical Care Surveys, the authors examined trends in the use of mood stabilizers, first- and second-generation antipsychotics, and antidepressants among psychiatrist visits for which bipolar disorder was listed among the primary diagnoses...
April 21, 2020: American Journal of Psychiatry
https://read.qxmd.com/read/32312110/intergenerational-effects-of-maternal-holocaust-exposure-on-fkbp5-methylation
#15
Linda M Bierer, Heather N Bader, Nikolaos P Daskalakis, Amy Lehrner, Nadine Provençal, Tobias Wiechmann, Torsten Klengel, Iouri Makotkine, Elisabeth B Binder, Rachel Yehuda
OBJECTIVE: There is growing evidence that exposure to trauma prior to conception can affect offspring. The authors have reported that adult offspring of Holocaust survivors showed lower methylation of FK506 binding protein 5 ( FKBP5 ) intron 7, site 6 compared with Jewish comparison volunteers. The present study sought to replicate this finding in a larger sample and to examine parental and offspring correlates of observed effects. METHODS: Cytosine methylation was measured in blood using pyrosequencing...
April 21, 2020: American Journal of Psychiatry
https://read.qxmd.com/read/32312109/association-between-ambient-air-pollution-and-daily-hospital-admissions-for-depression-in-75-chinese-cities
#16
Xuelin Gu, Tongjun Guo, Yaqin Si, Jinxi Wang, Wangjian Zhang, Furong Deng, Libo Chen, Chen Wei, Shao Lin, Xinbiao Guo, Shaowei Wu
OBJECTIVE: Although the association between ambient air pollution and risk of depression has been investigated in several epidemiological studies, the evidence is still lacking for hospital admissions for depression, which indicates a more severe form of depressive episode. The authors used national morbidity data to investigate the association between short-term exposure to ambient air pollution and daily hospital admissions for depression. METHODS: Using data from the Chinese national medical insurance databases for urban populations, the authors conducted a two-stage time-series analysis to investigate the associations of short-term exposure to major ambient air pollutants-fine particles (PM2...
April 21, 2020: American Journal of Psychiatry
https://read.qxmd.com/read/32605451/covid-19-medication-assisted-treatment-and-increased-risk-for-further-respiratory-depression
#17
LETTER
Jenny Boyer
No abstract text is available yet for this article.
July 1, 2020: American Journal of Psychiatry
https://read.qxmd.com/read/32605450/medical-marijuana-putting-the-cart-before-the-horse
#18
EDITORIAL
Kathleen T Brady
No abstract text is available yet for this article.
July 1, 2020: American Journal of Psychiatry
https://read.qxmd.com/read/32605449/alcohol-use-disorder-and-suicide-risk-a-fresh-and-closer-look
#19
EDITORIAL
Deborah S Hasin
No abstract text is available yet for this article.
July 1, 2020: American Journal of Psychiatry
https://read.qxmd.com/read/32605448/a-reckoning-and-research-agenda-for-neuroimaging-in-psychiatry-response-to-henderson-et-al
#20
LETTER
Amit Etkin
No abstract text is available yet for this article.
July 1, 2020: American Journal of Psychiatry
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