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Journal of Acquired Immune Deficiency Syndromes: JAIDS

Mathieu Maheu-Giroux, Souleymane Diabaté, Marie-Claude Boily, Nédjéda Jean-Paul, Juan F Vesga, Stefan Baral, Kouamé Abo, Venance Wognin, Daouda Diouf, Michel Alary
BACKGROUND: Despite Côte d'Ivoire epidemic being labelled as 'generalized', key populations (KP) are important to overall transmission. Using a dynamic model of HIV transmission, we previously estimated the impact of several treatment-as-prevention strategies that reached -or missed- the UNAIDS 90-90-90 targets in different populations groups, including KP and clients of female sex workers (CFSW). To inform program planning and resources allocation, we assessed the cost-effectiveness of these scenarios...
August 1, 2019: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Cai Jia, Giada Sebastiani
No abstract text is available yet for this article.
February 7, 2019: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Dr Nathan Hodson, Susan Bewley
No abstract text is available yet for this article.
February 7, 2019: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Sarah F Benki-Nugent, Ira Martopullo, Tony Laboso, Nancy Tamasha, Dalton C Wamalwa, Kenneth Tapia, Agnes Langat, Elizabeth Maleche-Obimbo, Christina M Marra, Paul Bangirana, Michael J Boivin, Grace C John-Stewart
BACKGROUND: Monocyte activation may contribute to neuronal injury in aviremic HIV-infected adults; data are lacking in children. We examined the relation between monocyte activation markers and early and long-term neurodevelopmental outcomes in early-treated HIV-infected children. SETTING: Prospective study of infant and child neurodevelopmental outcomes nested within a randomized clinical trial (NCT00428116) and extended cohort study in Kenya. METHODS: HIV-infected infants (N=67) initiated ART at age <5 months...
February 7, 2019: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Lisa Maher, Andrew Grulich, Adam Bourne, Mohamed Hammoud BPsych, Steffanie Vaccher, Benjamin Bavinton, Martin Holt, Fengyi Jin
INTRODUCTION: HIV pre-exposure prophylaxis (PrEP) has been increasingly adopted by gay and bisexual men (GBM). Little is known about whether individual GBM change their sexual behavior following PrEP initiation. METHODS: Following Lives Undergoing Change (Flux) is a national, online, prospective observational study among Australian GBM. Using McNemar statistics, we compare rates of sexual behaviors prior to and coincident with PrEP initiation among 1518 non HIV-positive men recruited between August 2014 and July 2017 who had not commenced PrEP at baseline and who completed at least one six-monthly follow-up surveys by July 2018...
February 7, 2019: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Yongjian Liu, Bin Su, Yu Zhang, Lei Jia, Hanping Li, Zhen Li, Jingwan Han, Tong Zhang, Tianyi Li, Hao Wu, Xiaolin Wang, Jingyun Li, Lin Li
BACKGROUND: Unique recombinant forms (URFs) were generated in dually-infected or multiply-infected individuals, and some of URFs can be transmitted to many people resulting in the emergence of circulating recombinant forms (CRFs). We examined whether there was evidence for onward transmission of multiple URFs among men who have sex with men (MSM) in Beijing. METHODS: A total of 146 MSM subjects with acute/early HIV-1 infection were recruited from the Beijing PRIMO clinical cohort between September 2010 and July 2012...
February 7, 2019: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Brittanny M Polanka, Suman Kundu, Kaku A So-Armah, Matthew S Freiberg, Samir K Gupta, Roger J Bedimo, Matthew J Budoff, Adeel A Butt, Chung-Chou H Chang, Stephen S Gottlieb, Vincent C Marconi, Julie A Womack, Jesse C Stewart
BACKGROUND: Insomnia is associated with increased cardiovascular disease (CVD) risk in the general population and is highly prevalent in people with HIV. The CVD risk conferred by insomnia in the HIV population is unknown. METHODS: Using the Veterans Aging Cohort Study-Survey Cohort, insomnia symptoms were measured and dummy coded with the item, "Difficulty falling or staying asleep?" (5-point scale from no difficulty to bothers a lot). Incident CVD event ICD-9 codes (acute myocardial infarction, stroke, or coronary artery revascularization) were identified with VA and Medicare administrative data and VA fee-for-service data...
February 7, 2019: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Elizabeth Fearon, Andrew Phillips, Sibongile Mtetwa, Sungai T Chabata, Phillis Mushati, Valentina Cambiano, Joanna Busza, Sue Napierala, Bernadette Hensen, Stefan Baral, Sharon S Weir, Brian Rice, Frances M Cowan, James R Hargreaves
BACKGROUND: 'HIV prevention cascades' have been proposed to support programmes by identifying gaps in demand for, access to and capability to adhere to HIV prevention tools, but there are few empirical examples to guide development. We apply a prevention cascade framework to examine prevention coverage and factors associated with condoms and/or PrEP adherence among female sex workers (FSW). SETTING: Seven sites across Zimbabwe. METHODS: Seven respondent-driven sampling (RDS) surveys from the intervention sites of a pragmatic cluster-randomised trial in Zimbabwe in 2016 were analysed, and 611/1439 women testing HIV-negative included...
