journal
https://read.qxmd.com/read/38775798/the-outcome-of-relapsed-childhood-acute-lymphoblastic-leukemia-after-allogeneic-hematopoietic-stem-cell-transplantations-a-single-center-experience
#1
JOURNAL ARTICLE
Utku Aygüneş, Barbaros Şahin Karagün, Ilgen Şaşmaz, Ali Bülent Antmen
In children with high-risk childhood acute leukemia who undergo allogeneic hematopoietic stem-cell transplantation (allo-HSCT), relapse is still the leading cause of treatment failure. The prognosis is poor, yet prospective studies have only limited data on risk factors and outcomes. We aimed to understand the outcomes and prognostic factors for patients with acute lymphoblastic leukemia (ALL) who relapsed following allo-HSCT. We analyzed retrospectively 46 children with childhood acute lymphoblastic leukemia who had relapsed after receiving their first alloHSCT...
May 2024: Clinical Transplantation
https://read.qxmd.com/read/38775413/surgical-complications-and-technical-failure-of-simultaneous-pancreas-kidney-transplantation-a-22-year-experience-from-a-single-center
#2
JOURNAL ARTICLE
Bruno Fraga Dias, Roberto Calças Marques, Catarina Cardoso, Vitória Faria, Patrícia Domingues, Catarina Ribeiro, José Silvano, Donzília Silva, Sofia Pedroso, Manuela Almeida, Jorge Malheiro, La Salete Martins
Simultaneous pancreas-kidney transplantation (SPKT) is the best treatment for selected individuals with type 1 diabetes mellitus and end-stage renal disease. Despite advances in surgical techniques, donor and recipient selection, and immunosuppressive therapies, SPKT remains a complex procedure with associated surgical complications and adverse consequences. We conducted a retrospective study that included 263 SPKT procedures performed between May 2000, and December 2022. A total of 65 patients (25%) required at least one relaparotomy, resulting in an all-cause relaparotomy rate of 2...
May 2024: Clinical Transplantation
https://read.qxmd.com/read/38762787/kidney-transplant-candidates-perspectives-on-the-implementation-of-a-canadian-willingness-to-cross-program-a-strategy-to-increase-access-to-kidney-transplantation-for-highly-sensitized-patients
#3
JOURNAL ARTICLE
Aliya Affdal, Mohamad Issa, Fabian Ballesteros, Marie-Françoise Malo, Gurvir Thind, Teresa Atkinson, Kristi Coldwell, Kuljit Grewal, KaYee Wong, James H Lan, Marie-Chantal Fortin
BACKGROUND: Kidney transplantation is the optimal treatment for end-stage renal disease. However, highly sensitized patients (HSPs) have reduced access to transplantation, leading to increased morbidity and mortality on the waiting list. The Canadian Willingness to Cross (WTC) program proposes allowing transplantation across preformed donor specific antibodies (DSA) determined to be at a low risk of rejection under the adaptive design framework. This study collected patients' perspectives on the development of this program...
May 2024: Clinical Transplantation
https://read.qxmd.com/read/38762786/postoperative-cognitive-dysfunction-in-heart-transplantation-recipients
#4
JOURNAL ARTICLE
Qian Qin, Yu Lei, Xiaojie Sun, Xiaona Fu, Wenliang Fan, Dongyong Zhu, Ziqiao Lei, Jia Liu, Jing Wang
OBJECTIVE: This study aimed to investigate the occurrence and risk factors of postoperative neurocognitive disorder (NCD) in patients who underwent heart transplantation. METHODS: Seventy-six heart transplant patients were analyzed for clinical data including gender, age, height, weight, education level, left ventricular ejection fraction (LVEF), stroke volume (SV), transplantation duration, and pretransplant medical history. Cognitive function was assessed using the mini-mental status examination (MMSE) and Montreal cognitive assessment (MoCA) scales...
May 2024: Clinical Transplantation
https://read.qxmd.com/read/38762783/asystolic-donor-warm-ischemia-time-is-associated-with-development-of-postreperfusion-syndrome-in-donation-after-circulatory-death-liver-transplant
#5
JOURNAL ARTICLE
Yuki Bekki, Chiara Rocha, Bryan Myers, Ryan Wang, Natalie Smith, Parissa Tabrizian, Joseph DiNorcia, Jang Moon, Antonios Arvelakis, Marcelo E Facciuto, Samuel DeMaria, Sander Florman
BACKGROUND: Individual events during donation after circulatory death (DCD) procurement, such as hypotensive or hypoxic warm ischemia, or circulatory arrest are all a part of donor warm ischemia time (dWIT), and may have differing effects on the outcome of the liver graft. This study aimed to identify risk factors for postreperfusion syndrome (PRS), a state of severe hemodynamic derangement following graft reperfusion, and its impact on DCD liver transplantation (LT) outcomes. METHODS: This was a retrospective analysis using 106 DCD LT...
