journal
https://read.qxmd.com/read/38686443/expanding-the-access-to-kidney-transplantation-strategies-for-kidney-transplant-programs
#21
REVIEW
Angie G Nishio Lucar, Ankita Patel, Shikha Mehta, Anju Yadav, Mona Doshi, Megan A Urbanski, Beatrice P Concepcion, Neeraj Singh, M Lee Sanders, Arpita Basu, Jessica L Harding, Ana Rossi, Oluwafisayo O Adebiyi, Milagros Samaniego-Picota, Kenneth J Woodside, Ronald F Parsons
Kidney transplantation is the most successful kidney replacement therapy available, resulting in improved recipient survival and societal cost savings. Yet, nearly 70 years after the first successful kidney transplant, there are still numerous barriers and untapped opportunities that constrain the access to transplant. The literature describing these barriers is extensive, but the practices and processes to solve them are less clear. Solutions must be multidisciplinary and be the product of strong partnerships among patients, their networks, health care providers, and transplant programs...
May 2024: Clinical Transplantation
https://read.qxmd.com/read/38686437/real-life-use-of-letermovir-prophylaxis-for-cytomegalovirus-in-heart-transplant-recipients
#22
JOURNAL ARTICLE
Grégoire Saltiel, Emmanuel Faure, Ady Assaf, Marie-Charlotte Chopin, Fanny Moreau, Karine Faure, Céline Goeminne, Fanny Vuotto
INTRODUCTION: Cytomegalovirus (CMV) remains the predominant opportunistic infection following solid organ transplantation (SOT). While valganciclovir is the drug of choice for CMV prophylaxis, its utility can be compromised due to the risk of cytopenia. Letermovir, a novel agent approved for CMV prophylaxis in allogeneic hematopoietic stem cell transplant recipients and high-risk kidney transplant recipients, exhibits reduced toxicity. This study aims to present the practical application of letermovir as both primary and secondary prophylaxis against CMV in heart transplant recipients (HTR)...
May 2024: Clinical Transplantation
https://read.qxmd.com/read/38683684/impact-of-delayed-listing-after-initiating-kidney-transplant-evaluation-on-transplant-outcomes
#23
JOURNAL ARTICLE
Lisa Ly, Danting Zhu, Douglas E Schaubel, Kenneth J Woodside, Randall S Sung
OBJECTIVE: Longer end-stage renal disease time has been associated with inferior kidney transplant outcomes. However, the contribution of transplant evaluation is uncertain. We explored the relationship between time from evaluation to listing (ELT) and transplant outcomes. METHODS: This retrospective study included 2535 adult kidney transplants from 2000 to 2015. Kaplan-Meier survival curves, log-rank tests, and Cox regression models were used to compare transplant outcomes...
May 2024: Clinical Transplantation
https://read.qxmd.com/read/38678589/impact-of-hyperparathyroidism-on-allograft-histology-and-function-after-kidney-transplantation-rethinking-its-causal-role-in-graft-dysfunction
#24
JOURNAL ARTICLE
Gabriel Cojuc-Konigsberg, Denisse Tinajero-Sánchez, Vianca Anabel Canaviri-Flores, Omar Fueyo-Rodríguez, Norma O Uribe-Uribe, Lluvia A Marino-Vazquez, Luis Eduardo Morales-Buenrostro, Juan C Ramirez-Sandoval
INTRODUCTION: The causal relationship between hyperparathyroidism and kidney graft dysfunction remains inconclusive. Applying Bradford-Hill's temporality and consistency causation principles, we assessed the effect of parathyroid hormone (iPTH) on graft histology and eGFR trajectory on kidney transplant recipients (KTRs) with normal time-zero graft biopsies. METHODS: Retrospective cohort study evaluating the effect of hyperparathyroidism on interstitial fibrosis and tubular atrophy (IF/TA) development in 1232 graft biopsies...
May 2024: Clinical Transplantation
https://read.qxmd.com/read/38678588/cxcl9-and-cxcl10-as-biomarkers-of-kidney-graft-inflammation-across-multiple-conditions
#25
LETTER
Ilaria Gandolfini, Benedetta Mordà, Elene Martinelli, Marco Delsante, GiovanniMaria Rossi, Micaela Gentile, Sara Alibrandi, Daniel Salvetti, Enrico Fiaccadori, Alessandra Palmisano, Paolo Cravedi, Umberto Maggiore
No abstract text is available yet for this article.
