collection
https://read.qxmd.com/read/30817367/safety-of-propofol-use-in-patients-allergic-to-soy-or-peanut-a-retrospective-observational-cohort-study
#1
LETTER
Jan Gelberg, Stefan Droguet, Peter Bentzer, David Grubb
No abstract text is available yet for this article.
April 2019: European Journal of Anaesthesiology
https://read.qxmd.com/read/28741272/an-up-down-determination-of-the-required-seated-duration-after-intrathecal-injection-of-bupivacaine-and-fentanyl-for-the-prevention-of-hypotension-during-cesarean-delivery
#2
RANDOMIZED CONTROLLED TRIAL
Albert Moore, Eva El-Mouallem, Aly El-Bahrawy, Ian Kaufman, Mahmoud Moustafa, Simone Derzi, Roupen Hatzakorzian, William Lipishan
PURPOSE: A prolonged seated time after intrathecal injection of hyperbaric bupivacaine and morphine is related to the incidence of hypotension during Cesarean delivery, but results in a high incidence of pain during peritoneal closure. We conducted this study to determine the effect of the addition of intrathecal fentanyl on the relationship between seated time and hypotension and intraoperative analgesia requirements. METHODS: Women undergoing Cesarean delivery were randomized to receive an intrathecal injection of either 11...
October 2017: Canadian Journal of Anaesthesia
https://read.qxmd.com/read/30373647/ascorbic-acid-corticosteroids-and-thiamine-in-sepsis-a-review-of-the-biologic-rationale-and-the-present-state-of-clinical-evaluation
#3
REVIEW
Ari Moskowitz, Lars W Andersen, David T Huang, Katherine M Berg, Anne V Grossestreuer, Paul E Marik, Robert L Sherwin, Peter C Hou, Lance B Becker, Michael N Cocchi, Pratik Doshi, Jonathan Gong, Ayan Sen, Michael W Donnino
The combination of thiamine, ascorbic acid, and hydrocortisone has recently emerged as a potential adjunctive therapy to antibiotics, infectious source control, and supportive care for patients with sepsis and septic shock. In the present manuscript, we provide a comprehensive review of the pathophysiologic basis and supporting research for each element of the thiamine, ascorbic acid, and hydrocortisone drug combination in sepsis. In addition, we describe potential areas of synergy between these therapies and discuss the strengths/weaknesses of the two studies to date which have evaluated the drug combination in patients with severe infection...
October 29, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/30367689/the-effect-of-dexmedetomidine-on-delirium-and-agitation-in-patients-in-intensive-care-systematic-review-and-meta-analysis-with-trial-sequential-analysis
#4
JOURNAL ARTICLE
K T Ng, C J Shubash, J S Chong
Delirium is common in intensive care patients. Dexmedetomidine is increasingly used for sedation in this setting, but its effect on delirium remains unclear. The primary aim of this review was to examine whether dexmedetomidine reduces the incidence of delirium and agitation in intensive care patients. We sought randomised clinical trials in MEDLINE, EMBASE, PubMed and CENTRAL from their inception until June 2018. Observational studies, case reports, case series and non-systematic reviews were excluded. Twenty-five trials including 3240 patients were eligible for inclusion in the data synthesis...
March 2019: Anaesthesia
https://read.qxmd.com/read/30246357/intraoperative-s-ketamine-for-the-reduction-of-opioid-consumption-and-pain-one-year-after-spine-surgery-a-randomized-clinical-trial-of-opioid-dependent-patients
#5
RANDOMIZED CONTROLLED TRIAL
Rikke Vibeke Nielsen, Jonna Storm Fomsgaard, Lone Nikolajsen, Jørgen Berg Dahl, Ole Mathiesen
BACKGROUND: We aimed to explore the effect of intraoperative S-ketamine on analgesic consumption and pain one year after spine surgery in chronic opioid-dependent patients undergoing spinal fusion surgery. METHODS: Single-centre, randomized, blinded trial of 147 patients. INTERVENTION: Perioperative S-ketamine bolus 0.5 mg/kg followed by S-ketamine 0.25 mg kg-1  hr-1 infusion or placebo. MAIN OUTCOMES: Analgesic use, pain (visual analogue scale 0-100 mm [VAS]) and labour market attachment one year after surgery assessed by written questionnaires...
