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MULTICENTER STUDY
Matteo Castrichini, Antonio De Luca, Giulia De Angelis, Raquel Neves, Alessia Paldino, Matteo Dal Ferro, Giulia Barbati, Kristen Medo, Andrea Barison, Chrysanthos Grigoratos, Marta Gigli, Davide Stolfo, Francesca Brun, Daniel W Groves, Robert Quaife, Ramone Eldemire, Sharon Graw, Jeffrey Addison, Giancarlo Todiere, Ignazio Alessio Gueli, Nicoletta Botto, Michele Emdin, Giovanni Donato Aquaro, Ramin Garmany, Naveen L Pereira, Matthew R G Taylor, Michael J Ackerman, Gianfranco Sinagra, Luisa Mestroni, John R Giudicessi, Marco Merlo
BACKGROUND: Nondilated left ventricular cardiomyopathy (NDLVC) has been recently differentiated from dilated cardiomyopathy (DCM). A comprehensive characterization of these 2 entities using cardiac magnetic resonance (CMR) and genetic testing has never been performed. OBJECTIVES: This study sought to provide a thorough characterization and assess clinical outcomes in a large multicenter cohort of patients with DCM and NDLVC. METHODS: A total of 462 patients with DCM (227) or NDLVC (235) with CMR data from 4 different referral centers were retrospectively analyzed...
May 14, 2024: Journal of the American College of Cardiology
#42
LETTER
J Sawalla Guseh, James L Januzzi
No abstract text is available yet for this article.
May 14, 2024: Journal of the American College of Cardiology
#43
EDITORIAL
Viviany R Taqueti, Valentin Fuster
No abstract text is available yet for this article.
May 7, 2024: Journal of the American College of Cardiology
#44
REVIEW
Rodrigo Estévez-Loureiro, Roberto Lorusso, Maurizio Taramasso, Gianluca Torregrossa, Annapoorna Kini, Pedro R Moreno
Severe acute mitral regurgitation after myocardial infarction includes partial and complete papillary muscle rupture or functional mitral regurgitation. Although its incidence is <1%, mitral regurgitation after acute myocardial infarction frequently causes hemodynamic instability, pulmonary edema, and cardiogenic shock. Medical management has the worst prognosis, and mortality has not changed in decades. Surgery represents the gold standard, but it is associated with high rates of morbidity and mortality...
May 7, 2024: Journal of the American College of Cardiology
#45
REVIEW
James A Goldstein, Stamatios Lerakis, Pedro R Moreno
Right ventricular infarction (RVI) complicates 50% of cases of acute inferior ST-segment elevation myocardial infarction, and is associated with high in-hospital morbidity and mortality. Ischemic right ventricular (RV) systolic dysfunction decreases left ventricular preload delivery, resulting in low-output hypotension with clear lungs, and disproportionate right heart failure. RV systolic performance is generated by left ventricular contractile contributions mediated by the septum. Augmented right atrial contraction optimizes RV performance, whereas very proximal occlusions induce right atrial ischemia exacerbating hemodynamic compromise...
May 7, 2024: Journal of the American College of Cardiology
#46
LETTER
Ron Blankstein, Arthur Shiyovich
No abstract text is available yet for this article.
May 7, 2024: Journal of the American College of Cardiology
#47
MULTICENTER STUDY
Meng-Meng Yu, Ming-Liang Wang, Jin-Jin Wang, Bo-Li Lin, Xin Zhao, Xin-Wei Tao, Yin-Yin Chen, Peng-Yang Li, Jing-Kun Zhang, Jun-Bo Ge, Hang Jin, Meng-Su Zeng
BACKGROUND: Lipoprotein(a) (Lp[a]) is associated with an increased risk of myocardial infarction (MI). However, the mechanism underlying this association has yet to be fully elucidated. OBJECTIVES: This multicenter study aimed to investigate whether association between Lp(a) and MI risk is reinforced by the presence of low-attenuation plaque (LAP) identified by coronary computed tomography angiography (CCTA). METHODS: In a derivation cohort, a total of 5,607 patients with stable chest pain suspected of coronary artery disease who underwent CCTA and Lp(a) measurement were prospectively enrolled...
May 7, 2024: Journal of the American College of Cardiology
#48
LETTER
Pradeep Natarajan, Tiffany R Bellomo
No abstract text is available yet for this article.
May 7, 2024: Journal of the American College of Cardiology
#49
JOURNAL ARTICLE
Roland Jäger, Matthias Hoke, Florian J Mayer, Stefanie Boden, Cornelia Englisch, Cihan Ay, Robert Kralovics, Christoph J Binder
BACKGROUND: The expansion of hematopoietic stem cells caused by acquired somatic mutations (clonal hematopoiesis [CH]) is a novel cardiovascular risk factor. The prognostic value of CH in patients with carotid atherosclerosis remains to be evaluated. OBJECTIVES: This study assessed the prognostic significance of CH in patients with atherosclerosis as detected by ultrasound of the carotid artery. METHODS: We applied deep sequencing of selected genomic regions within the genes DNMT3A, TET2, ASXL1, and JAK2 to screen for CH in 968 prospectively collected patients with asymptomatic carotid atherosclerosis evaluated by duplex sonography...
May 7, 2024: Journal of the American College of Cardiology
#50
EDITORIAL
Michele Emdin, Francesco Gentile, Alberto Giannoni
No abstract text is available yet for this article.
May 7, 2024: Journal of the American College of Cardiology
#51
(no author information available yet)
No abstract text is available yet for this article.
April 30, 2024: Journal of the American College of Cardiology
#52
LETTER
Raffaele Piccolo, Domenico Angellotti, Fiorenzo Simonetti, Attilio Leone, Marisa Avvedimento, Luca Bardi, Giuliana Fortunato, Carmen Anna Maria Spaccarotella, Anna Franzone, Giovanni Esposito
No abstract text is available yet for this article.
