journal
https://read.qxmd.com/read/38561464/plexiform-neurofibroma-masquerading-as-a-giant-congenital-melanocytic-nevus
#1
Gerilyn M Olsen, Dawn H Siegel, Olayemi Sokumbi, Yvonne E Chiu
A 4-month-old male presented for a large, hypertrichotic brown patch on the upper back with several scattered 0.5-1.5 cm, round to oval, brown macules and patches on the trunk and extremities. The lesion was initially diagnosed as a giant congenital melanocytic nevus based on clinical exam and histopathology with immunohistochemical stains. The patient was later diagnosed with neurofibromatosis type 1, and the lesion on the back developed a "bag of worms" texture consistent with a plexiform neurofibroma and found to harbor a pathogenic variant in the NF1 gene...
April 1, 2024: Pediatric Dermatology
https://read.qxmd.com/read/38561328/a-plantar-subcutaneous-nodule-in-a-healthy-infant
#2
JOURNAL ARTICLE
Luca Borg, Daniel Micallef, Alexandra Betts, Michael J Boffa
No abstract text is available yet for this article.
April 1, 2024: Pediatric Dermatology
https://read.qxmd.com/read/38558462/bone-marrow-transplantation-and-bone-marrow-derived-mesenchymal-stem-cell-therapy-in-epidermolysis-bullosa-a-systematic-review
#3
REVIEW
Maulidina Agustin, Anita Mahadewi, Retno Danarti
Epidermolysis bullosa (EB) is a genodermatosis that lacks effective treatments and requires supportive care for its severe, life-threatening manifestations. Bone marrow transplantation (BMT) and its derived cells have been suggested to improve clinical symptoms and quality of life. A comprehensive search was conducted for publications evaluating BMT and bone marrow-derived mesenchymal stem cell (BM-MSC) therapy for EB in PubMed/MEDLINE, Google Scholar, and Cochrane databases from inception until June 2023. A total of 55 participants with severe forms of EB had BMT and/or BM-MSCs, with recessive dystrophic EB as the most common EB type; 53 (96...
April 1, 2024: Pediatric Dermatology
https://read.qxmd.com/read/38558293/topical-everolimus-therapy-for-epidermal-nevi-associated-with-woolly-hair-nevus-in-a-patient-with-a-mosaic-hras-mutation
#4
Akaljot Singh, Emily S Gorell, Anne W Lucky
A patient with woolly hair nevus syndrome, presented with epidermal facial nevi by the age of 12 years. Despite transient improvement with topical 1% sirolimus cream, the facial nevus grew larger. The patient was then treated with topical 1% everolimus cream resulting in a reduction in the size of the nevus. This case highlights a novel use of topical 1% everolimus cream, which previously has not been used to treat epidermal nevi.
April 1, 2024: Pediatric Dermatology
https://read.qxmd.com/read/38556801/lymphoplasmocytic-plaque-in-children-a-report-of-an-atypical-location
#5
LETTER
João Teixeira, Sofia Pereira, Joana Resende Xará, José Carlos Cardoso, Leonor Ramos
Lymphoplasmocytic plaque in children (LPC) is a rare and distinctive skin disorder primarily affecting the pediatric population. Characterized by its unique histopathological features, the condition manifests as well-defined plaques with a predominance of lymphocytes and plasma cells infiltrating the dermis. Despite its limited prevalence, recognizing this entity is crucial for accurate diagnosis and appropriate management of affected patients. We report the case of a 10-year-old male presenting with LPC in the extensor surface of the upper arm, a rarely reported location, treated with both topical and intralesional corticosteroids resulting in partial improvement...
March 31, 2024: Pediatric Dermatology
https://read.qxmd.com/read/38556785/single-dominant-lesion-in-capillary-malformation-arteriovenous-malformation-cm-avm-rasa1-syndrome
#6
Luis Fernando Sánchez-Espino, Marta Ivars, Carolina Prat Torres, Cinzia E Lavarino, Nagore Gené Olaciregui, Carlota Rovira Zurriaga, Verónica P Celis Passini, Miguel Bejarano Serrano, Eulàlia Baselga
We report two cases with localized vascular malformations clinically resembling the "dominant lesion" seen in capillary malformation-arteriovenous malformation (CM-AVM) syndrome, however, lacking germline RASA1 variants but presenting double somatic RASA1 variants in affected tissue. Both patients presented with localized and superficial high-flow vascular malformations were treated with surgery and laser therapy and showed partial resolution. The study underscores the rarity of somatic RASA1 variants, contributes to understanding the "second-hit" pathophysiology in vascular lesions, and emphasizes the significance of clinical distinctions and genotyping for accurate diagnoses, offering implications for diagnosis, prognosis, and genetic counseling...
March 31, 2024: Pediatric Dermatology
https://read.qxmd.com/read/38532613/a-survey-assessment-of-combined-pediatric-dermatology-rheumatology-clinics
#7
JOURNAL ARTICLE
Olga S Cherepakhin, Sarah Ringold, Tova Ronis, A Yasmine Kirkorian, Heather Brandling-Bennett
The expertise of both dermatology and rheumatology may be beneficial when managing autoimmune conditions with cutaneous and systemic manifestations in children. This survey study was directed to pediatric dermatologists who participate in combined pediatric dermatology-rheumatology clinics; 13 sites in North America responded. The results provide information regarding clinic operations, benefits, and barriers to establishment. These findings have the potential to help institutions establish or modify combined pediatric dermatology-rheumatology clinics, although further research is needed to determine their impact...
