journal

American Journal of Psychiatry

journal
https://read.qxmd.com/read/31623459/hyperactivity-and-reduced-activation-of-anterior-hippocampus-in-early-psychosis
#1
Maureen McHugo, Pratik Talati, Kristan Armstrong, Simon N Vandekar, Jennifer Urbano Blackford, Neil D Woodward, Stephan Heckers
OBJECTIVE: In schizophrenia, the anterior hippocampus is hyperactive and shows reduced task-related recruitment, but the relationship between these two findings is unclear. The authors tested the hypothesis that hyperactivity impairs recruitment of the anterior hippocampus during scene processing. METHODS: Functional MRI data from 45 early-psychosis patients and 35 demographically matched healthy control subjects were analyzed using a block-design 1-back scene-processing task...
October 18, 2019: American Journal of Psychiatry
https://read.qxmd.com/read/31623458/lithium-exposure-during-pregnancy-and-the-postpartum-period-a-systematic-review-and-meta-analysis-of-safety-and-efficacy-outcomes
#2
Michele Fornaro, Elena Maritan, Roberta Ferranti, Leonardo Zaninotto, Alessandro Miola, Annalisa Anastasia, Andrea Murru, Eva Solé, Brendon Stubbs, André F Carvalho, Alessandro Serretti, Eduard Vieta, Paolo Fusar-Poli, Philip McGuire, Allan H Young, Paola Dazzan, Simone N Vigod, Christoph U Correll, Marco Solmi
OBJECTIVE: Uncertainty surrounds the risks of lithium use during pregnancy in women with bipolar disorder. The authors sought to provide a critical appraisal of the evidence related to the efficacy and safety of lithium treatment during the peripartum period, focusing on women with bipolar disorder and their offspring. METHODS: The authors conducted a systematic review and random-effects meta-analysis assessing case-control, cohort, and interventional studies reporting on the safety (primary outcome, any congenital anomaly) or efficacy (primary outcome, mood relapse prevention) of lithium treatment during pregnancy and the postpartum period...
October 18, 2019: American Journal of Psychiatry
https://read.qxmd.com/read/31581800/long-term-outcomes-of-subcallosal-cingulate-deep-brain-stimulation-for-treatment-resistant-depression
#3
Andrea L Crowell, Patricio Riva-Posse, Paul E Holtzheimer, Steven J Garlow, Mary E Kelley, Robert E Gross, Lydia Denison, Sinead Quinn, Helen S Mayberg
OBJECTIVE: Deep brain stimulation of the subcallosal cingulate (SCC DBS) has been studied as a potential treatment for severe and refractory major depressive disorder since 2005. The authors used an open-label, long-term follow-up design to examine participants enrolled in a clinical trial of SCC DBS for treatment-resistant depression. METHODS: Long-term outcome data were collected for 28 patients (20 with major depressive disorder and seven with bipolar II disorder; one patient in the major depression subgroup was later reclassified as having bipolar II disorder) receiving SCC DBS for 4-8 years...
October 4, 2019: American Journal of Psychiatry
https://read.qxmd.com/read/31581799/maternal-bacterial-infection-during-pregnancy-and-offspring-risk-of-psychotic-disorders-variation-by-severity-of-infection-and-offspring-sex
#4
Younga H Lee, Sara Cherkerzian, Larry J Seidman, George D Papandonatos, David A Savitz, Ming T Tsuang, Jill M Goldstein, Stephen L Buka
OBJECTIVE: Previous studies suggest that prenatal immune challenges may elevate the risk of schizophrenia and related psychoses in offspring, yet there has been limited research focused on maternal bacterial infection. The authors hypothesized that maternal bacterial infection during pregnancy increases offspring risk of psychotic disorders in adulthood, and that the magnitude of this association varies as a function of severity of infectious exposure and offspring sex. METHODS: The authors analyzed prospectively collected data from 15,421 pregnancies among women enrolled between 1959 and 1966 at two study sites through the Collaborative Perinatal Project...
October 4, 2019: American Journal of Psychiatry
https://read.qxmd.com/read/31581798/reduction-in-mental-health-treatment-utilization-among-transgender-individuals-after-gender-affirming-surgeries-a-total-population-study
#5
Richard Bränström, John E Pachankis
OBJECTIVE: Despite professional recommendations to consider gender-affirming hormone and surgical interventions for transgender individuals experiencing gender incongruence, the long-term effect of such interventions on mental health is largely unknown. The aim of this study was to ascertain the prevalence of mood and anxiety disorder health care visits and antidepressant and anxiolytic prescriptions in 2015 as a function of gender incongruence diagnosis and gender-affirming hormone and surgical treatment in the entire Swedish population...
