journal
https://read.qxmd.com/read/36415971/the-link-between-autism-and-sex-related-neuroanatomy-and-associated-cognition-and-gene-expression
#1
JOURNAL ARTICLE
Dorothea L Floris, Han Peng, Varun Warrier, Michael V Lombardo, Charlotte M Pretzsch, Clara Moreau, Alex Tsompanidis, Weikang Gong, Maarten Mennes, Alberto Llera, Daan van Rooij, Marianne Oldehinkel, Natalie J Forde, Tony Charman, Julian Tillmann, Tobias Banaschewski, Carolin Moessnang, Sarah Durston, Rosemary J Holt, Christine Ecker, Flavio Dell'Acqua, Eva Loth, Thomas Bourgeron, Declan G M Murphy, Andre F Marquand, Meng-Chuan Lai, Jan K Buitelaar, Simon Baron-Cohen, Christian F Beckmann
OBJECTIVE: The male preponderance in prevalence of autism is among the most pronounced sex ratios across neurodevelopmental conditions. The authors sought to elucidate the relationship between autism and typical sex-differential neuroanatomy, cognition, and related gene expression. METHODS: Using a novel deep learning framework trained to predict biological sex based on T1 -weighted structural brain images, the authors compared sex prediction model performance across neurotypical and autistic males and females...
November 23, 2022: American Journal of Psychiatry
https://read.qxmd.com/read/36349428/double-blind-sham-controlled-randomized-trial-testing-the-efficacy-of-fmri-neurofeedback-on-clinical-and-cognitive-measures-in-children-with-adhd
#2
JOURNAL ARTICLE
Sheut-Ling Lam, Marion Criaud, Steve Lukito, Samuel J Westwood, Deborah Agbedjro, Olivia S Kowalczyk, Sarah Curran, Nadia Barret, Chris Abbott, Holan Liang, Emily Simonoff, Gareth J Barker, Vincent Giampietro, Katya Rubia
OBJECTIVE: Functional MRI neurofeedback (fMRI-NF) could potentially be a novel, safe nonpharmacological treatment for attention deficit hyperactivity disorder (ADHD). A proof-of-concept randomized controlled trial of fMRI-NF of the right inferior frontal cortex (rIFC), compared to an active control condition, showed promising improvement of ADHD symptoms (albeit in both groups) and in brain function. However, comparison with a placebo condition in a larger trial is required to test efficacy...
November 9, 2022: American Journal of Psychiatry
https://read.qxmd.com/read/36285406/naltrexone-bupropion-and-behavior-therapy-alone-and-combined-for-binge-eating-disorder-randomized-double-blind-placebo-controlled-trial
#3
JOURNAL ARTICLE
Carlos M Grilo, Janet A Lydecker, Sarah K Fineberg, Jorge O Moreno, Valentina Ivezaj, Ralitza Gueorguieva
OBJECTIVE: Binge-eating disorder, the most prevalent eating disorder, is a serious public health problem associated with obesity, psychiatric and medical comorbidities, and functional impairments. Binge-eating disorder remains underrecognized and infrequently treated, and few evidence-based treatments exist. The authors tested the effectiveness of naltrexone-bupropion and behavioral weight loss therapy (BWL), alone and combined, for binge-eating disorder comorbid with obesity. METHODS: In a randomized double-blind placebo-controlled trial conducted from February 2017 to February 2021, using a 2×2 balanced factorial design, 136 patients with binge-eating disorder (81...
October 26, 2022: American Journal of Psychiatry
https://read.qxmd.com/read/36285405/performance-measurement-for-opioid-use-disorder-medication-treatment-and-care-retention
#4
JOURNAL ARTICLE
Arthur Robin Williams, Christine M Mauro, Tianshu Feng, Amanda Wilson, Angelo Cruz, Mark Olfson, Stephen Crystal, Hillary Samples, Lisa Chiodo
No abstract text is available yet for this article.
