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Journal of the American College of Cardiology

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https://read.qxmd.com/read/31085320/a-percutaneous-permanent-carotid-filter-for-stroke-prevention-in-atrial-fibrillation-the-capture-trial
#1
Vivek Y Reddy, Petr Neuzil, Tom de Potter, Jan van der Heyden, Selma C Tromp, Benno Rensing, Eva Jiresova, Libor Dujka, Veronika Lekesova
BACKGROUND: High stroke risk atrial fibrillation patients unsuitable to oral anticoagulants (OAC) require other stroke prevention strategies. A novel permanent coil filter directly placed into both common carotid arteries (CCAs) was designed to capture emboli >1.4mm diameter. OBJECTIVES: In a multicenter, non-randomized, first-in-human clinical trial (CAPTURE), to determine the feasibility and safety of bilateral CCA filter placement. METHODS: Eligible patients had atrial fibrillation, CHA2 DS2 -VASc ≥ 2, OAC unsuitability, CCA size 4...
May 8, 2019: Journal of the American College of Cardiology
https://read.qxmd.com/read/31097258/home-based-cardiac-rehabilitation-a-scientific-statement-from-the-american-association-of-cardiovascular-and-pulmonary-rehabilitation-the-american-heart-association-and-the-american-college-of-cardiology
#2
Randal J Thomas, Alexis L Beatty, Theresa M Beckie, LaPrincess C Brewer, Todd M Brown, Daniel E Forman, Barry A Franklin, Steven J Keteyian, Dalane W Kitzman, Judith G Regensteiner, Bonnie K Sanderson, Mary A Whooley
Cardiac rehabilitation (CR) is an evidence-based intervention that uses patient education, health behavior modification, and exercise training to improve secondary prevention outcomes in patients with cardiovascular disease. CR programs reduce morbidity and mortality rates in adults with ischemic heart disease, heart failure, or cardiac surgery but are significantly underused, with only a minority of eligible patients participating in CR in the United States. New delivery strategies are urgently needed to improve participation...
May 7, 2019: Journal of the American College of Cardiology
https://read.qxmd.com/read/31078637/his-corrective-pacing-or-biventricular-pacing-for-cardiac-resynchronization-in-heart-failure
#3
LETTER
Gaurav A Upadhyay, Pugazhendi Vijayaraman, Hemal M Nayak, Nishant Verma, Gopi Dandamudi, Parikshit S Sharma, Moeen Saleem, John Mandrola, Davide Genovese, Roderick Tung
No abstract text is available yet for this article.
May 7, 2019: Journal of the American College of Cardiology
https://read.qxmd.com/read/31071413/surgery-is-not-associated-with-improved-survival-compared-to-medical-therapy-in-isolated-severe-tricuspid-regurgitation
#4
Andrea L Axtell, Vijeta Bhambhani, Philicia Moonsamy, Emma W Healy, Michael H Picard, Thoralf M Sundt, Jason H Wasfy
BACKGROUND: Patients with isolated tricuspid regurgitation (TR) in the absence of left-sided valvular dysfunction are historically managed nonoperatively. OBJECTIVES: To assess the impact of surgery for isolated TR, we compared survival for isolated severe TR patients who underwent surgery to those who did not. METHODS: A longitudinal echocardiography database was used to perform a retrospective analysis on 3,276 adult patients with isolated severe TR from November 2001-March 2016...
May 3, 2019: Journal of the American College of Cardiology
https://read.qxmd.com/read/31085321/pulsed-field-ablation-for-pulmonary-vein-isolation-in-atrial-fibrillation
#5
Vivek Y Reddy, Petr Neuzil, Jacob S Koruth, Jan Petru, Moritoshi Funosako, Hubert Cochet, Lucie Sediva, Milan Chovanec, Srinivas R Dukkipati, Pierre Jais
BACKGROUND: Catheter ablation of atrial fibrillation using thermal energies such as radiofrequency or cryothermy is associated with indiscriminate tissue destruction. During pulsed field ablation (PFA), sub-second electric fields create microscopic pores in cell membranes - a process called electroporation. Among cell types, cardiomyocytes have among the lowest thresholds to these fields, potentially permitting preferential myocardial ablation. OBJECTIVES: To determine whether PFA allows durable pulmonary vein (PV) isolation without damage to collateral structures...