February 7, 2019: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Anna Kula, Nadège Delacourt, Sophie Bouchat, Gilles Darcis, Veronique Avettand-Fenoel, Roxane Verdikt, Francis Corazza, Coca Necsoi, Caroline Vanhulle, Maryam Bendoumou, Arsene Burny, Stephane DE Wit, Christine Rouzioux, Oliver Rohr, Carine van Lint
OBJECTIVES: Few single latency-reversing agents (LRAs) have been tested in vivo and only some of them have demonstrated an effect, albeit weak, on the decrease of latent reservoir. Therefore, other LRAs and combinations of LRAs need to be assessed. Here, we evaluated the potential of combined treatments of therapeutically promising LRAs, disulfiram and romidepsin. SETTING: and methods: We assessed the reactivation potential of individual disulfiram or simultaneous or sequential combined treatments with romidepsin in vitro in latently-infected cell lines of T-lymphoid and myeloid origins and in ex vivo cultures of CD8-depleted peripheral blood mononuclear cells (PBMCs) isolated from 18 HIV-1 cART-treated individuals...
February 7, 2019: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Lynae A Darbes, Nuala M Mcgrath, Victoria Hosegood, Mallory O Johnson, Katherine Fritz, Thulani Ngubane, Heidi Van Rooyen
BACKGROUND: Although couples-based HIV testing and counseling (CHTC) is effective for facilitating mutual disclosure and linkage to HIV care, uptake remains low. Using a randomized controlled design, we tested the efficacy of a behavioral couples-based intervention aimed to increase CHTC. SETTING: The Vulindlela district of KwaZulu-Natal, South Africa. METHODS: Couples were recruited from the community (e.g., markets, community events). Couples were excluded if mutual HIV serostatus disclosure had occurred...
January 30, 2019: Journal of Acquired Immune Deficiency Syndromes: JAIDS
J Carlo Hojilla, Derek D Satre, David V Glidden, Vanessa M McMahan, Monica Gandhi, Patricia Defechereux, Juan V Guanira, Megha Mehrotra, Robert M Grant, Adam W Carrico
BACKGROUND: Concomitant use of cocaine and HIV pre-exposure prophylaxis (PrEP) raises important clinical questions around adherence, retention in care, and renal toxicity. METHODS: We assessed the associations of confirmed cocaine use with PrEP adherence (both ascertained via objective measures), care engagement, and renal function in the iPrEx open label extension. Cocaine use was measured in scalp hair samples and categorized as: light (500-3,000 pg/mg) and moderate to heavy (>3,000 pg/mg)...
January 25, 2019: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Ramandip Grewal, Vanessa G Allen, Ahmed M Bayoumi, Sandra L Gardner, Rupert Kaul, Tony Mazzulli, Veronika Moravan, Tyler O'neill, Janet Raboud, Sean B Rourke, Darrell Hs Tan, Ann N Burchell
BACKGROUND: Incidence of syphilis continues to rise among HIV-positive men who have sex with men (MSM) in Ontario. Our objective was to determine the effect of acute syphilis on virologic failure (VF) among virally suppressed HIV-positive MSM taking antiretroviral therapy (ART) and determine if the relationship is confounded by drug use. SETTING: The OHTN Cohort Study is a voluntary cohort of people receiving HIV care in Ontario. Syphilis and viral load (VL) data were retrieved via linkage with the provincial laboratory...
January 25, 2019: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Daniel P O'Brien, Nathan Ford, Amadou Garba Djirmay, Alexandra Calmy, Marco Vitoria, Tomas O Jensen, Vanessa Christinet
Evidence suggests that there are important interactions between HIV and Female Genital Schistosomiasis (FGS) that may have significant effects on individual and population health. However, the exact way they interact and the health impacts of the interactions are not well understood. In this paper we discuss what is known about the interactions between FGS and HIV, and the potential impact of the interactions. This includes the likelihood that FGS is an important health problem for HIV positive women in schistosoma-endemic areas potentially associated with an increased risk of mortality, cancer and infertility...