May 2024: Clinical Transplantation
https://read.qxmd.com/read/38678586/recipient-donor-sex-combinations-in-solid-organ-transplantation-and-impact-on-clinical-outcome-a-scoping-review
#26
REVIEW
Christian Tibor Josef Magyar, Charlene Pierrine Gretener, Patricia Baldi, Federico Storni, Corina Kim-Fuchs, Daniel Candinas, Annalisa Berzigotti, Matthias Knecht, Guido Beldi, Cédric Hirzel, Daniel Sidler, David Reineke, Vanessa Banz
INTRODUCTION: Solid organ transplantation (SOT) is a lifesaving treatment for end-stage organ failure. Although many factors affect the success of organ transplantation, recipient and donor sex are important biological factors influencing transplant outcome. However, the impact of the four possible recipient and donor sex combinations (RDSC) on transplant outcome remains largely unclear. METHODS: A scoping review was carried out focusing on studies examining the association between RDSC and outcomes (mortality, graft rejection, and infection) after heart, lung, liver, and kidney transplantation...
May 2024: Clinical Transplantation
https://read.qxmd.com/read/38634157/influence-of-cardiac-diagnosis-on-outcomes-of-pediatric-heart-lung-transplantation
#27
JOURNAL ARTICLE
Sandeep Sainathan, John Ryan, Leonardo Mullinari, Pablo Sanchez
OBJECTIVE: Pediatric Heart-lung transplant (HLTX) is performed for endstage congenital heart disease (CHD) with irreversible pulmonary hypertension or non-congenital heart disease (NCHD) with end-stage heart and lung disease. CHD could influence the outcomes of HTLX due to increased complexity of the operation as compared to NCHD. In this study we evaluated the influence of cardiac diagnosis on outcomes of pediatric HTLX. METHODS: The UNOS database (1987-2022) was queried for primary HTLX in patients <18 years...
April 2024: Clinical Transplantation
https://read.qxmd.com/read/38628057/extracellular-vesicles-as-potential-diagnostic-markers-for-kidney-allograft-rejection
#28
REVIEW
Harit Thongwitokomarn, Kajohnsak Noppakun, Romanee Chaiwarith, Siriporn C Chattipakorn, Nipon Chattipakorn
Kidney transplantation is a highly effective treatment for end-stage kidney disease. However, allograft rejection remains a significant clinical challenge in kidney transplant patients. Although kidney allograft biopsy is the gold-standard diagnostic method, it is an invasive procedure. Since the current monitoring methods, including screening of serum creatinine and urinary protein, are not of sufficient sensitivity, there is a need for effective post-transplant monitoring to detect allograft rejection at an early stage...
April 2024: Clinical Transplantation
https://read.qxmd.com/read/38619321/transplant-nephropathology-wherefrom-wherein-and-whereto
#29
REVIEW
Kim Solez, Garabed Eknoyan
Renal pathology is a relatively recent entry in nephrology. While diseases of the kidney are old, their study began in the 19th century with the report of Richard Bright of the lesions of end-stage kidney disease. Its easy diagnosis from albuminuria soon elevated Bright's nephritis into a leading cause of death. The transformative events in the care of these cases were renal replacement therapy that converted a fatal into a chronic disease, and kidney biopsy that allowed study of the course and pathogenesis of kidney disease...
April 2024: Clinical Transplantation
https://read.qxmd.com/read/38616573/intraoperative-renal-replacement-therapy-during-liver-transplantation-in-children-safety-efficacy-and-impact-on-survival
#30
JOURNAL ARTICLE
Kristin J Dolan, Ayse Arikan, Anna M Banc-Husu, Muhammad Umair Mukhtar Mian, Sameer Thadani, Jeffrey Quinn Lee, Lacey Stribling, N Thao N Galván, John Goss, Rahul Baijal, Moreshwar S Desai
BACKGROUND: Intraoperative Continuous Renal Replacement Therapy (iCRRT) can prevent life-threatening complications, facilitate fluid management, and maintain metabolic homeostasis during liver transplantation (LT) in adults. There is a paucity of data in pediatric LT. We evaluated the safety, efficacy, and impact on survival of iCRRT in pediatric LT. METHODS: We conducted a retrospective cohort study of all children requiring CRRT pre-OLT at a quaternary children's hospital from 2014 to 2022...
April 2024: Clinical Transplantation
https://read.qxmd.com/read/38616569/kidney-after-liver-transplantation-does-not-have-an-increased-risk-of-rejection-compared-to-liver-alone
#31
JOURNAL ARTICLE
Peter Ghali, Ramez M Ibrahim, David Hodge, Launia White, Hani M Wadei
BACKGROUND: Simultaneous liver kidney (SLK) transplant protects against acute cellular rejection. In 2017, UNOS implemented a "safety net" policy to allow patients with renal recovery to avoid renal transplantation. Whether kidney after liver transplantation (KALT) increases the risk of rejection is unknown. METHODS: We performed a retrospective analysis of the Organ Procurement and Transplantation Network (OPTN) database of adult patients who received liver transplant, SLK or KALT between 2010 and 2020...