May 2024: Clinical Transplantation
https://read.qxmd.com/read/38757924/impact-of-prior-covid-19-infection-on-allogeneic-hematopoietic-stem-cell-transplantation-outcomes
#6
JOURNAL ARTICLE
Aleksandr Siniaev, Marina Popova, Yulia Rogacheva, Valeria Ianbukhtina, Egor Kulagin, Maria Vladovskaya, Sergey Bondarenko, Ivan Moiseev, Alexander D Kulagin
There are limited data on outcomes of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in recipients with prior COVID-19 infection. This single-center retrospective study included 54 adult patients who received allo-HSCT from July 2020 to September 2021 after previous COVID-19 infection and 122 control group patients without a history of COVID-19 who underwent HSCT during the same period, with a median follow-up of 17 months. Median time from COVID-19 to allo-HSCT was 211 days. The incidence of main complications in the post-transplant period was not significantly different between the two groups: deep vein thrombosis (p = ...
May 2024: Clinical Transplantation
https://read.qxmd.com/read/38739219/donor-heart-dysfunction-and-graft-survival-in-liver-and-kidney-transplants-a-register-based-study-from-sweden
#7
JOURNAL ARTICLE
Carl Johan Svensson, Josefin Öberg, Göran Dellgren, Markus Gäbel, Jonatan Oras
BACKGROUND AND AIM: Stress cardiomyopathy in donors can potentially affect graft function and longevity. This study aims to investigate the association between echocardiographic left ventricular ejection fraction (LVEF) < 50%, and/or the presence of left ventricular regional wall motion abnormalities (RWMA) in organ donors, and short- and long-term liver and kidney graft survival. Our secondary aim was to link graft survival with donor and recipient characteristics. METHODS: All donors considered for liver and kidney donation with echocardiographic records at Sahlgrenska University Hospital between 2006 and 2016 were matched with their recipients through the Scandiatransplant register...
May 2024: Clinical Transplantation
https://read.qxmd.com/read/38722085/association-of-bkv-viremia-and-nephropathy-with-adverse-alloimmune-outcomes-in-kidney-transplant-recipients
#8
JOURNAL ARTICLE
Christie Rampersad, Chris Wiebe, Robert Balshaw, Jared Bullard, Ian W Gibson, Aaron Trachtenberg, James Shaw, Armelle Perez Cortes Villalobos, Martin Karpinski, Aviva Goldberg, Patricia Birk, Maury Pinsk, David N Rush, Peter W Nickerson, Julie Ho
BACKGROUND: Immunosuppression reduction for BK polyoma virus (BKV) must be balanced against risk of adverse alloimmune outcomes. We sought to characterize risk of alloimmune events after BKV within context of HLA-DR/DQ molecular mismatch (mMM) risk score. METHODS: This single-center study evaluated 460 kidney transplant patients on tacrolimus-mycophenolate-prednisone from 2010-2021. BKV status was classified at 6-months post-transplant as "BKV" or "no BKV" in landmark analysis...
May 2024: Clinical Transplantation
https://read.qxmd.com/read/38716787/bridge-to-transplant-temporary-mechanical-circulatory-support-and-risk-of-allosensitization
#9
JOURNAL ARTICLE
Konstantinos Sideris, Eszter Lázár-Molnár, Christos P Kyriakopoulos, Iosif Taleb, Denise Hurst, Sharon Ugolini, Craig H Selzman, Lina Brinker, Stavros G Drakos, Joseph E Tonna, Laura Geer, Matthew L Goodwin, Omar Wever-Pinzon, Thomas C Hanff, James C Fang, Spencer Carter, Josef Stehlik
INTRODUCTION: Since the 2018 change in the US adult heart allocation policy, more patients are bridged-to-transplant on temporary mechanical circulatory support (tMCS). Previous studies indicate that durable left ventricular assist devices (LVAD) may lead to allosensitization. The goal of this study was to assess whether tMCS implantation is associated with changes in sensitization. METHODS: We included patients evaluated for heart transplants between 2015 and 2022 who had alloantibody measured before and after MCS implantation...
