journal
https://read.qxmd.com/read/37733704/conversion-to-tacrolimus-alone-compared-to-full-immunosuppression-following-cardiac-transplantation-tactful
#1
JOURNAL ARTICLE
Aaron P Pearston, Amanda I Ingemi, Zachary A Shaeffer, Chad M Cameron, Katharine T Biagi, Myra Gobble, Amin Yehya, David A Baran
BACKGROUND: Cardiac transplantation requires lifelong immunosuppressant medications to prevent rejection. However, some patients may not tolerate multiple immunosuppressants due to adverse effects. At our institution, patients may be converted to monotherapy with tacrolimus if unable to tolerate a combination regimen. This study evaluated the outcomes among patients converted to tacrolimus monotherapy compared with those maintained on combination immunosuppression. METHODS: This single-center, retrospective cohort study included patients who received heart transplants at Sentara Norfolk General Hospital between January 2015 and July 2021...
September 21, 2023: Clinical Transplantation
https://read.qxmd.com/read/37725341/a-randomized-trial-of-continuous-glucose-monitoring-to-improve-post-transplant-glycemic-control
#2
JOURNAL ARTICLE
Nicholas Jandovitz, Sam J George, Mersema Abate, Adam M Kressel, Alexandra C Bolognese, Lawrence Lau, Vinay Nair, Elliot Grodstein
INTRODUCTION: This study examines whether the use of inpatient Continuous Glucose Monitors provides improved glycemic control over finger-stick glucose monitoring post-transplant. METHODS: This is a single-site, prospective randomized controlled trial of 40 patients receiving conventional finger-stick glucose monitoring or continuous monitoring using the Medtronic Guardian Sensor 3 during the first 5 days post-transplant. Included patients were adult renal transplant recipients with a diagnosis of diabetes...
September 19, 2023: Clinical Transplantation
https://read.qxmd.com/read/37725339/a-single-center-israeli-experience-in-pregnancy-post-lung-transplantation-feasibility-of-successful-two-or-more-full-term-pregnancies-in-individual-lung-transplant-recipients
#3
JOURNAL ARTICLE
Osnat Shtraichman, Moshe Heching, Ilana Bakal, Dror Rosengarten, Dorit Shitenberg, Yael Shostak, Yaron D Barac, Yury Peysakhovich, Mordechai R Kramer
INTRODUCTION: Female lung transplant recipients (LTRs) of reproductive age are increasingly considering pregnancy due to advances in post-transplant management and improved survival. We report our experience with pregnancy in LTRs, with an emphasis on two or more successful full-term pregnancies in individual transplant recipients. METHODS: We conducted a retrospective analysis of pregnancies in LTRs at our transplant center and collected maternal and fetal outcomes...
September 19, 2023: Clinical Transplantation
https://read.qxmd.com/read/37725074/do-outcomes-for-heart-transplantation-differ-based-on-donor-and-recipient-race
#4
JOURNAL ARTICLE
David Blitzer, J'Undra N Pegues, Seth T Lirette, David A Baran, Monica Colvin, Awori Hayanga, Hannah Copeland
PURPOSE: There are limited data examining the impact of both donor and recipient race on outcomes following orthotopic heart transplant (OHT). The purpose of this study was to evaluate the relationship between donor and recipient race and OHT outcomes. METHODS: The United Network for Organ Sharing (UNOS) database was retrospectively reviewed from January 2000 to March 2018 for donor hearts. A comparison was conducted based on donor and recipient race (White, Black, Hispanic, Other/Unknown)...
September 19, 2023: Clinical Transplantation
https://read.qxmd.com/read/37725070/incidence-risk-factors-and-outcomes-of-recurrent-focal-segmental-glomerulosclerosis-in-pediatric-kidney-transplant-recipients-a-systematic-review-and-meta-analysis
#5
REVIEW
Jiang Bai, Xinyu Yin, Jiaqi Li, Jia-Qi Li, Yanna Niu, Zhenhua Li, Jing Li, Yun Zhou
BACKGROUND: Focal segmental glomerulosclerosis is the most prevalent acquired kidney disease leading to end-stage renal disease in children and has a propensity for recurring in the transplanted kidney. The recurrence of FSGS after kidney transplantation in children varies greatly. In addition, the risk factors and outcomes of recurrence of FSGS remain controversial. This study evaluated the recurrence rate, risk factors, and prognosis of FSGS after kidney transplantation in order to provide advice and assistance in clinical decision-making for pediatric kidney transplantation...
