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EDITORIAL
Emer Joyce
No abstract text is available yet for this article.
March 22, 2023: Journal of the American College of Cardiology
#2
Vandana Sachdev, Kavita Sharma, Steven J Keteyian, Charina F Alcain, Patrice Desvigne-Nickens, Jerome L Fleg, Viorel G Florea, Barry A Franklin, Maya Guglin, Martin Halle, Eric S Leifer, Gurusher Panjrath, Emily A Tinsley, Renee P Wong, Dalane W Kitzman
Heart failure with preserved ejection fraction (HFpEF) is one of the most common forms of heart failure; its prevalence is increasing, and outcomes are worsening. Affected patients often experience severe exertional dyspnea and debilitating fatigue, as well as poor quality of life, frequent hospitalizations, and a high mortality rate. Until recently, most pharmacological intervention trials for HFpEF yielded neutral primary outcomes. In contrast, trials of exercise-based interventions have consistently demonstrated large, significant, clinically meaningful improvements in symptoms, objectively determined exercise capacity, and usually quality of life...
March 14, 2023: Journal of the American College of Cardiology
#3
EDITORIAL
Valentin Fuster, Biykem Bozkurt, Y S Chandrashekhar, Julia Grapsa, Bonnie Ky, Douglas L Mann, David J Moliterno, Kalyanam Shivkumar, Candice K Silversides, Justine Varieur Turco, Jian'an Wang
No abstract text is available yet for this article.
March 14, 2023: Journal of the American College of Cardiology
#4
JOURNAL ARTICLE
Senqing Jiang, Chao Fang, Xueming Xu, Lei Xing, Sibo Sun, Cong Peng, Yanwei Yin, Fangmeng Lei, Yini Wang, Lulu Li, Yuzhu Chen, Xueying Pei, Ruyi Jia, Caiying Tang, Song Li, Shuang Li, Huai Yu, Tao Chen, Jinfeng Tan, Xiaohui Liu, Jingbo Hou, Jiannan Dai, Bo Yu
BACKGROUND: Optical coherence tomography (OCT) may provide a method for detecting histologically defined high-risk plaques in vivo. OBJECTIVES: The authors aimed to investigate the prognostic value of OCT for identifying patients and lesions that are at risk for adverse cardiac events. METHODS: Between January 2017 and May 2019, OCT of all the 3 main epicardial arteries was performed in 883 patients with acute myocardial infarction (MI) who were referred for primary percutaneous coronary intervention...
March 11, 2023: Journal of the American College of Cardiology
#5
EDITORIAL
Edward T A Fry, Daniel J Piñeiro
No abstract text is available yet for this article.
March 3, 2023: Journal of the American College of Cardiology
#6
JOURNAL ARTICLE
Maan Malahfji, Valentina Crudo, Yodying Kaolawanich, Duc T Nguyen, Amr Telmesani, Mujtaba Saeed, Michael J Reardon, William A Zoghbi, Venkateshwar Polsani, Michael Elliott, Robert O Bonow, Edward A Graviss, Raymond Kim, Dipan J Shah
BACKGROUND: Quantitative cardiac magnetic resonance (CMR) outcome studies in aortic regurgitation (AR) are few. It is unclear if volume measurements are beneficial over diameters. OBJECTIVES: To evaluate the association of CMR quantitative thresholds and outcomes in AR patients. METHODS: in a multicenter study, asymptomatic patients with moderate or severe AR on CMR with preserved LV ejection fraction (LVEF) were evaluated. Primary outcome was development of symptoms or decrease in LVEF to <50%, guideline indications for surgery based on LV dimensions, or death under medical management...
March 3, 2023: Journal of the American College of Cardiology
#7
JOURNAL ARTICLE
Gregg W Stone, Michael E Farkouh, Anuradha Lala, Elizabeth Tinuoye, Ovidiu Dressler, Pedro R Moreno, Igor F Palacios, Shaun G Goodman, Rodrigo B Esper, Alexandre Abizaid, Deepak Varade, Juan F Betancur, Alejandro Ricalde, Gerardo Payro, José María Castellano, Ivan Fn Hung, Girish N Nadkarni, Gennaro Giustino, Lucas C Godoy, Jason Feinman, Anton Camaj, Solomon W Bienstock, Remo H M Furtado, Carlos Granada, Jessica Bustamante, Carlos Peyra, Johanna Contreras, Ruth Owen, Deepak L Bhatt, Stuart J Pocock, Valentin Fuster
BACKGROUND: Prior studies of therapeutic-dose anticoagulation in patients with COVID-19 have reported conflicting results. OBJECTIVES: We sought to determine the safety and effectiveness of therapeutic-dose anticoagulation in non-critically ill patients with COVID-19. METHODS: Patients hospitalized with COVID-19 not requiring intensive care unit (ICU) treatment were randomized to prophylactic-dose enoxaparin, therapeutic-dose enoxaparin, or therapeutic-dose apixaban...
