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Henoch Schönlein purpura nephritis

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2 papers 0 to 25 followers
By P O Pediatrics, Nephrology
Yusuke Tanaka, Yuri Nakashima, Toru Mima, Masaki Ohya, Shuto Yamamoto, Sou Kobayashi, Asuka Masumoto, Koji Masumoto, Takurou Yano, Mari Moribata, Wataru Yoshimoto, Shintaro Yamanaka, Daisuke Koreeda, Yoshiyuki Hanba, Koichi Tatsuta, Toshifumi Sakaguchi, Shigeo Negi, Takashi Shigematsu
A 29-year-old woman was diagnosed with Henoch-Schönlein purpura nephritis (HSPN) based on the presence of purpura and histopathological findings showing crescent formation, mesangial proliferation and IgA deposition in the glomerular mesangium. She was treated with high-dose steroids; however, the nephritic syndrome persisted. Therefore, we diagnosed her with steroid-resistant HSPN and decided to add treatment with cyclosphamide pulse therapy. After one year of treatment, the histopathological findings, including crescent formation and IgA deposition, improved, as confirmed on a renal biopsy, and the patient fulfilled the criteria for complete remission...
2015: Internal Medicine
Fei Han, Liang-liang Chen, Ping-ping Ren, Jing-yun Le, Pei-jing Choong, Hong-ju Wang, Ying Xu, Jiang-hua Chen
OBJECTIVE: The treatment of Henoch-Schönlein purpura (HSP) with moderate proteinuria remains controversial. We retrospectively analyzed the efficacy of immune suppressants, with a particular emphasis on mycophenolate mofetil (MMF). METHODS: Ninety-five HSP patients with moderate proteinuria (1.0-3.5 g/24 h) after at least three months of therapy with angiotensin-converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB) were divided into three groups: an MMF group (n=33) that received MMF 1...
September 2015: Journal of Zhejiang University. Science. B
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