October 26, 2022: American Journal of Psychiatry
https://read.qxmd.com/read/36285404/targeted-oral-naltrexone-for-mild-to-moderate-alcohol-use-disorder-among-sexual-and-gender-minority-men-a-randomized-trial
#5
JOURNAL ARTICLE
Glenn-Milo Santos, Janet Ikeda, Phillip Coffin, John Walker, Tim Matheson, Arsheen Ali, Matthew McLaughlin, Jennifer Jain, Justine Arenander, Eric Vittinghoff, Steven Batki
OBJECTIVE: The authors sought to determine the efficacy of targeted naltrexone in sexual and gender minority men (SGM) who binge drink and have mild to moderate alcohol use disorder. METHODS: In a double-blind placebo-controlled trial, a total of 120 SGM who binge drink and have mild to moderate alcohol use disorder were randomized in a 1:1 ratio to receive targeted oral naltrexone (50 mg) or placebo with weekly counseling for 12 weeks. The study's primary endpoints were binge-drinking intensity, defined as 1) number of drinks in the past 30 days; 2) any binge drinking in the past week; 3) number of binge-drinking days in the past week; and 4) number of drinking days in the past week...
October 26, 2022: American Journal of Psychiatry
https://read.qxmd.com/read/36200276/effectiveness-of-antipsychotic-use-for-reducing-risk-of-work-disability-results-from-a-within-subject-analysis-of-a-swedish-national-cohort-of-21-551-patients-with-first-episode-nonaffective-psychosis
#6
JOURNAL ARTICLE
Marco Solmi, Heidi Taipale, Minna Holm, Antti Tanskanen, Ellenor Mittendorfer-Rutz, Christoph U Correll, Jari Tiihonen
OBJECTIVE: The authors sought to determine whether antipsychotic use, compared with nonuse, is associated with lower work disability in first-episode nonaffective psychosis, and if so, for how long. METHODS: A within-subject design was used to study the risk of sickness absence or disability pension during antipsychotic use compared with nonuse during a maximum of 11 years of follow-up (2006-2016) in a Swedish nationwide cohort of patients with first-episode nonaffective psychosis (N=21,551; age range, 16-45 years)...
October 6, 2022: American Journal of Psychiatry
https://read.qxmd.com/read/36200275/technology-and-mental-health-state-of-the-art-for-assessment-and-treatment
#7
REVIEW
Philip D Harvey, Colin A Depp, Albert A Rizzo, Gregory P Strauss, David Spelber, Linda L Carpenter, Ned H Kalin, John H Krystal, William M McDonald, Charles B Nemeroff, Carolyn I Rodriguez, Alik S Widge, John Torous
Technology is ubiquitous in society and is now being extensively used in mental health applications. Both assessment and treatment strategies are being developed and deployed at a rapid pace. The authors review the current domains of technology utilization, describe standards for quality evaluation, and forecast future developments. This review examines technology-based assessments of cognition, emotion, functional capacity and everyday functioning, virtual reality approaches to assessment and treatment, ecological momentary assessment, passive measurement strategies including geolocation, movement, and physiological parameters, and technology-based cognitive and functional skills training...
October 6, 2022: American Journal of Psychiatry
https://read.qxmd.com/read/36128684/a-novel-brief-fully-automated-intervention-to-extend-the-antidepressant-effect-of-a-single-ketamine-infusion-a-randomized-clinical-trial
#8
JOURNAL ARTICLE
Rebecca B Price, Crystal Spotts, Benjamin Panny, Angela Griffo, Michelle Degutis, Nicolas Cruz, Elizabeth Bell, Kevin Do-Nguyen, Meredith L Wallace, Sanjay J Mathew, Robert H Howland
OBJECTIVE: Intravenous ketamine, which displays rapid antidepressant properties, is posited to reverse depression by rapidly enhancing neuroplasticity. The authors tested whether an automated, computer-based approach could efficiently leverage enhanced neuroplasticity to extend the durability of rapid clinical response. METHODS: A total of 154 adults (ages 18-60) with treatment-resistant unipolar depression were randomized in a double-blind, parallel-arm design to receive an active/active treatment combination (ketamine plus active "automated self-association training" [ASAT]; N=53) or one of two control arms that lacked either the active drug component (saline plus active ASAT; N=51) or the active behavioral component (ketamine plus sham ASAT; N=50)...
