Marzia Corbetto, Fioravante Capone, Vincenzo Denaro, Carlo Quattrocchi, Cesare Colosimo, Giulio Maira, Vincenzo Di Lazzaro
No abstract text is available yet for this article.
April 22, 2014: Neurology
Ana Monteiro, Amélia Mendes, Fernando Silveira, Lígia Castro, Goreti Nadais
A previously healthy 49-year-old woman presented with progressive motor deficit. The complaints started the year before with weakness of the right arm. Over the subsequent months, she developed weakness in the left arm, followed by both legs, and, finally, difficulty speaking, with nasal voice, and swallowing. It was increasingly difficult to attend to her chores, and, by the time she sought medical attention, she needed help with all daily activities. In the last few weeks, she also complained of diffuse joint and muscle pain...
April 15, 2014: Neurology
Fei Han, Bin Peng, Shan Gao, Chen-Hui Mao, Li-Ying Cui, Bing Xing, Yi-Cheng Zhu
No abstract text is available yet for this article.
January 14, 2014: Neurology
Dimitrios Rallis, Anastasia Skafida, Georgios Alexopoulos, Adamantios Petsanas, Argyrios Foteinos, Smaragda Katsoulakou, Eleni Koutra
No abstract text is available yet for this article.
February 17, 2015: Neurology
Bardia Nourbakhsh, Julio C Rojas, Chirantan Banerjee, Roberta L Novakovic, Worthy Warnack
A 73-year-old woman with a history of hypertension and a recent stroke presented with recurrent nonsensical speech and visual problems. One month prior, she had been diagnosed with a stroke, after sudden-onset speech and visual difficulties that resolved after a few hours. Thirteen days before, she had had a second episode of similar symptoms. She was seen in our institution after a few hours of sudden-onset unintelligible speech. Her vital signs were within normal limits. She was not in distress, but appeared frustrated...
November 5, 2013: Neurology
Roy E Strowd, Ashley Wabnitz, Nikhil Balakrishnan, Jeffrey Craig, Charles H Tegeler
A 32-year-old woman with a history of bipolar disorder, polycystic ovarian syndrome, and hypertension and a 4-year history of uncontrolled type 2 diabetes mellitus (DM) presented with bifrontal headache, elevated blood sugars (>500 mg/dL), and abrupt-onset left homonymous hemianopia upon awakening. Vital signs included temperature 98.0°F, blood pressure 160/89 mm Hg, and heart rate 67 bpm. Neurologic examination showed dense left homonymous hemianopia with macular sparing and without other focal findings...
April 15, 2014: Neurology
Simon C Li, Marieke T de Graaf, Perumpillichira J Cherian
A 76-year-old man was admitted to the hospital after having a "cardiac arrest" while riding his bicycle and subsequently falling into a canal. Thirty minutes after the accident, he was resuscitated by an ambulance crew. They detected a ventricular tachycardia, which responded to defibrillation. Thereafter, there was a sinus bradycardia, which was treated with atropine and adrenaline. After 30 minutes of resuscitation, there was return of spontaneous circulation (ROSC). At admission to our hospital, the patient was comatose, with a body temperature of 30°C and Glasgow Coma Scale score (GCS) of E1M1V1...
February 4, 2014: Neurology
Sarah H Berth, Arjun Seth, Adam Cohen, Lucia Rivera Lara, Ferdinand Hui, Lisa R Sun
No abstract text is available yet for this article.
August 13, 2019: Neurology
Toshiaki Iba, Jerrold H Levy, Theodore E Warkentin, Jecko Thachil, Tom van der Poll, Marcel Levi
No abstract text is available yet for this article.
November 2019: Journal of Thrombosis and Haemostasis: JTH
Andre C Kalil, Paul G Thomas
Influenza virus affects the respiratory tract by direct viral infection or by damage from the immune system response. In humans, the respiratory epithelium is the only site where the hemagglutinin (HA) molecule is effectively cleaved, generating infectious virus particles. Virus transmission occurs through a susceptible individual's contact with aerosols or respiratory fomites from an infected individual. The inability of the lung to perform its primary function of gas exchange can result from multiple mechanisms, including obstruction of the airways, loss of alveolar structure, loss of lung epithelial integrity from direct epithelial cell killing, and degradation of the critical extracellular matrix...
July 19, 2019: Critical Care: the Official Journal of the Critical Care Forum
Monica Del Rey Gonzalez, Christopher Y Park
No abstract text is available yet for this article.
