American Journal of Ophthalmology

PURPOSE: To investigate the demographic and clinical characteristics of patients with sympathetic ophthalmia (SO) and define the risk factors for its incidence following trauma and ophthalmic procedures. DESIGN: Retrospective cohort study. PARTICIPANTS: Patients in the American Academy of Ophthalmology's (Academy) IRIS® Registry (Intelligent Research in Sight) who were (n=1,523) or were not diagnosed with SO following a documented procedure or trauma between January 1st , 2013, and December 31st , 2019...

PURPOSE: To systematically review the literature and quantitatively synthesize the currently available evidence to compare the accuracy of different intraocular lens calculation formulas in eyes with long axial length (AL). DESIGN: Network meta-analysis. METHODS: PubMed, Embase, Web of Science, and the Cochrane Library were systematically searched for studies published between January 2000 and June 2022. Included were prospective or retrospective clinical studies reporting the following outcomes in cataract patients with long AL (AL ≥ 26 mm): percentage of eyes with a prediction error (PE) within ±0...

No abstract text is available yet for this article.

PURPOSE: To assess longitudinal relationships among visual function and anatomical measures of gene therapy in G11778A Leber hereditary optic neuropathy (LHON). DESIGN: Phase 1 clinical trial. METHODS: Setting: single institution. PARTICIPANTS: Patients with G11778A LHON and chronic bilateral visual loss >12 months (Group 1,n=11), acute bilateral visual loss <12 months (Group 2,n=9), or unilateral visual loss (Group 3,n=8)...

PURPOSE: This study aimed to determine the threshold for defining abnormal retinal sensitivity (RS) that correlates with structural changes in diabetic macular ischemia (DMI) patients with stable treated proliferative diabetic retinopathy (PDR). DESIGN: Prospective cross-sectional study. METHODS: In a single center, we recruited 85 eyes (67 patients) with stable treated PDR with best-corrected visual acuity (BCVA) ≥54 Early Treatment Diabetic Retinopathy Study (ETDRS) letters (Snellen equivalent 20/80) and optical coherence tomography angiography evidence of DMI...

PURPOSE: To describe the association between visual field loss and frailty in a nationally representative cohort of U.S. adults. DESIGN: Retrospective cross-sectional study. METHODS: The cohort included adults 40 years or older with complete eye examination data from the 2005-2006 and 2007-2008 National Health and Nutrition Examination Surveys (NHANES). Visual field loss (VFL) was determined by frequency doubling technology and a 2-2-1 algorithm...

PURPOSE: The E-ROP study evaluated 1257 patients screened for retinopathy of prematurity (ROP) and found that no infant born at or after 27 weeks' gestational age and having birth weight over 750g developed treatable disease if they had no ROP at 37 weeks' gestational age. They suggested there is little value in continued screening of infants meeting these criteria who have no ROP at 37 weeks. We attempted to replicate these published data in a larger multi-center cohort to validate or refute this hypothesis...

BACKGROUND: It is unclear whether transient monocular vision loss (TMVL) warrants the same thorough systemic evaluation for potential embolic sources in young adults as it does in older adults. The objective of the present study was to evaluate the yield of investigations in patients under 45 years old presenting with TMVL. DESIGN: Prospective cohort study. METHODS: Young patients with TMVL presenting to a university-affiliated neuro-ophthalmology clinic were included...

PURPOSE: To investigate the effectiveness of a novel spectacle lens designed to slow the progression of myopia in children. DESIGN: A prospective, randomized, double blind clinical trial. METHODS: 126 Israeli children aged 6-13 with spherical equivalent (SER) refractive errors of -0.5 to -6.25 D, were randomized into either the Shamir Myopia Control (SMC) lens design group, or the conventional single-vision spectacle lenses (SVL), Control group...

PURPOSE: To investigate factors associated with the severity of prelaminar schisis (PLS) in heathy subjects and glaucoma patients. DESIGN: Prospective cross-sectional study METHODS: Two hundred seventeen eyes of 217 subjects (110 normal eyes and 107 open angle glaucoma eyes). Frequency and severity of PLS were compared between normal and glaucomatous eyes. Multivariate logistic models were used to assess factors associated with the severity of PLS. Factors considered were age, axial length, glaucomatous damage indices, Bruch's membrane opening (BMO) and anterior scleral canal opening parameters, tractional forces (posterior vitreous staging and the presence of Bergmeister's papilla), circumpapillary choroidal thickness, lamina cribrosa (LC) parameters and peripapillary scleral (PPS) angle...