April 29, 2019: Journal of the American College of Cardiology
https://read.qxmd.com/read/31076234/catheter-ablation-of-atrial-fibrillation-with-and-without-on-site-cardiothoracic-surgery
#6
LETTER
Daniel J Friedman, Sean D Pokorney, Rahul Khanna, Laura Goldstein, Brett D Atwater, Tristram D Bahnson, James P Daubert, Kevin P Jackson, E Kevin Heist, Jagmeet P Singh, Hugh Calkins, Jonathan P Piccini
No abstract text is available yet for this article.
April 29, 2019: Journal of the American College of Cardiology
https://read.qxmd.com/read/31060767/statistical-appraisal-of-6-recent-clinical-trials-in-cardiology-jacc-state-of-the-art-review
#7
REVIEW
Stuart J Pocock, Tim J Collier
In the past 12 months, many important new clinical trials in cardiology have had their first conference presentation and publication. This paper presents a constructive critical appraisal of 6 key studies. In time order of first presentation, they are CABANA, ATTR-ACT, COAPT, DECLARE, REDUCE-IT, and AUGUSTUS. For each study, the aim herein is to document and interpret the main findings, paying attention to new findings, their research context, and study limitations. These topical examples also provide methodological insights pertinent to future clinical trials research...
April 29, 2019: Journal of the American College of Cardiology
https://read.qxmd.com/read/31002877/correction
#8
P Overtchouk, P Guedeney, S Rouanet, J P Verhoye, T Lefevre, E Van Belle, H Eltchaninoff, M Gilard, P Leprince, B Iung, O Barthelemy, H Le Breton, G Souteyrand, E Vicaut, G Montalescot, J-P Collet
No abstract text is available yet for this article.
April 16, 2019: Journal of the American College of Cardiology
https://read.qxmd.com/read/31010719/2019-aats-acc-ase-scai-sts-expert-consensus-systems-of-care-document-a-proposal-to-optimize-care-for-patients-with-valvular-heart-disease-a-joint-report-of-the-american-association-for-thoracic-surgery-american-college-of-cardiology-american-society-of-echocardiography
#9
Rick A Nishimura, Patrick T O'Gara, Joseph E Bavaria, Ralph G Brindis, John D Carroll, Clifford J Kavinsky, Brian R Lindman, Jane A Linderbaum, Stephen H Little, Michael J Mack, Laura Mauri, William R Miranda, David M Shahian, Thoralf M Sundt
No abstract text is available yet for this article.
April 3, 2019: Journal of the American College of Cardiology
https://read.qxmd.com/read/30910539/correction
#10
I S Anand
No abstract text is available yet for this article.
March 22, 2019: Journal of the American College of Cardiology
https://read.qxmd.com/read/30898607/effects-of-icosapent-ethyl-on-total-ischemic-events-from-reduce-it
#11
Deepak L Bhatt, Ph Gabriel Steg, Michael Miller, Eliot A Brinton, Terry A Jacobson, Steven B Ketchum, Ralph T Doyle, Rebecca A Juliano, Lixia Jiao, Craig Granowitz, Jean-Claude Tardif, John Gregson, Stuart J Pocock, Christie M Ballantyne
BACKGROUND: In time-to-first-event analyses, icosapent ethyl significantly reduced the risk of ischemic events, including cardiovascular death, among patients with elevated triglycerides receiving statins. These patients are at risk for not only first but also subsequent ischemic events. OBJECTIVES: Pre-specified analyses determined the extent to which icosapent ethyl reduced total ischemic events. METHODS: The Reduction of Cardiovascular Events with EPA-Intervention Trial (REDUCE-IT) randomized 8,179 statin-treated patients with triglycerides ≥135 and <500 mg/dL (median baseline of 216 mg/dL) and LDL-cholesterol >40 and ≤100 mg/dL (median baseline of 75 mg/dL), and a history of atherosclerosis (71% patients) or diabetes (29% patients) to icosapent ethyl 4g/day or placebo...
