Anjian Xu, Jichao Zhou, Yanmeng Li, Luyao Qiao, Caicai Jin, Wei Chen, Lan Sun, Shanna Wu, Xiaojin Li, Donghu Zhou, Siyu Jia, Bei Zhang, Jingyi Yao, Xiaowei Zhang, Hong You, Jian Huang
Liver fibrosis, a major cause of morbidity and mortality worldwide, leads to liver damage, seriously threatening human health. In our previous study, we demonstrated that 14-kDa phosphohistidine phosphatase (PHP14) was upregulated in fibrotic liver tissue and involved in the migration and lamellipodia formation of hepatic stellate cells (HSCs). In this study, we evaluated PHP14 as a therapeutic target for liver fibrosis and investigated the mechanism by which it mediates liver fibrosis. AAV-shPhpt1 administration significantly attenuates CCl4 -induced liver fibrosis in mice...
January 6, 2021: American Journal of Physiology. Gastrointestinal and Liver Physiology