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RANDOMIZED CONTROLLED TRIAL
Oscar R Benavente, Robert G Hart, Leslie A McClure, Jeffrey M Szychowski, Christopher S Coffey, Lesly A Pearce
BACKGROUND: Lacunar infarcts are a frequent type of stroke caused mainly by cerebral small-vessel disease. The effectiveness of antiplatelet therapy for secondary prevention has not been defined. METHODS: We conducted a double-blind, multicenter trial involving 3020 patients with recent symptomatic lacunar infarcts identified by magnetic resonance imaging. Patients were randomly assigned to receive 75 mg of clopidogrel or placebo daily; patients in both groups received 325 mg of aspirin daily...
August 30, 2012: New England Journal of Medicine
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