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Daniel P Judge, Rodney H Falk, Mathew S Maurer, Sanjiv J Shah, Ronald M Witteles, Martha Grogan, Van N Selby, Daniel Jacoby, Mazen Hanna, Jose Nativi-Nicolau, Jignesh Patel, Satish Rao, Uma Sinha, Cameron W Turtle, Jonathan C Fox, Stephen B Heitner
BACKGROUND: Transthyretin (TTR) amyloidosis (ATTR) is an under-diagnosed disease caused by destabilization of TTR due to pathogenic mutations or aging. Both pathogenic and protective mutations illuminate mechanisms of disease and potential interventions. AG10 is a selective, oral TTR stabilizer under development for ATTR cardiomyopathy (ATTR-CM) that mimics a protective TTR mutation. OBJECTIVES: This randomized, double-blind, placebo-controlled study evaluated safety, tolerability, pharmacokinetics and pharmacodynamics of AG10 in ATTR-CM patients with symptomatic, chronic heart failure...
March 12, 2019: Journal of the American College of Cardiology
#2
Rishi K Wadhera, Colin W O'Brien, Karen E Joynt Maddox, Kalon K L Ho, Duane S Pinto, Frederic S Resnic, Pinak B Shah, Robert W Yeh
No abstract text is available yet for this article.
March 11, 2019: Journal of the American College of Cardiology
#3
LETTER
Subodh Verma, Christoph Wanner, Isabella Zwiener, Anne Pernille Ofstad, Jyothis T George, David Fitchett, Bernard Zinman
No abstract text is available yet for this article.
March 5, 2019: Journal of the American College of Cardiology
#4
Peder Langeland Myhre, Muthiah Vaduganathan, Brian Claggett, Milton Packer, Akshay S Desai, Jean L Rouleau, Michael R Zile, Karl Swedberg, Martin Lefkowitz, Victor Shi, John J V McMurray, Scott D Solomon
BACKGROUND: Natriuretic peptides are substrates of neprilysin; hence, B-type natriuretic peptide (BNP) concentrations rise with neprilysin inhibition. Thus, the clinical validity of measuring BNP in sacubitril/valsartan-treated patients has been questioned, and use of N-terminal pro-B-type natriuretic peptides (NT-proBNP) has been preferred and recommended. OBJECTIVES: The purpose of this study was to determine the prognostic performance of BNP measurements before and during treatment with sacubitril/valsartan...
February 28, 2019: Journal of the American College of Cardiology
#5
P A Schneider, J R Laird, G Doros, Q Gao, G Ansel, M Brodmann, A Micari, M H Shishehbor, G Tepe, T Zeller
No abstract text is available yet for this article.
February 28, 2019: Journal of the American College of Cardiology
#6
Paul Carter, Jakub Lagan, Christien Fortune, Deepak L Bhatt, Jørgen Vestbo, Robert Niven, Nazia Chaudhuri, Erik B Schelbert, Rahul Potluri, Christopher A Miller
BACKGROUND: The relationship between respiratory diseases and individual cardiovascular diseases, and the impact of cardiovascular diseases on mortality in patients with respiratory disease, are unclear. OBJECTIVES: This study sought to determine the relationship between chronic obstructive pulmonary disease (COPD), asthma and interstitial lung disease (ILD), and individual cardiovascular diseases, and evaluate the impact of individual cardiovascular diseases on all-cause mortality in respiratory conditions...
February 27, 2019: Journal of the American College of Cardiology
#7
LETTER
Cian McCarthy, Sean Murphy, Ramkumar V Venkateswaran, Avinainder Singh, Leslie L Chang, Melvin G Joice, Jose M Rivero, Muthiah Vaduganathan, James L Januzzi, Deepak L Bhatt
No abstract text is available yet for this article.
February 25, 2019: Journal of the American College of Cardiology
#8
C Michael Gibson, David Holmes, Ghiath Mikdadi, Dale Presser, David Wohns, Megan K Yee, Andrew Kaplan, Allen Ciuffo, Arthur L Eberly, Bruce Iteld, Mitchell W Krucoff
BACKGROUND: Symptoms remain a poor prompt for acute coronary syndromes (ACS). Timely restoration of perfusion in ST-segment elevation myocardial infarction is associated with improved left ventricular function and survival. OBJECTIVES: This report details the results of ALERTS (AngelMed for Early Recognition and Treatment of STEMI), a multicenter, randomized trial of an implantable cardiac monitor that alerts patients with rapidly progressive ST-segment deviation...
February 25, 2019: Journal of the American College of Cardiology
#9
LETTER
Cian P McCarthy, Sean Murphy, Joshua A Cohen, Saad Rehman, Maeve Jones-O'Connor, David S Olshan, Avinainder Singh, Muthiah Vaduganathan, James L Januzzi, Jason H Wasfy
No abstract text is available yet for this article.
February 22, 2019: Journal of the American College of Cardiology
#10
Li-Tan Yang, Hector I Michelena, Christopher G Scott, Maurice Enriquez-Sarano, Sorin V Pislaru, Hartzell V Schaff, Patricia A Pellikka
BACKGROUND: Few data exist on the contemporary profiles and outcomes of patients with significant aortic regurgitation (AR). OBJECTIVES: The study sought to assess the benefits of aortic valve repair or replacement (AVR) and the prognostic value of left ventricular (LV) dimensions in significant AR. METHODS: From 2006 to 2017, consecutive patients with ≥moderate-severe chronic AR without prior heart surgery, myocardial infarction, or overt coronary artery disease were included...