September 21, 2022: American Journal of Psychiatry
https://read.qxmd.com/read/36128683/anterior-insula-associated-social-novelty-recognition-pivotal-roles-of-a-local-retinoic-acid-cascade-and-oxytocin-signaling
#9
JOURNAL ARTICLE
Sun-Hong Kim, Kyongman An, Ho Namkung, Atsushi Saito, Matthew D Rannals, James R Moore, Marina Mihaljevic, Sneha Saha, Seyun Oh, Mari A Kondo, Koko Ishizuka, Kun Yang, Brady J Maher, Minae Niwa, Akira Sawa
OBJECTIVE: Deficits in social cognition consistently underlie functional disabilities in a wide range of psychiatric disorders. Neuroimaging studies have suggested that the anterior insula is a "common core" brain region that is impaired across neurological and psychiatric disorders, which include social cognition deficits. Nevertheless, neurobiological mechanisms of the anterior insula for social cognition remain elusive. This study aims to fill this knowledge gap. METHODS: To determine the role of the anterior insula in social cognition, the authors manipulated expression of Cyp26B1, an anterior insula-enriched molecule that is crucial for retinoic acid degradation and is involved in the pathology of neuropsychiatric conditions...
September 21, 2022: American Journal of Psychiatry
https://read.qxmd.com/read/36128682/genetic-and-environmental-contribution-to-the-co-occurrence-of-endocrine-metabolic-disorders-and-depression-a-nationwide-swedish-study-of-siblings
#10
JOURNAL ARTICLE
Marica Leone, Ralf Kuja-Halkola, Amy Leval, Agnieszka Butwicka, Jakob Skov, Ruyue Zhang, Shengxin Liu, Henrik Larsson, Sarah E Bergen
OBJECTIVE: Depression is common in individuals with endocrine-metabolic disorders and vice versa, and a better understanding of the underlying factors contributing to the comorbidity of these disorders is needed. This study investigated the familial coaggregation of depression and endocrine-metabolic disorders and estimated the contribution of genetic and environmental factors to their co-occurrence. METHODS: This population-based cohort study included 2.2 million individuals born in Sweden between 1973 and 1996, with follow-up through 2013...
September 21, 2022: American Journal of Psychiatry
https://read.qxmd.com/read/36069022/leveraging-large-scale-genetics-of-ptsd-and-cardiovascular-disease-to-demonstrate-robust-shared-risk-and-improve-risk-prediction-accuracy
#11
JOURNAL ARTICLE
Antonia V Seligowski, Burook Misganaw, Lucie A Duffy, Kerry J Ressler, Guia Guffanti
OBJECTIVE: Individuals with posttraumatic stress disorder (PTSD) are significantly more likely to be diagnosed with cardiovascular disease (CVD) (e.g., myocardial infarction, stroke). The evidence for this link is so compelling that the National Institutes of Health convened a working group to determine gaps in the literature, including the need for large-scale genomic studies to identify shared genetic risk. The aim of the present study was to address some of these gaps by utilizing PTSD and CVD genome-wide association study (GWAS) summary statistics in a large biobank sample to determine the shared genetic risk of PTSD and CVD...
September 7, 2022: American Journal of Psychiatry
https://read.qxmd.com/read/36069021/association-between-polygenic-risk-scores-and-outcome-of-ect
#12
JOURNAL ARTICLE
Robert Sigström, Kaarina Kowalec, Lina Jonsson, Caitlin C Clements, Robert Karlsson, Axel Nordenskjöld, Erik Pålsson, Patrick F Sullivan, Mikael Landén
OBJECTIVE: Identifying biomarkers associated with response to electroconvulsive therapy (ECT) may aid clinical decisions. The authors examined whether greater polygenic liabilities for major depressive disorder, bipolar disorder, and schizophrenia are associated with improvement following ECT for a major depressive episode. METHODS: Between 2013 and 2017, patients who had at least one treatment series recorded in the Swedish National Quality Register for ECT were invited to provide a blood sample for genotyping...
September 7, 2022: American Journal of Psychiatry
https://read.qxmd.com/read/36069020/lower-availability-of-mitochondrial-complex-i-in-anterior-cingulate-cortex-in-autism-a-positron-emission-tomography-study
#13
JOURNAL ARTICLE
Yasuhiko Kato, Masamichi Yokokura, Toshiki Iwabuchi, Chihiro Murayama, Taeko Harada, Takafumi Goto, Taishi Tamayama, Yosuke Kameno, Tomoyasu Wakuda, Hitoshi Kuwabara, Seico Benner, Atsushi Senju, Hideo Tsukada, Sadahiko Nishizawa, Yasuomi Ouchi, Hidenori Yamasue
OBJECTIVE: Mitochondrial dysfunction has been implicated in the pathophysiology of autism spectrum disorder (ASD) in previous studies of postmortem brain or peripheral samples. The authors investigated whether and where mitochondrial dysfunction occurs in the living brains of individuals with ASD and to identify the clinical correlates of detected mitochondrial dysfunction. METHODS: This case-control study used positron emission tomography (PET) with 2- tert -butyl-4-chloro-5-{6-[2-(2-[18 F]fluoroethoxy)-ethoxy]-pyridin-3-ylmethoxy}-2H-pyridazin-3-one ([18 F]BCPP-EF), a radioligand that binds to the mitochondrial electron transport chain complex I, to examine the topographical distribution of mitochondrial dysfunction in living brains of individuals with ASD...
