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American Journal of Ophthalmology

Karen Bitton, Jean-Marie Michot, Emmanuel Barreau, Olivier Lambotte, Oscar Haigh, Aurélien Marabelle, Anne-Laure Voisin, Christine Mateus, Anne-Laure Rémond, Chloé Couret, Stéphane Champiat, Marc Labetoulle, Antoine Rousseau
PURPOSE: Immune checkpoint inhibitors (ICI) targeting the programmed cell death protein 1 (PD-1), or its ligand PD-L1, are the mainstay of metastatic cancer treatment. Patients receiving these treatments may develop immune-related adverse events (irAEs). This study aimed to estimate the prevalence and describe the clinical patterns of moderate to severe ocular irAEs-associated with anti-PD-(L)1 treatment. DESIGN: Prospective case series. METHODS: This study included patients recruited via i) a single-center prospective cohort and ii) a national pharmacovigilance registry between June 2014 and March 2018, and focused on patients with moderate to severe ocular irAEs following anti-PD-(L)1...
February 14, 2019: American Journal of Ophthalmology
Carla J Siegfried, Ying-Bo Shui
PURPOSE: To investigate correlations of oxygen (pO2 ) in the ocular anterior segment of human eyes and aqueous humor antioxidant levels of ascorbate (AsA) and total reactive antioxidant potential (TRAP) with glaucoma and vitreous status. METHODS: This prospective, cross-sectional study stratified patients (n=288 eyes) by lens and vitreous status and presence of primary open angle glaucoma for statistical analyses. Intraocular pO2 measurements with a fiberoptic probe were made in patients at the beginning of planned glaucoma and/or cataract surgery...
February 14, 2019: American Journal of Ophthalmology
Jorge L Alió, Jorge L Alió Del Barrio, Mona El Zarif, Albert Azaar, Nehman Makdissy, Charbel Khalil, Walid Harb, Ibrahim El Achkar, Ziad Abdul Jawad, María P de Miguel
PURPOSE: To evaluate the one-year safety and efficacy of the cellular therapy of the corneal stroma by implanting autologous adipose derived adult stem cells (ADASc) with or without sheets of decellularized donor human corneal stroma within the stroma of patients with advanced keratoconus. METHODS: Prospective interventional non-randomized series of cases. Fourteen consecutive patients were selected and distributed into 3 experimental groups: A) Implantation of autologous ADASc alone (3x 106 /1mL ) (n:5); B) Decellularized donor 120 μm thick corneal stroma lamina alone (n:5); C) Recellularized donor lamina with 1x106 autologous ADASc+ another 1x106 /1mL cells at the time of the surgery (n:4)...
February 14, 2019: American Journal of Ophthalmology
Susanna Jouhi, Martine J Jager, Stefan J R de Geus, Laurence Desjardins, Nils Andreas Eide, Jean-Daniel Grange, Jens Folke Kiilgaard, Stefan Seregard, Edoardo Midena, Raffaele Parrozzani, Jean-Pierre Caujolle, Iwona Rospond-Kubiak, Tero T Kivelä
PURPOSE: To determine the size at which choroidal melanomas can metastasize and to report the characteristics of small fatal choroidal melanomas (SFCM). DESIGN: Retrospective case series. METHODS: Ten ocular oncology services submitted 45 patients with a choroidal melanoma 3 mm or less in thickness and 9 mm or less in largest basal diameter (LBD), when treated, who developed metastases. RESULTS: Median tumor thickness was 2...
February 14, 2019: American Journal of Ophthalmology
Maya Eiger-Moscovich, Oren Tomkins-Netzer, Radgonde Amer, Zohar Habot-Wilner, Ahmed Kasb, Ronit Friling, Michal Kramer
PURPOSE: To investigate the clinical course and visual outcome of macular edema (ME) in pediatric patients with chronic noninfectious uveitis. DESIGN: Retrospective case series. METHODS: The databases of the uveitis clinics of four tertiary medical centers in Israel and the UK were searched for all children treated for uveitic ME in 2005-2015. Data were collected from the medical records as follows: demographics, diagnosis, visual acuity, clinical and imaging findings, and treatment given specifically for ME...
February 14, 2019: American Journal of Ophthalmology
Theo G Seiler, Peng Shao, Amira Eltony, Theo Seiler, Seok-Hyun Yun
PURPOSE: To investigate the age-dependence of Brillouin spectroscopy of the cornea and to compare normal and keratoconus corneas. DESIGN: Retrospective case-control study STUDY POPULATION: Healthy patients and patients suffering from keratoconus seen at the Institut für Refraktive und Ophthalmo-Chirurgie (IROC) between December 2016 and March 2017. METHODS: Brillouin frequency shifts of patients of 2 different groups were examined with Brillouin spectroscopy perpendicular to the corneal surface...
