Sanne A M van Lith, Ilanah J Pruis, Nelleke Tolboom, Tom J Snijders, Dylan Henssen, Mark Ter Laan, Maarten Te Dorsthorst, William P J Leenders, Martin Gotthardt, James Nagarajah, Pierre A Robe, Philip De Witt Hamer, Harry Hendrikse, Daniela E Oprea-Lager, Maqsood Yaqub, Ronald Boellaard, Pieter Wesseling, Rutger K Balvers, Frederik A Verburg, Anita A Harteveld, Marion Smits, Martin van den Bent, Sophie E M Veldhuijzen van Zanten, Elsmarieke van de Giessen
Upregulation of prostate-specific membrane antigen (PSMA) in neovasculature has been described in glioblastoma multiforme (GBM), whereas vasculature in nonaffected brain shows hardly any expression of PSMA. It is unclear whether PSMA-targeting tracer uptake on PET is based on PSMA-specific binding to neovasculature or aspecific uptake in tumor. Here, we quantified uptake of various PSMA-targeting tracers in GBM and correlated this with PSMA expression in tumor biopsy samples from the same patients. Methods: Fourteen patients diagnosed with de novo ( n = 8) or recurrent ( n = 6) GBM underwent a preoperative PET scan after injection of 1...
August 31, 2023: Journal of Nuclear Medicine