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REVIEW
Christopher F Rose, Piero Amodio, Jasmohan S Bajaj, Radha Krishan Dhiman, Sara Montagnese, Simon D Taylor-Robinson, Hendrik Vilstrup, Rajiv Jalan
Hepatic encephalopathy (HE) is a frequent and serious complication of both chronic liver disease and acute liver failure. HE manifests as a wide spectrum of neuropsychiatric abnormalities, from subclinical changes (mild cognitive impairment) to marked disorientation, confusion and coma. The clinical and economic burden of HE is considerable, and it contributes greatly to impaired quality of life, morbidity and mortality. This review will critically discuss the latest classification of HE, as well as the pathogenesis and pathophysiological pathways underlying the neurological decline in patients with end-stage liver disease...
October 20, 2020: Journal of Hepatology
#2
REVIEW
Franziska Herpich, Fred Rincon
OBJECTIVES: Concise "synthetic" review of the state of the art of management of acute ischemic stroke. DATA SOURCES: Available literature on PubMed. STUDY SELECTION: We selected landmark studies, recent clinical trials, observational studies, and professional guidelines on the management of stroke including the last 10 years. DATA EXTRACTION: Eligible studies were identified and results leading to guideline recommendations were summarized...
November 2020: Critical Care Medicine
#3
JOURNAL ARTICLE
Matthew F Mart, E Wesley Ely
No abstract text is available yet for this article.
December 2020: Critical Care Medicine
#4
REVIEW
Lotte Boxhoorn, Rogier P Voermans, Stefan A Bouwense, Marco J Bruno, Robert C Verdonk, Marja A Boermeester, Hjalmar C van Santvoort, Marc G Besselink
Acute pancreatitis is an unpredictable and potentially lethal disease. The prognosis mainly depends on the development of organ failure and secondary infection of pancreatic or peripancreatic necrosis. In the past 10 years, treatment of acute pancreatitis has moved towards a multidisciplinary, tailored, and minimally invasive approach. Despite improvements in treatment and critical care, severe acute pancreatitis is still associated with high mortality rates. In this Seminar, we outline the latest evidence on diagnostic and therapeutic strategies for acute pancreatitis...
September 5, 2020: Lancet
#5
REVIEW
Mathias W Pletz, Francesco Blasi, James D Chalmers, Charles S Dela Cruz, Charles Feldman, Carlos M Luna, Julio A Ramirez, Yuichiro Shindo, Daiana Stolz, Antoni Torres, Brandon Webb, Tobias Welte, Richard Wunderink, Stefano Aliberti
In 2019, the American Thoracic Society (ATS) and Infectious Diseases Society of America (IDSA) issued a substantial revision of the 2007 guideline on community-acquired pneumonia (CAP). Despite the fact that generalization of infectious disease guidelines is limited because of substantial geographic differences in microbiologic etiology and antimicrobial resistance, the ATS/IDSA guideline is frequently applied outside the United States. Therefore, this project aimed to give a perspective on the ATS/IDSA CAP recommendations related to the management of CAP outside the United States...
November 2020: Chest
#6
REVIEW
W Joost Wiersinga, Andrew Rhodes, Allen C Cheng, Sharon J Peacock, Hallie C Prescott
IMPORTANCE: The coronavirus disease 2019 (COVID-19) pandemic, due to the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused a worldwide sudden and substantial increase in hospitalizations for pneumonia with multiorgan disease. This review discusses current evidence regarding the pathophysiology, transmission, diagnosis, and management of COVID-19. OBSERVATIONS: SARS-CoV-2 is spread primarily via respiratory droplets during close face-to-face contact...
August 25, 2020: JAMA
#7
MULTICENTER STUDY
Gajanan S Bhat, Anuradha Shastry
BACKGROUND: Orgasm in women is a complex phenomenon, and the sparse data about time to orgasm (TitOr) in women are an impediment to the research on this complex phenomenon. AIM: To evaluate the stopwatch measured TitOr in women in a monogamous stable heterosexual relationship. METHODS: The study was conducted through web-based and personal interview using a questionnaire, which addressed the issues related to TitOr. Sexually active women older than 18 years and women in a monogamous stable heterosexual relationship were included in the study...
April 2020: Journal of Sexual Medicine
#8
JOURNAL ARTICLE
Shazia Jamil, Nick Mark, Graham Carlos, Charles S Dela Cruz, Jane E Gross, Susan Pasnick
No abstract text is available yet for this article.
