journal
https://read.qxmd.com/read/38176725/psma-pet-auc-updates-inclusion-of-rh-psma-7-3
#41
JOURNAL ARTICLE
Thomas A Hope, Hossein Jadvar
No abstract text is available yet for this article.
January 4, 2024: Journal of Nuclear Medicine
https://read.qxmd.com/read/38176724/psma-pet-ct-dual-time-point-imaging-nice-to-have-or-need-to-have
#42
JOURNAL ARTICLE
Lena M Unterrainer, Kathleen Ruchalski, Martin S Allen-Auerbach, Jeremie Calais, Matthias R Benz
No abstract text is available yet for this article.
January 4, 2024: Journal of Nuclear Medicine
https://read.qxmd.com/read/38176723/is-212-pb-really-happening-the-post-177-lu-225-ac-blockbuster
#43
EDITORIAL
Richard Zimmermann
No abstract text is available yet for this article.
January 4, 2024: Journal of Nuclear Medicine
https://read.qxmd.com/read/38176722/hemodynamic-insights-into-combined-fractional-flow-reserve-and-instantaneous-wave-free-ratio-assessment-through-quantitative-15-o-h-2-o-pet-myocardial-perfusion-imaging
#44
JOURNAL ARTICLE
Ruben W de Winter, Pepijn A van Diemen, Stefan P Schumacher, Ruurt A Jukema, Yvemarie B O Somsen, Roel Hoek, Albert C van Rossum, Jos W R Twisk, Guus A de Waard, Alexander Nap, Pieter G Raijmakers, Roel S Driessen, Paul Knaapen, Ibrahim Danad
In patients evaluated for obstructive coronary artery disease (CAD), guidelines recommend using either fractional flow reserve (FFR) or instantaneous wave-free ratio (iFR) to guide coronary revascularization decision-making. The hemodynamic significance of lesions with discordant FFR and iFR measurements is debated. This study compared [15 O]H2 O PET-derived absolute myocardial perfusion between vessels with concordant and discordant FFR and iFR measurements. Methods: We included 197 patients suspected of obstructive CAD who had undergone [15 O]H2 O PET perfusion imaging and combined FFR/iFR interrogation in 468 vessels...
January 4, 2024: Journal of Nuclear Medicine
https://read.qxmd.com/read/38176721/prostate-specific-membrane-antigen-targeted-radioguided-pelvic-lymph-node-dissection-in-newly-diagnosed-prostate-cancer-patients-with-a-suspicion-of-locoregional-lymph-node-metastases-the-detect-trial
#45
JOURNAL ARTICLE
Melline G M Schilham, Diederik M Somford, Heidi V N Küsters-Vandevelde, Rick Hermsen, Jean Paul A van Basten, Robert J Hoekstra, Tom W J Scheenen, Martin Gotthardt, J P Michiel Sedelaar, Mark Rijpkema
Prostate-specific membrane antigen (PSMA)-targeted radioguided surgery (RGS) aims to optimize the peroperative detection and removal of PSMA-avid lymph node (LN) metastases (LNMs) and has been described in patients with recurrent prostate cancer (PCa). In newly diagnosed PCa patients undergoing pelvic LN dissections, PSMA RGS could guide the urologist toward PSMA-expressing LNMs as identified on preoperative 18 F-PSMA PET/CT imaging. The objective was to evaluate the safety and feasibility of 111 In-PSMA RGS in primary PCa patients with one or more suggestive LNs on preoperative 18 F-PSMA PET/CT...
January 4, 2024: Journal of Nuclear Medicine
https://read.qxmd.com/read/38176720/the-imperative-for-comparative-studies-in-nuclear-medicine-elevating-177-lu-psma-617-in-the-treatment-paradigm-for-mcrpc
#46
EDITORIAL
Kambiz Rahbar, Martin Boegemann
No abstract text is available yet for this article.