January 25, 2019: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Jeanne Sibiude, Josiane Warszawski, Roland Tubiana, Jérôme LE Chenadec, Françoise Meier, Albert Faye, Stéphane Blanche, Laurent Mandelbrot
BACKGROUND: High rates of liver enzyme elevation (LEE) in women receiving antiretroviral treatment (ART) during pregnancy have been reported but causes remain unclear. We estimated the prevalence and risk factors of LEE in a national prospective multicenter cohort. METHODS: We studied 5748 pregnant women living with HIV enrolled in the French Perinatal Cohort 2005-2014, treated with ART, with no active hepatitis B or C co-infection. Adjusted hazard ratio (aHR) were estimated using Cox models with ART as time-dependent variable, separately for women on ART at conception and those initiating ART during pregnancy...
January 17, 2019: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Heena Brahmbhatt, John Santelli, Joseph Kaagayi, Tom Lutalo, David Serwadda, Frederick Makumbi
BACKGROUND: The desire for more children and pregnancy rates are influenced by many relationship dynamics and HIV sero-status of couples. SETTING: Rakai Community Cohort Study (RCCS) in Uganda METHODS:: Couple data were retrospectively linked from survey rounds between 2007-15 to assess drivers of fertility desire and pregnancy incidence by HIV status (M-F-; M+F+; M-F+; M+F-). Multivariable modified Poisson regression was used to estimate Prevalence Ratios (PR) of fertility desire, while multivariable Poisson regression was used to estimate incidence rate ratios (IRR) of pregnancy associated with couple characteristics...
January 17, 2019: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Monica Gandhi, Peter Bacchetti, Matthew A SpinelliI, Hideaki Okochi, Jared M Baeten, Oraphan Siriprakaisil, Virat Klinbuayaem, Warren C Rodrigues, Guohang Wang, Michael Vincent, Tim R Cressey, Paul K Drain
BACKGROUND: Current pharmacologic adherence monitoring for antiretrovirals involves expensive, labor-intensive liquid-chromatography/tandem-mass-spectrometry (LC-MS/MS)-based methods. Antibody-based assays can monitor and support adherence in real-time. We developed a tenofovir (TFV)-based immunoassay and further validated it in a directly-observed-therapy (DOT) study. DESIGN: Pharmacologic DOT study of TFV disoproxil fumarate (TDF)/emtricitabine (FTC) administered to HIV-noninfected volunteers METHODS:: The TARGET study provided directly-observed TDF 300mg/FTC 200mg 7 (high adherence), 4 (moderate) and 2 doses/week (low) to 30 volunteers (10/group) in Thailand, collecting a total of 637 urine samples over 6-weeks of administration and during wash-out...
January 11, 2019: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Beverly Yu, Elizabeth Pasipanodya, Jessica L Montoya, Raeanne C Moore, Sara Gianella, Allen McCutchan, Ron Ellis, Robert K Heaton, Dilip V Jeste, David J Moore, María J Marquine
BACKGROUND: The adverse consequences of HIV and related comorbidities on the central nervous system remain prevalent in the era of combination antiretroviral therapy. Metabolic syndrome (MetS) is a common comorbidity in HIV and has been linked to increased neurocognitive impairment in the general population. We investigated the association between MetS and neurocognition among persons living with HIV (PLHIV). METHODS: Participants included 109 PLHIV and 92 HIV-uninfected (HIV-) adults from the Multi-dimensional Successful Aging cohort study at the University of California San Diego (Age: M=50...
January 9, 2019: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Nguyen K Tran, Mark L Hatzenbuehler, Neal D Goldstein
No abstract text is available yet for this article.
January 9, 2019: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Jeffrey A Boatman, Jason V Baker, Sean Emery, Hansjakob Furrer, David M Mushatt, Dalibor Sedlacek, Jens D Lundgren, James D Neaton
BACKGROUND: Low CD4+ recovery among HIV-positive individuals who achieve virologic suppression is common but has not been studied among individuals initiating treatment at CD4+ counts > 500 cells/mm. SETTING: United States, Africa, Asia, Europe & Israel, Australia, Latin America. METHODS: Among immediate-ART participants in the Strategic Timing of AntiRetroviral Therapy trial, low CD4+ recovery was defined as a CD4+ increase < 50 cells/mm from baseline after 8 months despite viral load ≤ 200 copies/mL...
January 9, 2019: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Jessica Long, Michalina Montaño, Robinson Cabello, Hugo Sanchez, Javier R Lama, Ann Duerr
BACKGROUND: Transgender women (TW) and men who have sex with men (MSM) are often conflated in HIV research and prevention programs, despite clear differences that exist in culture and behavior. METHODS: We examined baseline data from a large treatment-as-prevention study among TW and MSM in Lima, Peru, to assess differences in risk behavior. Baseline assessment included HIV testing and a questionnaire including socio-demographics, sexual behavior, social venue attendance, and drug and alcohol use...
January 9, 2019: Journal of Acquired Immune Deficiency Syndromes: JAIDS
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