March 18, 2019: Journal of the American College of Cardiology
https://read.qxmd.com/read/30894319/2019-acc-aha-guideline-on-the-primary-prevention-of-cardiovascular-disease-executive-summary-a-report-of-the-american-college-of-cardiology-american-heart-association-task-force-on-clinical-practice-guidelines
#12
Donna K Arnett, Roger S Blumenthal, Michelle A Albert, Andrew B Buroker, Zachary D Goldberger, Ellen J Hahn, Cheryl D Himmelfarb, Amit Khera, Donald Lloyd-Jones, J William McEvoy, Erin D Michos, Michael D Miedema, Daniel Muñoz, Sidney C Smith, Salim S Virani, Kim A Williams, Joseph Yeboah, Boback Ziaeian
No abstract text is available yet for this article.
March 17, 2019: Journal of the American College of Cardiology
https://read.qxmd.com/read/30894318/2019-acc-aha-guideline-on-the-primary-prevention-of-cardiovascular-disease-a-report-of-the-american-college-of-cardiology-american-heart-association-task-force-on-clinical-practice-guidelines
#13
Donna K Arnett, Roger S Blumenthal, Michelle A Albert, Andrew B Buroker, Zachary D Goldberger, Ellen J Hahn, Cheryl D Himmelfarb, Amit Khera, Donald Lloyd-Jones, J William McEvoy, Erin D Michos, Michael D Miedema, Daniel Muñoz, Sidney C Smith, Salim S Virani, Kim A Williams, Joseph Yeboah, Boback Ziaeian
No abstract text is available yet for this article.
March 17, 2019: Journal of the American College of Cardiology
https://read.qxmd.com/read/30898609/patients-with-recent-acute-coronary-syndrome-and-polyvascular-disease-derive-large-absolute-benefit-from-alirocumab-odyssey-outcomes-trial
#14
J Wouter Jukema, Michael Szarek, Laurien E Zijlstra, H Asita de Silva, Deepak L Bhatt, Vera A Bittner, Rafael Diaz, Jay M Edelberg, Shaun G Goodman, Corinne Hanotin, Robert A Harrington, Yuri Karpov, Angèle Moryusef, Robert Pordy, Juan C Prieto, Matthew T Roe, Harvey D White, Andreas M Zeiher, Gregory G Schwartz, Ph Gabriel Steg
BACKGROUND: Patients with acute coronary syndrome (ACS) and concomitant noncoronary atherosclerosis have a high risk of major adverse cardiovascular events (MACE) and death. The impact of lipid-lowering by proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibition in such patients is undetermined. OBJECTIVES: This pre-specified analysis from ODYSSEY OUTCOMES determined whether polyvascular disease (polyVD) influenced risks of MACE and death and their modification by alirocumab in patients with recent ACS and dyslipidemia despite intensive statin therapy...
March 12, 2019: Journal of the American College of Cardiology
https://read.qxmd.com/read/30898608/ticagrelor-versus-clopidogrel-in-patients-with-stemi-treated-with-fibrinolytic-therapy-treat-trial
#15
Otavio Berwanger, Renato D Lopes, Diogo D F Moia, Francisco A Fonseca, Lixin Jiang, Shaun G Goodman, Stephen J Nicholls, Alexander Parkhomenko, Oleg Averkov, Carlos Tajer, Germán Malaga, Jose F K Saraiva, Helio P Guimaraes, Pedro G M de Barros E Silva, Lucas P Damiani, Renato H N Santos, Denise M Paisani, Tamiris A Miranda, Nanci Valeis, Leopoldo S Piegas, Christopher B Granger, Harvey D White, Jose C Nicolau
BACKGROUND: The efficacy of ticagrelor in the long-term post ST-elevation myocardial infarction (STEMI) treated with fibrinolytic therapy remains uncertain. OBJECTIVES: To evaluate the efficacy of ticagrelor when compared with clopidogrel in STEMI patients treated with fibrinolytic therapy. METHODS: We conducted an international, multicenter, randomized, open-label with blinded endpoint adjudication trial that enrolled 3,799 patients (age < 75 years) with STEMI receiving fibrinolytic therapy...