February 22, 2019: Journal of the American College of Cardiology
#11
EDITORIAL
Patrick T O'Gara, Yee-Ping Sun
No abstract text is available yet for this article.
February 22, 2019: Journal of the American College of Cardiology
#12
LETTER
Eric A Secemsky, Harun Kundi, Ido Weinberg, Marc Schermerhon, Joshua A Beckman, Sahil A Parikh, Michael R Jaff, Jihad Mustapha, Kenneth Rosenfield, Robert W Yeh
No abstract text is available yet for this article.
February 21, 2019: Journal of the American College of Cardiology
#13
Stephen J Greene, Gregg C Fonarow, Adam D DeVore, Puza P Sharma, Muthiah Vaduganathan, Nancy M Albert, Carol I Duffy, C Larry Hill, Kevin McCague, J Herbert Patterson, John A Spertus, Laine Thomas, Fredonia B Williams, Adrian F Hernandez, Javed Butler
BACKGROUND: Guidelines recommend titration of medical therapy for heart failure with reduced ejection fraction (HFrEF) to target doses derived from clinical trials. The degree to which titration occurs in contemporary United States (U.S.) practice is unknown. OBJECTIVES: We sought to characterize longitudinal titration of HFrEF medical therapy in clinical practice and identify associated factors and reasons for medication changes. METHODS: Among 2,588 U...
February 20, 2019: Journal of the American College of Cardiology
#14
LETTER
Fabien Picard, Deepak L Bhatt, Grégory Ducrocq, Yedid Elbez, Roberto Ferrari, Ian Ford, Jean Claude Tardif, Michal Tendera, Kim M Fox, Philippe Gabriel Steg
No abstract text is available yet for this article.
February 16, 2019: Journal of the American College of Cardiology
#15
REVIEW
James L Januzzi, Simon A Mahler, Robert H Christenson, Jennifer Rymer, L Kristin Newby, Richard Body, David A Morrow, Allan S Jaffe
High-sensitivity cardiac troponin (hs-cTn) I or T methods have been in use in certain regions for years but are now increasingly globally adopted, including in the United States. Accordingly, inevitable challenges are created for institutions transitioning from conventional cardiac troponin (cTn) assays. hs-cTn assays have higher analytic precision at lower concentrations, yielding greater clinical sensitivity for myocardial injury and allowing accurate recognition of small changes in troponin concentration (rise or fall) within a short time frame...
February 16, 2019: Journal of the American College of Cardiology
#16
Susan E Wiegers, Thomas Ryan, James A Arrighi, Samuel M Brown, Barry Canaday, Julie B Damp, Jose L Diaz-Gomez, Vincent M Figueredo, Mario J Garcia, Linda D Gillam, Brian P Griffin, James N Kirkpatrick, Kyle W Klarich, George K Lui, Scott Maffett, Tasneem Z Naqvi, Amit R Patel, Marie-France Poulin, Geoffrey A Rose, Madhav Swaminathan
No abstract text is available yet for this article.
February 12, 2019: Journal of the American College of Cardiology
#17
Takehiro Nakahara, Jagat Narula, Jan G P Tijssen, Sunil Agarwal, Mohammed M Chowdhury, Patrick A Coughlin, Marc R Dweck, James H F Rudd, Masahiro Jinzaki, John Mulhall, H William Strauss
BACKGROUND: Fluorine-18 sodium fluoride (NaF), a bone-seeking radiopharmaceutical used to detect osseous metastases, localizes in regions of microcalcification in atherosclerosis. OBJECTIVES: To determine if atherosclerosis of penile arteries plays a role in erectile dysfunction (ED), this study analyzed NaF images in prostate cancer patients. METHODS: NaF positron emission tomography-computed tomography bone scans were evaluated in 437 prostate cancer patients (age 66...
February 7, 2019: Journal of the American College of Cardiology
#18
EDITORIAL
Ahmed Tawakol, Michael T Osborne, Francis J McGovern
No abstract text is available yet for this article.
February 7, 2019: Journal of the American College of Cardiology
#19
Peter A Schneider, John R Laird, Gheorghe Doros, Qi Gao, Gary Ansel, Marianne Brodmann, Antonio Micari, Mehdi H Shishehbor, Gunnar Tepe, Thomas Zeller
BACKGROUND: Five years of prospective clinical trials confirm that paclitaxel drug-coated balloons (DCB) is safe and effective to treat femoropopliteal artery disease. A recent meta-analysis of heterogenous trials of paclitaxel-based balloons and stents reported they are associated with increased mortality and higher doses are linked to higher mortality from 2-5 years. OBJECTIVES: Determine if there is a correlation between paclitaxel exposure and mortality by conducting an independent patient-level meta-analysis of 1,980 patients with up to 5-year follow-up...
January 25, 2019: Journal of the American College of Cardiology
#20
Craig T January, L Samuel Wann, Hugh Calkins, Lin Y Chen, Joaquin E Cigarroa, Joseph C Cleveland, Patrick T Ellinor, Michael D Ezekowitz, Michael E Field, Karen L Furie, Paul A Heidenreich, Katherine T Murray, Julie B Shea, Cynthia M Tracy, Clyde W Yancy
No abstract text is available yet for this article.
January 21, 2019: Journal of the American College of Cardiology
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