July 11, 2019: Blood
Matthew Banks, David Graham, Marnix Jansen, Takuji Gotoda, Sergio Coda, Massimiliano di Pietro, Noriya Uedo, Pradeep Bhandari, D Mark Pritchard, Ernst J Kuipers, Manuel Rodriguez-Justo, Marco R Novelli, Krish Ragunath, Neil Shepherd, Mario Dinis-Ribeiro
Gastric adenocarcinoma carries a poor prognosis, in part due to the late stage of diagnosis. Risk factors include Helicobacter pylori infection, family history of gastric cancer-in particular, hereditary diffuse gastric cancer and pernicious anaemia. The stages in the progression to cancer include chronic gastritis, gastric atrophy (GA), gastric intestinal metaplasia (GIM) and dysplasia. The key to early detection of cancer and improved survival is to non-invasively identify those at risk before endoscopy. However, although biomarkers may help in the detection of patients with chronic atrophic gastritis, there is insufficient evidence to support their use for population screening...
September 2019: Gut
Clara Westwell-Roper, Iwona Niemietz, Lori B Tucker, Kelly L Brown
Familial Mediterranean fever (FMF) is the most common monogenic autoinflammatory disease in Canada and is characterized by a clinical syndrome of episodic inflammatory symptoms. Traditionally, the disease is defined by autosomal recessive inheritance of MEFV gene variants, yet FMF also not uncommonly manifests in individuals with only one identified disease-associated allele. Increasing availability and affordability of gene sequencing has led to the identification of multiple MEFV variants; however, they are often of unknown clinical significance...
May 14, 2019: Pediatric Rheumatology Online Journal
Daniel Puebla-Neira, William J Calhoun
No abstract text is available yet for this article.
September 2019: Journal of Allergy and Clinical Immunology
Ryuji Okamoto, Yusuf Ali, Ryotaro Hashizume, Noboru Suzuki, Masaaki Ito
Brain natriuretic peptide (BNP) is an important biomarker for patients with heart failure, hypertension and cardiac hypertrophy. Although it is known that BNP levels are relatively higher in patients with chronic kidney disease and no heart disease, the mechanism remains unknown. Here, we review the functions and the roles of BNP in the heart-kidney interaction. In addition, we discuss the relevant molecular mechanisms that suggest BNP is protective against chronic kidney diseases and heart failure, especially in terms of the counterparts of the renin-angiotensin-aldosterone system (RAAS)...
July 22, 2019: International Journal of Molecular Sciences
Tommaso Mauri, Yu-Mei Wang, Francesca Dalla Corte, Nadia Corcione, Elena Spinelli, Antonio Pesenti
Nasal high flow (NHF) is a promising novel oxygen delivery device, whose mechanisms of action offer some beneficial effects over conventional oxygen systems. It is considered to have a number of physiological effects: it improves oxygenation, dynamic lung compliance, homogeneity and end expiratory lung volume; it decreases anatomical dead space and generates a positive airway pressure that can reduce respiratory rate, the work of breathing, and enhance patient comfort. NHF has been used as a prophylactic tool or as a treatment device mostly in patients with acute hypoxemic respiratory failure such as pre-oxygenation before intubation, immunocompromised patients and acute heart failure...
2019: Open Access Emergency Medicine: OAEM
Jerry L Spivak
Since its discovery, polycythemia vera (PV) has challenged clinicians responsible for its diagnosis and management and scientists investigating its pathogenesis. As a clonal hematopoietic stem cell (HSC) disorder, PV is a neoplasm but its driver mutations result in overproduction of morphologically and functionally normal blood cells. PV arises in an HSC but it can present initially as isolated erythrocytosis, leukocytosis, thrombocytosis, or any combination of these together with splenomegaly or myelofibrosis, and it can take years for a true panmyelopathy to appear...
July 25, 2019: Blood
Daniel Bates, B Carsten Schultheis, Michael C Hanes, Suneil M Jolly, Krishnan V Chakravarthy, Timothy R Deer, Robert M Levy, Corey W Hunter
BACKGROUND: The objective of this review was to merge current treatment guidelines and best practice recommendations for management of neuropathic pain into a comprehensive algorithm for primary physicians. The algorithm covers assessment, multidisciplinary conservative care, nonopioid pharmacological management, interventional therapies, neurostimulation, low-dose opioid treatment, and targeted drug delivery therapy. METHODS: Available literature was identified through a search of the US National Library of Medicine's Medline database, PubMed...
June 1, 2019: Pain Medicine
Kirtida Mistry
The dialysis disequilibrium syndrome (DDS) is a clinical constellation of neurologic symptoms and signs occurring during or shortly following dialysis, especially when dialysis is first initiated. It is a diagnosis of exclusion occurring in those that are uremic and hyperosmolar, in whom rapid correction with renal replacement therapy leads to cerebral edema and raised intracranial pressure with resultant clinical neurologic manifestations. DDS is most commonly described in association with hemodialysis but can occur in patients with acute kidney injury requiring continuous renal replacement therapy (CRRT)...
2019: International Journal of Nephrology and Renovascular Disease
Valentin Amrhein, Sander Greenland, Blake McShane
No abstract text is available yet for this article.
March 2019: Nature
2019-07-17 05:41:44
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