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Journals European Journal of Nuclear Me...

European Journal of Nuclear Medicine and Molecular Imaging

https://read.qxmd.com/read/38761187/-68-ga-ga-fapi-46-pet-ct-for-penile-cancer-a-feasibility-study
#1
JOURNAL ARTICLE
Lennert Eismann, Stephan T Ledderose, Benazir Enzinger, Elena Berg, Thilo Westhofen, Severin Rodler, Gerald B Schulz, Johannes Toms, Adrien Holzgreve, Franz J Gildehaus, Matthias Brendel, Clemens C Cyran, Marcus Unterrainer, Christian G Stief, Peter Bartenstein, Boris Schlenker, Lena M Unterrainer
PURPOSE: Penile cancer is a rare entity and has a good prognosis in localized stage. Delayed surgical treatment of lymphatic disease is associated with poor overall survival but conventional imaging cannot detect occult lymph node metastasis sufficiently. Imaging cancer related fibroblasts has shown promising results as non-invasive staging tool in various tumor entities but has not yet been evaluated in penile cancer. METHODS: In this single-center pilot study, patients planned for surgical treatment for penile cancer underwent preoperatively [68 Ga]Ga-FAPI-46 PET/CT...
May 18, 2024: European Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/38758370/assessment-of-cerebral-drug-occupancy-in-humans-using-a-single-pet-scan-a-11-c-ucb-j-pet-study
#2
JOURNAL ARTICLE
Maja R Marstrand-Joergensen, Gjertrud L Laurell, Susan Herrmann, Arafat Nasser, Annette Johansen, Anton Lund, Thomas L Andersen, Gitte M Knudsen, Lars H Pinborg
PURPOSE: Here, we evaluate a PET displacement model with a Single-step and Numerical solution in healthy individuals using the synaptic vesicle glycoprotein (SV2A) PET-tracer [11 C]UCB-J and the anti-seizure medication levetiracetam (LEV). We aimed to (1) validate the displacement model by comparing the brain LEV-SV2A occupancy from a single PET scan with the occupancy derived from two PET scans and the Lassen plot and (2) determine the plasma LEV concentration-SV2A occupancy curve in healthy individuals...
May 17, 2024: European Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/38758369/distinct-18-f-fdg-pet-imaging-features-of-a-newly-recognized-and-yet-uncharacterized-rdd-ecd-overlap-disease-entity
#3
JOURNAL ARTICLE
Martin W Huellner, Marco M Bühler, Viktor H Kölzer, Perparim Limani, Wiebke Rösler
No abstract text is available yet for this article.
May 17, 2024: European Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/38750372/fapi-pet-uptake-patterns-after-invasive-medical-interventions-a-single-center-retrospective-analysis
#4
JOURNAL ARTICLE
Peter George Maliha, Masatoshi Hotta, Andrea Farolfi, Tristan Grogan, Rejah Alano, Andrea Limon, Ethan Lam, Giuseppe Carlucci, Shadfar Bahri, Ali Salavati, Matthias Benz, Daniel Silverman, Pawan Gupta, Andrew Quon, Martin Allen-Auerbach, Johannes Czernin, Jeremie Calais
PURPOSE: Fibroblast activation protein (FAP)-inhibitor (FAPI)-PET tracers allow imaging of the FAP-expressing cancer associated fibroblasts (CAF) and also the normal activated fibroblasts (NAF) involved in inflammation/fibrosis that may be present after invasive medical interventions. We evaluated [68Ga]Ga-FAPI-46 uptake patterns post-medical/invasive non-systemic interventions. METHODS: This single-center retrospective analysis was conducted in 79 consecutive patients who underwent [68 Ga]Ga-FAPI-46 PET/CT...
May 16, 2024: European Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/38743134/comment-on-is-work-overload-associated-with-diagnostic-errors-on-18-f-fdg-pet-ct
#5
LETTER
Guillaume Hourcau, David Taïeb
No abstract text is available yet for this article.
