Carmen Leon-Astudillo, Prasad D Trivedi, Ramon C Sun, Matthew S Gentry, David D Fuller, Barry J Byrne, Manuela Corti
PURPOSE OF REVIEW: Pompe disease is a rare, inherited, devastating condition that causes progressive weakness, cardiomyopathy and neuromotor disease due to the accumulation of glycogen in striated and smooth muscle, as well as neurons. While enzyme replacement therapy has dramatically changed the outcome of patients with the disease, this strategy has several limitations. Gene therapy in Pompe disease constitutes an attractive approach due to the multisystem aspects of the disease and need to address the central nervous system manifestations...
October 1, 2023: Current Opinion in Neurology