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Diet and Disease - Diet and Disease Prevention

https://read.qxmd.com/read/32061413/a-practical-approach-for-the-management-of-the-mixed-opioid-agonist-antagonist-buprenorphine-during-acute-pain-and-surgery
#1
REVIEW
Nafisseh S Warner, Matthew A Warner, Julie L Cunningham, Halena M Gazelka, W Michael Hooten, Bhanuprakash Kolla, David O Warner
The use of buprenorphine, a mixed opioid agonist-antagonist, for the management of chronic pain and/or opioid use disorder is increasing. As such, medical providers will more frequently encounter patients on this therapy. In this paper, we synthesize existing knowledge (derived through keyword searches using MEDLINE databases) in a novel conceptual framework for patients on buprenorphine presenting with acute pain or for those requiring surgical or invasive procedures. This framework is based on three unique domains: the patient, the features of the acute pain insult, and the environment...
February 12, 2020: Mayo Clinic Proceedings
https://read.qxmd.com/read/30529689/loperamide-overcomes-the-resistance-of-colon-cancer-cells-to-bortezomib-by-inducing-chop-mediated-paraptosis-like-cell-death
#2
In Young Kim, Min June Shim, Dong Min Lee, A Reum Lee, Mi Ae Kim, Mi Jin Yoon, Mi Ri Kwon, Hae In Lee, Min Ji Seo, Yong Won Choi, Kyeong Sook Choi
Although the proteasome inhibitor (PI) bortezomib (Btz) is in current clinical use as a front-line treatment for multiple myeloma, its clinical efficacy in solid tumors has not been satisfactory. Here, we show that loperamide (Lop), an antidiarrheal drug, effectively sensitizes various colon cancer cells, but not normal epithelial cells, to PI-mediated cell death. We report that combined treatment with Btz and Lop induces paraptosis-like cell death accompanied by severe endoplasmic reticulum (ER)-derived vacuolation...
April 2019: Biochemical Pharmacology
https://read.qxmd.com/read/28806640/the-importance-of-nutrition-in-aiding-recovery-from-substance-use-disorders-a-review
#3
REVIEW
Kendall D Jeynes, E Leigh Gibson
BACKGROUND: Nutrition is a prerequisite for health; yet, there is no special nutritional assessment or guidance for drug and alcohol dependent individuals, despite the fact that their food consumption is often very limited, risking malnutrition. Further, the premise is examined that malnutrition may promote drug seeking and impede recovery from substance use disorders (SUD). METHOD: A narrative review addressed the relationship between substance use disorders and nutrition, including evidence for malnutrition, as well as their impact on metabolism and appetite regulation...
October 1, 2017: Drug and Alcohol Dependence
https://read.qxmd.com/read/28388917/influence-of-diet-on-the-gut-microbiome-and-implications-for-human-health
#4
REVIEW
Rasnik K Singh, Hsin-Wen Chang, Di Yan, Kristina M Lee, Derya Ucmak, Kirsten Wong, Michael Abrouk, Benjamin Farahnik, Mio Nakamura, Tian Hao Zhu, Tina Bhutani, Wilson Liao
Recent studies have suggested that the intestinal microbiome plays an important role in modulating risk of several chronic diseases, including inflammatory bowel disease, obesity, type 2 diabetes, cardiovascular disease, and cancer. At the same time, it is now understood that diet plays a significant role in shaping the microbiome, with experiments showing that dietary alterations can induce large, temporary microbial shifts within 24 h. Given this association, there may be significant therapeutic utility in altering microbial composition through diet...
April 8, 2017: Journal of Translational Medicine
https://read.qxmd.com/read/28438745/management-of-chronic-pain-using-complementary-and-integrative-medicine
#5
REVIEW
Lucy Chen, Andreas Michalsen
Complementary and integrative medicine (CIM) encompasses both Western-style medicine and complementary health approaches as a new combined approach to treat a variety of clinical conditions. Chronic pain is the leading indication for use of CIM, and about 33% of adults and 12% of children in the US have used it in this context. Although advances have been made in treatments for chronic pain, it remains inadequately controlled for many people. Adverse effects and complications of analgesic drugs, such as addiction, kidney failure, and gastrointestinal bleeding, also limit their use...
April 24, 2017: BMJ: British Medical Journal
https://read.qxmd.com/read/26927171/dairy-product-consumption-and-risk-of-non-hodgkin-lymphoma-a-meta-analysis
#6
REVIEW
Jia Wang, Xutong Li, Dongfeng Zhang
Many epidemiologic studies have explored the association between dairy product consumption and the risk of non-Hodgkin lymphoma (NHL), but the results remain controversial. A literature search was performed in PubMed, Web of Science and Embase for relevant articles published up to October 2015. Pooled relative risks (RRs) with 95% confidence intervals (CIs) were calculated with a random-effects model. The dose-response relationship was assessed by restricted cubic spline. A total of 16 articles were eligible for this meta-analysis...
February 27, 2016: Nutrients
https://read.qxmd.com/read/26900949/the-role-of-low-acid-load-in-vegetarian-diet-on-bone-health-a-narrative-review
#7
REVIEW
Peter Burckhardt
Vegetarian and vegan diets contain low amounts of protein and calcium. For this reason they are supposed to cause low bone mineral density (BMD) and osteoporosis. But this is not the case, except for vegans with a particularly low calcium intake. The absence of osteoporosis or low BMD can be explained by the low acid load of these diets. Nutritional acid load is negatively correlated with bone mineral density (BMD) and positively with fracture risk. Low acid load is correlated with lower bone resorption and higher BMD...
2016: Swiss Medical Weekly
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