April 2024: Clinical Transplantation
https://read.qxmd.com/read/38607291/lightgbm-outperforms-other-machine-learning-techniques-in-predicting-graft-failure-after-liver-transplantation-creation-of-a-predictive-model-through-large-scale-analysis
#32
JOURNAL ARTICLE
Rintaro Yanagawa, Kazuhiro Iwadoh, Miho Akabane, Yuki Imaoka, Kliment Krassimirov Bozhilov, Marc L Melcher, Kazunari Sasaki
BACKGROUND: The incidence of graft failure following liver transplantation (LTx) is consistent. While traditional risk scores for LTx have limited accuracy, the potential of machine learning (ML) in this area remains uncertain, despite its promise in other transplant domains. This study aims to determine ML's predictive limitations in LTx by replicating methods used in previous heart transplant research. METHODS: This study utilized the UNOS STAR database, selecting 64,384 adult patients who underwent LTx between 2010 and 2020...
April 2024: Clinical Transplantation
https://read.qxmd.com/read/38607287/impact-of-age-over-70-years-in-the-new-allocation-system-on-the-outcomes-of-heart-transplantation-in-the-us
#33
JOURNAL ARTICLE
Marco Gemelli, Ilias P Doulamis, Mariangela Addonizio, Aspasia Tzani, Athanasios Rempakos, Polydoros Kampaktsis, Alvise Guariento, Ernesto Ruiz Dunque, Rabea Asleh, Paulino Alvarez, Alexandros Briasoulis
BACKGROUND: United Network for Organ Sharing (UNOS) allocation criteria changed in 2018 to accommodate the increased prevalence of patients on a ventricular assist device as a bridge to heart transplant and prioritize sicker people in anticipation of a heart graft. We aimed to assess the impact of patient age in the new allocation policy on mortality following heart transplantation. Secondary outcomes included the effect of age ≥70 on post-transplant events, including stroke, dialysis, pacemaker, and rejection requiring treatment...
April 2024: Clinical Transplantation
https://read.qxmd.com/read/38591128/performance-status-at-the-time-of-lung-retransplant-predicts-long-term-function
#34
JOURNAL ARTICLE
Rachel L Deitz, Sarah Clifford, John P Ryan, Ernest G Chan, Jenalee N Coster, Masashi Furukawa, Chadi A Hage, Pablo G Sanchez
BACKGROUND: Lung retransplantation is offered to select patients with chronic allograft dysfunction. Given the increased risk of morbidity and mortality conferred by retransplantation, post-transplant function should be considered in the decision of who and when to list. The aim of this study is to identify predictors of post-operative disability in patients undergoing lung retransplantation. METHODS: Data were collected from the UNOS national dataset and included all patients who underwent lung retransplant from May 2005-March 2023...
April 2024: Clinical Transplantation
https://read.qxmd.com/read/38591111/cardiovascular-outcomes-in-solid-organ-transplant-recipients-undergoing-cardiac-surgery-a-matched-pair-analysis
#35
JOURNAL ARTICLE
Kitae Kim, Sung-Ho Jung, Hong Rae Kim, Jae Suk Yoo, Joon Bum Kim, Cheol Hyun Chung
INTRODUCTION: This study aimed to compare postoperative outcomes after cardiac surgery in solid-organ transplant recipients and nontransplant patients. METHODS: We performed a retrospective analysis of 78 consecutive transplant recipients who underwent cardiac surgery at Asan Medical Center between 2000 and 2022 and were matched with 312 nontransplant patients who underwent cardiac surgery at a 1:4 ratio. The outcomes included 30-day mortality, all-cause death, cardiac death, readmission, and cardiac readmission...
April 2024: Clinical Transplantation
https://read.qxmd.com/read/38581299/effects-of-cd34-cell-dose-on-engraftment-and-long-term-outcomes-after-allogeneic-bone-marrow-transplantation
#36
JOURNAL ARTICLE
Takashi Oyama, Shin-Ichiro Fujiwara, Ryutaro Tominaga, Daizo Yokoyama, Atsuto Noguchi, Shuka Furuki, Shunsuke Koyama, Rui Murahashi, Hirotomo Nakashima, Kazuki Hyodo, Takashi Ikeda, Shin-Ichiro Kawaguchi, Yumiko Toda, Takashi Nagayama, Kento Umino, Daisuke Minakata, Kaoru Morita, Masahiro Ashizawa, Chihiro Yamamoto, Kaoru Hatano, Kazuya Sato, Ikuko Otsuki, Ken Ohmine, Yoshinobu Kanda
BACKGROUND: The number of CD34+ cells in the graft is generally associated with time to engraftment and survival in transplantation using cord blood or allogeneic peripheral blood stem cells. However, the significance of abundant CD34+ in bone marrow transplantation (BMT) remained unclear. METHODS: We retrospectively reviewed 207 consecutive adult patients who underwent their first BMT at Jichi Medical University between January 2009 and June 2021. RESULTS: The median nucleated cell count (NCC) and CD34+ cell dose were 2...