October 4, 2019: American Journal of Psychiatry
https://read.qxmd.com/read/31537091/the-devastating-clinical-consequences-of-child-abuse-and-neglect-increased-disease-vulnerability-and-poor-treatment-response-in-mood-disorders
#6
Elizabeth T C Lippard, Charles B Nemeroff
A large body of evidence has demonstrated that exposure to childhood maltreatment at any stage of development can have long-lasting consequences. It is associated with a marked increase in risk for psychiatric and medical disorders. This review summarizes the literature investigating the effects of childhood maltreatment on disease vulnerability for mood disorders, specifically summarizing cross-sectional and more recent longitudinal studies demonstrating that childhood maltreatment is more prevalent and is associated with increased risk for first mood episode, episode recurrence, greater comorbidities, and increased risk for suicidal ideation and attempts in individuals with mood disorders...
September 20, 2019: American Journal of Psychiatry
https://read.qxmd.com/read/31537090/effect-of-intrinsic-patterns-of-functional-brain-connectivity-in-moderating-antidepressant-treatment-response-in-major-depression
#7
Cherise R Chin Fatt, Manish K Jha, Crystal M Cooper, Gregory Fonzo, Charles South, Bruce Grannemann, Thomas Carmody, Tracy L Greer, Benji Kurian, Maurizio Fava, Patrick J McGrath, Phillip Adams, Melvin McInnis, Ramin V Parsey, Myrna Weissman, Mary L Phillips, Amit Etkin, Madhukar H Trivedi
OBJECTIVE: Major depressive disorder is associated with aberrant resting-state functional connectivity across multiple brain networks supporting emotion processing, executive function, and reward processing. The purpose of this study was to determine whether patterns of resting-state connectivity between brain regions predict differential outcome to antidepressant medication (sertraline) compared with placebo. METHODS: Participants in the Establishing Moderators and Biosignatures of Antidepressant Response in Clinical Care (EMBARC) study underwent structural and resting-state functional MRI at baseline...
September 20, 2019: American Journal of Psychiatry
https://read.qxmd.com/read/31509006/limbic-hyperactivity-in-response-to-emotionally-neutral-stimuli-in-schizophrenia-a-neuroimaging-meta-analysis-of-the-hypervigilant-mind
#8
Jules R Dugré, Nathalie Bitar, Alexandre Dumais, Stéphane Potvin
OBJECTIVE: It has long been assumed that paranoid ideation may stem from an aberrant limbic response to threatening stimuli. However, results from functional neuroimaging studies using negative emotional stimuli have failed to confirm this assumption. One of the potential reasons for the lack of effect is that study participants with psychosis may display aberrant brain responses to neutral material rather than to threatening stimuli. The authors conducted a functional neuroimaging meta-analysis to test this hypothesis...
September 6, 2019: American Journal of Psychiatry
https://read.qxmd.com/read/31509005/characterizing-covariant-trajectories-of-individuals-at-clinical-high-risk-for-psychosis-across-symptomatic-and-functional-domains
#9
Dana M Allswede, Jean Addington, Carrie E Bearden, Kristin S Cadenhead, Barbara A Cornblatt, Daniel H Mathalon, Thomas McGlashan, Diana O Perkins, Larry J Seidman, Ming T Tsuang, Elaine F Walker, Scott W Woods, Tyrone D Cannon
OBJECTIVE: The authors sought to characterize differences in outcomes among help-seeking individuals at clinical high risk for psychosis by identifying covariant longitudinal patterns of symptoms and functioning. METHODS: Group-based multitrajectory modeling was applied to longitudinal ratings of four symptom domains (positive, negative, disorganized, general) and general functioning among clinical high-risk individuals in an initial discovery sample (N=422). An independent sample (N=133) was used to test replicability...
September 6, 2019: American Journal of Psychiatry
https://read.qxmd.com/read/31509004/adverse-childhood-experiences-implications-for-offspring-telomere-length-and-psychopathology
#10
Kyle C Esteves, Christopher W Jones, Mark Wade, Keegan Callerame, Alicia K Smith, Katherine P Theall, Stacy S Drury
OBJECTIVE: Adverse childhood experiences (ACEs) are associated with mental and physical health risks that, through biological and psychosocial pathways, likely span generations. Within an individual, telomere length (TL), an established marker of cellular stress and aging, is associated with both ACE exposure and psychopathology, providing the basis for an emerging literature suggesting that TL is a biomarker of the health risks linked to early-life adversity both within and across generations...