April 30, 2024: Journal of the American College of Cardiology
#53
REVIEW
Odayme Quesada, Daniela Crousillat, Fatima Rodriguez, Katia Bravo-Jaimes, Joan Briller, Modele O Ogunniyi, Deirdre J Mattina, Niti R Aggarwal, Carlos J Rodriguez, Glaucia Maria Moraes De Oliveira, Gladys Velarde
Cardiovascular disease affects 37% of Hispanic women and is the leading cause of death among Hispanic women in the United States. Hispanic women have a higher burden of cardiovascular risk factors, are disproportionally affected by social determinants of health, and face additional barriers related to immigration, such as discrimination, language proficiency, and acculturation. Despite this, Hispanic women show lower rates of cardiovascular disease and mortality compared with non-Hispanic White women. However, this "Hispanic paradox" is challenged by recent studies that account for the diversity in culture, race, genetic background, country of origin, and social determinants of health within Hispanic subpopulations...
April 30, 2024: Journal of the American College of Cardiology
#54
REVIEW
Romain Boulestreau, Mateusz Śpiewak, Andrzej Januszewicz, Reinhold Kreutz, Tomasz J Guzik, Magdalena Januszewicz, Maria Lorenza Muiesan, Alexandre Persu, Pantelis Sarafidis, Massimo Volpe, Anna Zaleska-Żmijewska, Bert-Jan H van den Born, Franz H Messerli
Malignant hypertension (MHT) is a hypertensive emergency with excessive blood pressure (BP) elevation and accelerated disease progression. MHT is characterized by acute microvascular damage and autoregulation failure affecting the retina, brain, heart, kidney, and vascular tree. BP must be lowered within hours to mitigate patient risk. Both absolute BP levels and the pace of BP rise determine risk of target-organ damage. Nonadherence to the antihypertensive regimen remains the most common cause for MHT, although antiangiogenic and immunosuppressant therapy can also trigger hypertensive emergencies...
April 30, 2024: Journal of the American College of Cardiology
#55
EDITORIAL
Tianyi Huang
No abstract text is available yet for this article.
April 30, 2024: Journal of the American College of Cardiology
#56
LETTER
Pavan Atluri, Amit Iyengar, David Rekhtman
No abstract text is available yet for this article.
April 30, 2024: Journal of the American College of Cardiology
#57
JOURNAL ARTICLE
Alexander Iribarne, Sundos H Alabbadi, Alan J Moskowitz, Gorav Ailawadi, Vinay Badhwar, Marc Gillinov, Vinod H Thourani, Keith B Allen, Michael E Halkos, Nirav C Patel, Robert S Kramer, David D'Alessandro, Samantha Raymond, Helena L Chang, Lopa Gupta, Kathleen N Fenton, Wendy C Taddei-Peters, Michael W A Chu, Volkmar Falk, Joanna Chikwe, Neal Jeffries, Emilia Bagiella, Patrick T O'Gara, Annetine C Gelijns, Natalia N Egorova
BACKGROUND: Tricuspid valve annuloplasty (TA) during mitral valve repair (MVr) is associated with increased risk of permanent pacemaker (PPM) implantation, but the magnitude of risk and long-term clinical consequences have not been firmly established. OBJECTIVES: This study assesses the incidence rates of PPM implantation after isolated MVr and following MVr with TA as well as the associated long-term clinical consequences of PPM implantation. METHODS: State-mandated hospital discharge databases of New York and California were queried for patients undergoing MVr (isolated or with concomitant TA) between 2004 and 2019...
April 30, 2024: Journal of the American College of Cardiology
#58
LETTER
C Anwar A Chahal, Andrew P Landstrom
No abstract text is available yet for this article.
April 30, 2024: Journal of the American College of Cardiology
#59
MULTICENTER STUDY
Eva Cabrera-Romero, Juan Pablo Ochoa, Roberto Barriales-Villa, Francisco José Bermúdez-Jiménez, Vicente Climent-Payá, Esther Zorio, María Angeles Espinosa, María Gallego-Delgado, Marina Navarro-Peñalver, Xabier Arana-Achaga, Jesús Piqueras-Flores, Victoria Espejo-Bares, José F Rodríguez-Palomares, Gemma Lacuey-Lecumberri, Javier López, Coloma Tiron, María Luisa Peña-Peña, Jose M García-Pinilla, Rebeca Lorca, Tomas Ripoll-Vera, Carles Díez-López, María Victoria Mogollon, Ana García-Álvarez, Luis Martínez-Dolz, María Brion, Jose María Larrañaga-Moreira, Juan Jiménez-Jáimez, María Isabel García-Álvarez, Silvia Vilches, Eduardo Villacorta, María Sabater-Molina, Itziar Solla-Ruiz, Ana Royuela, Fernando Domínguez, Jesús G Mirelis, Pablo Garcia-Pavia
BACKGROUND: Disease penetrance in genotype-positive (G+) relatives of families with dilated cardiomyopathy (DCM) and the characteristics associated with DCM onset in these individuals are unknown. OBJECTIVES: This study sought to determine the penetrance of new DCM diagnosis in G+ relatives and to identify factors associated with DCM development. METHODS: The authors evaluated 779 G+ patients (age 35.8 ± 17.3 years; 459 [59%] females; 367 [47%] with variants in TTN) without DCM followed at 25 Spanish centers...
April 30, 2024: Journal of the American College of Cardiology
#60
EDITORIAL
Subhash Banerjee, Zachary P Rosol
No abstract text is available yet for this article.
April 30, 2024: Journal of the American College of Cardiology
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