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By Julian Zilli Colorectal Surgery Resident.
Jéssica Alessandra-Perini, Karina Cristina Rodrigues-Baptista, Daniel Escorsim Machado, Luiz Eurico Nasciutti, Jamila Alessandra Perini
Cancer is an increasingly frequent malignancy worldwide, and despite the advances in drug development, it is still necessary to develop new plant-derived medicines. Euterpe oleracea (açaí) is abundant in South and Central America and has health benefits due to its high levels of phytochemicals, including lignans and polyphenols. The aim of this review was to systematically describe the safety and antitumor effects of açaí in preclinical models using rodents to provide a more comprehensive assessment of açaí for both therapeutic uses and the development of future clinical studies in cancer...
2018: PloS One
Ammar W Ashor, Jose Lara, John C Mathers, Mario Siervo
BACKGROUND: Observational studies indicate that higher vitamin C intake is associated with reduced risk for cardiovascular diseases. However, randomised controlled trials (RCT) examining the effect of vitamin C on endothelial function (EF) have reported inconsistent results. The aims of this systematic review and meta-analysis were to determine the effect of vitamin C supplementation on EF and to investigate whether the effect was influenced by health status, study duration, dose and route of vitamin C administration...
July 2014: Atherosclerosis
Heleen M Oudemans-van Straaten, Angelique Me Spoelstra-de Man, Monique C de Waard
This narrative review summarizes the role of vitamin C in mitigating oxidative injury-induced microcirculatory impairment and associated organ failure in ischemia/reperfusion or sepsis. Preclinical studies show that high-dose vitamin C can prevent or restore microcirculatory flow impairment by inhibiting activation of nicotinamide adenine dinucleotide phosphate-oxidase and inducible nitric oxide synthase, augmenting tetrahydrobiopterin, preventing uncoupling of oxidative phosphorylation, and decreasing the formation of superoxide and peroxynitrite, and by directly scavenging superoxide...
August 6, 2014: Critical Care: the Official Journal of the Critical Care Forum
Jihye Yun, Edouard Mullarky, Changyuan Lu, Kaitlyn N Bosch, Adam Kavalier, Keith Rivera, Jatin Roper, Iok In Christine Chio, Eugenia G Giannopoulou, Carlo Rago, Ashlesha Muley, John M Asara, Jihye Paik, Olivier Elemento, Zhengming Chen, Darryl J Pappin, Lukas E Dow, Nickolas Papadopoulos, Steven S Gross, Lewis C Cantley
More than half of human colorectal cancers (CRCs) carry either KRAS or BRAF mutations and are often refractory to approved targeted therapies. We found that cultured human CRC cells harboring KRAS or BRAF mutations are selectively killed when exposed to high levels of vitamin C. This effect is due to increased uptake of the oxidized form of vitamin C, dehydroascorbate (DHA), via the GLUT1 glucose transporter. Increased DHA uptake causes oxidative stress as intracellular DHA is reduced to vitamin C, depleting glutathione...
December 11, 2015: Science
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