January 4, 2024: Journal of Nuclear Medicine
https://read.qxmd.com/read/38176718/fibroblast-activation-protein-%C3%AE-directed-imaging-and-therapy-of-solitary-fibrous-tumor
#47
JOURNAL ARTICLE
Rainer Hamacher, Kim M Pabst, Phyllis F Cheung, Christoph E Heilig, Jennifer Hüllein, Sven-Thorsten Liffers, Sabrina Borchert, Pedro Fragoso Costa, Benedikt M Schaarschmidt, Lukas Kessler, Monika A Miera, Margret Droste, Merve Akbulut, Johanna Falkenhorst, Fadi Zarrad, Karina Kostbade, Ilektra A Mavroeidi, Hanno Glimm, Lale Umutlu, Martin Schuler, Daniel Hübschmann, Sebastian Bauer, Stefan Fröhling, Ken Herrmann, Jens T Siveke, Hans-Ulrich Schildhaus, Wolfgang P Fendler
Fibroblast activation protein α (FAPα) is expressed at high levels in several types of tumors. Here, we report the expression pattern of FAPα in solitary fibrous tumor (SFT) and its potential use as a radiotheranostic target. Methods: We analyzed FAPα messenger RNA and protein expression in biopsy samples from SFT patients using immunohistochemistry and multiplexed immunofluorescence. Tracer uptake and detection efficacy were assessed in patients undergoing clinical 68 Ga-FAPα inhibitor (FAPI)-46 PET,18 F-FDG PET, and contrast-enhanced CT...
January 4, 2024: Journal of Nuclear Medicine
https://read.qxmd.com/read/38176717/toward-quantitative-multisite-preclinical-imaging-studies-in-acute-myocardial-infarction-evaluation-of-the-immune-fibrosis-axis
#48
JOURNAL ARTICLE
Maja Strunk, Gyu Seong Heo, Annika Hess, Hannah Luehmann, Tobias L Ross, Robert J Gropler, Frank M Bengel, Yongjian Liu, James T Thackeray
The immune-fibrosis axis plays a critical role in cardiac remodeling after acute myocardial infarction. Imaging approaches to monitor temporal inflammation and fibroblast activation in mice have seen wide application in recent years. However, the repeatability of quantitative measurements remains challenging, particularly across multiple imaging centers. We aimed to determine reproducibility of quantitative inflammation and fibroblast activation images acquired at 2 facilities after myocardial infarction in mice...
January 4, 2024: Journal of Nuclear Medicine
https://read.qxmd.com/read/38176716/comparison-of-3-different-therapeutic-particles-in-radioembolization-of-locally-advanced-intrahepatic-cholangiocarcinoma
#49
JOURNAL ARTICLE
Martijn E H M Wagemans, Britt Kunnen, Martina Stella, Rob van Rooij, Marnix G E H Lam, Hugo W A M de Jong, Arthur J A T Braat
Our objective was to compare 3 different therapeutic particles used for radioembolization in locally advanced intrahepatic cholangiocarcinoma. Methods: 90 Y-glass, 90 Y-resin, and 166 Ho-labeled poly(l-lactic acid) microsphere prescribed activity was calculated as per manufacturer recommendations. Posttreatment quantitative 90 Y PET/CT and quantitative 166 Ho SPECT/CT were used to determine tumor-absorbed dose, whole-normal-liver-absorbed dose, treated-normal-liver-absorbed dose, tumor-to-nontumor ratio, lung-absorbed dose, and lung shunt fraction...
January 4, 2024: Journal of Nuclear Medicine
https://read.qxmd.com/read/38176715/commentary-on-radioactive-iodine-a-living-history
#50
LETTER
Bennett S Greenspan, Michael S Hofman, John Buscombe
No abstract text is available yet for this article.
