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REVIEW
Jan M Keppel Hesselink, David J Kopsky
In 1908 phenytoin (5,5-diphenylhydantoin) was first synthesized as a barbiturate derivative in Germany by professor Heinrich Biltz (1865-1943) and subsequently resynthesized by an American chemist of the pharmaceutical company Parke-Davis in 1923 in Detroit. Screening phenytoin did not reveal comparable sedative side effects as barbiturates and, thus, Parke-Davis discarded this compound as a useful drug. In 1936, phenytoin's anticonvulsive properties were identified via a new animal model for convulsive disorders, developed by Putnam and Merritt, who also evaluated its clinical value in a number of patients in the period 1937-1940...
August 2017: Journal of Neurology
#2
JOURNAL ARTICLE
Matthew C Kiernan
No abstract text is available yet for this article.
October 2016: Practical Neurology
#3
LETTER
Moisés León Ruiz, Miguel Ángel García-Soldevilla, Julián Benito-León, María Belén Vidal Díaz, José Tejeiro-Martínez, Esteban García-Albea Ristol
No abstract text is available yet for this article.
July 2016: Journal of Clinical Neurology
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