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February 2016: Journal of Hepatology
Francesco A D'Angelo, Laura Antolino, Mara La Rocca, Niccolò Petrucciani, Paolo Magistri, Paolo Aurello, Giovanni Ramacciato
The timing of surgery and antineoplastic therapies in patients with resectable non-metastatic pancreatic cancer is still a controversial matter of debate, with special regard to neoadjuvant approaches. Following the criteria of the PRISMA statement, a literature search was conducted looking for RCTs focusing on adjuvant and neoadjuvant therapies in resectable pancreatic cancer. The quality of the available evidence was assessed using the Cochrane Collaboration's tool for assessing risk of bias. Data extraction was carried out by two independent investigators...
March 2016: Medical Oncology
Milka Marinova, Maximilian Rauch, Martin Mücke, Roman Rolke, Maria A Gonzalez-Carmona, Jana Henseler, Henning Cuhls, Lukas Radbruch, Christian P Strassburg, Lian Zhang, Hans H Schild, Holger M Strunk
OBJECTIVES: Prognosis of patients with locally advanced pancreatic adenocarcinoma is extremely poor. They often suffer from cancer-related pain reducing their quality of life. This prospective observational study aimed to evaluate feasibility, local tumour response, and changes in quality of life and symptoms in Caucasian patients with locally advanced pancreatic cancer treated by ultrasound-guided high-intensity focused ultrasound (HIFU). METHODS: Thirteen patients underwent HIFU, five with stage III, eight with stage IV UICC disease...
November 2016: European Radiology
Omar Barakat, Martha N Cagigas, Shima Bozorgui, Claire F Ozaki, R Patrick Wood
BACKGROUND: Delayed gastric emptying (DGE) is a common complication of pancreaticoduodenectomy. We determined the efficiency of a new reconstruction technique, designed to preserve motilin-secreting cells and maximize the utility of their receptors, in reducing the incidence of DGE after pancreaticoduodenectomy. METHODS: From April 2005 to September 2014, 217 consecutive patients underwent pancreaticoduodenectomy at our institution. Nine patients who underwent total pancreatectomy were excluded...
May 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
Thierry Conroy, Jean-Baptiste Bachet, Ahmet Ayav, Florence Huguet, Aurélien Lambert, Caroline Caramella, Raphaël Maréchal, Jean-Luc Van Laethem, Michel Ducreux
Pancreatic adenocarcinoma remains a devastating disease with a 5-year survival rate not exceeding 6%. Treatment of this disease remains a major challenge. This article reviews the state-of-the-art in the management of this disease and the new innovative approaches that may help to accelerate progress in treating its victims. After careful pre-therapeutic evaluation, only 15-20% of patients diagnosed with a pancreatic cancer (PC) are eligible for upfront radical surgery. After R0 or R1 resection in such patients, evidence suggests a significantly positive impact on survival of adjuvant chemotherapy comprising 6 months of gemcitabine or fluorouracil/folinic acid...
April 2016: European Journal of Cancer
David M Levi, Joe U Levi
No abstract text is available yet for this article.
April 2016: Journal of the American College of Surgeons
Barbara M Grüner, Isabel Winkelmann, Annette Feuchtinger, Na Sun, Benjamin Balluff, Nicole Teichmann, Alexander Herner, Evdokia Kalideris, Katja Steiger, Rickmer Braren, Michaela Aichler, Irene Esposito, Roland M Schmid, Axel Walch, Jens T Siveke
Pancreatic ductal adenocarcinoma (PDAC) is likely the most aggressive and therapy-resistant of all cancers. The aim of this study was to investigate the emerging technology of matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS) as a powerful tool to study drug delivery and spatial tissue distribution in PDAC. We utilized an established genetically engineered mouse model of spontaneous PDAC to examine the distribution of the small-molecule inhibitor erlotinib in healthy pancreas and PDAC...