May 14, 2024: European Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/38740576/joint-eanm-snmmi-guideline-on-the-role-of-2-18-f-fdg-pet-ct-in-no-special-type-breast-cancer-endorsed-by-the-acr-%C3%A2-esso-estro-eusobi-esr-and-eusoma
#6
JOURNAL ARTICLE
Sofia C Vaz, John Patrick Pilkington Woll, Fatima Cardoso, David Groheux, Gary J R Cook, Gary A Ulaner, Heather Jacene, Isabel T Rubio, Jan W Schoones, Marie-Jeanne Vrancken Peeters, Philip Poortmans, Ritse M Mann, Stephanie L Graff, Elizabeth H Dibble, Lioe-Fee de Geus-Oei
INTRODUCTION: There is much literature about the role of 2-[18 F]FDG PET/CT in patients with breast cancer (BC). However, there exists no international guideline with involvement of the nuclear medicine societies about this subject. PURPOSE: To provide an organized, international, state-of-the-art, and multidisciplinary guideline, led by experts of two nuclear medicine societies (EANM and SNMMI) and representation of important societies in the field of BC (ACR, ESSO, ESTRO, EUSOBI/ESR, and EUSOMA)...
May 14, 2024: European Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/38740575/cholecystokinin-2-receptor-targeting-by-68-ga-ga-dota-mgs5-pet-ct-in-a-patient-with-extensive-disease-small-cell-lung-cancer
#7
JOURNAL ARTICLE
Gianpaolo Di Santo, Giulia Santo, Vladan Martinovic, Dominik Wolf, Andreas Pircher, Anna Sviridenko, Judith Löffler-Ragg, Elisabeth von Guggenberg, Irene Virgolini
No abstract text is available yet for this article.
May 14, 2024: European Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/38735885/the-eanm-snmmi-guideline-on-the-role-of-18f-fdg-pet-ct-in-breast-cancer-important-milestones-and-perspectives-for-the-future
#8
EDITORIAL
Elif Hindié
No abstract text is available yet for this article.
May 13, 2024: European Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/38730087/radiolabelling-and-preclinical-characterisation-of-89-zr-zr-df-atg-101-bispecific-to-pd-l1-4-1bb
#9
JOURNAL ARTICLE
Zhipeng Cao, Christian Werner Wichmann, Ingrid Julienne Georgette Burvenich, Laura Danielle Osellame, Nancy Guo, Angela Rigopoulos, Graeme Joseph O'Keefe, Fiona Elizabeth Scott, Nirmal Lorensuhewa, Kevin Patrick Lynch, Andrew Mark Scott
PURPOSE: ATG-101, a bispecific antibody that simultaneously targets the immune checkpoint PD-L1 and the costimulatory receptor 4-1BB, activates exhausted T cells upon PD-L1 crosslinking. Previous studies demonstrated promising anti-tumour efficacy of ATG-101 in preclinical models. Here, we labelled ATG-101 with 89 Zr to confirm its tumour targeting effect and tissue biodistribution in a preclinical model. We also evaluated the use of immuno-PET to study tumour uptake of ATG-101 in vivo...
May 11, 2024: European Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/38730086/cyp3a4-inhibitors-may-influence-the-quantification-of-123-i-i-fp-cit-spect-scans
#10
JOURNAL ARTICLE
Jan Booij, Eda Yağci, Zulfiqar H Sheikh, Youssef Chahid
PURPOSE: [123 I]I-FP-CIT SPECT is an imaging tool to support the diagnosis of parkinsonian syndromes characterized by nigrostriatal dopaminergic degeneration. After intravenous injection, [123 I]I-FP-CIT is metabolized for a small part by the enzyme CYP3A4, leading to the formation of [123 I]I-nor-β-CIT. [123 I]I-nor-β-CIT passes the blood-brain barrier and has a very high affinity for the serotonin transporter (SERT). The SERT is expressed in the striatum and cortical areas...
May 11, 2024: European Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/38730085/biological-characterization-of-renal-masses-using-immuno-pet
#11
EDITORIAL
Fabrizia Gelardi, Alessandro Larcher, Lidija Antunovic, Umberto Capitanio, Andrea Salonia, Arturo Chiti
No abstract text is available yet for this article.
May 11, 2024: European Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/38730084/coronary-sodium-18-f-fluoride-activity-predicts-outcomes-post-cabg-a-comparative-evaluation-with-conventional-metrics
#12
JOURNAL ARTICLE
Mingxin Gao, Wanwan Wen, Haiyang Li, Yaqi Zheng, Mingkai Yun, Jingjing Meng, Shipan Wang, Bolin Wang, Biao Hu, Tiantian Mou, Yang Yu, Xiaoli Zhang, Xiang Li
PURPOSE: The value of preoperative multidisciplinary approach remains inadequately delineated in forecasting postoperative outcomes of patients undergoing coronary artery bypass grafting (CABG). Herein, we aimed to ascertain the efficacy of multi-modality cardiac imaging in predicting post-CABG cardiovascular outcomes. METHODS: Patients with triple coronary artery disease underwent cardiac sodium [18 F]fluoride ([18 F]NaF) positron emission tomography/computed tomography (PET/CT), coronary angiography, and CT-based coronary artery calcium scoring before CABG...
