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Prediabetes: ParuchMD

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5 papers 0 to 25 followers A collection of studies pertaining to prediabetes. #ParuchMD
By John Paruch Combined training in Internal Medicine-Psychiatry with holistic, evidence-based, preventive approach to implementation and promotion of wellness.
Richard F Hamman, Edward Horton, Elizabeth Barrett-Connor, George A Bray, Costas A Christophi, Jill Crandall, Jose C Florez, Sarah Fowler, Ronald Goldberg, Steven E Kahn, William C Knowler, John M Lachin, Mary Beth Murphy, Elizabeth Venditti
During the first 7 years of the Diabetes Prevention Program Outcomes Study (DPPOS), diabetes incidence rates, when compared with the Diabetes Prevention Program (DPP), decreased in the placebo (-42%) and metformin (-25%), groups compared with the rates in the intensive lifestyle intervention (+31%) group. Participants in the placebo and metformin groups were offered group intensive lifestyle intervention prior to entering the DPPOS. The following two hypotheses were explored to explain the rate differences: "effective intervention" (changes in weight and other factors due to intensive lifestyle intervention) and "exhaustion of susceptible" (changes in mean genetic and diabetes risk scores)...
March 2015: Diabetes
Nidhi Bansal
Prediabetes is an intermediate state of hyperglycemia with glycemic parameters above normal but below the diabetes threshold. While, the diagnostic criteria of prediabetes are not uniform across various international professional organizations, it remains a state of high risk for developing diabetes with yearly conversion rate of 5%-10%. Observational evidence suggests as association between prediabetes and complications of diabetes such early nephropathy, small fiber neuropathy, early retinopathy and risk of macrovascular disease...
March 15, 2015: World Journal of Diabetes
V R Aroda, C A Christophi, S L Edelstein, P Zhang, W H Herman, E Barrett-Connor, L M Delahanty, M G Montez, R T Ackermann, X Zhuo, W C Knowler, R E Ratner
CONTEXT: Gestational diabetes (GDM) confers a high risk of type 2 diabetes. In the Diabetes Prevention Program (DPP), intensive lifestyle (ILS) and metformin prevented or delayed diabetes in women with a history of GDM. OBJECTIVE: The objective of the study was to evaluate the impact of ILS and metformin intervention over 10 years in women with and without a history of GDM in the DPP/Diabetes Prevention Program Outcomes Study. DESIGN: This was a randomized controlled clinical trial with an observational follow-up...
April 2015: Journal of Clinical Endocrinology and Metabolism
(no author information available yet)
OBJECTIVE: Glycated hemoglobin (HbA1c), a standard measure of chronic glycemia for managing diabetes, has been proposed to diagnose diabetes and identify people at risk. The Diabetes Prevention Program (DPP) was a 3.2-year randomized clinical trial of preventing type 2 diabetes with a 10-year follow-up study, the DPP Outcomes Study (DPPOS). We evaluated baseline HbA1c as a predictor of diabetes and determined the effects of treatments on diabetes defined by an HbA1c ≥6.5% (48 mmol/mol)...
January 2015: Diabetes Care
Samuel Dagogo-Jack, Chimaroke Edeoga, Sotonte Ebenibo, Ebenezer Nyenwe, Jim Wan
BACKGROUND: Although the incidence of type 2 diabetes (T2D) among persons with prediabetes is well known (∼10%/y), the incidence of prediabetes among normoglycemic persons is unclear. Also, in the Diabetes Prevention Program, no racial/ethnic differences were seen in diabetes incidence, whereas marked racial/ethnic disparities are reported in the prevalence of T2D. We aimed to obtain estimates of incident prediabetes and determine whether racial disparities manifest during transition to prediabetes...
June 2014: Journal of Clinical Endocrinology and Metabolism
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