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REVIEW
Sarah Sonja Hugger, Thien Phu Do, Håkan Ashina, Maria Teresa Goicochea, Bronwyn Jenkins, Simona Sacco, Mi Ji Lee, K C Brennan, Faisal Mohammad Amin, Timothy J Steiner, Messoud Ashina
Migraine is an evolving, and sometimes lifelong disorder. The prevalence of episodic migraine peaks among individuals aged in their late 30s, implying a tendency for the disorder to remit with increasing age thereafter, whereas chronic migraine is more likely to persist into later life. Diagnosis and treatment of migraine in older adults, defined as individuals aged 60 years or older, is rendered more complex by increasing probabilities of atypical clinical features and comorbidities, with patients' comorbidities sometimes limiting their therapeutic options...
September 13, 2023: Lancet Neurology
#2
(no author information available yet)
No abstract text is available yet for this article.
September 1, 2023: Lancet Neurology
#3
JOURNAL ARTICLE
Charlene J Ong
No abstract text is available yet for this article.
August 28, 2023: Lancet Neurology
#4
JOURNAL ARTICLE
Mauro Oddo, Fabio S Taccone, Matteo Petrosino, Rafael Badenes, Aaron Blandino-Ortiz, Pierre Bouzat, Anselmo Caricato, Randall M Chesnut, Anders C Feyling, Nawfel Ben-Hamouda, J Claude Hemphill, Julia Koehn, Frank Rasulo, Jose I Suarez, Francesca Elli, Alessia Vargiolu, Paola Rebora, Stefania Galimberti, Giuseppe Citerio
BACKGROUND: Improving the prognostication of acute brain injury is a key element of critical care. Standard assessment includes pupillary light reactivity testing with a hand-held light source, but findings are interpreted subjectively; automated pupillometry might be more precise and reproducible. We aimed to assess the association of the Neurological Pupil index (NPi)-a quantitative measure of pupillary reactivity computed by automated pupillometry-with outcomes of patients with severe non-anoxic acute brain injury...
August 28, 2023: Lancet Neurology
#5
(no author information available yet)
No abstract text is available yet for this article.
August 25, 2023: Lancet Neurology
#6
JOURNAL ARTICLE
Mie Rizig, Sara Bandres-Ciga, Mary B Makarious, Oluwadamilola Omolara Ojo, Peter Wild Crea, Oladunni Victoria Abiodun, Kristin S Levine, Sani Atta Abubakar, Charles Obiora Achoru, Dan Vitale, Olaleye Akinmola Adeniji, Osigwe Paul Agabi, Mathew J Koretsky, Uchechi Agulanna, Deborah A Hall, Rufus Olusola Akinyemi, Tao Xie, Mohammed Wulgo Ali, Ejaz A Shamim, Ifeyinwa Ani-Osheku, Mahesh Padmanaban, Ohwotemu Michael Arigbodi, David G Standaert, Abiodun Hamzat Bello, Marissa N Dean, Cyril Oshomah Erameh, Inas Elsayed, Temitope Hannah Farombi, Olaitan Okunoye, Michael Bimbola Fawale, Kimberley J Billingsley, Frank Aiwansoba Imarhiagbe, Pilar Alvarez Jerez, Emmanuel Uzodinma Iwuozo, Breeana Baker, Morenikeji Adeyoyin Komolafe, Laksh Malik, Paul Osemeke Nwani, Kensuke Daida, Ernest Okwundu Nwazor, Abigail Miano-Burkhardt, Yakub Wilberforce Nyandaiti, Zih-Hua Fang, Yahaya Olugbo Obiabo, Jillian H Kluss, Olanike Adedoyin Odeniyi, Dena G Hernandez, Francis Ehidiamen Odiase, Nahid Tayebi, Francis Ibe Ojini, Ellen Sidranksy, Gerald Awele Onwuegbuzie, Andrea M D'Souza, Godwin Osawaru Osaigbovo, Bahafta Berhe, Nosakhare Osemwegie, Xylena Reed, Olajumoke Olufemi Oshinaike, Hampton L Leonard, Folajimi Morenikeji Otubogun, Chelsea X Alvarado, Shyngle Imiewan Oyakhire, Simon Izuchukwu Ozomma, Sarah Chabiri Samuel, Funmilola Tolulope Taiwo, Kolawole Wasiu Wahab, Yusuf Agboola Zubair, Hirotaka Iwaki, Jonggeol Jeffrey Kim, Huw R Morris, John Hardy, Mike A Nalls, Karl Heilbron, Lucy Norcliffe-Kaufmann, Cornelis Blauwendraat, Henry Houlden, Andrew Singleton, Njideka Ulunma Okubadejo
BACKGROUND: An understanding of the genetic mechanisms underlying diseases in ancestrally diverse populations is an important step towards development of targeted treatments. Research in African and African admixed populations can enable mapping of complex traits, because of their genetic diversity, extensive population substructure, and distinct linkage disequilibrium patterns. We aimed to do a comprehensive genome-wide assessment in African and African admixed individuals to better understand the genetic architecture of Parkinson's disease in these underserved populations...
August 23, 2023: Lancet Neurology
#7
(no author information available yet)
No abstract text is available yet for this article.
August 9, 2023: Lancet Neurology
#8
(no author information available yet)
No abstract text is available yet for this article.