May 11, 2024: European Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/38730083/seasonal-variation-in-d2-3-dopamine-receptor-availability-in-the-human-brain
#13
JOURNAL ARTICLE
Lihua Sun, Tuulia Malén, Jouni Tuisku, Valtteri Kaasinen, Jarmo A Hietala, Juha Rinne, Pirjo Nuutila, Lauri Nummenmaa
PURPOSE: Brain functional and physiological plasticity is essential to combat dynamic environmental challenges. The rhythmic dopamine signaling pathway, which regulates emotion, reward and learning, shows seasonal patterns with higher capacity of dopamine synthesis and lower number of dopamine transporters during dark seasons. However, seasonal variation of the dopamine receptor signaling remains to be characterized. METHODS: Based on a historical database of healthy human brain [11 C]raclopride PET scans (n = 291, 224 males and 67 females), we investigated the seasonal patterns of D2/3 dopamine receptor signaling...
May 11, 2024: European Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/38727829/diagnostic-efficacy-of-68-ga-ga-dota-gpfapi-04-in-patients-with-solid-tumors-in-a-head-to-head-comparison-with-18-f-f-fdg-results-from-a-prospective-clinical-study
#14
JOURNAL ARTICLE
Hui Yuan, Entao Liu, Guojin Zhang, Chaoquan Lai, Qing Zhang, Yuxiang Shang, Zhen Cheng, Lei Jiang
PURPOSE: To identify the biodistribution and diagnostic performance of a novel fibroblast activation protein (FAP) targeted positron emission tomography (PET) tracer, [68 Ga]Ga-DOTA-GPFAPI-04, in patients with solid tumors in a head-to-head comparison with [18 F]F-FDG. METHODS: Twenty-six patients histologically proven with cancers of nasopharyngeal (n = 5), esophagus (n = 5), gastro-esophagus (n = 1), stomach (n = 7), liver (n = 3), and colorectum (n = 5) were recruited for [68 Ga]Ga-DOTA-GPFAPI-04 and [18 F]F-FDG PET/CT scans on consecutive days...
May 10, 2024: European Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/38724654/a-head-to-head-comparison-of-68-ga-ga-dotatate-and-68-ga-ga-fapi-pet-ct-in-patients-with-nasopharyngeal-carcinoma-a-single-center-prospective-study
#15
JOURNAL ARTICLE
Jieling Zheng, Guochang Wang, Qian Ru, Yun Yang, Li Su, Wenlong Lv, Chunlin Ke, Peirong Wang, Xiaohui Liu, Li Zhang, Feng Liu, Weibing Miao
PURPOSE: We aimed to compare the staging efficiency of [68 Ga]Ga-DOTATATE and [68 Ga]Ga-FAPI PET/CT in nasopharyngeal carcinoma (NPC) patients. METHODS: Thirty-nine patients with pathologically confirmed NPC were enrolled in this prospective study. Each patient underwent paired [68 Ga]Ga-DOTATATE and [68 Ga]Ga-FAPI PET/CT on 2 successive days. The accuracy of two PET/CT for assessing T, N, and M stages was compared by using head-and-neck MRI, histopathologic diagnosis and follow-up results as reference standards...
May 10, 2024: European Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/38724653/pre-therapy-pet-based-voxel-wise-dosimetry-prediction-by-characterizing-intra-organ-heterogeneity-in-psma-directed-radiopharmaceutical-theranostics
#16
JOURNAL ARTICLE
Song Xue, Andrei Gafita, Yu Zhao, Lorenzo Mercolli, Fangxiao Cheng, Isabel Rauscher, Calogero D'Alessandria, Robert Seifert, Ali Afshar-Oromieh, Axel Rominger, Matthias Eiber, Kuangyu Shi
BACKGROUND AND OBJECTIVE: Treatment planning through the diagnostic dimension of theranostics provides insights into predicting the absorbed dose of RPT, with the potential to individualize radiation doses for enhancing treatment efficacy. However, existing studies focusing on dose prediction from diagnostic data often rely on organ-level estimations, overlooking intra-organ variations. This study aims to characterize the intra-organ theranostic heterogeneity and utilize artificial intelligence techniques to localize them, i...