March 26, 2024: Pediatric Dermatology
https://read.qxmd.com/read/38532574/comparison-of-the-skindex-teen-and-the-skindex-29-quality-of-life-survey-instruments-in-a-predominantly-american-indian-adolescent-population
#8
JOURNAL ARTICLE
Micah G Pascual, Sarah J Schmiege, Spero M Manson, Lucinda L Kohn
BACKGROUND/OBJECTIVES: The Skindex-29 and Skindex-Teen assess dermatology-related quality of life among adults and adolescents, respectively. This study directly compared the same adolescents' responses to the Skindex-29 relative to Skindex-Teen in a predominantly American Indian and/or Alaska Native population. This population is underrepresented in medical research. Although skin-related quality-of-life issues are widespread, American Indian and/or Alaska Native adolescents are not well-represented in related studies...
March 26, 2024: Pediatric Dermatology
https://read.qxmd.com/read/38529765/painless-bleeding-in-a-4-year-old-boy
#9
JOURNAL ARTICLE
Debdeep Mitra, Karthi Kishore, Siva Chaitanya Senapathi
No abstract text is available yet for this article.
March 26, 2024: Pediatric Dermatology
https://read.qxmd.com/read/38529733/an-enlarging-ulcerative-nodule
#10
JOURNAL ARTICLE
Steffany Poupart, Jerome Coulombe
No abstract text is available yet for this article.
March 26, 2024: Pediatric Dermatology
https://read.qxmd.com/read/38516988/scrofuloderma-of-the-chest-with-mediastinal-tb
#11
Vanessa Bustamante Estrada, Ana Claudia Lada Lemos, Pedro Machado Luz, Iara Regina Siqueira Lucena, Valentina Coutinho Baldoto Gava Chakr, Anneliese Hoffmann
Cutaneous tuberculosis is a rare manifestation of extrapulmonary tuberculosis caused by Mycobacterium tuberculosis in most cases and rarely by Mycobacterium bovis. Diagnosis may be challenging due to a wide range of clinical findings and similarities to other chronic dermatoses, leading to delayed treatment. We present a case of scrofuloderma in a 4-year-old girl that arose from a contiguous spread from the anterior mediastinum with associated pulmonary involvement.
March 22, 2024: Pediatric Dermatology
https://read.qxmd.com/read/38507267/seeking-shade-equity-tree-canopy-coverage-in-public-schools-in-austin-tx
#12
JOURNAL ARTICLE
Georgia E Williams, Dayna G Diven
BACKGROUND/OBJECTIVES: Tree canopies have dermatologic and environmental benefits, especially on school campuses. However, inequities likely exist, and tree planting initiatives may further exacerbate disparities. We sought to identify any relationship between tree canopy shade on public school campuses in Austin, TX and the socioeconomic makeup of the student population, as well as whether current initiatives appropriately address any inequities. METHODS: In this cross-sectional study, we used ArcGIS, a publicly available geographic information system (GIS), to calculate the percentage of tree canopy on campuses within the Austin Independent School District (AISD) for the years 2006 and 2022...
March 20, 2024: Pediatric Dermatology
https://read.qxmd.com/read/38500340/the-occurrence-of-mental-health-symptoms-in-isotretinoin-treated-adolescents
#13
JOURNAL ARTICLE
Keith Miller, Alastair McKean, Jennifer Hand, Sandra Rackley, Jonathan G Leung, Allison LeMahieu, Jennifer Geske, J Michael Bostwick
BACKGROUND: Isotretinoin treatment for acne can reduce adverse psychiatric outcomes in adults, but there has been little investigation of the incidence of psychiatric outcomes in treated adolescents. METHODS: This retrospective cohort study using the Rochester Epidemiology Project identified 606 patients aged 12-18 prescribed isotretinoin over a 10-year period between January 1, 2008 and December 31, 2017. Medical records were reviewed to identify psychiatric diagnoses before and during isotretinoin therapy, as well as psychiatric symptoms not captured by formal diagnoses and changes to isotretinoin dosing because of psychiatric diagnoses or symptoms...
March 18, 2024: Pediatric Dermatology
https://read.qxmd.com/read/38500311/melanoma-like-features-in-pediatric-longitudinal-melanonychia-a-systematic-review-and-meta-analysis
#14
JOURNAL ARTICLE
Serena Yun-Chen Tsai, Claire E Hamilton, Mia A Mologousis, Elena B Hawryluk
BACKGROUND: Pediatric longitudinal melanonychia (LM) can exhibit atypical features that mimic red-flag signs for subungual melanoma in adults and lead to diagnostic uncertainty. Nail biopsy may be unnecessary if clinical inspection and dermoscopy suggest a benign nature. METHODS: We searched PubMed and Embase from inception to February 2023 for studies of any design reporting either the number or proportion of clinical and dermoscopic features in at least five children (≤18 years) with LM...