PURPOSE: To describe baseline results of the Alabama Screening and Intervention for Glaucoma and eye Health through Telemedicine (AL-SIGHT) for patients at federally qualified health centers (FQHC's). Candidates were persons at-risk for glaucoma associated diseases (GAD) based on age, race/ethnicity, current diagnosis of GAD, family history, and diabetes. DESIGN: Baseline screening visit followed by remote diagnosis and referral for follow-up examinations. METHODS: Patients presenting to FQHCs ≥18 years old were enrolled and underwent screening for acuity, autorefraction, intraocular pressure, visual field testing, and fundus imaging...

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PURPOSE: To determine the prevalence and magnitude of OCT exposed neural canal (ENC), externally oblique choroidal border tissue (EOCBT), and exposed scleral flange (ESF) regions in 362 non-highly myopic (spherical equivalent -6.00 to 5.75 diopters) eyes of 362 healthy subjects. DESIGN: Cross-sectional study METHODS: After OCT optic nerve head (ONH) imaging, Bruch's membrane opening (BMO), the anterior scleral canal opening (ASCO), and the scleral flange opening (SFO) were manually segmented...

No abstract text is available yet for this article.

PURPOSE: To define the external scleral sulcus (ESS) on a Scheimpflug image and use it for a morphometric analysis of corneal diameter (CD). DESIGN: Retrospective, cross-sectional study of pediatric Asian-Indian eyes. METHODS: One random eye of 353 subjects between 5 to 18 years underwent 25-scan Pentacam HR imaging. For all scans, densitometry values along the anterior corneal edge were recorded and differentiated. The peaks on the differentiated curve were chosen as the ESS points and this distance between them was called CD...

PURPOSE: To examine rates of stroke, myocardial infarction (MI), deep vein thrombosis (DVT), pulmonary embolism (PE), and death in patients after retinal vein occlusion (RVO) compared to controls. DESIGN: Retrospective cohort study. METHODS: An aggregated electronic health records research network, TriNetX (Cambridge, MA, USA), was used to identify patients with diagnosis of RVO and a control group of patients with cataract. Patients were excluded if they had history of stroke, MI, DVT, or PE within 2 years of diagnosis of RVO or cataract...

PURPOSE: To systematically review and report the rate of exudative progression over time in patients with non-exudative macular neovascularization (MNV) in age-related macular degeneration (AMD). DESIGN: Systematic review with prevalence meta-analyses and individual participant meta-analysis. METHODS: We searched 10 literature databases on March 26, 2023, for studies of consecutive patients with treatment-naïve non-exudative MNV in AMD...

PURPOSE: To assess the relationship between diabetic retinopathy (DR) and corneal sensitivity. METHODS: In this prospective study, 100 eyes of 50 patients from primarily underrepresented racial and ethnic backgrounds with DR underwent assessment of corneal sensitivity using a Cochet-Bonnet esthesiometer. Severity of DR was graded by a masked reading center. Corneal sensitivity was compared in eyes with current or regressed proliferative DR (PDR) (n=35) and eyes with non-proliferative DR (NPDR) with no history of PDR (n=65)...

PURPOSE: To investigate longitudinal changes in the anterior segment (AS) using serial optical coherence tomography (OCT) images and determine impact of these changes on the anterior chamber angle (ACA) in eyes with primary angle closure disease (PACD) treated with laser peripheral iridotomy (LPI). DESIGN: Retrospective clinical cohort study. METHODS: This study included 103 patients with PACD who underwent LPI and were followed-up by a mean 6...

PURPOSE: To estimate the risk of incidence of optic neuritis and identify the high-risk group among patients with fibromyalgia (FM) DESIGN: Population-based cohort study METHODS: A nationwide, population-based study was conducted using data from the Korean National Health Claims database from 2012 to 2021. This study included all the patients with FM from the entire South Korean population aged 20-79 years (FM group). Moreover, those with pain but not diagnosed with FM were considered as the non-FM group...