May 2024: Clinical Transplantation
https://read.qxmd.com/read/38716786/induction-therapy-in-heart-transplantation-a-systematic-review-and-network-meta-analysis-for-developing-evidence-based-recommendations
#10
JOURNAL ARTICLE
Lakshmi Kugathasan, Daniel G Rayner, Sabrina Mianchen Wang, Eduardo Rodenas-Alesina, Ani Orchanian-Cheff, Josef Stehlik, Finn Gustafsson, Douglas Greig, Michael McDonald, Alejandro Mario Bertolotti, Penny Demas-Clarke, Stella Kozuszko, Gordon Guyatt, Farid Foroutan, Ana Carolina Alba
INTRODUCTION: Induction therapy (IT) utility in heart transplantation (HT) remains contested. Commissioned by a clinical-practice guidelines panel to evaluate the effectiveness and safety of IT in adult HT patients, we conducted this systematic review and network meta-analysis (NMA). METHODS: We searched for studies from January 2000 to October 2022, reporting on the use of any IT agent in adult HT patients. Based on patient-important outcomes, we performed frequentist NMAs separately for RCTs and observational studies with adjusted analyses, and assessed the certainty of evidence using the GRADE framework...
May 2024: Clinical Transplantation
https://read.qxmd.com/read/38716774/disposable-grasper-integrated-flexible-cystoscope-for-ureteral-stent-removal-in-transplanted-patients-focus-on-feasibility-safety-and-patient-experience-results-and-micro-cost-analysis-from-a-tertiary-referral-center
#11
JOURNAL ARTICLE
Andrea Bosio, Eugenio Alessandria, Claudia Gozzo, Eugenia Vercelli, Luca Micai, Glauco Bertello, Giovanni Pasquale, Omidreza Sedigh, Marco Oderda, Luigi Biancone, Paolo Gontero
INTRODUCTION & OBJECTIVES: To evaluate ureteral stent removal (SR) using a grasper-integrated disposable flexible cystoscope (giFC-Isiris ®, Coloplast ®) after kidney transplantation (KT), with a focus on feasibility, safety, patient experience, and costs. MATERIAL AND METHODS: All consecutive KT undergoing SR through giFC were prospectively enrolled from January 2020 to June 2023. Patient characteristics, KT and SR details, urine culture results, antimicrobial prescriptions, and the incidence of urinary tract infections (UTI) within 1 month were recorded...
May 2024: Clinical Transplantation
https://read.qxmd.com/read/38716770/hepatitis-c-viremic-lung-transplantation-to-aviremic-recipients-comprehensive-outcomes-and-post-transplant-viremia
#12
JOURNAL ARTICLE
Sarah Khan, Ritika Mazumder, Xiaofeng Wang, Yifan Wang, Omar T Sims, Marie Budev, William Carey
BACKGROUND/AIMS: Direct-acting antiviral (DAA) therapy has revolutionized solid organ transplantation by providing an opportunity to utilize organs from HCV-viremic donors. Though transplantation of HCV-viremic donor organs into aviremic recipients is safe in the short term, midterm data on survival and post-transplant complications is lacking. We provide a midterm assessment of complications of lung transplantation (LT) up to 2 years post-transplant, including patient and graft survival between HCV-viremic transplantation (D+) and HCV-aviremic transplantation (D-)...
May 2024: Clinical Transplantation
https://read.qxmd.com/read/38690617/risk-factors-for-pneumocystis-jirovecii-pneumonia-after-kidney-transplantation-a-systematic-review-and-meta-analysis
#13
REVIEW
Bingjie Cheng, Chang Qi, Senlin Zhang, Xiaowen Wang
BACKGROUND AND OBJECTIVE: Pneumocystis jirovecii pneumonia (PJP), an opportunistic infection, often leads to an increase in hospitalization time and mortality rates in kidney transplant (KT) recipients. However, the risk factors associated with PJP in KT recipients remain debatable. Therefore, we conducted this meta-analysis to identify risk factors for PJP, which could potentially help to reduce PJP incidence and improve outcome of KT recipients. METHODS: We systematically retrieved relevant studies in PubMed, EMBASE, and the Cochrane Library up to November 2023...
May 2024: Clinical Transplantation
https://read.qxmd.com/read/38690616/transplant-surgeons-already-account-for-inaccuracies-in-the-kidney-donor-profile-index-kdpi-calculation
#14
LETTER
Grace Guan, Itai Ashlagi, Marc L Melcher
No abstract text is available yet for this article.
May 2024: Clinical Transplantation
https://read.qxmd.com/read/38686446/psychological-assessment-of-patients-on-the-heart-transplant-waiting-list-a-single-center-experience
#15
JOURNAL ARTICLE
Simona De Santis, Valeria Ladisa, Lorenzo Giovannico, Giuseppe Fischetti, Domenico Parigino, Luca Savino, Aline Maria Silva, Nicola Di Bari, Paolo Taurisano, Maria Fara De Caro, Tomaso Bottio
OBJECTIVE: To analyze the data of the psychological assessment, focusing attention on the quality of life and the psychological status of patients who are listed for heart transplant. METHODS: All heart failure patients listed for heart transplant at the Cardiac Surgery Unit of Bari University, Italy, were evaluated from September to November 2023, by administering the Symptom Checklist-90-R (SCL-90-R) and the Short Form Health Survey 36 (SF-36). RESULTS: Overall, 27 patients were studied...
