journal
https://read.qxmd.com/read/38490885/robotic-assisted-pediatric-thoracic-and-abdominal-tumor-resection-an-initial-multi-center-review
#1
JOURNAL ARTICLE
Wendy Jo Svetanoff, Michela Carter, Karen A Diefenbach, Marc Michalsky, Daniel DaJusta, Edward Gong, Timothy B Lautz, Jennifer H Aldrink
INTRODUCTION: Robotic-assisted minimally invasive surgery (RA-MIS) for tumor resection is an emerging technology in the pediatric population with significant promise but unproven safety and feasibility. METHODS: A multi-center retrospective review of patients ≤18 years undergoing RA-MIS tumor resection from December 2015-March 2023 was performed. Patient demographics, perioperative variables, and complication rates were analyzed. RESULTS: Thirty-nine procedures were performed on 38 patients (17 thoracic, 22 abdominal); 37% female and 68% non-Hispanic White...
February 26, 2024: Journal of Pediatric Surgery
https://read.qxmd.com/read/38490883/proliferative-effects-of-mesenchymal-stromal-cells-on-neuroblastoma-cell-lines-are-they-tumor-promoting-or-tumor-inhibiting
#2
JOURNAL ARTICLE
Kathleen Doyle, Maria Sutter, Monica Rodriguez, Abd-Elrahman Hassan, Priyadarsini Kumar, Erin Brown
BACKGROUND: Neuroblastoma is a common pediatric malignancy with poor survival for high-risk disease. Mesenchymal stromal cells (MSCs) have innate tumor-homing properties, enabling them to serve as a cellular delivery vehicle, but MSCs have demonstrated variable effects on tumor growth. We compared how placental MSCs (PMSCs) and bone marrow-derived MSCs (BM-MSCs) affect proliferation of neuroblastoma (NB) cells in vitro. METHODS: Indirect co-culture assessed proliferative effects of 18 MSCs (early-gestation PMSCs (n = 9), term PMSCs (n = 5), BM-MSCs (n = 4) on three high-risk NB cell lines (NB1643, SH-SY5Y, and CHLA90)...
February 26, 2024: Journal of Pediatric Surgery
https://read.qxmd.com/read/38490882/incidence-and-risk-factors-for-chyle-leaks-after-neuroblastic-tumor-resection-a-systematic-review-of-published-studies
#3
REVIEW
Arimatias Raitio, Paul D Losty
BACKGROUND: Chyle leakage/ascites after surgical resection of neuroblastic tumors may delay the start of chemotherapy and worsen prognosis. Previous studies have reported a highly variable incidence and risk factors remain largely unknown. This study aims to analyze the true incidence of chyle leaks and ascites and seeks to identify risk factors and optimal treatment strategies. METHODS: Medline/Embase databases were searched according to PRISMA guidelines. Literature reviews, case reports, and non-English papers were excluded...
February 26, 2024: Journal of Pediatric Surgery
https://read.qxmd.com/read/38485535/should-pediatric-surgical-oncologists-receive-training-in-vascular-surgery-a-practice-survey-report-from-the-international-society-of-paediatric-surgical-oncology-ipso
#4
JOURNAL ARTICLE
Prince Raj, Paul D Losty, Martin T Corbally
BACKGROUND: Is vascular training in paediatric surgical oncology considered desirable ? METHODS: A voluntary survey of work practice was undertaken with the surgeon membership of The International Society Of Paediatric Surgical Oncology (IPSO) using a structured designed questionnaire. RESULTS: A total of 149 IPSO surgeon members completed the survey. 57% (N = 84) of surgeons surveyed had no specific training in vascular surgery...
February 26, 2024: Journal of Pediatric Surgery
https://read.qxmd.com/read/38494399/the-use-of-a-high-flow-picc-catheter-for-stem-cell-and-lymphocyte-apheresis-the-initial-experience-of-a-pediatric-oncology-center-in-brazil
#5
JOURNAL ARTICLE
Vilani Kremer, Andréia Rheinheimer, Ana Luiza Rodrigues, Andressa Taborda, Robson Coelho, Antonella Zanette
BACKGROUND: Autologous hematopoietic stem cell transplant (HSCT), characterized by high intensity chemotherapy followed by the infusion of HSC previously collected from the peripheral blood, is a procedure used in the treatment of several malignancies. In pediatrics, the apheresis procedure represents a challenge, due to the need for insertion of a rigid central venous catheter (CVC) in small children. The CVC is usually used for stem cell collection and then removed. Later, the patient will need a new device for cell infusion...
