Iman Karimzadeh, Erin F Barreto, John A Kellum, Linda Awdishu, Patrick T Murray, Marlies Ostermann, Azra Bihorac, Ravindra L Mehta, Stuart L Goldstein, Kianoush B Kashani, Sandra L Kane-Gill
Drug-induced kidney disease (DIKD) accounts for about one-fourth of all cases of acute kidney injury (AKI) in hospitalized patients, especially in critically ill setting. There is no standard definition or classification system of DIKD. To address this, a phenotype definition of DIKD using expert consensus was introduced in 2015. Recently, a novel framework for DIKD classification was proposed that incorporated functional change and tissue damage biomarkers. Medications were stratified into four categories, including "dysfunction without damage," "damage without dysfunction," "both dysfunction and damage," and "neither dysfunction nor damage" using this novel framework along with predominant mechanism(s) of nephrotoxicity for drugs and drug classes...
November 9, 2023: Critical Care: the Official Journal of the Critical Care Forum