Journal of Thoracic and Cardiovascular Surgery

OBJECTIVES: To evaluate the feasibility and safety of sleeve lobectomy after neoadjuvant therapy by assessing the postoperative morbidity. METHODS: Patients who underwent sleeve lobectomy for non-small cell lung cancer (NSCLC) were retrospectively analyzed from January 2018 to December 2021. A total of 613 patients were enrolled, including 124 patients who received prior neoadjuvant therapy and 489 patients who did not. Propensity score matching (PSM) was adopted to create a balanced cohort consisting of 97 paired cases...

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Achieving prolonged donor heart preservation and considerable reductions in primary graft dysfunction will require a multi-pronged approach against a number of key processes. This goal is unlikely to be achieved by intervening on a single pathway or target molecule. Wu et al shows that the cGAS-STING pathway is an important piece of the puzzle in the relentless march toward organ banking. Further work is needed to demonstrate its relevance in human hearts and large animal studies are needed to satisfy the regulatory rigors for reaching clinical translation...

OBJECTIVE: Evaluate the feasibility of prophylactic radiofrequency isolation of the pulmonary veins, with left atrial appendage amputation, to reduce the incidence of postoperative atrial fibrillation (POAF) after cardiac surgery in patients aged 70 and older. METHODS: The Federal Food and Drug Administration granted an investigational device exemption to utilize a bipolar radiofrequency clamp for prophylactic pulmonary vein isolation in a limited, feasibility trial...

OBJECTIVES: Pulmonary emphysema is characterized by the destruction of alveolar units and reduced gas exchange capacity. In the present study, we aimed to deliver induced pluripotent stem cell (iPSCs)-derived endothelial cells and pneumocytes to repair and regenerate distal lung tissue in an elastase-induced emphysema model. METHODS: We induced emphysema in athymic rats via intratracheal injection of elastase as previously reported. At 21 and 35 days after elastase treatment, we suspended 80 million iPSCs-derived endothelial cells and 20 million iPSCs-derived pneumocytes in hydrogel and injected the mixture intra-tracheally...

OBJECTIVE: We aimed to identify outcomes and factors that independently associate with early mortality after open repair of Crawford extent IV thoracoabdominal aortic aneurysms (TAAAs), defined as aneurysms confined to the segment below the diaphragm. METHODS: This retrospective analysis included 721 extent IV TAAA repairs performed in our institution from 1986 to 2021. Indications for repair were aneurysm without dissection in 627 cases (87.0%) and aortic dissection in 94 (13...

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