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JOURNAL ARTICLE
Violeta Dimova, Myriam Selma Herrnberger, Fabiola Escolano-Lozano, Heike Lydia Rittner, Eva Vlckova, Claudia Sommer, Christian Maihöfner, Frank Birklein
OBJECTIVE: We pursued the hypothesis that complex regional pain syndrome (CRPS) signs observed by neurologic examination display a structure allowing for alignment of patients to particular phenotype clusters. METHODS: Clinical examination data were obtained from 3 independent samples of 444, 391, and 202 patients with CRPS. The structure among CRPS signs was analyzed in sample 1 and validated with sample 2 using hierarchical clustering. For patients with CRPS in sample 3, an individual phenotype score was submitted to k-means clustering...
January 28, 2020: Neurology
#2
Cyprian Popescu
Fluoroquinolones increase the risk of peripheral neuropathy. The present work aims to report a case of fluoroquinolone-related severe axonal neuropathy. The subject of this study was a 62-year-old man who exhibited generalized sensory disturbances 4 days after treatment by ciprofloxacin prescribed for urinary infection. Electrodiagnostic studies revealed severe motor-sensory axonal neuropathy with widespread fibrillation potentials in support of generalized motor polyradiculopathy. There was no evidence of conduction blocks or albuminocytologic dissociation in favor of an autoimmune inflammatory reaction...
2018: Case Reports in Neurology
#3
JOURNAL ARTICLE
Viorica Chelban, Matthew P Wilson, Jodi Warman Chardon, Jana Vandrovcova, M Natalia Zanetti, Eleni Zamba-Papanicolaou, Stephanie Efthymiou, Simon Pope, Maria R Conte, Giancarlo Abis, Yo-Tsen Liu, Eloise Tribollet, Nourelhoda A Haridy, Juan A Botía, Mina Ryten, Paschalis Nicolaou, Anna Minaidou, Kyproula Christodoulou, Kristin D Kernohan, Alison Eaton, Matthew Osmond, Yoko Ito, Pierre Bourque, James E C Jepson, Oscar Bello, Fion Bremner, Carla Cordivari, Mary M Reilly, Martha Foiani, Amanda Heslegrave, Henrik Zetterberg, Simon J R Heales, Nicholas W Wood, James E Rothman, Kym M Boycott, Philippa B Mills, Peter T Clayton, Henry Houlden
OBJECTIVE: To identify disease-causing variants in autosomal recessive axonal polyneuropathy with optic atrophy and provide targeted replacement therapy. METHODS: We performed genome-wide sequencing, homozygosity mapping, and segregation analysis for novel disease-causing gene discovery. We used circular dichroism to show secondary structure changes and isothermal titration calorimetry to investigate the impact of variants on adenosine triphosphate (ATP) binding...
August 2019: Annals of Neurology
#4
JOURNAL ARTICLE
Stephan Mittas, Einar Wilder-Smith
No abstract text is available yet for this article.
May 14, 2019: Neurology
#5
JOURNAL ARTICLE
Christine Verboon, Alex Y Doets, Giuliana Galassi, Amy Davidson, Waqar Waheed, Yann Péréon, Nortina Shahrizaila, Susumu Kusunoki, Helmar C Lehmann, Thomas Harbo, Soledad Monges, Peter Van den Bergh, Hugh J Willison, David R Cornblath, Bart C Jacobs
OBJECTIVE: To define the current treatment practice of Guillain-Barré syndrome (GBS). METHODS: The study was based on prospective observational data from the first 1,300 patients included in the International GBS Outcome Study. We described the treatment practice of GBS in general, and for (1) severe forms (unable to walk independently), (2) no recovery after initial treatment, (3) treatment-related fluctuations, (4) mild forms (able to walk independently), and (5) variant forms including Miller Fisher syndrome, taking patient characteristics and hospital type into account...