May 2024: Clinical Transplantation
https://read.qxmd.com/read/38686443/expanding-the-access-to-kidney-transplantation-strategies-for-kidney-transplant-programs
#16
REVIEW
Angie G Nishio Lucar, Ankita Patel, Shikha Mehta, Anju Yadav, Mona Doshi, Megan A Urbanski, Beatrice P Concepcion, Neeraj Singh, M Lee Sanders, Arpita Basu, Jessica L Harding, Ana Rossi, Oluwafisayo O Adebiyi, Milagros Samaniego-Picota, Kenneth J Woodside, Ronald F Parsons
Kidney transplantation is the most successful kidney replacement therapy available, resulting in improved recipient survival and societal cost savings. Yet, nearly 70 years after the first successful kidney transplant, there are still numerous barriers and untapped opportunities that constrain the access to transplant. The literature describing these barriers is extensive, but the practices and processes to solve them are less clear. Solutions must be multidisciplinary and be the product of strong partnerships among patients, their networks, health care providers, and transplant programs...
May 2024: Clinical Transplantation
https://read.qxmd.com/read/38686437/real-life-use-of-letermovir-prophylaxis-for-cytomegalovirus-in-heart-transplant-recipients
#17
JOURNAL ARTICLE
Grégoire Saltiel, Emmanuel Faure, Ady Assaf, Marie-Charlotte Chopin, Fanny Moreau, Karine Faure, Céline Goeminne, Fanny Vuotto
INTRODUCTION: Cytomegalovirus (CMV) remains the predominant opportunistic infection following solid organ transplantation (SOT). While valganciclovir is the drug of choice for CMV prophylaxis, its utility can be compromised due to the risk of cytopenia. Letermovir, a novel agent approved for CMV prophylaxis in allogeneic hematopoietic stem cell transplant recipients and high-risk kidney transplant recipients, exhibits reduced toxicity. This study aims to present the practical application of letermovir as both primary and secondary prophylaxis against CMV in heart transplant recipients (HTR)...
May 2024: Clinical Transplantation
https://read.qxmd.com/read/38683684/impact-of-delayed-listing-after-initiating-kidney-transplant-evaluation-on-transplant-outcomes
#18
JOURNAL ARTICLE
Lisa Ly, Danting Zhu, Douglas E Schaubel, Kenneth J Woodside, Randall S Sung
OBJECTIVE: Longer end-stage renal disease time has been associated with inferior kidney transplant outcomes. However, the contribution of transplant evaluation is uncertain. We explored the relationship between time from evaluation to listing (ELT) and transplant outcomes. METHODS: This retrospective study included 2535 adult kidney transplants from 2000 to 2015. Kaplan-Meier survival curves, log-rank tests, and Cox regression models were used to compare transplant outcomes...
May 2024: Clinical Transplantation
https://read.qxmd.com/read/38678589/impact-of-hyperparathyroidism-on-allograft-histology-and-function-after-kidney-transplantation-rethinking-its-causal-role-in-graft-dysfunction
#19
JOURNAL ARTICLE
Gabriel Cojuc-Konigsberg, Denisse Tinajero-Sánchez, Vianca Anabel Canaviri-Flores, Omar Fueyo-Rodríguez, Norma O Uribe-Uribe, Lluvia A Marino-Vazquez, Luis Eduardo Morales-Buenrostro, Juan C Ramirez-Sandoval
INTRODUCTION: The causal relationship between hyperparathyroidism and kidney graft dysfunction remains inconclusive. Applying Bradford-Hill's temporality and consistency causation principles, we assessed the effect of parathyroid hormone (iPTH) on graft histology and eGFR trajectory on kidney transplant recipients (KTRs) with normal time-zero graft biopsies. METHODS: Retrospective cohort study evaluating the effect of hyperparathyroidism on interstitial fibrosis and tubular atrophy (IF/TA) development in 1232 graft biopsies...
May 2024: Clinical Transplantation
https://read.qxmd.com/read/38678588/cxcl9-and-cxcl10-as-biomarkers-of-kidney-graft-inflammation-across-multiple-conditions
#20
LETTER
Ilaria Gandolfini, Benedetta Mordà, Elene Martinelli, Marco Delsante, GiovanniMaria Rossi, Micaela Gentile, Sara Alibrandi, Daniel Salvetti, Enrico Fiaccadori, Alessandra Palmisano, Paolo Cravedi, Umberto Maggiore
No abstract text is available yet for this article.
May 2024: Clinical Transplantation
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