Patrick A Williams, Kaitlyn E Naughton, Lauren A Simon, Gloria E Soto, Louis R Parham, Xianghui Ma, Charles H Danan, Weiming Hu, Elliot S Friedman, Emily A McMillan, Hritik Mehta, Madison A Stoltz, Joshua Soto Ocaña, Joseph Zackular, Kyle Bittinger, Kelly A Whelan, Tatiana A Karakasheva, Kathryn E Hamilton
Calorie restriction can enhance the regenerative capacity of the injured intestinal epithelium. Among other metabolic changes, calorie restriction can activate the autophagy pathway. While independent studies have attributed the regenerative benefit of calorie restriction to downregulation of mTORC1, it is not known whether autophagy itself is required for the regenerative benefit of calorie restriction. We used mouse and organoid models with autophagy gene deletion to evaluate the contribution of autophagy to intestinal epithelial regeneration following calorie restriction...
February 28, 2023: American Journal of Physiology. Gastrointestinal and Liver Physiology