March 12, 2019: Journal of the American College of Cardiology
https://read.qxmd.com/read/30885685/transthyretin-stabilization-by-ag10-in-symptomatic-transthyretin-amyloid-cardiomyopathy
#16
Daniel P Judge, Rodney H Falk, Mathew S Maurer, Sanjiv J Shah, Ronald M Witteles, Martha Grogan, Van N Selby, Daniel Jacoby, Mazen Hanna, Jose Nativi-Nicolau, Jignesh Patel, Satish Rao, Uma Sinha, Cameron W Turtle, Jonathan C Fox, Stephen B Heitner
BACKGROUND: Transthyretin (TTR) amyloidosis (ATTR) is an under-diagnosed disease caused by destabilization of TTR due to pathogenic mutations or aging. Both pathogenic and protective mutations illuminate mechanisms of disease and potential interventions. AG10 is a selective, oral TTR stabilizer under development for ATTR cardiomyopathy (ATTR-CM) that mimics a protective TTR mutation. OBJECTIVES: This randomized, double-blind, placebo-controlled study evaluated safety, tolerability, pharmacokinetics and pharmacodynamics of AG10 in ATTR-CM patients with symptomatic, chronic heart failure...
March 12, 2019: Journal of the American College of Cardiology
https://read.qxmd.com/read/30885686/public-reporting-of-percutaneous-coronary-intervention-outcomes-institutional-costs-and-physician-burden
#17
Rishi K Wadhera, Colin W O'Brien, Karen E Joynt Maddox, Kalon K L Ho, Duane S Pinto, Frederic S Resnic, Pinak B Shah, Robert W Yeh
No abstract text is available yet for this article.
March 11, 2019: Journal of the American College of Cardiology
https://read.qxmd.com/read/30894317/sonothrombolysis-in-st-segment-elevation-myocardial-infarction-treated-with-primary-percutaneous-coronary-intervention
#18
Wilson Mathias, Jeane M Tsutsui, Bruno G Tavares, Agostina M Fava, Miguel O D Aguiar, Bruno C Borges, Mucio T Oliveira, Alexandre Soeiro, Jose C Nicolau, Henrique B Ribeiro, Hsu Pochiang, João C N Sbano, Abdulrahman Morad, Andrew Goldsweig, Carlos E Rochitte, Bernardo B C Lopes, José A F Ramirez, Roberto Kalil Filho, Thomas R Porter
BACKGROUND: Pre-clinical studies have demonstrated that high mechanical index (MI) impulses from a diagnostic ultrasound transducer (DUS) during an intravenous microbubble infusion (Sonothrombolysis) can restore epicardial and microvascular flow in acute ST-segment elevation myocardial infarction (STEMI). OBJECTIVE: We tested the clinical effectiveness of sonothrombolysis in patients with STEMI. METHODS: Patients with their first STEMI were prospectively randomized to either DUS-guided high MI impulses during an intravenous ultrasound agent infusion prior to, and following, emergent percutaneous coronary intervention (PCI), or to a control group that received PCI only (n=50 in each group)...
March 7, 2019: Journal of the American College of Cardiology
https://read.qxmd.com/read/30885684/influence-of-microvascular-disease-on-cardiovascular-events-in-type-2-diabetes
#19
LETTER
Subodh Verma, Christoph Wanner, Isabella Zwiener, Anne Pernille Ofstad, Jyothis T George, David Fitchett, Bernard Zinman
No abstract text is available yet for this article.
March 5, 2019: Journal of the American College of Cardiology
https://read.qxmd.com/read/30826429/correction
#20
P A Schneider, J R Laird, G Doros, Q Gao, G Ansel, M Brodmann, A Micari, M H Shishehbor, G Tepe, T Zeller
No abstract text is available yet for this article.
February 28, 2019: Journal of the American College of Cardiology
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