August 8, 2023: Lancet Neurology
#9
JOURNAL ARTICLE
Ahmed Abdelhak, Franziska Petermeier, Pascal Benkert, Sabine Schädelin, Johanna Oechtering, Aleksandra Maleska Maceski, Michael Kabesch, Tobias Geis, Otto Laub, Georg Leipold, Claudio Gobbi, Chiara Zecca, Ari Green, Hayrettin Tumani, Eline Willemse, Heinz Wiendl, Cristina Granziera, Ludwig Kappos, David Leppert, Emmanuelle Waubant, Sven Wellmann, Jens Kuhle
BACKGROUND: Neurological conditions represent an important driver of paediatric disability burden worldwide. Measurement of serum neurofilament light chain (sNfL) concentrations, a specific marker of neuroaxonal injury, has the potential to contribute to the management of children with such conditions. In this context, the European Medicines Agency recently declared age-adjusted reference values for sNfL a top research priority. We aimed to establish an age-adjusted sNfL reference range database in a population of healthy children and adolescents, and to validate this database in paediatric patients with neurological conditions to affirm its clinical applicability...
July 28, 2023: Lancet Neurology
#10
JOURNAL ARTICLE
Hollie Sherwood-Martin
No abstract text is available yet for this article.
July 25, 2023: Lancet Neurology
#11
(no author information available yet)
No abstract text is available yet for this article.
July 20, 2023: Lancet Neurology
#12
REVIEW
Roberta Messina, Maria A Rocca, Peter J Goadsby, Massimo Filippi
Migraine is one of the most common neurological diseases and it has a huge social and personal impact. Although head pain is the core symptom, individuals with migraine can have a plethora of non-headache symptoms that precede, accompany, or follow the pain. Neuroimaging studies have shown that the involvement of specific brain areas can explain many of the symptoms reported during the different phases of migraine. Recruitment of the hypothalamus, pons, spinal trigeminal nucleus, thalamus, and visual and pain-processing cortical areas starts during the premonitory phase and persists through the headache phase, contributing to the onset of pain and associated symptoms...
July 18, 2023: Lancet Neurology
#13
JOURNAL ARTICLE
Christopher R S Belder, Jonathan M Schott, Nick C Fox
No abstract text is available yet for this article.
July 14, 2023: Lancet Neurology
#14
JOURNAL ARTICLE
Giovanni B Frisoni
No abstract text is available yet for this article.
July 13, 2023: Lancet Neurology
#15
JOURNAL ARTICLE
Jessica Catchpole
No abstract text is available yet for this article.
July 11, 2023: Lancet Neurology
#16
(no author information available yet)
No abstract text is available yet for this article.
June 29, 2023: Lancet Neurology
#17
REVIEW
Bendix Labeit, Emilia Michou, Shaheen Hamdy, Michaela Trapl-Grundschober, Sonja Suntrup-Krueger, Paul Muhle, Philip M Bath, Rainer Dziewas
Dysphagia is a major complication following an acute stroke that affects the majority of patients. Clinically, dysphagia after stroke is associated with increased risk of aspiration pneumonia, malnutrition, mortality, and other adverse functional outcomes. Pathophysiologically, dysphagia after stroke is caused by disruption of an extensive cortical and subcortical swallowing network. The screening of patients for dysphagia after stroke should be provided as soon as possible, starting with simple water-swallowing tests at the bedside or more elaborate multi-consistency protocols...
September 2023: Lancet Neurology
#18
MULTICENTER STUDY
Alissa M D'Gama, Sarah Mulhern, Beth R Sheidley, Fadil Boodhoo, Sarah Buts, Natalie J Chandler, Joanna Cobb, Meredith Curtis, Edward J Higginbotham, Jonathon Holland, Tayyaba Khan, Julia Koh, Nicole S Y Liang, Lyndsey McRae, Sarah E Nesbitt, Brandon T Oby, Ben Paternoster, Alistair Patton, Graham Rose, Elizabeth Scotchman, Rozalia Valentine, Kimberly N Wiltrout, Robin Z Hayeems, Puneet Jain, Sebastian Lunke, Christian R Marshall, Shira Rockowitz, Neil J Sebire, Zornitza Stark, Susan M White, Lyn S Chitty, J Helen Cross, Ingrid E Scheffer, Vann Chau, Gregory Costain, Annapurna Poduri, Katherine B Howell, Amy McTague
BACKGROUND: Most neonatal and infantile-onset epilepsies have presumed genetic aetiologies, and early genetic diagnoses have the potential to inform clinical management and improve outcomes. We therefore aimed to determine the feasibility, diagnostic yield, and clinical utility of rapid genome sequencing in this population. METHODS: We conducted an international, multicentre, cohort study (Gene-STEPS), which is a pilot study of the International Precision Child Health Partnership (IPCHiP)...
September 2023: Lancet Neurology
#19
RANDOMIZED CONTROLLED TRIAL
Mona Guterud, Helge Fagerheim Bugge, Jo Røislien, Jo Kramer-Johansen, Mathias Toft, Hege Ihle-Hansen, Kristi G Bache, Karianne Larsen, Anne-Cathrine Braarud, Else Charlotte Sandset, Maren Ranhoff Hov
BACKGROUND: Timely treatment of acute stroke depends on early identification and triage. Improved methods for recognition of stroke in the prehospital setting are needed. We aimed to assess whether use of the National Institutes of Health Stroke Scale (NIHSS) by paramedics in the ambulance could improve communication with the hospital, augment triage, and enhance diagnostic accuracy of acute stroke. METHODS: The Paramedic Norwegian Acute Stroke Prehospital Project (ParaNASPP) was a stepped-wedge, single-blind, cluster-randomised controlled trial...
September 2023: Lancet Neurology
#20
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
September 2023: Lancet Neurology
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