Naoki Mizutani, Hayato Hikita, Yoshinobu Saito, Yuta Myojin, Katsuhiko Sato, Makiko Urabe, Tomohide Kurahashi, Yuto Shiode, Sadatsugu Sakane, Kazuhiro Murai, Yasutoshi Nozaki, Takahiro Kodama, Ryotaro Sakamori, Yuichi Yoshida, Tomohide Tatsumi, Tetsuo Takehara
Grb2-associated binder 1 (Gab1) is an adaptor protein that is important for intracellular signal transduction by receptor tyrosine kinases that are receptors for various growth factors and plays an important role in rapid liver regeneration after partial hepatectomy and during acute hepatitis. On the other hand, mild liver regeneration is induced in livers of individuals with chronic hepatitis, where hepatocyte apoptosis is persistent; however, the impact of Gab1 on such livers remains unclear. We examined the role of Gab1 in chronic hepatitis...
March 31, 2021: American Journal of Physiology. Gastrointestinal and Liver Physiology