Arnab Basu, Aleksandar Antanasijevic, Minxiu Wang, Bing Li, Debra M Mills, Jessica A Ames, Peter J Nash, John D Williams, Norton P Peet, Donald T Moir, Mark N Prichard, Kathy A Keith, Dale L Barnard, Michael Caffrey, Lijun Rong, Terry L Bowlin
Influenza viruses are a major public health threat worldwide, and options for antiviral therapy are limited by the emergence of drug-resistant virus strains. The influenza virus glycoprotein hemagglutinin (HA) plays critical roles in the early stage of virus infection, including receptor binding and membrane fusion, making it a potential target for the development of anti-influenza drugs. Using pseudotype virus-based high-throughput screens, we have identified several new small molecules capable of inhibiting influenza virus entry...
February 2014: Journal of Virology