collection
https://read.qxmd.com/read/35965783/glucagon-like-peptide-1-and-glucose-dependent-insulinotropic-peptide-hormones-and-novel-receptor-agonists-protect-synapses-in-alzheimer-s-and-parkinson-s-diseases
#1
REVIEW
Christian Hölscher
Glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) are peptide hormones and growth factors. A major pathological feature of both Alzheimer's dis-ease (AD) and Parkinson's disease (PD) is the loss of synaptic transmission in the cortex in AD and the loss of dopaminergic synapses in the nigra-striatal dopaminergic projection. Several studies demonstrate that GLP-1 and GIP receptor agonists protect synapses and synaptic transmission from the toxic events that underlie AD and PD...
2022: Frontiers in Synaptic Neuroscience
https://read.qxmd.com/read/32034530/a-closer-look-at-the-nosological-status-of-the-highs-hypomanic-symptoms-in-the-postpartum-period
#2
REVIEW
Verinder Sharma, Priyanka Singh, Christine Baczynski, Mustaq Khan
Studies from several countries have reported occurrence of the highs (hypomanic symptoms) immediately after childbirth; however, questions remain about the relationship of the highs with mood disorders. This systematic review aims to clarify this relationship, critically review important aspects of the highs, and make treatment recommendations and suggestions for future research. The electronic databases of MEDLINE/PubMed, PsycINFO, CINAHL, Cochrane Database of Systematic Reviews, and Evidence-Based Medicine Reviews (EBMR) were searched using the keywords and their combinations: postpartum, euphoria, hypomania, and baby pinks...
February 7, 2020: Archives of Women's Mental Health
https://read.qxmd.com/read/27106747/a-novel-selective-androgen-receptor-modulator-sarm-mk-4541-exerts-anti-androgenic-activity-in-the-prostate-cancer-xenograft-r-3327g-and-anabolic-activity-on-skeletal-muscle-mass-function-in-castrated-mice
#3
JOURNAL ARTICLE
Michael J Chisamore, Michael A Gentile, Gregory Michael Dillon, Matthew Baran, Carlo Gambone, Sean Riley, Azriel Schmidt, Osvaldo Flores, Hilary Wilkinson, Stephen E Alves
The androgen receptor (AR) is a member of the nuclear hormone receptor super family of transcription factors. Androgens play an essential role in the development, growth, and maintenance of male sex organs, as well as the musculoskeletal and central nervous systems. Yet with advancing age, androgens can drive the onset of prostate cancer, the second leading cause of cancer death in males within the United States. Androgen deprivation therapy (ADT) by pharmacologic and/or surgical castration induces apoptosis of prostate cells and subsequent shrinkage of the prostate and prostate tumors...
October 2016: Journal of Steroid Biochemistry and Molecular Biology
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