February 24, 2024: Journal of Pediatric Surgery
https://read.qxmd.com/read/38493026/systematic-lymphatic-repair-for-reduction-of-postoperative-lymphatic-leak-following-neuroblastoma-resection
#6
JOURNAL ARTICLE
Gideon Purwono, York Tien Lee, Joyce Hy Chua, Amos Hp Loh
BACKGROUND: Gross total resection of neuroblastoma is associated with lymphatic leaks that can delay postoperative resumption of treatment. To prevent postoperative lymphatic leak, we introduced systematic lymphatic repair (SLR), which involved oversewing the entire edge of the disrupted lymphatic plane after neuroblastoma resection. We sought to study the impact of SLR on postoperative lymphatic leak and time to return to treatment. METHODS: We reviewed 60 neuroblastoma patients who underwent gross total resection at KK Women's and Children's Hospital...
February 24, 2024: Journal of Pediatric Surgery
https://read.qxmd.com/read/38490884/factors-associated-with-long-term-survival-in-children-with-bronchial-and-lung-carcinoid-tumors
#7
JOURNAL ARTICLE
Swathi R Raikot, Courtney N Day, R Paul Boesch, Wendy Allen-Rhoades, Stephanie F Polites
BACKGROUND AND AIMS: Bronchial carcinoids are rare in children and the treatment is based on tumor behavior in adults. The purpose of this study was to determine factors and management strategies associated with long-term survival in the pediatric population using a national cohort. METHODS: Patients aged ≤20 years with bronchial carcinoid tumors were identified in the 2004-2020 National Cancer Database using ICD-O-3 codes. Tumor characteristics and management were compared among typical (TC) and atypical (AC) histological subtypes using Chi-square and Fisher's exact tests...
February 24, 2024: Journal of Pediatric Surgery
https://read.qxmd.com/read/38485536/international-society-of-paediatric-surgical-oncology-ipso-a-short-history-developments-and-current-status
#8
REVIEW
Paul D Losty, Pablo Lobos, Chan Hon Chui, Andrew M Davidoff
The International Society of Paediatric Surgical Oncology (IPSO) was officially inaugurated in 1991 through the creativeness and inspiration of a collective dynamic group of paediatric surgeons committed to advancing childhood cancer. This article traces the origins and birth of IPSO tracking its modern day development to a growing world community of paediatric surgeon oncology members. LEVEL OF EVIDENCE: 5.
February 24, 2024: Journal of Pediatric Surgery
https://read.qxmd.com/read/38480030/ovarian-tissue-collection-for-fertility-preservation-in-children-the-need-for-standardised-surgical-practice-guidance
#9
JOURNAL ARTICLE
Sarah Braungart, Sheila Lane, Christian M Becker, Nicholas Alexander
BACKGROUND: Chemotherapy, pelvic radiotherapy (including total body irradiation) and novel compounds used to treat children and teenagers with benign or malignant diseases can lead to impaired fertility. For prepubertal female patients at high risk of treatment-related infertility, upfront storage of ovarian tissue is increasingly being recognised as standard of care. No surgical guidelines exist to ensure best practice technique. We reviewed current UK practice to assess surgical management...
February 24, 2024: Journal of Pediatric Surgery
https://read.qxmd.com/read/38472040/clinical-application-and-further-development-of-augmented-reality-guidance-for-the-surgical-localization-of-pediatric-chest-wall-tumors
#10
JOURNAL ARTICLE
Rémi van der Woude, Matthijs Fitski, Jasper M van der Zee, Cornelis P van de Ven, Guus M J Bökkerink, Marc H W A Wijnen, Jene W Meulstee, Tristan P C van Doormaal, Françoise J Siepel, Alida F W van der Steeg
BACKGROUND: Surgical treatment of pediatric chest wall tumors requires accurate surgical planning and tumor localization to achieve radical resections while sparing as much healthy tissue as possible. Augmented Reality (AR) could facilitate surgical decision making by improving anatomical understanding and intraoperative tumor localization. We present our clinical experience with the use of an AR system for intraoperative tumor localization during chest wall resections. Furthermore, we present the pre-clinical results of a new registration method to improve our conventional AR system...
