journal
https://read.qxmd.com/read/37727098/long-term-use-of-benzodiazepines-and-benzodiazepine-related-drugs-a-register-based-danish-cohort-study-on-determinants-and-risk-of-dose-escalation
#1
JOURNAL ARTICLE
Thomas Wolff Rosenqvist, Marie Kim Wium-Andersen, Ida Kim Wium-Andersen, Martin Balslev Jørgensen, Merete Osler
OBJECTIVE: The authors investigated the frequency and determinants of long-term use and risk of dose escalation of benzodiazepines and benzodiazepine-related drugs (benzodiazepine receptor agonists, or BZRAs). METHODS: All adults ages 20-80 years living in Denmark on January 1, 2000 (N=4,297,045) were followed for redeemed prescriptions of BZRAs in the Danish National Prescription Registry from January 1, 2000, to December 31, 2020. For each drug class, we calculated long-term use for more than 1 or 7 years, and dose escalation measured as increase in dose to a level above the recommended level...
September 20, 2023: American Journal of Psychiatry
https://read.qxmd.com/read/37727097/recent-secular-trends-of-body-mass-index-in-individuals-with-bipolar-disorders-and-in-the-general-population
#2
JOURNAL ARTICLE
Hemen Najar, Erik Joas, Viktor Jonsson, Erik Pålsson, Mikael Landén
OBJECTIVE: The aims of this study were to investigate secular trends and distribution of body mass index (BMI) among individuals with bipolar disorders and the general population between 2008 and 2019. METHODS: Data were from the Swedish National Quality Register for Bipolar Disorder, where 24,423 adults with bipolar disorders were identified, and from the national Swedish Living Conditions Surveys, where 77,485 adults from the general population were identified...
September 20, 2023: American Journal of Psychiatry
https://read.qxmd.com/read/37670606/maternal-perinatal-stress-trajectories-and-negative-affect-and-amygdala-development-in-offspring
#3
JOURNAL ARTICLE
Mollie C Marr, Alice M Graham, Eric Feczko, Saara Nolvi, Elina Thomas, Darrick Sturgeon, Emma Schifsky, Jerod M Rasmussen, John H Gilmore, Martin Styner, Sonja Entringer, Pathik D Wadhwa, Riikka Korja, Hasse Karlsson, Linnea Karlsson, Claudia Buss, Damien A Fair
OBJECTIVE: Maternal psychological stress during pregnancy is a common risk factor for psychiatric disorders in offspring, but little is known about how heterogeneity of stress trajectories during pregnancy affect brain systems and behavioral phenotypes in infancy. This study was designed to address this gap in knowledge. METHODS: Maternal anxiety, stress, and depression were assessed at multiple time points during pregnancy in two independent low-risk mother-infant cohorts (N=115 and N=2,156)...
September 6, 2023: American Journal of Psychiatry
https://read.qxmd.com/read/37644812/genetic-contribution-to-the-heterogeneity-of-major-depressive-disorder-evidence-from-a-sibling-based-design-using-swedish-national-registers
#4
JOURNAL ARTICLE
Thuy-Dung Nguyen, Kaarina Kowalec, Joëlle Pasman, Henrik Larsson, Paul Lichtenstein, Christina Dalman, Patrick F Sullivan, Ralf Kuja-Halkola, Yi Lu
OBJECTIVE: Major depressive disorder (MDD) is highly heterogeneous. Standard typology partly captures the disorder's symptomatic heterogeneity, although whether it adequately captures etiological heterogeneity remains elusive. The aim of this study was to investigate the genetic characterization of MDD heterogeneity. METHODS: Using Swedish patient register data on 1.5 million individuals, the authors identified 46,255 individuals with specialist-diagnosed MDD. Eighteen subgroups were identified based on nine comparison groups defined by clinical and psychosocial features, including severity, recurrence, comorbidities, suicidality, impairment, disability, care unit, and age at diagnosis...
August 30, 2023: American Journal of Psychiatry
https://read.qxmd.com/read/37644811/a-functional-connectome-based-neural-signature-for-individualized-prediction-of-antipsychotic-response-in-first-episode-psychosis
#5
JOURNAL ARTICLE
Hengyi Cao, Todd Lencz, Juan A Gallego, Jose M Rubio, Majnu John, Anita D Barber, Michael L Birnbaum, Delbert G Robinson, Anil K Malhotra
OBJECTIVE: Identification of robust biomarkers that predict individualized response to antipsychotic treatment at the early stage of psychotic disorders remains a challenge in precision psychiatry. The aim of this study was to investigate whether any functional connectome-based neural traits could serve as such a biomarker. METHODS: In a discovery sample, 49 patients with first-episode psychosis received multi-paradigm fMRI scans at baseline and were clinically followed up for 12 weeks under antipsychotic monotherapies...
