Alan N Baer, Mara McAdams DeMarco, Stephen C Shiboski, Mi Y Lam, Stephen Challacombe, Troy E Daniels, Yi Dong, John S Greenspan, Bruce W Kirkham, Hector E Lanfranchi, Morten Schiødt, Muthiah Srinivasan, Hisanori Umehara, Frederick B Vivino, Cristina F Vollenweider, Yan Zhao, Lindsey A Criswell, Caroline H Shiboski
OBJECTIVE: To determine whether the Sjögren's syndrome B (SSB)-positive/Sjögren's syndrome A (SSA)-negative antibody profile is associated with key phenotypic features of SS. METHODS: Among registrants in the Sjögren's International Collaborative Clinical Alliance (SICCA) with possible or established SS, we compared anti-SSA/anti-SSB reactivity profiles against concurrent phenotypic features. We fitted logistic regression models to explore the association between anti-SSA/anti-SSB reactivity profile and each key SS phenotypic feature, controlling for potential confounders...
August 2015: Annals of the Rheumatic Diseases