May 9, 2024: European Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/38722383/total-body-imaging-of-mu-opioid-receptors-with-11-c-carfentanil-in-non-human-primates
#17
JOURNAL ARTICLE
Chia-Ju Hsieh, Catherine Hou, Hsiaoju Lee, Cosette Tomita, Alexander Schmitz, Konstantinos Plakas, Jacob G Dubroff, Robert H Mach
PURPOSE: Mu-opioid receptors (MORs) are widely expressed in the central nervous system (CNS), peripheral organs, and immune system. This study measured the whole body distribution of MORs in rhesus macaques using the MOR selective radioligand [11 C]carfentanil ([11 C]CFN) on the PennPET Explorer. Both baseline and blocking studies were conducted using either naloxone or GSK1521498 to measure the effect of the antagonists on MOR binding in both CNS and peripheral organs. METHODS: The PennPET Explorer was used for MOR total-body PET imaging in four rhesus macaques using [11 C]CFN under baseline, naloxone pretreatment, and naloxone or GSK1521498 displacement conditions...
May 9, 2024: European Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/38722382/imaging-car-nk-cells-targeted-to-her2-ovarian-cancer-with-human-sodium-iodide-symporter-based-positron-emission-tomography
#18
JOURNAL ARTICLE
Nourhan Shalaby, Ying Xia, John J Kelly, Rafael Sanchez-Pupo, Francisco Martinez, Matthew S Fox, Jonathan D Thiessen, Justin W Hicks, Timothy J Scholl, John A Ronald
Chimeric antigen receptor (CAR) cell therapies utilize CARs to redirect immune cells towards cancer cells expressing specific antigens like human epidermal growth factor receptor 2 (HER2). Despite their potential, CAR T cell therapies exhibit variable response rates and adverse effects in some patients. Non-invasive molecular imaging can aid in predicting patient outcomes by tracking infused cells post-administration. CAR-T cells are typically autologous, increasing manufacturing complexity and costs. An alternative approach involves developing CAR natural killer (CAR-NK) cells as an off-the-shelf allogeneic product...
May 9, 2024: European Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/38722381/the-impact-of-pet-ct-and-brain-mri-for-metastasis-detection-among-patients-with-clinical-t1-category-lung-cancer-findings-from-a-large-scale-cohort-study
#19
JOURNAL ARTICLE
Yi Feng, Bo Cheng, Shuting Zhan, Haiping Liu, Jianfu Li, Peiling Chen, Zixun Wang, Xiaoyan Huang, Xiuxia Fu, Wenjun Ye, Runchen Wang, Qixia Wang, Yang Xiang, Huiting Wang, Feng Zhu, Xin Zheng, Wenhai Fu, Guodong Hu, Zhuxing Chen, Jianxing He, Wenhua Liang
PURPOSE: [18 F]-FDG PET/CT and brain MRI are common approaches to detect metastasis in patients of lung cancer. Current guidelines for the use of PET/CT and MRI in clinical T1-category lung cancer lack risk-based stratification and require optimization. This study stratified patients based on metastatic risk in terms of the lesions' size and morphological characteristics. METHODS: The detection rate of metastasis was measured in different sizes and morphological characteristics (solid and sub-solid) of tumors...
May 9, 2024: European Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/38717592/assessment-of-18-f-pi-2620-tau-pet-quantification-via-non-invasive-automatized-image-derived-input-function
#20
JOURNAL ARTICLE
Maria Meindl, Artem Zatcepin, Johannes Gnörich, Maximilian Scheifele, Mirlind Zaganjori, Mattes Groß, Simon Lindner, Rebecca Schaefer, Marcel Simmet, Sebastian Roemer, Sabrina Katzdobler, Johannes Levin, Günter Höglinger, Ann-Cathrin Bischof, Henryk Barthel, Osama Sabri, Peter Bartenstein, Thomas Saller, Nicolai Franzmeier, Sibylle Ziegler, Matthias Brendel
PURPOSE: [18 F]PI-2620 positron emission tomography (PET) detects misfolded tau in progressive supranuclear palsy (PSP) and Alzheimer's disease (AD). We questioned the feasibility and value of absolute [18 F]PI-2620 PET quantification for assessing tau by regional distribution volumes (VT ). Here, arterial input functions (AIF) represent the gold standard, but cannot be applied in routine clinical practice, whereas image-derived input functions (IDIF) represent a non-invasive alternative...
May 8, 2024: European Journal of Nuclear Medicine and Molecular Imaging
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