September 19, 2023: Clinical Transplantation
https://read.qxmd.com/read/37715601/disparities-in-telemedicine-utilization-among-kidney-transplant-patients-during-the-covid-19-pandemic-barriers-and-opportunities
#6
JOURNAL ARTICLE
Rachel C Forbes, Wali R Johnson, Nigel D'Souza, Anthony Dreher, Scott A Rega, Irene D Feurer, Beatrice P Concepcion
INTRODUCTION: The COVID-19 pandemic allowed for the rapid implementation of telemedicine for kidney transplant patients; however, widespread adoption may worsen existing health care inequities among vulnerable populations. This study aimed to characterize telemedicine utilization by kidney transplant patients during the early pandemic with particular attention to healthcare equity. METHODS: A retrospective analysis of kidney transplant patients interacting with telemedicine was performed...
September 16, 2023: Clinical Transplantation
https://read.qxmd.com/read/37715587/malnutrition-in-solid-organ-transplant-patients-a-review-of-the-literature
#7
REVIEW
Heather Lorden, Jessa Engelken, Katrina Sprang, Megan Rolfson, Didier Mandelbrot, Sandesh Parajuli
Screening for malnutrition is of vital importance for solid organ transplant candidates to optimize nutrition status before transplant, to improve clinical outcomes and to inform selection committees of nutritional contraindications and risks. There are multiple criteria and screening tools available for determining malnutrition diagnosis and risk. Registered Dietitian Nutritionists use these tools for nutrition assessments to quantify the severity of malnutrition, provide patient-centered interventions, and monitor progression...
September 16, 2023: Clinical Transplantation
https://read.qxmd.com/read/37705389/bk-polyomavirus-dnaemia-in-pancreas-transplant-recipients-compared-to-pancreas-kidney-recipients
#8
JOURNAL ARTICLE
Zachary A Yetmar, Yogish C Kudva, Maria Teresa Seville, Wendelyn Bosch, Patrick G Dean, Janna L Huskey, Pooja Budhiraja, Tambi Jarmi, Aleksandra Kukla, Elena Beam
BACKGROUND: BK polyomavirus (BKV) infection is a common complication of kidney transplantation. While BKV has been described in non-kidney transplant recipients, data are limited regarding its epidemiology and outcomes in pancreas transplant recipients. METHODS: We conducted a retrospective cohort study of adults who underwent pancreas transplantation from 2010-2020. The primary outcome was BKV DNAemia. Secondary outcomes were estimated glomerular filtration rate (eGFR) reduction by 30%, eGFR < 30 mL/min/1...
September 13, 2023: Clinical Transplantation
https://read.qxmd.com/read/37705388/outcomes-of-asymptomatic-histologic-pyelonephritis-of-kidney-transplant
#9
JOURNAL ARTICLE
Pooja Budhiraja, Richard Butterfield, Juan Gea-Banacloche, Sundararaman Swaminathan, Maxwell L Smith, Hassan A Khamash, Hay Me Me, Lavanya Kodali, Girish K Mour, Sumi Nair, Suman Misra, Raymond L Heilman
BACKGROUND: Urinary Tract Infections are the most common post-transplant infection and can have varied presentations. This study aimed to describe the outcomes of kidney transplant recipients with asymptomatic histologic pyelonephritis on allograft biopsy. Histologic Pyelonephritis was defined as neutrophil cast or neutrophilic tubulitis, interstitial infiltrates with predominant neutrophils, and no evidence of rejection or glomerulonephritis on biopsy. METHODS: The study included 123 kidney transplant recipients, of whom 95 underwent protocol biopsies, and 28 had biopsies for elevated creatinine within the first 2 years of a kidney transplant...
September 13, 2023: Clinical Transplantation
https://read.qxmd.com/read/37705387/indeterminate-etiology-of-acute-liver-failure-in-north-america-less-common-still-grave-prognosis
#10
JOURNAL ARTICLE
Parita V Patel, Sherry Livingston, Jorge L Rakela, R Todd Stravitz, Adrian Reuben, Nathan M Bass, Shannan R Tujios, Anne M Larson, Norman L Sussman, Jody A Rule, Valerie L Durkalski-Mauldin, William M Lee, Daniel R Ganger
BACKGROUND: The etiology of acute liver failure (ALF) remains one of the most important factors in determining prognosis and predicting outcomes. In a significant proportion of ALF cases, however, the etiology remains unknown and is categorized as indeterminate ALF (IND-ALF). In this study, we summarize findings from patients with IND-ALF from 32 transplant centers across the United States, and we compare laboratory, prognostic, and outcome data for patients with IND-ALF. METHODS: Between 1998 and 2019, 3364 adult patients with ALF or acute liver injury (ALI) from 32 liver transplant centers were enrolled in the ALFSG registry...