March 2019: European Journal of Pain: EJP
https://read.qxmd.com/read/30169405/addition-of-neostigmine-and-atropine-to-conventional-management-of-postdural-puncture-headache-a-randomized-controlled-trial
#6
RANDOMIZED CONTROLLED TRIAL
Ahmed Abdelaal Ahmed Mahmoud, Amr Zaki Mansour, Hany Mahmoud Yassin, Hazem Abdelwahab Hussein, Ahmed Moustafa Kamal, Mohamed Elayashy, Mohamed Farid Elemady, Hany W Elkady, Hatem Elmoutaz Mahmoud, Barbara Cusack, Hisham Hosny, Mohamed Abdelhaq
BACKGROUND: Postdural puncture headache (PDPH) lacks a standard evidence-based treatment. A patient treated with neostigmine for severe PDPH prompted this study. METHODS: This randomized, controlled, double-blind study compared neostigmine and atropine (n = 41) versus a saline placebo (n = 44) for treating PDPH in addition to conservative management of 85 patients with hydration and analgesics. The primary outcome was a visual analog scale score of ≤3 at 6, 12, 24, 36, 48, and 72 hours after intervention...
December 2018: Anesthesia and Analgesia
https://read.qxmd.com/read/27465522/current-evidence-is-not-in-support-of-lipid-rescue-therapy-in-local-anaesthetic-systemic-toxicity
#7
EDITORIAL
P H Rosenberg
No abstract text is available yet for this article.
September 2016: Acta Anaesthesiologica Scandinavica
https://read.qxmd.com/read/28639236/the-effects-of-intranasal-dexmedetomidine-premedication-in-children-a-systematic-review-and-meta-analysis
#8
REVIEW
Jong Hun Jun, Kyu Nam Kim, Ji Yoon Kim, Shin Me Song
PURPOSE: Intranasal dexmedetomidine premedication is a newly introduced method for reducing stress and anxiety before general anesthesia in children. We performed a meta-analysis to identify the effects of intranasal dexmedetomidine premedication in children. SOURCE: We conducted a systematic review to find published randomized-controlled trials using intranasal dexmedetomidine as premedication. We searched databases in EMBASE™, MEDLINE®, and the Cochrane Controlled Trials Register using the Ovid platform...
September 2017: Canadian Journal of Anaesthesia
https://read.qxmd.com/read/29167102/coffee-consumption-and-health-umbrella-review-of-meta-analyses-of-multiple-health-outcomes
#9
REVIEW
Robin Poole, Oliver J Kennedy, Paul Roderick, Jonathan A Fallowfield, Peter C Hayes, Julie Parkes
Objectives  To evaluate the existing evidence for associations between coffee consumption and multiple health outcomes. Design  Umbrella review of the evidence across meta-analyses of observational and interventional studies of coffee consumption and any health outcome. Data sources  PubMed, Embase, CINAHL, Cochrane Database of Systematic Reviews, and screening of references. Eligibility criteria for selecting studies  Meta-analyses of both observational and interventional studies that examined the associations between coffee consumption and any health outcome in any adult population in all countries and all settings...
November 22, 2017: BMJ: British Medical Journal
https://read.qxmd.com/read/28953501/neostigmine-administration-after-spontaneous-recovery-to-a-train-of-four-ratio-of-0-9-to-1-0-a-randomized-controlled-trial-of-the-effect-on-neuromuscular-and-clinical-recovery
#10
RANDOMIZED CONTROLLED TRIAL
Glenn S Murphy, Joseph W Szokol, Michael J Avram, Steven B Greenberg, Torin D Shear, Mark A Deshur, Jessica Benson, Rebecca L Newmark, Colleen E Maher
BACKGROUND: When a muscle relaxant is administered to facilitate intubation, the benefits of anticholinesterase reversal must be balanced with potential risks. The aim of this double-blinded, randomized noninferiority trial was to evaluate the effect of neostigmine administration on neuromuscular function when given to patients after spontaneous recovery to a train-of-four ratio of 0.9 or greater. METHODS: A total of 120 patients presenting for surgery requiring intubation were given a small dose of rocuronium...
January 2018: Anesthesiology
https://read.qxmd.com/read/26332857/dexmedetomidine-as-a-rapid-bolus-for-treatment-and-prophylactic-prevention-of-emergence-agitation-in-anesthetized-children
#11
RANDOMIZED CONTROLLED TRIAL
John A Hauber, Peter J Davis, Laima P Bendel, Slava V Martyn, Denise L McCarthy, Minh-Chau Evans, Franklyn P Cladis, Sarah Cunningham, Robert Scott Lang, Neal F Campbell, Jay B Tuchman, Michael C Young
BACKGROUND: Administration of dexmedetomidine (DEX) in the pediatric population for its sedative, analgesic, and anxiolytic properties has been widely reported, despite there being no label indication approved by the U.S. Food and Drug Administration for pediatric patients. Infusions of DEX, rather than bolus administration, are recommended to attenuate the hemodynamic response caused by the α2-adrenoreceptor agonist. In this prospective, double-blind, randomized study, we examined the effect of rapid IV bolus injection of DEX on emergence agitation and the hemodynamic response in a large sample of children undergoing tonsillectomy with or without adenoidectomy, with or without myringotomy, and/or tympanostomy tube insertion...