March 18, 2024: Pediatric Dermatology
https://read.qxmd.com/read/38500310/dermoscopy-of-hypopigmented-macules-unveiling-genetic-diagnosis-of-tuberous-sclerosis-complex-type-2-in-an-infant-presenting-with-sacral-chordoma
#15
LETTER
Ananya Sharma, Bhawana Aggarwal, Aanchal Kakkar, Niraj Nirmal Pandey, Neha Taneja
A 2-month-old male with surgically resected sacral chordoma presented with multiple hypopigmented macules showing characteristic patchy, sharply demarcated areas of pigment network on dermoscopy. These dermoscopic findings were suggestive of the ash-leaf macules of tuberous sclerosis over other common hypopigmented macules in neonates. Chordomas presenting in early childhood in the sacral location have been reported as a rare manifestation of tuberous sclerosis complex. The combination of these findings led to a diagnosis of tuberous sclerosis, confirmed with the finding of a heterozygous TSC2 gene deletion; treatment with sirolimus resulted in regression of cardiac rhabdomyomas and hypopigmented macules...
March 18, 2024: Pediatric Dermatology
https://read.qxmd.com/read/38500261/dermatology-life-quality-index-survey-in-patients-with-down-syndrome-and-caregivers
#16
JOURNAL ARTICLE
Morgan Dykman, Madison Ernst, Tasya Rakasiwi, Amy Buros Stein, David J Satin, Kristen E Holland, Stephanie L Santoro, Jillian F Rork
Down syndrome (DS) is associated with many dermatological conditions, including hidradenitis suppurativa, folliculitis, and alopecia areata. Despite the high incidence of skin conditions in this population, there are no quality of life (QoL) studies in the dermatology literature focused on patients with DS or their caregivers. The frequently used QoL assessment tool, the Dermatology Life Quality Index (DLQI), has yet to be studied in this population. This study addresses these disparities by capturing how various skin conditions affect the QoL of people with DS and their caregivers and assessing the utility of the DLQI...
March 18, 2024: Pediatric Dermatology
https://read.qxmd.com/read/38500253/chest-wall-bruising-from-5-point-car-seat-harness-as-a-mimicker-of-child-abuse
#17
Jordan K Bui, Pyae Naing, Phillip H Cathers, Mizna Ahmad, Bernard Cohen
Bruising rarely presents in infants younger than 9 months who are not ambulatory and is more prevalent among children beginning to walk, or "cruisers." We present the case of a healthy 3-month-old infant with asymptomatic, symmetric, bilateral, large bruises on the bony chest sparing the mid-chest/sternum with a negative non-accidental trauma work-up. The noted pattern of bruises matched the bilateral shoulder straps of a 5-point harness of the car seat belt designed for infants. Awareness of this unique pattern of bruises will help elicit a better-informed history to guide care in an appropriate setting...
March 18, 2024: Pediatric Dermatology
https://read.qxmd.com/read/38480674/distal-toxic-acral-erythema-and-mucositis-secondary-to-6-mercaptopurine-in-a-thiopurine-methyltransferase-super-shunter
#18
Sydney Smith, Daniel Grove
Toxic erythema of chemotherapy is a broad but useful diagnosis used to summate the non-infectious, non-allergic, and reproducible reaction of certain chemotherapeutics. Due to overlapping chemotherapy side effects and often multiple drug exposures, identification of a singular culprit drug is challenging for dermatologists. Herein, we report a patient with 6-mercaptopurine (6-MP) toxic erythema confirmed via toxic metabolite markers secondary to increased levels of thiopurine methyltransferase activity, or so called "super shunting...
March 13, 2024: Pediatric Dermatology
https://read.qxmd.com/read/38459646/-our-hair-our-strength-our-identity-native-american-reflections-and-what-dermatologists-can-learn
#19
JOURNAL ARTICLE
Dante Rangel, Evan Choate, Yolandra Toya, Anthony Fleg, Aimee C Smidt
Issues of health equity are rightfully in the national spotlight. Here we present a narrative piece on the sacred importance of hair and its ties to cultural identity among many Native communities in the United States. We introduce unique values ascribed to hair in some Native cultures, and include examples of how hair has played an important role in both abuse and generational trauma for many individuals and families. By sharing experiences, we hope to illuminate perspectives often underrepresented, and to enable more culturally humble, responsive, and informed dermatologic care...
March 8, 2024: Pediatric Dermatology
https://read.qxmd.com/read/38459636/diffuse-neurofibroma-with-hypertrichosis-in-a-toddler
#20
Robert P Bower, Paul Leiphart, Thomas Samson, Klaus F Helm, Andrea Zaenglein
Diffuse neurofibroma is a rare type of neurofibroma uncommonly reported in infancy. It is a slow growing tumor originating in the peripheral nerve sheath. We present the case of a 17-month-old boy with diffuse neurofibroma of the scalp associated with hypertrichosis. His genetic and clinical workup for neurofibromatosis was negative.
March 8, 2024: Pediatric Dermatology
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