September 13, 2023: Clinical Transplantation
https://read.qxmd.com/read/37705362/reduction-of-hla-donor-specific-antibodies-in-heart-transplant-patients-treated-with-proteasome-inhibitors-for-antibody-mediated-rejection
#11
JOURNAL ARTICLE
Edward T Horn, Qingyong Xu, Julie N Dibridge, Jessica H Huston, Gavin W Hickey, David J Kaczorowski, Mary E Keebler, Adriana Zeevi
In this project, we describe proteasome inhibitor (PI) treatment of antibody-mediated rejection (AMR) in heart transplantation (HTX). From January 2018 to September 2021, 10 patients were treated with PI for AMR: carfilzomib (CFZ) n = 8; bortezomib (BTZ) n = 2. Patients received 1-3 cycles of PI. All patients had ≥1 strong donor-specific antibody (DSA) (mean fluorescence intensity [MFI] > 8000) in undiluted serum. Most DSAs (20/21) had HLA class II specificity. The MFI of strong DSAs had a median reduction of 56% (IQR = 13%-89%) in undiluted serum and 92% (IQR = 53%-95%) at 1:16 dilution...
September 13, 2023: Clinical Transplantation
https://read.qxmd.com/read/37698469/a-novel-scoring-system-to-predict-survival-in-cirrhotic-patients-undergoing-isolated-lung-transplantation-the-pens-cept-score
#12
JOURNAL ARTICLE
Eric J Hyzny, Ernest G Chan, Chadi Hage, Vikrant Rachakonda, Pablo G Sanchez, Shahid M Malik
Cirrhosis is usually regarded as a contraindication to isolated lung transplantation (ILT). We sought to determine which patients with cirrhosis could safely undergo ILT. Based on a retrospective analysis of patients with cirrhosis who underwent ILT at our center between 2007 and 2020, we developed an exclusionary algorithm (PENS-CEPT: Pittsburgh ExclusioN Score in Cirrhotics Evaluated for Pulmonary Transplant) to help determine which patients can undergo ILT with minimal incurred risk from their underlying liver disease...
September 12, 2023: Clinical Transplantation
https://read.qxmd.com/read/37694497/hemodynamic-failure-and-graft-dysfunction-after-lung-transplant-a-possible-clinical-continuum-with-immediate-and-long-term-consequences
#13
JOURNAL ARTICLE
Vittorio Scaravilli, Amedeo Guzzardella, Fabiana Madotto, Letizia Corinna Morlacchi, Marco Bosone, Claudia Bonetti, Valeria Musso, Valeria Rossetti, Filippo Maria Russo, Lorenzo Del Sorbo, Francesco Blasi, Mario Nosotti, Alberto Zanella, Giacomo Grasselli
INTRODUCTION: The postoperative hemodynamic management after lung transplant (LUTX) is guided by limited evidence. We aimed to describe and evaluate risk factors and outcomes of postoperative vasoactive support of LUTX recipients. METHODS: In a single-center retrospective analysis of consecutive adult LUTX, two cohorts were identified: (1) patients needing prolonged vasoactive support (>12 h from ICU admission) (VASO+); (2) or not (VASO-). Postoperative hemodynamic characteristics were thoroughly analyzed...
September 11, 2023: Clinical Transplantation
https://read.qxmd.com/read/37688341/utilization-of-hepatitis-c-virus-infected-donors-in-heart-transplant-recipients-with-elevated-meld-xi-score
#14
JOURNAL ARTICLE
Rahim Hirani, Kenji Okumura, Ameesh Isath, Vasiliki Gregory, Shazli Khan, Abhay Dhand, Gregg M Lanier, David Spielvogel, Masashi Kai, Suguru Ohira
BACKGROUND: The advent of direct-acting antivirals has helped to increase the safe utilization of organs from hepatitis C virus positive (HCV+) donors. However, the outcomes of heart transplantation (HT) using an HCV+ donor are unclear in recipients with underlying liver disease represented by an elevated model for end-stage liver disease excluding international normalized ratio (MELD-XI). METHODS: The United Network of Organ Sharing database was queried from Jan 2016 to Dec 2021...
September 8, 2023: Clinical Transplantation
https://read.qxmd.com/read/37676472/the-decline-in-kidney-function-after-heart-transplantation-and-its-impact-on-survival
#15
JOURNAL ARTICLE
Tasigan Chaemchoi, Wannee Ittiwattanakul, Puangpen Ritteeverakul, Ai-Lada Intrarakamhang, Kanokwan Thammanatsakul, Supanee Sinphurmsukskul, Sarawut Siwamogsatham, Sarinya Puwanant, Aekarach Ariyachaipanich
BACKGROUND: Evidence of decline in native renal function after heart transplantation (HTx) in the Asian population is limited. This study determined the incidence and risk factors associated with declining kidney function after HTx and its impact on survival. METHODS: A retrospective study of consecutive adult heart transplant patients was conducted in a single center between 2010 and 2020. The decline in kidney function was defined as the presence of one of the following criteria, including a ≥ 40% decline in eGFR, absolute value <15 mL/min/1...