May 15, 2020: American Journal of Respiratory and Critical Care Medicine
#9
JOURNAL ARTICLE
Jasmeet Soar, Ian Maconochie, Myra H Wyckoff, Theresa M Olasveengen, Eunice M Singletary, Robert Greif, Richard Aickin, Farhan Bhanji, Michael W Donnino, Mary E Mancini, Jonathan P Wyllie, David Zideman, Lars W Andersen, Dianne L Atkins, Khalid Aziz, Jason Bendall, Katherine M Berg, David C Berry, Blair L Bigham, Robert Bingham, Thomaz Bittencourt Couto, Bernd W Böttiger, Vere Borra, Janet E Bray, Jan Breckwoldt, Steven C Brooks, Jason Buick, Clifton W Callaway, Jestin N Carlson, Pascal Cassan, Maaret Castrén, Wei-Tien Chang, Nathan P Charlton, Adam Cheng, Sung Phil Chung, Julie Considine, Keith Couper, Katie N Dainty, Jennifer Anne Dawson, Maria Fernanda de Almeida, Allan R de Caen, Charles D Deakin, Ian R Drennan, Jonathan P Duff, Jonathan L Epstein, Raffo Escalante, Raúl J Gazmuri, Elaine Gilfoyle, Asger Granfeldt, Anne-Marie Guerguerian, Ruth Guinsburg, Tetsuo Hatanaka, Mathias J Holmberg, Natalie Hood, Shigeharu Hosono, Ming-Ju Hsieh, Tetsuya Isayama, Taku Iwami, Jan L Jensen, Vishal Kapadia, Han-Suk Kim, Monica E Kleinman, Peter J Kudenchuk, Eddy Lang, Eric Lavonas, Helen Liley, Swee Han Lim, Andrew Lockey, Bo Lofgren, Matthew Huei-Ming Ma, David Markenson, Peter A Meaney, Daniel Meyran, Lindsay Mildenhall, Koenraad G Monsieurs, William Montgomery, Peter T Morley, Laurie J Morrison, Vinay M Nadkarni, Kevin Nation, Robert W Neumar, Kee-Chong Ng, Tonia Nicholson, Nikolaos Nikolaou, Chika Nishiyama, Gabrielle Nuthall, Shinichiro Ohshimo, Deems Okamoto, Brian O'Neil, Gene Yong-Kwang Ong, Edison F Paiva, Michael Parr, Jeffrey L Pellegrino, Gavin D Perkins, Jeffrey Perlman, Yacov Rabi, Amelia Reis, Joshua C Reynolds, Giuseppe Ristagno, Charles C Roehr, Tetsuya Sakamoto, Claudio Sandroni, Stephen M Schexnayder, Barnaby R Scholefield, Naoki Shimizu, Markus B Skrifvars, Michael A Smyth, David Stanton, Janel Swain, Edgardo Szyld, Janice Tijssen, Andrew Travers, Daniele Trevisanuto, Christian Vaillancourt, Patrick Van de Voorde, Sithembiso Velaphi, Tzong-Luen Wang, Gary Weiner, Michelle Welsford, Jeff A Woodin, Joyce Yeung, Jerry P Nolan, Mary Fran Hazinski
The International Liaison Committee on Resuscitation has initiated a continuous review of new, peer-reviewed, published cardiopulmonary resuscitation science. This is the third annual summary of the International Liaison Committee on Resuscitation International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations. It addresses the most recent published resuscitation evidence reviewed by International Liaison Committee on Resuscitation Task Force science experts...
December 2019: Resuscitation
#10
JOURNAL ARTICLE
Rebecca R Chamley, David A Holdsworth, Kim Rajappan, Edward D Nicol
No abstract text is available yet for this article.
August 21, 2019: European Heart Journal
#11
EDITORIAL
Peter J Hotez, Kristy O Murray
No abstract text is available yet for this article.
August 2017: PLoS Neglected Tropical Diseases
#12
REVIEW
André J Scheen
The management of type 2 diabetes mellitus (T2DM) essentially consists in controlling hyperglycaemia, together with other vascular risk factors, in order to reduce the incidence and severity of diabetic complications. Whereas glucose control using classical glucose-lowering agents (except perhaps metformin) largely fails to reduce cardiovascular disease (CVD), two new pharmacological classes, glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter type 2 inhibitors (SGLT2is), have proven their ability to reduce major cardiovascular events in patients with established CVD...
