Katherine Püttgen, Anne Lucky, Denise Adams, Elena Pope, Catherine McCuaig, Julie Powell, Dana Feigenbaum, Yulia Savva, Eulalia Baselga, Kristen Holland, Beth Drolet, Dawn Siegel, Kimberly D Morel, Maria C Garzon, Erin Mathes, Christine Lauren, Amy Nopper, Kimberly Horii, Brandon Newell, Wei Song, Ilona Frieden
BACKGROUND: There has been a dramatic increase in the off-label use of ophthalmic timolol maleate, a β-blocker used for infantile hemangioma (IH) treatment as a topical counterpart to oral propranolol. Its safety and efficacy in a pediatric population with IH have not been evaluated in a large cohort. Our goal was to retrospectively assess timolol's effectiveness, discern characteristics associated with response, and document reported adverse events. METHODS: A multicenter retrospective cohort study of 731 patients treated with topical timolol was completed at 9 centers...
September 2016: Pediatrics