July 2, 2019: Neurology
#6
JOURNAL ARTICLE
Aiman K Al-Wahaibi, Santosh Kumar, Ali Al-Risi, Farook Wali
Acute polyneuropathy is a rare manifestation of severe hyperthyroidism. We report a 22-year-old Omani male who presented to the Sohar Hospital, Sohar, Oman, in 2016 with acute-onset rapidly progressive flaccid areflexic paraplegia as the presenting manifestation of thyrotoxicosis. Nerve conduction studies revealed mixed axonal and demyelinating polyneuropathy in both the motor and sensory nerves. Treatment of the hyperthyroidism with β-blockers and carbimazole along with physiotherapy resulted in the patient's full recovery and the alleviation of his symptoms...
November 2017: Sultan Qaboos University Medical Journal
#7
JOURNAL ARTICLE
Amanda Stafford, Chinar Osman
No abstract text is available yet for this article.
January 8, 2019: Neurology
#8
JOURNAL ARTICLE
Teruaki Masuda, Mitsuharu Ueda, Mika Kitajima, Kosuke Morita, Yohei Misumi, Taro Yamashita, Konen Obayashi, Yasuyuki Yamashita, Yukio Ando
No abstract text is available yet for this article.
November 6, 2018: Neurology
#9
JOURNAL ARTICLE
Masahiro Oomura, Yuto Uchida, Keita Sakurai, Takanari Toyoda, Kenji Okita, Noriyuki Matsukawa
We herein report a patient with Miller Fisher syndrome mimicking Tolosa-Hunt syndrome. A 47-year-old man presented with right orbital pain and diplopia. On a neurological examination, he had right oculomotor nerve palsy and diminished deep tendon reflexes. Brain magnetic resonance imaging failed to show any parenchymal lesions; however, the bilateral oculomotor nerves were gadolinium-enhanced. The presence of a triad of orbital pain, ipsilateral oculomotor nerve palsy, and a rapid response to steroid therapy met the diagnostic criteria for Tolosa-Hunt syndrome...
September 15, 2018: Internal Medicine
#10
JOURNAL ARTICLE
Jun Liang Yuan, Shuang Kun Wang, Tao Jiang, Wen Li Hu
BACKGROUND: Nitrous oxide (N2O), a long-standing anesthetic, is also neurotoxic by interfering with the bioavailability of vitamin B12 if abused. A few case studies have reported the neurological and psychiatric complications of N2O. CASE PRESENTATION: Here, we reported a patient of N2O induced subacute combined degeneration (SCD) with longitudinally extensive myelopathy with inverted V-sign exhibiting progressive limb paresthesia and unsteady gait. CONCLUSIONS: This case raises the awareness of an important mechanism of neural toxicity of N2O, and clinical physicians should be well recognized this in the field of substance-related disorders...
December 28, 2017: BMC Neurology
#11
REVIEW
Giuseppe Lauria, Ingemar S J Merkies, Catharina G Faber
PURPOSE OF REVIEW: This review summarizes the most recent advances in classification, diagnostic assessment, and treatment of small fibre neuropathy (SFN). RECENT FINDINGS: Clinically based diagnostic criteria for SFN have been proposed and reliably supported by the recent availability of age-adjusted and sex-adjusted normative values for intraepidermal nerve fibre density. Apart from skin biopsy, corneal confocal microscopy and nociceptive evoked potentials have been implemented to investigate SFN of different causes, and correlated with skin biopsy findings, especially in diabetic patients...
October 2012: Current Opinion in Neurology
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REVIEW
Aris Garro, Lise E Nigrovic
No abstract text is available yet for this article.
May 2018: Annals of Emergency Medicine
#13
JOURNAL ARTICLE
Masashi Watanabe, Yushi Matsumoto, Kensho Okamoto, Bungo Okuda, Ikuko Mizuta, Toshiki Mizuno
A 49-year-old man had developed gradually personality change, gait disturbance, and hearing loss for five years. On admission, he presented with frontal release signs, stuttering, vertical gaze palsy, sensorineural deafness, muscle rigidity, ataxia, and sensory disturbance with areflexia in the lower extremities. Brain MRI demonstrated atrophy in the cerebellum and midbrain tegmentum as well as cerebral atrophy, predominantly in the frontal lobe. He was tentatively diagnosed as progressive supranuclear palsy on the basis of clinical features and imagings...
