Richard F Hamman, Edward Horton, Elizabeth Barrett-Connor, George A Bray, Costas A Christophi, Jill Crandall, Jose C Florez, Sarah Fowler, Ronald Goldberg, Steven E Kahn, William C Knowler, John M Lachin, Mary Beth Murphy, Elizabeth Venditti
During the first 7 years of the Diabetes Prevention Program Outcomes Study (DPPOS), diabetes incidence rates, when compared with the Diabetes Prevention Program (DPP), decreased in the placebo (-42%) and metformin (-25%), groups compared with the rates in the intensive lifestyle intervention (+31%) group. Participants in the placebo and metformin groups were offered group intensive lifestyle intervention prior to entering the DPPOS. The following two hypotheses were explored to explain the rate differences: "effective intervention" (changes in weight and other factors due to intensive lifestyle intervention) and "exhaustion of susceptible" (changes in mean genetic and diabetes risk scores)...
March 2015: Diabetes