January 4, 2024: Journal of Nuclear Medicine
https://read.qxmd.com/read/38176714/design-preclinical-evaluation-and-clinical-translation-of-68-ga-fapi-lm3-a-heterobivalent-molecule-for-pet-imaging-of-nasopharyngeal-carcinoma
#51
JOURNAL ARTICLE
Liang Zhao, Yizhen Pang, Jianyang Fang, Jianhao Chen, Yangfan Zhou, Long Sun, Hua Wu, Zhide Guo, Qin Lin, Haojun Chen
Extensive research has been conducted on radiolabeled fibroblast activation protein (FAP) inhibitors (FAPIs) and p-Cl-Phe-cyclo(d-Cys-Tyr-d-4-amino-Phe(carbamoyl)-Lys-Thr-Cys)d-Tyr-NH2 (LM3) peptides for imaging of FAP and somatostatin receptor 2 (SSTR2)-positive tumors. In this study, we designed and synthesized a FAPI-LM3 heterobivalent molecule radiolabeled with 68 Ga and evaluated its effectiveness in both tumor xenografts and patients with nasopharyngeal carcinoma (NPC). Methods: The synthesis of FAPI-LM3 was based on the structures of FAPI-46 and LM3...
January 4, 2024: Journal of Nuclear Medicine
https://read.qxmd.com/read/38164615/identification-of-r-18-f-yh134-for-monoacylglycerol-lipase-neuroimaging-and-exploration-of-its-use-for-central-nervous-system-and-peripheral-drug-development
#52
JOURNAL ARTICLE
Yingfang He, Stefanie D Krämer, Uwe Grether, Matthias B Wittwer, Ludovic Collin, Bernd Kuhn, Andreas Topp, Dominik Heer, Fionn O'Hara, Michael Honer, Anto Pavlovic, Hans Richter, Martin Ritter, Didier Rombach, Claudia Keller, Luca Gobbi, Linjing Mu
This study aimed to evaluate ( R )-[18 F]YH134 as a novel PET tracer for imaging monoacylglycerol lipase (MAGL). Considering the ubiquitous expression of MAGL throughout the whole body, the impact of various MAGL inhibitors on ( R )-[18 F]YH134 brain uptake and its application in brain-periphery crosstalk were explored. Methods: MAGL knockout and wild-type mice were used to evaluate ( R )-[18 F]YH134 in in vitro autoradiography and PET experiments. To explore the impact of peripheral MAGL occupancy on ( R )-[18 F]YH134 brain uptake, PET kinetics with an arterial input function were studied in male Wistar rats under baseline and blocking conditions...
December 21, 2023: Journal of Nuclear Medicine
https://read.qxmd.com/read/38164592/peptide-receptor-radionuclide-therapy-is-effective-for-clinical-control-of-symptomatic-metastatic-insulinoma-a-long-term-retrospective-analysis
#53
JOURNAL ARTICLE
Liene Friebe, Martin T Freitag, Martin Braun, Guillaume Nicolas, Andreas Bauman, David Bushnell, Emanuel Christ, Damian Wild
Metastatic insulinoma is a rare malignant neuroendocrine tumor characterized by inappropriate insulin secretion, resulting in life-threatening hypoglycemia, which is often difficult to treat. There is currently very limited information about the efficacy of peptide receptor radionuclide therapy (PRRT) for clinical control of hypoglycemia. The aim of this long-term retrospective study was to evaluate the therapeutic efficacy of PRRT for improving hypoglycemia, to evaluate the change of medication after PRRT, and to calculate progression-free survival (PFS) and overall survival (OS)...