February 14, 2019: American Journal of Ophthalmology
Fahriye Groen-Hakan, Suzanne van de Laar, Annemiek A van der Eijk-Baltissen, Ninette Ten Dam van Loon, Joke de Boer, Aniki Rothova
PURPOSE: To assess the clinical and laboratory manifestations and vaccination status of uveitis patients positive for Rubella virus (RV) in aqueous humor and investigate its relationship to Fuchs Uveitis Syndrome (FUS). METHODS: Retrospective study of all uveitis patients, positive for RV in aqueous humor analysis (polymerase chain reaction (PCR) and/or Goldmann-Witmer coefficient (GWC)) between January 2010 and October 2016 at the ophthalmology departments in the Erasmus Medical Center (Rotterdam) and University Medical Center Utrecht...
February 13, 2019: American Journal of Ophthalmology
Talal Alabduljalil, Rachel C Patel, Abdullah A Alqahtani, Simon S Gao, Michael J Gale, Miao Zhang, Yali Jia, David Huang, Pei-Wen Chiang, Rui Chen, Jun Wang, Richard G Weleber, Mark E Pennesi, Paul Yang
PURPOSE: Measure and correlate degeneration of the inner segment/outer segment junction (IS/OS), retinal pigment epithelium (RPE) and choriocapillaris (CC) in Stargardt disease (STGD) DESIGN: Prospective cross-sectional study METHODS SETTING: Casey Eye Institute POPULATION: 23 patients with STGD PROCEDURES: OCT angiography (OCTA) scans were centered on the fovea. OCT slab projection and en face boundary maps were used to create masks to measure total IS/OS loss or RPE atrophy, as well as regions of isolated IS/OS loss, isolated RPE atrophy, matched IS/OS and RPE degeneration, or intact IS/OS and RPE...
February 13, 2019: American Journal of Ophthalmology
Sally L Baxter, Brian J Nguyen, Michael Kinori, Don O Kikkawa, Shira L Robbins, David B Granet
PURPOSE: To report the characteristics of patients with restrictive diplopia following pterygium excision and a successful treatment approach for the strabismus. DESIGN: Retrospective interventional case series. METHODS SETTING: Single academic institution. PATIENT POPULATION: Fifteen patients with restrictive diplopia after pterygium excision. EXCLUSION CRITERIA: any other reason for strabismus...
February 13, 2019: American Journal of Ophthalmology
John F Payne, Charles C Wykoff, W Lloyd Clark, Beau B Bruce, David S Boyer, David M Brown
PURPOSE: To prospectively evaluate a treat & extend algorithm of ranibizumab with and without navigated laser to monthly dosing for center-involving diabetic macular edema. DESIGN: Multicenter, randomized, clinical trial METHODS: 150 eyes were randomized into three cohorts: Monthly (n=30), TReat and EXtend without laser photocoagulation (TREX; n=60), and treat and extend with angiography-GuIded LAser photocoagulation (GILA; n=60). Monthly cohort eyes received ranibizumab 0...
February 13, 2019: American Journal of Ophthalmology
María Jesús Muniesa Royo, Juan Ezpeleta Campaña, Iván Benítez Iglesias
PURPOSE: To compare fluctuations in intraocular pressure (IOP) in medically versus surgically treated glaucoma patients. DESIGN: Prospective, non-randomized case series. METHODS: IOP-related fluctuations were measured for 24 hours using a contact lens sensor (CLS). SUBJECTS: We perform monitoring with CLS in 91 eyes of 77 patients; 59 eyes were receiving ocular hypotensive medication and had no previous history of glaucoma surgery (medical group), while 32 eyes with open angle glaucoma (OAG) had previously undergone glaucoma surgery (surgical group)...
February 13, 2019: American Journal of Ophthalmology
Alisa T Thavikulwat, Dingcai Cao, Thasarat S Vajaranant, Jennifer I Lim
PURPOSE: To determine the rate of retinal nerve fiber layer (RNFL) thinning in patients with sickle cell hemoglobinopathies. Design; Prospective cohort study METHODS: Sixty-seven patients averaging 35.8±11.5 years old at enrollment with electrophoretically-confirmed sickle cell hemoglobinopathies followed by the University of Illinois at Chicago retina clinic for ≥1 year were included. Exclusion criteria included a history of diabetes, uncontrolled hypertension, glaucoma, ocular opacities, other retinopathies, and previous retinal procedures...
