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COMPARATIVE STUDY
W M Machado, A P Prestes, T P Costa, R T Mendes, L R Olchanheski, R Sordi, M F Otuki, G M Fávero, J C R Vellosa, F A Santos, D Fernandes
BACKGROUND AND OBJECTIVE: It has been demonstrated that periodontitis induces systemic inflammation, which may impair endothelial function leading to increased cardiovascular risk. The aim of this study was to evaluate the effect of simvastatin on systemic inflammatory markers and endothelial dysfunction induced by periodontitis. MATERIAL AND METHODS: Wistar rats were subjected to ligature-induced experimental periodontitis. Eight days after the procedure, the ligature and sham groups were randomly assigned to receive simvastatin or vehicle once a day until the 14th day, when the effects of acetylcholine and sodium nitroprusside on blood pressure were evaluated...
October 2014: Journal of Periodontal Research
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