February 24, 2024: Journal of Pediatric Surgery
https://read.qxmd.com/read/38461108/multi-modal-3-dimensional-visualization-of-pediatric-neuroblastoma-aiding-surgical-planning-beyond-anatomical-information
#11
JOURNAL ARTICLE
Dominique C Simons, Myrthe A D Buser, Matthijs Fitski, Cornelis P van de Ven, Bernhard Ten Haken, Marc H W A Wijnen, Can Ozan Tan, Alida F W van der Steeg
BACKGROUND: Patient-specific 3D models of neuroblastoma and relevant anatomy are useful tools for surgical planning. However, these models do not represent the heterogenous biology of neuroblastoma. This heterogeneity is visualized with the ADC and 123 I-MIGB-SPECT-CT imaging. Combining these multi-modal data into preoperative 3D heatmaps, may allow differentiation of the areas of vital and non-vital tumor tissue. We developed a workflow to create multi-modal preoperative 3D models for neuroblastoma surgery...
February 24, 2024: Journal of Pediatric Surgery
https://read.qxmd.com/read/38493027/transition-from-pediatric-to-adult-healthcare-for-colorectal-conditions-a-systematic-review
#12
REVIEW
Emma J Moore, Susan M Sawyer, Sebastian K King, Melissa Y Tien, Misel Trajanovska
BACKGROUND: Despite surgical advances for complex congenital colorectal conditions, such as anorectal malformation (ARM) and Hirschsprung disease (HD), many adolescents require transfer from specialist pediatric to adult providers for ongoing care. METHODOLOGY: A systematic review of PubMed, MEDLINE and Embase was conducted to identify what is known about the transitional care of patients with ARM and HD (PROSPERO # CRD42022281558). The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) framework guided our reporting of studies that focused on the transition care of 10-30-year-olds with ARM and HD...
February 23, 2024: Journal of Pediatric Surgery
https://read.qxmd.com/read/38443293/functional-and-health-related-quality-of-life-outcomes-into-adulthood-for-females-surgically-treated-for-anorectal-malformation
#13
JOURNAL ARTICLE
Joshua Gertler, Anna Löf Granström, Jenny Oddsberg, Anna Gunnarsdóttir, Anna Svenningsson, Tomas Wester, Lisa Örtqvist
BACKGROUND: Controlled outcomes into adulthood for females with anorectal malformation (ARM) are still scantily studied. The primary aim was to investigate bowel function, bladder function and health-related quality of life (HRQoL) in females operated for ARM. METHODS: A cross-sectional questionnaire-based observational study was performed including females treated for ARM at our institution between 1994 and 2017. The bowel function was assessed with bowel function score (BFS) and urinary tract function with lower urinary tract symptoms (LUTS) questionnaires...
February 20, 2024: Journal of Pediatric Surgery
https://read.qxmd.com/read/38413259/living-donor-whole-and-partial-liver-grafts-deceased-donor-whole-liver-and-split-outcome-comparison
#14
JOURNAL ARTICLE
João Seda Neto, Carolina M Costa, Renata Pugliese, Rodrigo Vincenzi, Marcel R Benavides, Nathália P R Travassos, Caio M V de Oliveira, Karina Roda, Debora P Fernandes, Mário Kondo, Eduardo A Fonseca
BACKGROUND: Currently, graft options for pediatric liver transplantation (PLT) include whole (WL) and partial (P) grafts, in the form of either deceased donor transplantation (DD) or living donor liver transplantation (LD). WL transplants from LD are commonly referred to as domino LT. The objective of this manuscript is to compare the outcomes of PLT performed with each of the available graft options. METHODS: Retrospective cohort study from Jan. 2010 to Dec. 2022...
February 19, 2024: Journal of Pediatric Surgery
https://read.qxmd.com/read/38413260/an-electronic-health-record-integrated-web-application-augments-a-qi-directed-morbidity-mortality-conference-and-improves-quality-of-care
#15
JOURNAL ARTICLE
Nitin Sajankila, Thomas Javens, Josh Hampl, Courtney Coleman, Jami Murnane, Brian D Kenney, Gail E Besner
BACKGROUND: In 2014, we developed a QI-directed Morbidity and Mortality (M&M) Conference, prioritizing discussion of individual and system failures, as well as development of action items to prevent failure recurrence. However, due to a reliance on individual electronic documents to store M&M data, our ability to assess trends in failures and action item implementation was hindered. To address this issue, in 2019, we created a secure electronic health record (EHR)-integrated web application (web app) to store M&M data...