November 2015: Anesthesia and Analgesia
https://read.qxmd.com/read/27918778/efficacy-of-oral-risperidone-haloperidol-or-placebo-for-symptoms-of-delirium-among-patients-in-palliative-care-a-randomized-clinical-trial
#12
RANDOMIZED CONTROLLED TRIAL
Meera R Agar, Peter G Lawlor, Stephen Quinn, Brian Draper, Gideon A Caplan, Debra Rowett, Christine Sanderson, Janet Hardy, Brian Le, Simon Eckermann, Nicola McCaffrey, Linda Devilee, Belinda Fazekas, Mark Hill, David C Currow
IMPORTANCE: Antipsychotics are widely used for distressing symptoms of delirium, but efficacy has not been established in placebo-controlled trials in palliative care. OBJECTIVE: To determine efficacy of risperidone or haloperidol relative to placebo in relieving target symptoms of delirium associated with distress among patients receiving palliative care. DESIGN, SETTING, AND PARTICIPANTS: A double-blind, parallel-arm, dose-titrated randomized clinical trial was conducted at 11 Australian inpatient hospice or hospital palliative care services between August 13, 2008, and April 2, 2014, among participants with life-limiting illness, delirium, and a delirium symptoms score (sum of Nursing Delirium Screening Scale behavioral, communication, and perceptual items) of 1 or more...
January 1, 2017: JAMA Internal Medicine
https://read.qxmd.com/read/26936022/a-comparison-of-intranasal-dexmedetomidine-for-sedation-in-children-administered-either-by-atomiser-or-by-drops
#13
COMPARATIVE STUDY
B L Li, N Zhang, J X Huang, Q Q Qiu, H Tian, J Ni, X R Song, V M Yuen, M G Irwin
Intranasal dexmedetomidine has been used successfully for sedation in children. A mucosal atomisation device delivers an atomised solution to the nasal mucosa which facilitates rapid and effective delivery of medication to the systemic circulation. We compared intranasal delivery of dexmedetomidine in a dose of 3 μg.kg(-1) by either atomiser or drops from a syringe in children < 3 years old undergoing transthoracic echocardiography. Two hundred and seventy-nine children were randomly assigned to one or other group...
May 2016: Anaesthesia
https://read.qxmd.com/read/27780181/benefit-and-harm-of-adding-ketamine-to-an-opioid-in-a-patient-controlled-analgesia-device-for-the-control-of-postoperative-pain-systematic-review-and-meta-analyses-of-randomized-controlled-trials-with-trial-sequential-analyses
#14
REVIEW
Benjamin Assouline, Martin R Tramèr, Lukas Kreienbühl, Nadia Elia
Ketamine is often added to opioids in patient-controlled analgesia devices. We tested whether in surgical patients, ketamine added to an opioid patient-controlled analgesia decreased pain intensity by ≥25%, cumulative opioid consumption by ≥30%, the risk of postoperative nausea and vomiting by ≥30%, the risk of respiratory adverse effects by ≥50%, and increased the risk of hallucination not more than 2-fold. In addition, we searched for evidence of dose-responsiveness. Nineteen randomized trials (1349 adults, 104 children) testing different ketamine regimens added to various opioids were identified through searches in databases and bibliographies (to 04...
December 2016: Pain
https://read.qxmd.com/read/23506796/strategies-for-prevention-of-postoperative-delirium-a-systematic-review-and-meta-analysis-of-randomized-trials
#15
REVIEW
Hao Zhang, Yan Lu, Meng Liu, Zui Zou, Long Wang, Feng-Ying Xu, Xue-Yin Shi
INTRODUCTION: The ideal measures to prevent postoperative delirium remain unestablished. We conducted this systematic review and meta-analysis to clarify the significance of potential interventions. METHODS: The PRISMA statement guidelines were followed. Two researchers searched MEDLINE, EMBASE, CINAHL and the Cochrane Library for articles published in English before August 2012. Additional sources included reference lists from reviews and related articles from 'Google Scholar'...