December 27, 2017: Rinshō Shinkeigaku, Clinical Neurology
#14
REVIEW
Mohammad Khan, Shamima Easmin Nishi, Siti Nazihahasma Hassan, Md Asiful Islam, Siew Hua Gan
Neuropathic pain is a common phenomenon that affects millions of people worldwide. Maxillofacial structures consist of various tissues that receive frequent stimulation during food digestion. The unique functions (masticatory process and facial expression) of the maxillofacial structure require the exquisite organization of both the peripheral and central nervous systems. Neuralgia is painful paroxysmal disorder of the head-neck region characterized by some commonly shared features such as the unilateral pain, transience and recurrence of attacks, and superficial and shock-like pain at a trigger point...
2017: Pain Research & Management
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REVIEW
Stine Maarbjerg, Giulia Di Stefano, Lars Bendtsen, Giorgio Cruccu
Introduction Trigeminal neuralgia (TN) is characterized by touch-evoked unilateral brief shock-like paroxysmal pain in one or more divisions of the trigeminal nerve. In addition to the paroxysmal pain, some patients also have continuous pain. TN is divided into classical TN (CTN) and secondary TN (STN). Etiology and pathophysiology Demyelination of primary sensory trigeminal afferents in the root entry zone is the predominant pathophysiological mechanism. Most likely, demyelination paves the way for generation of ectopic impulses and ephaptic crosstalk...
June 2017: Cephalalgia: An International Journal of Headache
#16
REVIEW
Valérie Biousse, Nancy J Newman
Disorders of the optic nerves (optic neuropathies) are some of the most common causes of visual loss, and can present in isolation or with associated neurological or systemic symptoms and signs. Several optic neuropathies-especially inflammatory optic neuropathies-are associated with neurological disorders and thus are often diagnosed and treated by neurologists. The mechanisms underlying optic neuropathies are diverse and typically manifest with decreased visual acuity, altered colour vision, and abnormal visual field in the affected eye...
December 2016: Lancet Neurology
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REVIEW
Donald B Sanders, Gil I Wolfe, Michael Benatar, Amelia Evoli, Nils E Gilhus, Isabel Illa, Nancy Kuntz, Janice M Massey, Arthur Melms, Hiroyuki Murai, Michael Nicolle, Jacqueline Palace, David P Richman, Jan Verschuuren, Pushpa Narayanaswami
OBJECTIVE: To develop formal consensus-based guidance for the management of myasthenia gravis (MG). METHODS: In October 2013, the Myasthenia Gravis Foundation of America appointed a Task Force to develop treatment guidance for MG, and a panel of 15 international experts was convened. The RAND/UCLA appropriateness methodology was used to develop consensus guidance statements. Definitions were developed for goals of treatment, minimal manifestations, remission, ocular MG, impending crisis, crisis, and refractory MG...
July 26, 2016: Neurology
#18
REVIEW
Wenzhuan He, Weizhen Wang, Cristy Gustas, Jozef Malysz, Divpreet Kaur
Sciatic nerve neuropathy due to infiltrating of a high grade B-cell lymphoma is a very rare situation and has not often been reported. We report a case with a previous history of indolent lymphoma who presented with isolated sciatic nerve neuropathy and was found to have diffuse large B cell lymphoma involving the sciatic nerve. Although the current case is not a primary sciatic nerve lymphoma given the systematic involvement shown on MRI and PET/CT scan, the case represents a neurolymphomatosis of the sciatic nerve given the direct invasion of the lymphoma cells into the sciatic nerve...
October 2016: Clinical Neurology and Neurosurgery
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