April 2024: Clinical Transplantation
https://read.qxmd.com/read/38581296/association-of-physical-activity-with-fractures-in-kidney-transplant-recipients-a-korean-nationwide-cohort-study
#37
JOURNAL ARTICLE
Sungmi Kim, Jin-Hyung Jung, Kyungho Lee, Junseok Jeon, Dong Wook Shin, Hye Ryoun Jang, Jung Eun Lee, Kyungdo Han, Wooseong Huh
Kidney transplant recipients are at high risk for fractures, primarily due to post-transplant bone disease. This retrospective cohort study analyzed data from the Korean National Health Insurance Service, including 10 083 kidney transplant recipients examined from 2009 to 2017. We assessed fracture incidence, emphasizing vertebral and hip fractures, and the association of physical activity and traditional risk factors with fracture risk. Kidney transplant recipients were categorized into three groups according to physical activity levels: non-activity, metabolic equivalent of task (MET) 1-499, and MET ≥500...
April 2024: Clinical Transplantation
https://read.qxmd.com/read/38567897/a-heart-transplant-center-experience-with-basiliximab-induction-strategies-a-double-edged-sword
#38
JOURNAL ARTICLE
Luise Holzhauser, Maxwell Norris, Maria Molina, Susan Chambers, Swethika Sundaravel, Eman Rashed, Ketan Gala, Tara Fallah, Therese Bittermann, Nosheen Reza, Teresa Wang, Pavan Atluri, Lee Goldberg, Rhondalyn McLean, Eliot Peyster
BACKGROUND: The use of induction immunosuppression for heart transplantation (HT) is debated given the uncertain benefit and potential risks of infection and malignancy. METHODS: This is a retrospective single-center analysis of 475 consecutive HT recipients from 2003 to 2020 grouped by use of induction with basiliximab group (BG) and the no basiliximab group (NBG). Subgroup analysis by era compared pre-2016 standard-basiliximab (BX) induction and 2016-2020 with selective-BX use as part of a calcineurin-inhibitor-sparing regimen...
April 2024: Clinical Transplantation
https://read.qxmd.com/read/38567895/continuous-flow-local-anesthetic-wound-infusion-for-post-operative-analgesia-following-kidney-transplantation
#39
JOURNAL ARTICLE
Parth U Thakker, Davis M Temple, Caroline Minnick, Dominick Ponzi, Gopal Badlani, Ashok Hemal, William Doares, Christopher Webb, Emily McCracken, Giuseppe Orlando, Colleen Jay, Alan Farney, Robert J Stratta
BACKGROUND: Some patients with end stage renal disease are or will become narcotic-dependent. Chronic narcotic use is associated with increased graft loss and mortality following kidney transplantation. We aimed to compare the efficacy of continuous flow local anesthetic wound infusion pumps (CFLAP) with patient controlled analgesia pumps (PCA) in reducing inpatient narcotic consumption in patients undergoing kidney transplantation. MATERIALS AND METHODS: In this single-center, retrospective analysis of patients undergoing kidney transplantation, we collected demographic and operative data, peri-operative outcomes, complications, and inpatient oral morphine milligram equivalent (OME) consumption...
April 2024: Clinical Transplantation
https://read.qxmd.com/read/38567883/mortality-and-morbidity-after-combined-heart-and-liver-transplantation-in-the-failing-fontan-an-updated-dual-center-retrospective-study
#40
JOURNAL ARTICLE
Sumeet S Vaikunth, Juan M Ortega-Legaspi, Desiree R Conrad, Sharon Chen, Tami Daugherty, Christiane L Haeffele, Jeffrey Teuteberg, Rhondalynn Mclean, John W MacArthur, Y Joseph Woo, Katsuhide Maeda, Michael Ma, Teimour Nasirov, Marrouf Hoteit, Moira B Hilscher, Joyce Wald, Tal Mandelbaum, Kim M Olthoff, Peter L Abt, Pavan Atluri, Marisa Cevasco, Constantine D Mavroudis, Stephanie Fuller, George K Lui, Yuli Y Kim
INTRODUCTION: As the adult Fontan population with Fontan associated liver disease continues to increase, more patients are being referred for transplantation, including combined heart and liver transplantation. METHODS: We report updated mortality and morbidity outcomes after combined heart and liver transplant in a retrospective cohort series of 40 patients (age 14 to 49 years) with Fontan circulation across two centers from 2006-2022. RESULTS: The 30-day, 1-year, 5-year and 10-year survival rate was 90%, 80%, 73% and 73% respectively...
April 2024: Clinical Transplantation
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