February 1, 2024: Journal of Nuclear Medicine
https://read.qxmd.com/read/38164586/first-safety-and-efficacy-data-with-the-radiohybrid-177-lu-rhpsma-10-1-for-the-treatment-of-metastatic-prostate-cancer
#54
JOURNAL ARTICLE
Alexander Dierks, Alexander Gäble, Andreas Rinscheid, Georgine Wienand, Christian H Pfob, Malte Kircher, Johanna S Enke, Tilman Janzen, Marianne Patt, Martin Trepel, Dorothea Weckermann, Ralph A Bundschuh, Constantin Lapa
We recently published the first dosimetry data, to our knowledge, for the radioligand therapy agent 177 Lu-rhPSMA-10.1, providing an intrapatient comparison with 177 Lu-PSMA-I&T in patients with metastatic prostate cancer. Here, we report efficacy and safety findings from these patients. Methods: Four consecutive patients with prostate-specific membrane antigen (PSMA)-positive metastatic prostate cancer received up to 6 cycles of 177 Lu-rhPSMA-10.1 (7.4-7.7 GBq per cycle). Efficacy (prostate-specific antigen response according to Prostate Cancer Working Group 3 criteria and the Response Evaluation Criteria in PSMA PET/CT), progression-free survival, and overall survival were evaluated...
December 21, 2023: Journal of Nuclear Medicine
https://read.qxmd.com/read/38164579/-18-f-fdg-pet-ct-avid-discordant-volume-as-a-biomarker-in-patients-with-gastroenteropancreatic-neuroendocrine-neoplasms-a-multicenter-study
#55
JOURNAL ARTICLE
David L Chan, Aimee R Hayes, Ioannis Karfis, Alice Conner, Magdalena Mileva, Elizabeth Bernard, Geoffrey Schembri, Shaunak Navalkissoor, Gopinath Gnanasegaran, Nick Pavlakis, Clémentine Marin, Bruno Vanderlinden, Patrick Flamen, Paul Roach, Martyn E Caplin, Christos Toumpanakis, Dale L Bailey
[18 F]FDG PET/CT and [68 Ga]Ga-DOTATATE PET/CT are both used to predict tumor biology in neuroendocrine neoplasms. Although the presence of discordant ([18 F]FDG-avid/non-[68 Ga]Ga-DOTATATE-avid) disease predicts poor prognosis, the significance of the volume of such discordant disease remains undetermined. The aim of this study is to investigate discordant tumor volume as a potential biomarker in patients with advanced gastroenteropancreatic neuroendocrine neoplasms (GEPNENs). Methods: A multicenter retrospective study in patients with advanced GEPNENs and paired [18 F]FDG and [68 Ga]Ga-DOTATATE PET/CT no more than 85 d apart was conducted...
December 21, 2023: Journal of Nuclear Medicine
https://read.qxmd.com/read/38164576/prediction-of-177-lu-dotatate-prrt-outcome-using-multimodality-imaging-in-patients-with-gastroenteropancreatic-neuroendocrine-tumors-results-from-a-prospective-phase-ii-lumen-study
#56
JOURNAL ARTICLE
Magdalena Mileva, Gwennaëlle Marin, Hugo Levillain, Carlos Artigas, Camille Van Bogaert, Clémentine Marin, Rachele Danieli, Amelie Deleporte, Simona Picchia, Konstantinos Stathopoulos, Christiane Jungels, Bruno Vanderlinden, Marianne Paesmans, Lieveke Ameye, Gabriela Critchi, Loubna Taraji-Schiltz, Chloe Velghe, Zéna Wimana, Maria Bali, Alain Hendlisz, Patrick Flamen, Ioannis Karfis
Our objective was to predict the outcome of peptide receptor radionuclide therapy (PRRT) using multimodality imaging and tumor dosimetry on gastroenteropancreatic neuroendocrine tumor (GEP-NET) lesions and patients. Methods: This prospective study included patients with progressive GEP-NETs. Treatment consisted of 4 cycles of 7.4 GBq of 177 Lu-DOTATATE. Imaging parameters were measured on 68 Ga-DOTATATE PET/CT (SUVmax/mean , somatostatin receptor [SSTR] tumor volume [TV], total lesion SSTR expression, and tumor-to-blood and tumor-to-spleen ratios), 18 F-FDG PET/CT (SUVmax/mean , metabolically active TV, and total lesion glycolysis), and diffusion-weighted MRI (apparent diffusion coefficient) in a maximum of 5 target lesions per patient at approximately 10 wk after each injection...