February 16, 2024: Journal of Pediatric Surgery
https://read.qxmd.com/read/38403489/chest-wall-dermatitis-patterns-following-thoracoscopic-intercostal-nerve-cryoablation-for-surgical-correction-of-pectus-excavatum
#16
JOURNAL ARTICLE
J Benjamin Pitt, Michela Carter, Suhail Zeineddin, Laurie Sands, Suzanne Kujawa, Amparo Perez, Walter J Liszewski, Fizan Abdullah, Seth D Goldstein
BACKGROUND: Intercostal nerve cryoablation (INC) has been shown to reduce postoperative pain and length of stay following surgical correction of pectus excavatum (SCOPE). Some patients have developed chest wall dermatological symptoms after INC that can be mistaken for metal allergy or infection. The purpose of this study is to report the symptoms, severity, incidence, and treatment of post-cryoablation dermatitis. METHODS: A retrospective single institution review was performed for patients who underwent SCOPE with and without INC between June 2016 and March 2023 to assess for incidence of postoperative dermatological findings...
February 16, 2024: Journal of Pediatric Surgery
https://read.qxmd.com/read/38413261/microinjection-with-nanoparticles-to-deliver-drugs-in-prenatal-lung-explants-a-pilot-study-for-prenatal-therapy-in-congenital-diaphragmatic-hernia
#17
JOURNAL ARTICLE
Yuichiro Miyake, Wai Hei Tse, Jia Qi Wang, Daywin Patel, Arzu Ozturk, Atsuyuki Yamataka, Richard Keijzer
BACKGROUND: Fetoscopic endoluminal tracheal occlusion (FETO) improves the survival rate in fetuses with severe congenital diaphragmatic hernia (CDH). We hypothesize that prenatal therapies into the trachea during FETO can further improve outcomes. Here, we present an ex vivo microinjection technique with rat lung explants to study prenatal therapy with nanoparticles. METHODS: We used microsurgery to isolate lungs from rats on embryonic day 18. We injected chitosan nanoparticles loaded with fluorescein (FITC) into the trachea of the lung explants...
February 14, 2024: Journal of Pediatric Surgery
https://read.qxmd.com/read/38418276/the-state-of-artificial-intelligence-in-pediatric-surgery-a%C3%A2-systematic-review
#18
JOURNAL ARTICLE
Mohamed Elahmedi, Riya Sawhney, Elena Guadagno, Fabio Botelho, Dan Poenaru
BACKGROUND: Artificial intelligence (AI) has been recently shown to improve clinical workflows and outcomes - yet its potential in pediatric surgery remains largely unexplored. This systematic review details the use of AI in pediatric surgery. METHODS: Nine medical databases were searched from inception until January 2023, identifying articles focused on AI in pediatric surgery. Two authors reviewed full texts of eligible articles. Studies were included if they were original investigations on the development, validation, or clinical application of AI models for pediatric health conditions primarily managed surgically...
February 13, 2024: Journal of Pediatric Surgery
https://read.qxmd.com/read/38402131/modifiable-preoperative-risk-factors-to-mitigate-postoperative-site-infection-following-pediatric-gastrostomy
#19
JOURNAL ARTICLE
Shelby R Sferra, Sara Donnelly, Sandra Kabagambe, Erica M Fallon
PURPOSE: There are limited studies assessing modifiable preoperative risk factors for pediatric laparoscopic gastrostomy tubes (LGT) and percutaneous endoscopic gastrostomy (PEG) tubes. We sought to evaluate the effect of demographics and surgical/infectious history on the superficial infection rate following gastrostomy tube (GT) placement. METHODS: After IRB approval, we conducted a single-institution retrospective cohort study from 2015 to 2021 of pediatric patients undergoing LGT or PEG tube...
February 13, 2024: Journal of Pediatric Surgery
https://read.qxmd.com/read/38413258/letter-to-the-editor-in-response-to-risk-factors-for-preoperative-pneumothorax-in-neonates-with-isolated-left-sided-congenital-diaphragmatic-hernia-an-international-cohort-study
#20
LETTER
Pablo Lohmann, Caraciolo J Fernandes
No abstract text is available yet for this article.
February 12, 2024: Journal of Pediatric Surgery
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