May 2016: Molecular Cancer Therapeutics
Venkata S Katabathina, Erin M Flaherty, Anil K Dasyam, Christine O Menias, Nicole D Riddle, Narayan Lath, Kazuto Kozaka, Osamu Matsui, Yasuni Nakanuma, Srinivasa R Prasad
On the basis of the similarities in the histopathologic findings and the clinical-biologic behaviors of select biliary and pancreatic conditions, a new disease concept, "biliary diseases with pancreatic counterparts," has been proposed. Both nonneoplastic and neoplastic pathologic conditions of the biliary tract have their counterparts in the pancreas. Immunoglobulin G4 (IgG4)-related sclerosing cholangitis is the biliary manifestation of IgG4-related sclerosing disease, and type 1 autoimmune pancreatitis is its pancreatic counterpart...
March 2016: Radiographics: a Review Publication of the Radiological Society of North America, Inc
Adam Kaczorowski, Katharina Hammer, Li Liu, Sabine Villhauer, Clifford Nwaeburu, Pei Fan, Zhefu Zhao, Jury Gladkich, Wolfgang Groß, Dirk M Nettelbeck, Ingrid Herr
Pancreatic ductal adenocarcinoma (PDA) is one of the most aggressive malignancies and has poor therapeutic options. We evaluated improved oncolytic adenoviruses (OAds), in which the adenoviral gene E1B19K was deleted or a TRAIL transgene was inserted. Bone marrow mesenchymal stromal cells (MSCs) served as carriers for protected and tumor-specific virus transfers. The infection competence, tumor migration, and oncolysis were measured in cancer stem cell (CSC) models of primary and established tumor cells and in tumor xenografts...
February 23, 2016: Oncotarget
Travis A Shutt, Prejesh Philips, Charles R Scoggins, Kelly M McMasters, Robert C G Martin
PURPOSE: Major (>3 segments of the liver) or minor hepatectomy has been demonstrated to provide the most definitive chance for long-term remission and disease-free survival in hepatic malignancies. However, concerns remain in regards to the ability of the elderly (>70 years old) and older (>80 years old) patients to "tolerate" this type of resection. Thus, the aim of this study was to determine the short- and long-term effects of hepatectomies in the elderly patient population...
May 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
H A Burris, M J Moore, J Andersen, M R Green, M L Rothenberg, M R Modiano, M C Cripps, R K Portenoy, A M Storniolo, P Tarassoff, R Nelson, F A Dorr, C D Stephens, D D Von Hoff
PURPOSE: Most patients with advanced pancreas cancer experience pain and must limit their daily activities because of tumor-related symptoms. To date, no treatment has had a significant impact on the disease. In early studies with gemcitabine, patients with pancreas cancer experienced an improvement in disease-related symptoms. Based on those findings, a definitive trial was performed to assess the effectiveness of gemcitabine in patients with newly diagnosed advanced pancreas cancer...
June 1997: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Douglas C Morran, Jianmin Wu, Nigel B Jamieson, Agata Mrowinska, Gabriela Kalna, Saadia A Karim, Amy Y M Au, Christopher J Scarlett, David K Chang, Malgorzata Z Pajak, Karin A Oien, Colin J McKay, C Ross Carter, Gerry Gillen, Sue Champion, Sally L Pimlott, Kurt I Anderson, T R Jeffry Evans, Sean M Grimmond, Andrew V Biankin, Owen J Sansom, Jennifer P Morton
OBJECTIVE: Pancreatic cancer is a leading cause of cancer-related death in the Western world. Current chemotherapy regimens have modest survival benefit. Thus, novel, effective therapies are required for treatment of this disease. DESIGN: Activating KRAS mutation almost always drives pancreatic tumour initiation, however, deregulation of other potentially druggable pathways promotes tumour progression. PTEN loss leads to acceleration of Kras(G12D)-driven pancreatic ductal adenocarcinoma (PDAC) in mice and these tumours have high levels of mammalian target of rapamycin (mTOR) signalling...
September 2014: Gut
M Ducreux, A Sa Cuhna, C Caramella, A Hollebecque, P Burtin, D Goéré, T Seufferlein, K Haustermans, J L Van Laethem, T Conroy, D Arnold
No abstract text is available yet for this article.
