Hannah Williams, Dana M Omer, Hannah M Thompson, Sabrina T Lin, Floris S Verheij, Joao Miranda, Jonathan B Yuval, James Buckley, Michael R Marco, Li-Xuan Qin, David A Dombroski, Rajendra Kedar, Aytekin Oto, Elena Korngold, Joseph C Veniero, Sunil Gandhi, Arun Krishnaraj, Minal Jagtiani, Kirk Ohanian, Dan Vu, Thomas A Hope, Sonia Lee, Ashish P Wasnik, Nikhil Madhuripan, Marc J Gollub, Julio Garcia-Aguilar
Background MRI plays a crucial role in restaging locally advanced rectal cancer treated with total neoadjuvant therapy (TNT); however, prospective studies have not evaluated its ability to accurately select patients for nonoperative management. Purpose To evaluate the ability of restaging MRI to predict oncologic outcomes and identify imaging features associated with residual disease (RD) after TNT. Materials and Methods This was a secondary analysis of the Organ Preservation in Rectal Adenocarcinoma (OPRA) trial, which randomized participants from April 2014 to March 2020 with stages II or III rectal adenocarcinoma to undergo either induction or consolidation TNT...
September 2024: Radiology