February 27, 2023: Journal of the American College of Cardiology
#8
JOURNAL ARTICLE
John K Forrest, G Michael Deeb, Steven J Yakubov, Hemal Gada, Mubashir A Mumtaz, Basel Ramlawi, Tanvir Bajwa, Paul S Teirstein, Michael DeFrain, Murali Muppala, Bruce J Rutkin, Atul Chawla, Bart Jenson, Stanley J Chetcuti, Robert C Stoler, Marie-France Poulin, Kamal Khabbaz, Melissa Levack, Kashish Goel, Didier Tchétché, Ka Yan Lam, Pim A L Tonino, Saki Ito, Jae K Oh, Jian Huang, Jeffrey J Popma, Neal Kleiman, Michael J Reardon
BACKGROUND: Randomized data comparing outcomes of transcatheter aortic valve replacement (TAVR) to surgery in low surgical risk patients at time points beyond 2 years is limited. This presents an unknown for physicians striving to educate patients as part of a shared decision-making process. OBJECTIVE: We evaluated 3-year clinical and echocardiographic outcomes from the Evolut Low Risk trial. METHODS: Low-risk patients were randomized to TAVR with a self-expanding, supra-annular valve or surgery...
February 24, 2023: Journal of the American College of Cardiology
#9
JOURNAL ARTICLE
Ankeet S Bhatt, Anubodh S Varshney, Alea Moscone, Brian L Claggett, Zi Michael Miao, Safia Chatur, Mathew S Lopes, John W Ostrominski, Maria A Pabon, Ozan Unlu, Xiaowen Wang, Thomas D Bernier, Leo F Buckley, Bryan Cook, Rachael Eaton, Jillian Fiene, Dareen Kanaan, Julie Kelly, Danielle M Knowles, Kenneth Lupi, Lina S Matta, Liriany Y Pimentel, Megan N Rhoten, Rhynn Malloy, Clara Ting, Rosette Chhor, Joshua R Guerin, Scott L Schissel, Brenda Hoa, Connie H Lio, Kristina Milewski, Michelle E Espinosa, Zhenzhen Liu, Ralph McHatton, Jonathan W Cunningham, Karola S Jering, John H Bertot, Gurleen Kaur, Adeel Ahmad, Muhammad Akash, Farideh Davoudi, Mona Z Hinrichsen, David L Rabin, Patrick L Gordan, David J Roberts, Daniela Urma, Erin E McElrath, Emily D Hinchey, Niteesh K Choudhry, Mahan Nekoui, Scott D Solomon, Dale S Adler, Muthiah Vaduganathan
BACKGROUND: Scalable and safe approaches for heart failure GDMT optimization are needed. OBJECTIVE: We assessed the safety and effectiveness of a virtual care team-guided strategy on GDMT use in hospitalized patients with HFrEF. METHODS: In a multicenter implementation trial, we allocated 252 hospital encounters in patients with LVEF≤40% to a virtual care team-guided strategy(107 encounters among 83 patients) or usual care(145 encounters among 115 patients) across 3 centers in an integrated health system...
February 21, 2023: Journal of the American College of Cardiology
#10
JOURNAL ARTICLE
Christie M Ballantyne, Puja Banka, Gustavo Mendez, Raymundo Garcia, Julio Rosenstock, Anthony Rodgers, Geraldine Mendizabal, Yale Mitchel, Alberico L Catapano
BACKGROUND: MK-0616 is an oral PCSK9 macrocyclic peptide inhibitor in development for the treatment of hypercholesterolemia. OBJECTIVES: This Phase 2b, randomized, double-blind, placebo-controlled, multi-center trial (NCT05261126) aimed to evaluate the efficacy and safety of MK-0616 in participants with hypercholesterolemia. METHODS: This study planned to include 375 adult participants with a wide range of ASCVD risk. Participants were assigned randomly (1:1:1:1:1 ratio) to MK-0616 (6, 12, 18, or 30 mg QD) or matching placebo...