September 6, 2019: American Journal of Psychiatry
https://read.qxmd.com/read/31416339/association-of-childhood-maltreatment-with-interpersonal-distance-and-social-touch-preferences-in-adulthood
#11
Ayline Maier, Caroline Gieling, Luca Heinen-Ludwig, Vlad Stefan, Johannes Schultz, Onur Güntürkün, Benjamin Becker, René Hurlemann, Dirk Scheele
OBJECTIVE: Childhood maltreatment is a major risk factor for psychopathology associated with interpersonal problems in adulthood, but the etiological pathways involved are still unclear. The authors propose that childhood maltreatment confers risk for dysfunctional behavior in social interactions by altering interpersonal distance preference and the processing of social touch. METHODS: Ninety-two medication-free adults (64 of them female) with low, medium, and high levels of childhood maltreatment were tested with an interpersonal distance paradigm and subsequently underwent a social touch functional MRI task during which they rated the perceived comfort of slow touch (C-tactile [CT] optimal speed; 5 cm/s) and fast touch (non-CT-optimal speed; 20 cm/s)...
August 16, 2019: American Journal of Psychiatry
https://read.qxmd.com/read/31672045/developing-innovative-and-novel-treatment-strategies
#12
Ned H Kalin
No abstract text is available yet for this article.
November 1, 2019: American Journal of Psychiatry
https://read.qxmd.com/read/31672044/whither-tms-a-one-trick-pony-or-the-beginning-of-a-neuroscientific-revolution
#13
Mark S George
Psychiatry has been at the forefront of advancing clinical transcranial magnetic stimulation (TMS) since the mid-1990s, shortly after the invention of modern TMS in 1985 by Barker. Clinical TMS for psychiatric applications is advancing rapidly, with novel methods and innovations for treating depression, as well as a new clinical indication in obsessive-compulsive disorder. This review summarizes the recent findings and peers into the near future of this fertile and rapidly changing field. It is possible that many, perhaps even most, psychiatrists will be incorporating some form of brain stimulation into their practice within the next decade...
November 1, 2019: American Journal of Psychiatry
https://read.qxmd.com/read/31672043/reducing-suicidality-through-insomnia-treatment-critical-next-steps-in-suicide-prevention
#14
EDITORIAL
Jessica L Hamilton, Daniel J Buysse
No abstract text is available yet for this article.
November 1, 2019: American Journal of Psychiatry
https://read.qxmd.com/read/31672042/cannabidiol-not-a-cure-all-but-a-candidate-for-coping-with-cue-induced-craving
#15
EDITORIAL
David H Epstein
No abstract text is available yet for this article.
November 1, 2019: American Journal of Psychiatry
https://read.qxmd.com/read/31672041/targeting-ptsd
#16
EDITORIAL
William M McDonald, Sanne J H van Rooij
No abstract text is available yet for this article.
November 1, 2019: American Journal of Psychiatry
https://read.qxmd.com/read/31672040/searching-for-treatments-for-cocaine-use-disorder-the-quest-continues
#17
EDITORIAL
Kathleen T Brady
No abstract text is available yet for this article.
November 1, 2019: American Journal of Psychiatry
https://read.qxmd.com/read/31672039/esketamine-and-the-need-for-a-new-type-of-registry-for-drugs-with-abuse-potential
#18
LETTER
Rupert McShane, David S Baldwin, R Hamish McAllister-Williams, James M Stone, David Taylor, Adam R Winstock, Allan H Young
No abstract text is available yet for this article.
November 1, 2019: American Journal of Psychiatry
https://read.qxmd.com/read/31672038/fulminant-onset-of-valproate-associated-hyperammonemic-encephalopathy
#19
Josef Baumgartner, Anna Hoeflich, Barbara Hinterbuchinger, Matthaeus Fellinger, Irene Graf, Fabian Friedrich, Richard Frey, Nilufar Mossaheb
No abstract text is available yet for this article.
November 1, 2019: American Journal of Psychiatry
https://read.qxmd.com/read/31537089/reducing-suicidal-ideation-through-insomnia-treatment-rest-it-a-randomized-clinical-trial
#20
William V McCall, Ruth M Benca, Peter B Rosenquist, Nagy A Youssef, Laryssa McCloud, Jill C Newman, Doug Case, Meredith E Rumble, Steven T Szabo, Marjorie Phillips, Andrew D Krystal
OBJECTIVE: The authors sought to determine whether targeted treatment of insomnia with controlled-release zolpidem (zolpidem-CR) in suicidal adults with insomnia would provide a reduction in suicidal ideation superior to placebo. METHODS: Reducing Suicidal Ideation Through Insomnia Treatment was an 8-week three-site double-blind placebo-controlled parallel-group randomized controlled trial of zolpidem-CR hypnotic therapy compared with placebo, in conjunction with an open-label selective serotonin reuptake inhibitor...
November 1, 2019: American Journal of Psychiatry
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