September 7, 2023: Clinical Transplantation
https://read.qxmd.com/read/37676427/risk-factors-for-bk-virus-associated-hemorrhagic-cystitis-after-allogeneic-hematopoietic-stem-cell-transplantation-a-systematic-review-and-meta-analysis
#16
REVIEW
Xuemei Zhou, Senlin Zhang, Junjie Fan, Xiaoping Zhu, Shaoyan Hu
OBJECTIVE AND BACKGROUND: BK virus-associated hemorrhagic cystitis (BKV-HC) is an intractable complication leading to higher mortality and prolonged hospitalization among allogeneic hematopoietic stem cell transplantation (allo-HCT) recipients. Therefore, identifying the potential risk factors of BKV-HC after allo-HCT is crucial to improve prognosis and for early prevention. However, the risk factors for BKV-HC remain debatable. Therefore, we conducted a systematic review and meta-analysis to identify the risk factors for BKV-HC, for early prevention of the occurrence of BKV-HC and to improve the quality of life and prognosis of allo-HCT recipients...
September 7, 2023: Clinical Transplantation
https://read.qxmd.com/read/37658833/evolution-of-anti-spike-responses-to-sars-cov-2-vaccination-within-6-months-post-transplantation-in-patients-previously-vaccinated-while-on-the-transplant-waiting-list
#17
LETTER
Pierre Braud, Nizar Joher, Gilles Blancho, Philippe Grimbert, Le Bouter Anne, Claire Garandeau, Diego Cantarovich, Aurélie Houzet, Magali Giral, Jacques Dantal, Marie Matignon, Christophe Masset
No abstract text is available yet for this article.
September 2, 2023: Clinical Transplantation
https://read.qxmd.com/read/37658832/pure-laparoscopic-donor-right-hepatectomy-in-patients-over-50%C3%A2-years-old-why-age-should-not-be-a-barrier
#18
JOURNAL ARTICLE
Eui Soo Han, Suk Kyun Hong, Kwangpyo Hong, Su Young Hong, Jeong-Moo Lee, YoungRok Choi, Nam-Joon Yi, Kwang-Woong Lee, Kyung-Suk Suh
INTRODUCTION: Given the global aging population, the average age of liver donors is increasing. This study aimed to evaluate the surgical outcomes of grafts from pure laparoscopic donor right hepatectomy (PLDRH) in liver donors aged > 50 years. METHODS: The medical records of liver donors were retrospectively reviewed. The donors underwent conventional donor right hepatectomy (CDRH) from January 2011 to May 2019 or PLDRH from March 2016 to May 2019...
September 2, 2023: Clinical Transplantation
https://read.qxmd.com/read/37658824/a-proposed-objective-scale-for-extracorporeal-membrane-oxygenation-circuit-thrombosis
#19
LETTER
Haley Konsek, Corey Mealer, Savannah Skidmore, Monika Collins, Vakhtang Tchantchaleishvili, Taufiek Konrad Rajab
Patients undergoing extracorporeal membrane oxygenation (ECMO) are susceptible to thrombosis, which is a major cause of death and morbidity. However, there is no objective ECMO thrombosis grading scale to standardize evaluation, guide treatment, and facilitate further research. In this letter, we propose an objective grading scale for ECMO circuit thrombosis based on physical characteristics and location within the circuit. This ECMO thrombosis scale will allow for protocolized escalation of ECMO thrombosis treatment, ranging from watchful observation, intensified anticoagulation, and circuit exchange...
September 2, 2023: Clinical Transplantation
https://read.qxmd.com/read/37650442/high-grade-urothelial-carcinoma-in-kidney-transplant-patients-with-a-history-of-bk-viremia-just-a-coincidence
#20
JOURNAL ARTICLE
Emma Cannon, Chara Ntala, Nicola Joss, Maeve Rahilly, Wendy Metcalfe, Marie O'Donnell, Paul J Phelan
INTRODUCTION: Kidney transplant recipients (KTR) have a three-to-four-fold increased risk of developing urothelial carcinoma (UC) compared to the general population. BK polyoma virus (BKV) infection is known to affect approximately 15% of KTR. In vitro models support a potential pathogenic role for BKV in the development of UC. We describe a series of UC in kidney transplant recipients. METHODS: Electronic patient records were searched to identify KTR with UC who had undergone kidney only or simultaneous kidney and pancreas transplantation in a single UK center between 2009 and 2015...
August 31, 2023: Clinical Transplantation
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