December 21, 2023: Journal of Nuclear Medicine
https://read.qxmd.com/read/38164574/value-of-68-ga-fapi-04-and-18-f-fdg-pet-ct-in-early-prediction-of-pathologic-response-to-neoadjuvant-chemotherapy-in-locally-advanced-gastric-cancer
#57
JOURNAL ARTICLE
Ying Miao, Runhua Feng, Teng Yu, Rui Guo, Min Zhang, Yue Wang, Wangxi Hai, Chengfang Shangguan, Zhenggang Zhu, Biao Li
This prospective study investigated whether PET parameters from 18 F-FDG and 68 Ga-fibroblast activation protein inhibitor (FAPI)-04 PET/CT can predict a pathologic response to neoadjuvant chemotherapy (NAC) early in patients with locally advanced gastric cancer (LAGC). Methods: The study included 28 patients with LAGC who underwent 18 F-FDG PET/CT and 68 Ga-FAPI-04 PET/CT at baseline and after 1 cycle of NAC. PET parameters including SUV and tumor-to-background ratio (TBR), as well as the change rate of SUV and TBR, were recorded...
December 21, 2023: Journal of Nuclear Medicine
https://read.qxmd.com/read/38164565/diagnostic-performance-of-18-f-tfb-pet-ct-compared-with-therapeutic-activity-131-i-iodine-spect-ct-and-18-f-fdg-pet-ct-in-recurrent-differentiated-thyroid-carcinoma
#58
JOURNAL ARTICLE
David Ventura, Matthias Dittmann, Florian Büther, Michael Schäfers, Kambiz Rahbar, Daniel Hescheler, Michael Claesener, Philipp Schindler, Burkhard Riemann, Robert Seifert, Wolfgang Roll
[18 F]tetrafluoroborate ([18 F]TFB) is an emerging PET tracer with excellent properties for human sodium iodide symporter (NIS)-based imaging in patients with differentiated thyroid cancer (DTC). The aim of this study was to compare [18 F]TFB PET with high-activity posttherapeutic [131 I]iodine whole-body scintigraphy and SPECT/CT in recurrent DTC and with [18 F]FDG PET/CT in suspected dedifferentiation. Methods: Twenty-six patients treated with high-activity radioactive [131 I]iodine therapy (range, 5.00-10...
December 21, 2023: Journal of Nuclear Medicine
https://read.qxmd.com/read/38124218/dynamic-human-brain-imaging-with-a-portable-pet-camera-comparison-to-a-standard-scanner
#59
JOURNAL ARTICLE
Elizabeth A Bartlett, Mohammad Lesanpezeshki, Sergey Anishchenko, Ilia Shkolnik, R Todd Ogden, J John Mann, David Beylin, Jeffrey M Miller, Francesca Zanderigo
Portable, cost-effective PET cameras can radically expand the applicability of PET. We present here a within-participant comparison of fully quantified [18 F]FDG dynamic scans in healthy volunteers using the standard Biograph mCT scanner and portable CerePET scanner. Methods: Each of 20 healthy volunteers underwent dynamic [18 F]FDG imaging with both scanners (1-154 d apart) and concurrent arterial blood sampling. Tracer SUV, net influx rate (Ki ), and the corresponding cerebral metabolic rate of glucose (CMRglu ) were quantified at regional and voxel levels...
December 14, 2023: Journal of Nuclear Medicine
https://read.qxmd.com/read/38124209/%C3%AE-synuclein-seeding-amplification-assay-a-breakthrough-in-diagnosing-parkinson-disease
#60
JOURNAL ARTICLE
John P Seibyl
No abstract text is available yet for this article.
December 14, 2023: Journal of Nuclear Medicine
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