August 30, 2023: American Journal of Psychiatry
https://read.qxmd.com/read/37583326/networks-of-neurodevelopmental-traits-socioenvironmental-factors-emotional-dysregulation-in-childhood-and-depressive-symptoms-across-development-in-two-u-k-cohorts
#6
JOURNAL ARTICLE
Luis C Farhat, Rachel Blakey, George Davey Smith, André Fujita, Elizabeth Shephard, Evie Stergiakouli, Thalia C Eley, Anita Thapar, Guilherme V Polanczyk
OBJECTIVE: Previous population-based studies have identified associations between childhood neurodevelopmental traits and depression in childhood, adolescence, and young adulthood. However, neurodevelopmental traits are highly correlated with each other, which could confound associations when traits are examined in isolation. The authors sought to identify unique associations between multiple neurodevelopmental traits in childhood and depressive symptoms across development, while taking into account co-occurring difficulties, in multivariate analyses...
August 16, 2023: American Journal of Psychiatry
https://read.qxmd.com/read/37491938/zuranolone-for-the-treatment-of-postpartum-depression
#7
JOURNAL ARTICLE
Kristina M Deligiannidis, Samantha Meltzer-Brody, Bassem Maximos, E Quinn Peeper, Marlene Freeman, Robert Lasser, Amy Bullock, Mona Kotecha, Sigui Li, Fiona Forrestal, Nilanjana Rana, Manny Garcia, Bridgette Leclair, James Doherty
OBJECTIVE: Postpartum depression (PPD) is a common perinatal complication with adverse maternal and infant outcomes. This study investigated the efficacy and safety of zuranolone, a positive allosteric modulator of synaptic and extrasynaptic GABAA receptors and neuroactive steroid, as an oral, once-daily, 14-day treatment course for patients with severe PPD. METHODS: In this double-blind phase 3 trial, women with severe PPD were randomized in a 1:1 ratio to receive zuranolone 50 mg/day or placebo for 14 days...
July 26, 2023: American Journal of Psychiatry
https://read.qxmd.com/read/37491937/single-nucleus-transcriptome-profiling-of-dorsolateral-prefrontal-cortex-mechanistic-roles-for-neuronal-gene-expression-including-the-17q21-31-locus-in-ptsd-stress-response
#8
JOURNAL ARTICLE
Chris Chatzinakos, Cameron D Pernia, Filomene G Morrison, Artemis Iatrou, Kenneth M McCullough, Heike Schuler, Clara Snijders, Thomas Bajaj, Christopher P DiPietro, Marina Soliva Estruch, Nils C Gassen, Constantin Anastasopoulos, Rahul A Bharadwaj, Benjamin C Bowlby, Jakob Hartmann, Adam X Maihofer, Caroline M Nievergelt, Nicholas M Ressler, Erika J Wolf, William A Carlezon, John H Krystal, Joel E Kleinman, Matthew J Girgenti, Bertrand R Huber, Manolis Kellis, Mark W Logue, Mark W Miller, Kerry J Ressler, Nikolaos P Daskalakis
OBJECTIVE: Multidisciplinary studies of posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) implicate the dorsolateral prefrontal cortex (DLPFC) in disease risk and pathophysiology. Postmortem brain studies have relied on bulk-tissue RNA sequencing (RNA-seq), but single-cell RNA-seq is needed to dissect cell-type-specific mechanisms. The authors conducted the first single-nucleus RNA-seq postmortem brain study in PTSD to elucidate disease transcriptomic pathology with cell-type-specific resolution...
July 26, 2023: American Journal of Psychiatry
https://read.qxmd.com/read/37434509/must-psilocybin-always-assist-psychotherapy
#9
JOURNAL ARTICLE
Guy M Goodwin, Ekaterina Malievskaia, Gregory A Fonzo, Charles B Nemeroff
No abstract text is available yet for this article.
July 12, 2023: American Journal of Psychiatry
https://read.qxmd.com/read/37434487/association-of-cortico-striatal-engagement-during-cue-reactivity-reappraisal-and-savoring-of-drug-and-non-drug-stimuli-with-craving-in-heroin-addiction
#10
JOURNAL ARTICLE
Yuefeng Huang, Ahmet O Ceceli, Greg Kronberg, Sarah King, Pias Malaker, Muhammad A Parvaz, Nelly Alia-Klein, Eric L Garland, Rita Z Goldstein
OBJECTIVE: The authors investigated cortico-striatal reactivity to drug cues (as compared with neutral and food cues), drug cue reappraisal, food cue savoring, and their correlations with heroin craving in individuals with heroin use disorder compared with healthy control subjects. METHODS: Cross-sectional changes in functional MRI blood-oxygen-level-dependent signal during a novel cue reactivity task were assessed in 32 individuals with heroin use disorder (mean age, 40...
July 12, 2023: American Journal of Psychiatry
https://read.qxmd.com/read/37654117/correction-to-kalin
#11
(no author information available yet)
No abstract text is available yet for this article.
September 1, 2023: American Journal of Psychiatry
https://read.qxmd.com/read/37654116/sexual-orientation-and-suicidal-behavior-is-it-getting-better
#12
EDITORIAL
Gregory E Simon
No abstract text is available yet for this article.
