Noor Samuels, Rob A van de Graaf, Maxim J H L Mulder, Scott Brown, Bob Roozenbeek, Pieter Jan van Doormaal, Mayank Goyal, Bruce C V Campbell, Keith W Muir, Nelly Agrinier, Serge Bracard, Phil M White, Luis San Román, Tudor G Jovin, Michael D Hill, Peter J Mitchell, Andrew M Demchuk, Alain Bonafe, Thomas G Devlin, Adriaan C G M van Es, Hester F Lingsma, Diederik W J Dippel, Aad van der Lugt
BACKGROUND: Current guidelines for ischaemic stroke treatment recommend a strict, but arbitrary, upper threshold of 185/110 mm Hg for blood pressure before endovascular thrombectomy. Nevertheless, whether admission blood pressure influences the effect of endovascular thrombectomy on outcome remains unknown. Our aim was to study the influence of admission systolic blood pressure (SBP) on functional outcome and on the effect of endovascular thrombectomy. METHODS: We used individual patient data from seven randomised controlled trials (MR CLEAN, ESCAPE, EXTEND-IA, SWIFT PRIME, REVASCAT, PISTE, and THRACE) that randomly assigned patients with anterior circulation ischaemic stroke to endovascular thrombectomy (predominantly using stent retrievers) or standard medical therapy (control) between June 1, 2010, and April 30, 2015...
April 2023: Lancet Neurology