September 7, 2022: American Journal of Psychiatry
https://read.qxmd.com/read/36069019/interplay-of-adhd-polygenic-liability-with-birth-related-somatic-and-psychosocial-factors-in-adhd-a-nationwide-study
#14
JOURNAL ARTICLE
Isabell Brikell, Theresa Wimberley, Clara Albiñana, Bjarni Jóhann Vilhjálmsson, Esben Agerbo, Anders D Børglum, Ditte Demontis, Andrew J Schork, Sonja LaBianca, Thomas Werge, David M Hougaard, Merete Nordentoft, Ole Mors, Preben Bo Mortensen, Liselotte Vogdrup Petersen, Søren Dalsgaard
OBJECTIVE: Attention deficit hyperactivity disorder (ADHD) is a multifactorial neurodevelopmental disorder, yet the interplay between ADHD polygenic risk scores (PRSs) and other risk factors remains relatively unexplored. The authors investigated associations, confounding, and interactions of ADHD PRS with birth-related, somatic, and psychosocial factors previously associated with ADHD. METHODS: Participants included a random general population sample (N=21,578) and individuals diagnosed with ADHD (N=13,697) from the genotyped Danish iPSYCH2012 case cohort, born between 1981 and 2005...
September 7, 2022: American Journal of Psychiatry
https://read.qxmd.com/read/36069018/charting-the-landscape-of-genetic-overlap-between-mental-disorders-and-related-traits-beyond-genetic-correlation
#15
JOURNAL ARTICLE
Guy Hindley, Oleksandr Frei, Alexey A Shadrin, Weiqiu Cheng, Kevin S O'Connell, Romain Icick, Nadine Parker, Shahram Bahrami, Naz Karadag, Daniel Roelfs, Børge Holen, Aihua Lin, Chun C Fan, Srdjan Djurovic, Anders M Dale, Olav B Smeland, Ole A Andreassen
OBJECTIVE: Mental disorders are heritable and polygenic, and genome-wide genetic correlations (rg ) have indicated widespread shared genetic risk across multiple disorders and related traits, mirroring their overlapping clinical characteristics. However, rg may underestimate the shared genetic underpinnings of mental disorders and related traits because it does not differentiate mixtures of concordant and discordant genetic effects from an absence of genetic overlap. Using novel statistical genetics tools, the authors aimed to evaluate the genetic overlap between mental disorders and related traits when accounting for mixed effect directions...
September 7, 2022: American Journal of Psychiatry
https://read.qxmd.com/read/36453037/a-case-of-prolonged-mania-psychosis-and-severe-depression-after-psilocybin-use-implications-of-increased-psychedelic-drug-availability
#16
JOURNAL ARTICLE
Gregory Barber, Charles B Nemeroff, Steven Siegel
No abstract text is available yet for this article.
December 1, 2022: American Journal of Psychiatry
https://read.qxmd.com/read/36453036/neurofeedback-for-adhd-time-to-call-it-quits
#17
EDITORIAL
James J McGough
No abstract text is available yet for this article.
December 1, 2022: American Journal of Psychiatry
https://read.qxmd.com/read/36453035/naltrexone-and-alcohol-use
#18
EDITORIAL
Jonathan Avery
No abstract text is available yet for this article.
December 1, 2022: American Journal of Psychiatry
https://read.qxmd.com/read/36453034/new-therapeutic-approaches-involving-psychopharmacology-digital-technology-and-fmri-neurofeedback
#19
EDITORIAL
Ned H Kalin
No abstract text is available yet for this article.
December 1, 2022: American Journal of Psychiatry
https://read.qxmd.com/read/36453033/an-innovative-approach-to-extending-the-antidepressant-effects-of-intravenous-ketamine-in-major-depression
#20
EDITORIAL
Alan F Schatzberg
No abstract text is available yet for this article.
December 1, 2022: American Journal of Psychiatry
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