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glucocort y preterm

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Cynthia Gyamfi-Bannerman, Elizabeth A Thom, Sean C Blackwell, Alan T N Tita, Uma M Reddy, George R Saade, Dwight J Rouse, David S McKenna, Erin A S Clark, John M Thorp, Edward K Chien, Alan M Peaceman, Ronald S Gibbs, Geeta K Swamy, Mary E Norton, Brian M Casey, Steve N Caritis, Jorge E Tolosa, Yoram Sorokin, J Peter VanDorsten, Lucky Jain
BACKGROUND: Infants who are born at 34 to 36 weeks of gestation (late preterm) are at greater risk for adverse respiratory and other outcomes than those born at 37 weeks of gestation or later. It is not known whether betamethasone administered to women at risk for late preterm delivery decreases the risks of neonatal morbidities. METHODS: We conducted a multicenter, randomized trial involving women with a singleton pregnancy at 34 weeks 0 days to 36 weeks 5 days of gestation who were at high risk for delivery during the late preterm period (up to 36 weeks 6 days)...
April 7, 2016: New England Journal of Medicine
Amita Bansal, Frank H Bloomfield, Kristin L Connor, Mike Dragunow, Eric B Thorstensen, Mark H Oliver, Deborah M Sloboda, Jane E Harding, Jane M Alsweiler
Adults born preterm are at increased risk of impaired glucose tolerance and diabetes. Late gestation fetuses exposed to high blood glucose concentration also are at increased risk of impaired glucose tolerance as adults. Preterm babies commonly become hyperglycemic and are thus exposed to high blood glucose concentration at an equivalent stage of pancreatic maturation. It is not known whether preterm birth itself, or complications of prematurity, such as hyperglycemia, alter later pancreatic function. To distinguish these, we made singleton preterm lambs hyperglycemic (HYPER) for 12 days after birth with a dextrose infusion and compared them with vehicle-treated preterm and term controls and with HYPER lambs made normoglycemic with an insulin infusion...
October 2015: Endocrinology
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