September 1, 2023: American Journal of Psychiatry
https://read.qxmd.com/read/37654115/subcortical-anatomy-in-neurogenetic-disorders-new-findings-and-future-questions
#13
EDITORIAL
Konrad Wagstyl, Armin Raznahan
No abstract text is available yet for this article.
September 1, 2023: American Journal of Psychiatry
https://read.qxmd.com/read/37654114/through-a-developmental-lens-emerging-insights-to-understand-and-treat-pediatric-ptsd
#14
REVIEW
Justin D Russell, Sara A Heyn, Ryan J Herringa
No abstract text is available yet for this article.
September 1, 2023: American Journal of Psychiatry
https://read.qxmd.com/read/37654113/zuranolone-treatment-for-depression-steady-progress-in-mechanism-focused-therapeutics
#15
EDITORIAL
Daniel S Pine
No abstract text is available yet for this article.
September 1, 2023: American Journal of Psychiatry
https://read.qxmd.com/read/37654112/seeking-new-solutions-addressing-structural-racism-childhood-trauma-suicidal-behaviors-across-sexual-orientations-and-postpartum-depression
#16
JOURNAL ARTICLE
Ned H Kalin
No abstract text is available yet for this article.
September 1, 2023: American Journal of Psychiatry
https://read.qxmd.com/read/37434504/subcortical-brain-alterations-in-carriers-of-genomic-copy-number-variants
#17
JOURNAL ARTICLE
Kuldeep Kumar, Claudia Modenato, Clara Moreau, Christopher R K Ching, Annabelle Harvey, Sandra Martin-Brevet, Guillaume Huguet, Martineau Jean-Louis, Elise Douard, Charles-Olivier Martin, Nadine Younis, Petra Tamer, Anne M Maillard, Borja Rodriguez-Herreros, Aurélie Pain, Leila Kushan, Dmitry Isaev, Kathryn Alpert, Anjani Ragothaman, Jessica A Turner, Lei Wang, Tiffany C Ho, Lianne Schmaal, Ana I Silva, Marianne B M van den Bree, David E J Linden, Michael J Owen, Jeremy Hall, Sarah Lippé, Guillaume Dumas, Bogdan Draganski, Boris A Gutman, Ida E Sønderby, Ole A Andreassen, Laura M Schultz, Laura Almasy, David C Glahn, Carrie E Bearden, Paul M Thompson, Sébastien Jacquemont
OBJECTIVE: Copy number variants (CNVs) are well-known genetic pleiotropic risk factors for multiple neurodevelopmental and psychiatric disorders (NPDs), including autism (ASD) and schizophrenia. Little is known about how different CNVs conferring risk for the same condition may affect subcortical brain structures and how these alterations relate to the level of disease risk conferred by CNVs. To fill this gap, the authors investigated gross volume, vertex-level thickness, and surface maps of subcortical structures in 11 CNVs and six NPDs...
September 1, 2023: American Journal of Psychiatry
https://read.qxmd.com/read/37073513/structural-racism-in-psychiatric-research-careers-eradicating-barriers-to-a-more-diverse-workforce
#18
REVIEW
Alik S Widge, Ayana Jordan, Nina V Kraguljac, Christi R P Sullivan, Saydra Wilson, Tami D Benton, Jonathan E Alpert, Linda L Carpenter, John H Krystal, Charles B Nemeroff, Kafui Dzirasa
Investigators from minoritized backgrounds are underrepresented in psychiatric research. That underrepresentation contributes to disparities in outcomes of access to mental health care. Drawing on lived experience, scholarly qualitative reports, and empirical data, the authors review how the underrepresentation of minoritized researchers arises from interlocking, self-reinforcing effects of structural biases in our research training and funding institutions. Minoritized researchers experience diminished early access to advanced training and opportunities, stereotype threats and microaggressions, isolation due to lack of peers and senior mentors, decreased access to early funding, and unique community and personal financial pressures...
September 1, 2023: American Journal of Psychiatry
https://read.qxmd.com/read/37525606/alcohol-consumption-and-alcohol-use-disorder-exposing-an-increasingly-shared-genetic-architecture
#19
EDITORIAL
Julie D White, Laura J Bierut
No abstract text is available yet for this article.
August 1, 2023: American Journal of Psychiatry
https://read.qxmd.com/read/37525605/translating-developmental-neuroscience-to-understand-risk-for-psychiatric-disorders
#20
REVIEW
Heidi C Meyer, Francis S Lee
The transition from childhood to adulthood represents the developmental time frame in which the majority of psychiatric disorders emerge. Recent efforts to identify risk factors mediating the susceptibility to psychopathology have led to a heightened focus on both typical and atypical trajectories of neural circuit maturation. Mounting evidence has highlighted the immense neural plasticity apparent in the developing brain. Although in many cases adaptive, the capacity for neural circuit alteration also induces a state of vulnerability to environmental perturbations, such that early-life experiences have long-lasting implications for cognitive and emotional functioning in adulthood...
August 1, 2023: American Journal of Psychiatry
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