February 13, 2019: American Journal of Ophthalmology
Weilin Chan, Janey L Wiggs, Lucia Sobrin
PURPOSE: To provide evidence that corticosteroid-induced ocular hypertension has a genetic component. DESIGN: Evidence-based Perspective. METHODS: We conducted a comprehensive literature search for studies exploring genetic influences on intraocular pressure responses to corticosteroid treatment. RESULTS: Studies demonstrating increased risk of corticosteroid-induced ocular hypertension among first-degree relatives of affected individuals support a genetic contribution to the disease...
February 11, 2019: American Journal of Ophthalmology
Claudia Taipale, Lotta Ilveskoski, Reeta Danni, Raimo Tuuminen
No abstract text is available yet for this article.
February 8, 2019: American Journal of Ophthalmology
Rachael L Niederer, Ahmed Al-Janabi, Sue L Lightman, Oren Tomkins-Netzer
No abstract text is available yet for this article.
February 7, 2019: American Journal of Ophthalmology
Namrata Sharma, Renu Venugopal, Prafulla K Maharana, Manthan Chaniyara, Tushar Agarwal, Neelam Pushker, Ravinder Mohan Pandey, Sushil Sangwan, Seema Sen, Seema Kashyap, Arundhati Sharma, Neena Khanna, Rasik B Vajpayee
PURPOSE: To propose a new scoring system for grading of chronic ocular sequelae in Stevens-Johnson syndrome (SJS). DESIGN: Reliability and validity analysis PARTICIPANTS: Four hundred eyes of 200 patients with chronic ocular SJS/TEN were included in the study. SETTINGS: Single centre, tertiary eye care referral centre METHODS: All patients of SJS/TEN with chronic (more than one year) ocular sequelae were recruited for the study. Corneal, eyelid and conjunctival signs were evaluated and given scores ranging from 0 to 5 depending on the increasing severity...
February 4, 2019: American Journal of Ophthalmology
Sepehr Feizi, Mohammad Ali Javadi, Bahareh Kheiri
PURPOSE: To evaluate the effect of keratoconus severity on the visual and refractive outcomes and complications after deep anterior lamellar keratoplasty (DALK). DESIGN: Consecutive interventional case series. METHODS: This study enrolled 227 keratoconus-affected eyes that underwent DALK. Amsler-Krumeich keratoconus classification was used to categorize the patients: stage II, 47 eyes; stage III, 60 eyes; and stage IV, 120 eyes. The outcome measures, including postoperative best-spectacle corrected visual acuity (BSCVA), spherical equivalent refraction, mean keratometry, keratometric astigmatism, and complications, were analyzed and compared based on keratoconus stage...
February 4, 2019: American Journal of Ophthalmology
A Nanda, M McClements, P Clouston, M E Shanks, R E MacLaren
PURPOSE: Mutations in the photoreceptor gene RP1 lead to recessive or dominantly inherited retinitis pigmentosa (RP). Since the dominantly inherited phenotype is generally milder than recessive cases, it raises the possibility that it could arise by haploinsufficiency, however most mutations are in the terminal exon 4, which would be predicted to generate truncated proteins. We therefore assessed a cohort of RP patients with confirmed mutations in RP1 in order to examine the genetic basis of the exon 4 mutations...
February 4, 2019: American Journal of Ophthalmology
Yunping Li, Qi Wei, Alan Le, Bola Ayoub Gawargious, Joseph L Demer
PURPOSE: To investigate the relationship between displacement of extraocular muscles (EOMs) and staphyloma in high myopia using magnetic resonance imaging (MRI). DESIGN: Retrospective case-control study. METHODS: Setting: Institutional Study. POPULATION: 29 highly myopic patients (46 eyes), 11 age-matched healthy control subjects (21 eyes), and 34 patients (66 eyes) with sagging eye syndrome. PROCEDURES: MRI was analyzed for aspect ratio (AR) of the ocular cross section, locations of staphylomata and EOMs, and status of superior rectus to lateral rectus (SR-LR) band ligament...
February 4, 2019: American Journal of Ophthalmology
Kunal A Gadhvi, Vito Romano, Luis Fernández-Vega Cueto, Francesco Aiello, Alexander C Day, Bruce D Allan
PURPOSE: To examine clinical outcomes in deep anterior lamellar keratoplasty (DALK) for keratoconus using contemporary techniques in a multi-surgeon public healthcare setting. DESIGN: Consecutive, retrospective case series. SETTING: Moorfields Eye Hospital, London STUDY POPULATION: Consecutive cases of keratoconus treated with non-laser assisted DALK from September 1st , 2012, to September 31st , 2016. OBSERVATION PROCEDURE: Data on preoperative status, operative details, intraoperative and postoperative complications, secondary interventions, and visual outcomes were archived for analysis...
February 2, 2019: American Journal of Ophthalmology
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