February 16, 2023: Journal of the American College of Cardiology
#11
Theodore A Bass, J Dawn Abbott, Ehtisham Mahmud, Sahil A Parikh, Jamil Aboulhosn, Mahi L Ashwath, Bryan Baranowski, Lisa Bergersen, Hannah I Chaudry, Megan Coylewright, Ali E Denktas, Kamal Gupta, J Antonio Gutierrez, Jonathan Haft, Beau M Hawkins, Howard C Herrmann, Navin K Kapur, Sena Kilic, John Lesser, C Huie Lin, Rodrigo Mendirichaga, Vuyisile T Nkomo, Linda G Park, Dawn R Phoubandith, Nishath Quader, Michael W Rich, Kenneth Rosenfield, Saher S Sabri, Murray L Shames, Stanton K Shernan, Kimberly A Skelding, Jacqueline Tamis-Holland, Vinod H Thourani, Jennifer A Tremmel, Seth Uretsky, Jessica Wageman, Frederick Welt, Brian K Whisenant, Christopher J White, Celina M Yong
No abstract text is available yet for this article.
February 14, 2023: Journal of the American College of Cardiology
#12
JOURNAL ARTICLE
Amrita Mukhopadhyay, Harmony R Reynolds, Lawrence M Phillips, Arielle R Nagler, William C King, Adam Szerencsy, Archana Saxena, Rod Aminian, Nathan Klapheke, Leora I Horwitz, Stuart D Katz, Saul Blecker
BACKGROUND: Mineralocorticoid receptor antagonists (MRA) are under-prescribed for patients with heart failure with reduced ejection fraction (HFrEF). OBJECTIVE: To compare effectiveness of two automated, electronic health record (EHR)-embedded tools vs. usual care on MRA prescribing in eligible patients with HFrEF. METHODS: BETTER CARE-HF (Building Electronic Tools To Enhance and Reinforce CArdiovascular REcommendations for Heart Failure) was a three-arm, pragmatic, cluster-randomized trial comparing the effectiveness of an alert during individual patient encounters vs...
February 9, 2023: Journal of the American College of Cardiology
#13
JOURNAL ARTICLE
Safia Chatur, Brian L Claggett, Finnian R McCausland, Jean Rouleau, Michael R Zile, Milton Packer, Marc A Pfeffer, Martin Lefkowitz, John Jv McMurray, Scott D Solomon, Muthiah Vaduganathan
BACKGROUND: Some patients with heart failure may experience transient changes in kidney function upon transition to sacubitril/valsartan. Whether such changes portend adverse outcomes or influence long-term treatment benefits with sacubitril/valsartan continuation is unknown. OBJECTIVES: To evaluate the association between the occurrence of moderate eGFR decline(>15%) after initial exposure to sacubitril/valsartan and subsequent cardiovascular outcomes and its treatment benefits in PARADIGM-HF and PARAGON-HF...
February 9, 2023: Journal of the American College of Cardiology
#14
LETTER
Joy Jiang, Lili Chan, Justin Kauffman, Jagat Narula, Alexander W Charney, Wonsuk Oh, GIrish Nadkarni
Taken from the largest U.S. cohort of patients with SARS-CoV2, our results demonstrate the association of even partial vaccination with lower risk of MACE after SARS-CoV-2 infection.
January 27, 2023: Journal of the American College of Cardiology
#15
EDITORIAL
Yuchi Han, Tiffany Chen, Karima Addetia
No abstract text is available yet for this article.
January 27, 2023: Journal of the American College of Cardiology
#16
JOURNAL ARTICLE
Andrada C Guta, Kinan C El-Tallawi, Duc T Nguyen, Fatima Qamar, Thuy Nguyen, William A Zoghbi, Gerald Lawrie, Edward A Graviss, Dipan J Shah
BACKGROUND: Tricuspid valve prolapse (TVP) is an uncertain diagnosis with unknown clinical significance because of a scarcity of published data. OBJECTIVES: In this study, cardiac magnetic resonance was used to: 1) propose diagnostic criteria for TVP; 2) evaluate the prevalence of TVP in patients with primary mitral regurgitation (MR); and 3) identify the clinical implications of TVP with regard to tricuspid regurgitation (TR). METHODS: Forty-one healthy volunteers were analyzed to identify normal tricuspid leaflet displacement and propose criteria for TVP...
January 27, 2023: Journal of the American College of Cardiology
#17
LETTER
Antonio Bozzani, Antonio V Sterpetti, Vittorio Arici, Franco Ragni, Eloisa Arbustini
No abstract text is available yet for this article.
March 28, 2023: Journal of the American College of Cardiology
#18
LETTER
Jiayu Li, Yanguo Xin
No abstract text is available yet for this article.
March 28, 2023: Journal of the American College of Cardiology
#19
LETTER
Massimiliano Camilli, Michele Russo, Riccardo Rinaldi, Filippo Crea, Rocco A Montone
No abstract text is available yet for this article.
March 28, 2023: Journal of the American College of Cardiology
#20
EDITORIAL
Valentin Fuster, Justine Varieur Turco, Marta Cortes-Canteli
No abstract text is available yet for this article.
March 28, 2023: Journal of the American College of Cardiology
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