March 18, 2013: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/23329341/carbetocin-in-comparison-with-oxytocin-in-several-dosing-regimens-for-the-prevention-of-uterine-atony-after-elective-caesarean-section-in-the-netherlands
#16
COMPARATIVE STUDY
C A G Holleboom, J van Eyck, S V Koenen, I A M Kreuwel, F Bergwerff, E C Creutzberg, H W Bruinse
PURPOSE: The aim of the study was to compare the prophylactic effects of carbetocin with those of oxytocin for the prevention of uterine atony in patients undergoing elective caesarean section (CS) in the Netherlands. The primary endpoint was the need for additional uterotonic medication. METHODS: Each of the five participating Dutch hospitals treated 50-100 term patients with 100 μg of intravenous carbetocin on prescription. Each centre retrieved charts of 250 patients treated with oxytocin according to the hospital's policy for the prevention of uterine atony (oxytocin bolus 5 IU, bolus 10 IU or bolus 5 IU followed by 10 IU in 2 h)...
June 2013: Archives of Gynecology and Obstetrics
https://read.qxmd.com/read/12100762/effects-of-norepinephrine-epinephrine-and-norepinephrine-dobutamine-on-systemic-and-gastric-mucosal-oxygenation-in-septic-shock
#17
RANDOMIZED CONTROLLED TRIAL
Shao-Xia Zhou, Hai-Bo Qiu, Ying-Zi Huang, Yi Yang, Rui-Qiang Zheng
AIM: To compare the effects of dopamine, norepinephrine, epinephrine, and the combination of norepinephrine and dobutamine on systemic and gastric mucosal oxygen metabolism in patients with septic shock. METHODS: Sixteen patients with septic shock were enrolled in the present study. Each patient received dopamine firstly, then in a random succession epinephrine, norepinephrine, or norepinephrine-dobutamine, a mean systemic arterial pressure adjusted to >9.31 kPa...
July 2002: Acta Pharmacologica Sinica
https://read.qxmd.com/read/25851818/impact-of-early-haemodynamic-goal-directed-therapy-in-patients-undergoing-emergency-surgery-an-open-prospective-randomised-trial
#18
RANDOMIZED CONTROLLED TRIAL
Gordana Pavlovic, John Diaper, Christoph Ellenberger, Angela Frei, Karim Bendjelid, Fanny Bonhomme, Marc Licker
Haemodynamic goal-directed therapies (GDT) may improve outcome following elective major surgery. So far, few data exist regarding haemodynamic optimization during emergency surgery. In this randomized, controlled trial, 50 surgical patients with hypovolemic or septic conditions were enrolled and we compared two algorithms of GDTs based either on conventional parameters and pressure pulse variation (control group) or on cardiac index, global end-diastolic volume index and stroke volume variation as derived from the PiCCO monitoring system (optimized group)...
February 2016: Journal of Clinical Monitoring and Computing
https://read.qxmd.com/read/27542303/dexmedetomidine-for-prevention-of-delirium-in-elderly-patients-after-non-cardiac-surgery-a-randomised-double-blind-placebo-controlled-trial
#19
RANDOMIZED CONTROLLED TRIAL
Xian Su, Zhao-Ting Meng, Xin-Hai Wu, Fan Cui, Hong-Liang Li, Dong-Xin Wang, Xi Zhu, Sai-Nan Zhu, Mervyn Maze, Daqing Ma
BACKGROUND: Delirium is a postoperative complication that occurs frequently in patients older than 65 years, and presages adverse outcomes. We investigated whether prophylactic low-dose dexmedetomidine, a highly selective α2 adrenoceptor agonist, could safely decrease the incidence of delirium in elderly patients after non-cardiac surgery. METHODS: We did this randomised, double-blind, placebo-controlled trial in two tertiary-care hospitals in Beijing, China...
October 15, 2016: Lancet
https://read.qxmd.com/read/24237879/intranasal-dexmedetomidine-vs-midazolam-for-premedication-in-children-undergoing-complete-dental-rehabilitation-a-double-blinded-randomized-controlled-trial
#20
RANDOMIZED CONTROLLED TRIAL
Saad A Sheta, Maha A Al-Sarheed, Ashraf A Abdelhalim
BACKGROUND: This prospective, randomized, double-blind study was designed to evaluate the use of intranasally administered dexmedetomidine vs intranasal midazolam as a premedication in children undergoing complete dental rehabilitation. METHODS: Seventy-two children of American Society of Anesthesiology classification (ASA) physical status (I & II), aged 3-6 years, were randomly assigned to one of two equal groups. Group M received intranasal midazolam (0.2 mg·kg(-1)), and group D received intranasal dexmedetomidine (1 μg·kg(-1))...
February 2014: Paediatric Anaesthesia
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