January 2020: Diabetes Research and Clinical Practice
#13
REVIEW
Alison B Evert, Michelle Dennison, Christopher D Gardner, W Timothy Garvey, Ka Hei Karen Lau, Janice MacLeod, Joanna Mitri, Raquel F Pereira, Kelly Rawlings, Shamera Robinson, Laura Saslow, Sacha Uelmen, Patricia B Urbanski, William S Yancy
No abstract text is available yet for this article.
May 2019: Diabetes Care
#14
REVIEW
Leigh Perreault, Lauren Vincent, Joshua J Neumiller, Tricia Santos-Cavaiola
Basal insulin therapy is a critical part of effective type 2 diabetes (T2D) management for many patients, yet its initiation and titration are often delayed or avoided. Aversion to basal insulin therapy contributes to unnecessary hyperglycemia and poorer outcomes for patients. Primary care physicians often make decisions regarding the initiation of basal insulin in T2D, as they work closely with patients and are well placed to discuss and manage the transition to basal insulin therapy. However, many primary care clinicians hesitate to initiate basal insulin due to concerns regarding time or effort needed to educate patients, doubts about patient acceptance or ability to manage titration or injection, or patient fears of hypoglycemia...
2019: Journal of the American Board of Family Medicine: JABFM
#15
JOURNAL ARTICLE
Fred M Kusumoto, Mark H Schoenfeld, Coletta Barrett, James R Edgerton, Kenneth A Ellenbogen, Michael R Gold, Nora F Goldschlager, Robert M Hamilton, José A Joglar, Robert J Kim, Richard Lee, Joseph E Marine, Christopher J McLeod, Keith R Oken, Kristen K Patton, Cara N Pellegrini, Kimberly A Selzman, Annemarie Thompson, Paul D Varosy
No abstract text is available yet for this article.
August 20, 2019: Journal of the American College of Cardiology
#16
REVIEW
Jonathan D Casey, Ryan M Brown, Matthew W Semler
PURPOSE OF REVIEW: Intravenous fluid administration is a fundamental therapy in critical care, yet key questions remain unanswered regarding optimal fluid composition and dose. This review evaluates recent evidence regarding the effects of fluid resuscitation on pathophysiology, organ function, and clinical outcomes for critically ill patients. RECENT FINDINGS: Recent findings suggest that intravenous fluid composition affects risk of kidney injury and death for critically ill adults...
December 2018: Current Opinion in Critical Care
#17
REVIEW
Kalliopi Pafili, Manfredi Rizzo, Nikolaos Papanas
PURPOSE OF REVIEW: Cardiovascular disease (CVD) substantially increases mortality in diabetes mellitus. This narrative review highlights recent research on the putative associations between dipeptyl peptidase 4 inhibitors, glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium glucose co-transporter 2 inhibitors (SGLT-2is) and several cardiovascular risk factors. RECENT FINDINGS: New antihyperglycaemic agents favourably modulate several CVD risk factors, including fasting and postprandial plasma glucose levels, body weight, blood pressure, lipids, microalbuminuria, nonalcoholic fatty liver disease, serum uric acid, and arterial stiffness...
July 2018: Current Opinion in Cardiology
#18
JOURNAL ARTICLE
Michel Burnier
No abstract text is available yet for this article.
March 14, 2018: European Heart Journal
#19
REVIEW
Xavier Monnet, Jean-Louis Teboul
PURPOSE OF REVIEW: In the field of prediction of fluid responsiveness, the most recent studies have focused on validating new tests, on clarifying the limitations of older ones, and better defining their modalities. RECENT FINDINGS: The limitations of pulse pressure/stroke volume variations are numerous, but recent efforts have been made to overcome these limitations, like in case of low tidal volume ventilation. Following pulse pressure/stroke volume variations, new tests have emerged which assess preload responsiveness by challenging cardiac preload through heart-lung interactions, like during recruitment manoeuvres and end-expiratory/inspiratory occlusions...
June 2018: Current Opinion in Critical Care
#20
JOURNAL ARTICLE
Marcela Ewing, Peter Naredi, Chenyang Zhang, Jörgen Månsson
Background: Many patients with common cancers are late diagnosed. Objectives: Identify consultation profiles and clinical features in patients with the seven most common cancers, who had consulted a general practitioner (GP) frequently before their cancer diagnosis. Methods: A case-control study was conducted in Region Västra Götaland, Sweden. A total of 2570 patients, diagnosed in 2011 with prostate, breast, colorectal, lung, gynaecological and skin cancers including malignant melanoma, and 9424 controls were selected from the Swedish Cancer Register and a regional health care database...
September 18, 2018: Family Practice
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