September 2015: Annals of Oncology: Official Journal of the European Society for Medical Oncology
Chad G Ball, Elijah Dixon, Charles M Vollmer, Thomas J Howard
Pancreaticoduodenectomy remains the exclusive technique for surgical resection of cancers located within both the pancreatic head and periampullary region. Amongst peri-procedural complications, hemorrhage is particularly problematic given that allogenic blood transfusions are known to increase the risk of infection, acute lung injury, cancer recurrence and overall 30-day morbidity and mortality rates. Because blood loss can be considered a modifiable factor that reflects surgical technique, rates of perioperative blood loss and transfusion have been advocated as robust quality indicators...
November 25, 2015: BMC Surgery
Jenny Rystedt, Gert Lindell, Agneta Montgomery
BACKGROUND: Bile duct injury (BDI) is a rare complication associated with cholecystectomy, and recommendations for treatment are based on publications from referral centers with a selection of major injuries and failures after primary repair. The aim was to analyze the frequency, treatment, and outcome of BDIs in an unselected population-based cohort. METHODS: This was a retrospective cohort study including all BDIs registered in GallRiks (Swedish quality register for gallstone surgery and ERCP) during 2007-2011...
January 2016: World Journal of Surgery
Hwai-Ding Lam, Aude Vanlander, Frederik Berrevoet
AIM: We retrospectively analyzed incisional hernia (IH) outcomes of liver transplant (LT) vs. hepatopancreaticobiliary (HPB) cases sharing the same incision. METHODS: IH repair patients with a history of LT were compared with those with HPB surgical history sharing the same type of incision and using the European Hernia Society classification and nomenclature for reporting outcome. RESULTS: Eighty-two patients (27 HPB and 55 LT) between February 2001 and February 2014 were analyzed...
March 2016: Clinical Transplantation
Jae Uk Chong, Sangguen Nam, Hee Jung Kim, Rami Lee, Yunjung Choi, Jae Gil Lee, Kyung Sik Kim
INTRODUCTION: Perioperative fluid restriction is advocated to reduce complications after major surgeries. Current methods of monitoring body fluids rely on indirect volume markers that may at times be inadequate. In our study, bioimpedance analysis (BIA) was used to explore fluid dynamics, in terms of intercompartmental shift, of perioperative patients undergoing operation for hepato-pancreato-biliary (HPB) diseases. METHODS: A retrospective review was conducted, examining 36 patients surgically treated for HPB diseases between March 2010 and August 2012...
May 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
Derek O'Reilly, Rachel Edmiston, Pooja Bijoor, Rahul Deshpande, Nicola de'Liguori Carino, Basil Ammori, David J Sherlock
This project aims to assess the impact of the introduction of a hepatobiliary and pancreatic (HPB) Quality Improvement Program (QIP) on postoperative complications following liver, biliary and pancreatic surgery. A prospective analysis of postoperative complications over a six month period was performed. Complications were analysed and graded according to internationally agreed definitions. Justification was sought and errors identified. Weekly meetings were performed to review each complication enabling an action plan to be created to prevent future recurrence...
2014: BMJ Quality Improvement Reports
Jon Kroll Bjerregaard, Michael Bau Mortensen, Per Pfeiffer
BACKGROUND: Cancers of the liver, bile duct, gall bladder and pancreas (HPB-c) are a heterogeneous group, united almost exclusively by a poor prognosis. As the number of elderly in the Western world continues to rise and HPB-c are associated with age, we wanted to examine changes in incidence, mortality, prevalence and relative survival for these cancers. MATERIALS AND METHODS: HBP-c was defined as ICD-10 codes C22 (liver), C23-24 (gall bladder), and C25 (pancreas)...
2016: Acta Oncologica
Nicholas George Mowbray, Ali Al-Sarira, Bilal Al-Sarireh
OBJECTIVES: Laparoscopic techniques have been slow to establish a role in pancreatic surgery. Worldwide, laparoscopic left pancreatectomy (LLP) is gaining in popularity; however, there remains little published data from the United Kingdom.We aimed to evaluate the results of LLP performed in a single UK pancreatic unit. METHODS: Patients undergoing LLP for lesions in the body and tail of the pancreas between April 2009 and April 2015 were identified. Patient records were reviewed retrospectively...
September 2016: Pancreas
2016-01-23 21:29:00
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